Sid Gilman MD FRCP

Page S2

Table (E)T-1. Clinical features in 13 patients with multiple system atrophy.

C = cerebellar disorders, A = autonomic failure, P = parkinsonian features.

The sequence of letters (CAP) indicates the systems affected in chronological order of onset.

Patient Number / 1 / 2 / 3 / 4 / 5 / 6 / 7 / 8 / 9 / 10 / 11 / 12 / 13
MSA
type / CAP / CA / CA / CA / CAP / CA / CAP / PA / CAP / CAP / CA / CAP / CA
Gender / Female / Male / Female / Male / Male / Female / Female / Male / Male / Male / Male / Male / Male
Age (Years) / 58 / 53 / 49 / 45 / 48 / 49 / 54 / 58 / 56 / 53 / 62 / 70 / 53
Symptom
Duration (Years) / 8 / 4 / 3 / 1 / 1 / 13 / 3 / 5 / 8 / 9 / 3 / 11 / 2
Bradykinesia / ++ / - / - / - / + / - / +++ / +++ / + / ++ / + / ++ / -
Rigidity / + / - / + / - / + / - / +++ / +++ / + / + / + / ++ / -
Parkinsonian
Gait / ++ / - / - / - / + / - / +++ / +++ / + / ++ / - / + / -
Parkinsonian
Tremor / + / - / - / - / - / - / - / - / - / - / - / + / -
Hypokinetic Speech / ++ / + / - / - / ++ / - / ++ / +++ / + / ++ / - / + / -
Ocular Dysmetria / ++ / - / + / + / ++ / + / +++ / - / + / +++ / - / +++ / ++
Gait Ataxia / ++ / + / ++ / ++ / +++ / ++ / +++ / - / +++ / +++ / ++ / +++ / ++
Limb Ataxia / + / + / ++ / ++ / ++ / + / + / - / ++ / +++ / ++ / ++ / +
Table (E)T-1. (continued) Clinical features in 13 patients with multiple system atrophy.
C = cerebellar disorders, A = autonomic failure, P = parkinsonian
features. The sequence of letters (CAP) indicates the systems affected in chronological order of onset.
Ataxic Speech / ++ / + / + / + / ++ / +++ / + / - / ++ / +++ / +++ / ++ / +
Patient Number / 1 / 2 / 3 / 4 / 5 / 6 / 7 / 8 / 9 / 10 / 11 / 12 / 13
Spastic speech / ++ / + / + / - / ++ / - / ++ / - / - / ++ / + / + / -
Plantar responses / Flexor / Flexor / Flexor / Flexor / Flexor / Extensor / Flexor / Flexor / Flexor / Flexor / Flexor / Flexor / Flexor
Orthostatic BP Decrease
Systolic/Diastolic / 14/2 / 32/10 / 10/5 / 15/0 / 30/2 / 35/12 / 65/45 / 30/15 / 30/10 / 40/20 / 13/7 / 40/10 / 20/10
Urinary Incontinence / ++ / + / + / ++ / ++ / + / +++ / +++ / ++ / +++ / +++ / +++ / +++

Scales: - = none, + = mild, ++ = moderate, +++ = marked. Orthostatic BP decrease indicates the mm (Hg) decrease of systolic and diastolic blood pressure

measured with the patient supine for 2 minutes and then standing for 2 minutes.

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