Supplement 2: Additional Clinical, Immune and Inflammatory Marker S Information

Patient / Hepatitis* / IL-12 (pg/ml) / IFN-γ (pg/ml) / IL-4 (pg/ml) / IL-5 (pg/ml) / IL-10 (pg/ml) / IL-13 (pg/ml) / IL-1β (pg/ml) / IL-6 (pg/ml) / IL-8 (pg/ml) / TNF-α (pg/ml) / IL-2 (pg/ml) / CRP (mg/dl) / Absolute T-cell count/mm3 / Absolute B-cell count/mm3 / Absolute NK-cell count/mm3

Supplement 2: Additional clinical, immune and inflammatory marker’s information

Patient / Hepatitis* / IL-12 (pg/ml) / IFN-γ (pg/ml) / IL-4 (pg/ml) / IL-5 (pg/ml) / IL-10 (pg/ml) / IL-13 (pg/ml) / IL-1β (pg/ml) / IL-6 (pg/ml) / IL-8 (pg/ml) / TNF-α (pg/ml) / IL-2 (pg/ml) / CRP (mg/dl) / Absolute T-cell count/mm3 / Absolute B-cell count/mm3 / Absolute NK-cell count/mm3
P1 / yes / - / - / - / - / - / - / - / - / - / - / - / 9.4 / low / low / Low
P2 / no / <5 / <5 / <5 / <5 / 17 / <5 / <5 / <5 / 8 / <5 / <5 / 4.3 / low / normal / normal
P3 / yes / <5 / <5 / <5 / <5 / 10 / <5 / <5 / 1369 / <5 / 8 / 9 / 29.6 / normal / low / normal
P4 / yes / 21 / 47 / 12 / <5 / 134 / 17 / 7 / 166 / <5 / 25 / 31 / 17.8 / high / - / -
P5 / yes / 5 / 24 / <5 / <5 / 8 / 42 / 6 / 17 / <5 / 47 / 7 / 2 / - / - / -
P6 / no / 8 / 44 / <5 / <5 / 945 / 8 / 7 / 53 / 7 / <5 / 9 / 9.3 / low / normal / normal
P7 / yes / <5 / 7 / <5 / <5 / 416 / 10 / <5 / 24 / 20 / <5 / 5 / 1.9 / - / - / -
P8 / yes / 63 / 365 / 297 / 63 / 2600 / 557 / 39 / 68 / 14 / 2923 / 229 / 3 / low / low / low
P9 / yes / <5 / 17 / <5 / <5 / 21 / <5 / <5 / 30 / 6 / 6 / <5 / 11.3* / - / - / -
P10 / yes / <5 / <5 / <5 / <5 / 81 / 10 / <5 / 315 / 98 / 38 / <5 / 26.5 / normal / normal / normal
P11 / yes / 8 / 5 / <5 / 20 / 12 / 9 / <5 / 193 / <5 / 21 / 28 / 28.4 / normal / normal / normal
P12 / yes / <5 / <5 / <5 / <5 / 8390 / <5 / <5 / <5 / 163 / <5 / <5 / 5.9 / - / - / -
P13 / yes / 13 / 25 / 5 / <5 / 14 / 26 / 15 / 51 / < 5 / 113 / 11 / 14.3 / - / - / -
P14 / yes / <5 / 13 / <5 / <5 / 32 / 7 / <5 / 10 / <5 / 14 / <5 / 4.2 / normal / normal / normal
P15 / yes / <5 / <5 / <5 / <5 / 13 / <5 / <5 / <5 / <5 / <5 / <5 / 6.7 / - / - / -
P16 / yes / <5 / 13 / <5 / <5 / 87 / 6 / <5 / 22 / 19 / 5 / <5 / 2.4 / low / low / low
P17 / yes / <5 / 5 / <5 / <5 / 1860 / 5 / <5 / 20 / 73 / 6 / <5 / 4.2 / - / - / -
P18 / yes / <5 / 9 / <5 / <5 / 7 / <5 / <5 / 6 / <5 / <5 / <5 / 1.8 / - / - / -
P19 / yes / - / - / - / - / - / - / - / - / - / - / - / 8.3 / low / low / low

* Hepatitis: Elevated Aspartate Aminotransferase (AST) (Reference range: 0-32U/L) and/or elevated Alanine Aminotransferase (ALT) (Reference range: 0-33U/L)

IL-12 Reference range: 0-6 pg/mL

IFN-γ Reference range: 0-5 pg/mL

IL-4 Reference range: 0-5 pg/mL

IL-4 Reference range: 0-5 pg/mL

IL-5 Reference range: 0-5 pg/mL

IL-10 Reference range: 0-18 pg/mL

IL-13 Reference range: 0-5 pg/mL

IL-1β Reference range: 0-36 pg/mL

IL-6 Reference range: 0-5 pg/mL

IL-8 Reference range: 0-5 pg/mL

TNF-α Reference range: 0-22 pg/mL

IL-2 Reference range: 0-12 pg/mL

CRP Reference range: 5 mg/dL

Absolute T(CD3+) cell count Reference range: 569-2804/mm3

Absolute B(CD19+) cell count Reference range: 53-276/mm3

Absolute NK (CD16+/CD56+) cell count Reference range: 44-957/mm3