1Le Bon A, Thompson C, Kamphuis E, Durand V, Rossmann C, Kalinke U et al. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 2006; 176: 2074-8.

2Kolumam GA, Thomas S, Thompson LJ, Sprent J, Murali-Krishna K. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med 2005; 202: 637-50.

3Miro F, Nobile C, Blanchard N, Lind M, Filipe-Santos O, Fieschi C et al. T cell-dependent activation of dendritic cells requires IL-12 and IFN-gamma signaling in T cells. J Immunol 2006; 177: 3625-34.

4Tau GZ, Cowan SN, Weisburg J, Braunstein NS, Rothman PB. Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells. J Immunol 2001; 167: 5574-82.

5Pernis A, Gupta S, Gollob KJ, Garfein E, Coffman RL, Schindler C et al. Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. Science 1995; 269: 245-7.

6Bach EA, Szabo SJ, Dighe AS, Ashkenazi A, Aguet M, Murphy KM et al. Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets. Science 1995; 270: 1215-8.

7Ank N, Iversen MB, Bartholdy C, Staeheli P, Hartmann R, Jensen UB et al. An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol 2008; 180: 2474-85.

8Taga K, Cherney B, Tosato G. IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int Immunol 1993; 5: 1599-608.

9Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM et al. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol 2009; 183: 1569-76.

10Valente G, Ozmen L, Novelli F, Geuna M, Palestro G, Forni G et al. Distribution of interferon-gamma receptor in human tissues. Eur J Immunol 1992; 22: 2403-12.

11Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu DH et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A 1992; 89: 1890-3.

12Rubio N, Palomo M, Alcami A. Interferon-alpha/beta genes are up-regulated in murine brain astrocytes after infection with Theiler's murine encephalomyelitis virus. J Interferon Cytokine Res 2009; 30: 253-62.

13Brodie C. Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes. FEBS Lett 1996; 394: 117-20.

14Nguyen KB, Salazar-Mather TP, Dalod MY, Van Deusen JB, Wei XQ, Liew FY et al. Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection. J Immunol 2002; 169: 4279-87.

15Farrar MA, Schreiber RD. The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 1993; 11: 571-611.

16Rosenfeld CS, Han CS, Alexenko AP, Spencer TE, Roberts RM. Expression of interferon receptor subunits, IFNAR1 and IFNAR2, in the ovine uterus. Biol Reprod 2002; 67: 847-53.

17Sommereyns C, Paul S, Staeheli P, Michiels T. IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog 2008; 4: e1000017.

18Denning TL, Campbell NA, Song F, Garofalo RP, Klimpel GR, Reyes VE et al. Expression of IL-10 receptors on epithelial cells from the murine small and large intestine. Int Immunol 2000; 12: 133-9.

19da Silva AJ, Brickelmaier M, Majeau GR, Lukashin AV, Peyman J, Whitty A et al. Comparison of gene expression patterns induced by treatment of human umbilical vein endothelial cells with IFN-alpha 2b vs. IFN-beta 1a: understanding the functional relationship between distinct type I interferons that act through a common receptor. J Interferon Cytokine Res 2002; 22: 173-88.

20Imaizumi T, Kumagai M, Sasaki N, Kurotaki H, Mori F, Seki M et al. Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. J Leukoc Biol 2002; 72: 486-91.

21Scholzen T, Hartmeyer M, Fastrich M, Brzoska T, Becher E, Schwarz T et al. Ultraviolet light and interleukin-10 modulate expression of cytokines by transformed human dermal microvascular endothelial cells (HMEC-1). J Invest Dermatol 1998; 111: 50-6.

22Asselin-Paturel C, Boonstra A, Dalod M, Durand I, Yessaad N, Dezutter-Dambuyant C et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol 2001; 2: 1144-50.

23Fortsch D, Rollinghoff M, Stenger S. IL-10 converts human dendritic cells into macrophage-like cells with increased antibacterial activity against virulent Mycobacterium tuberculosis. J Immunol 2000; 165: 978-87.

24Dupont SA, Goelz S, Goyal J, Green M. Mechanisms for regulation of cellular responsiveness to human IFN-beta1a. J Interferon Cytokine Res 2002; 22: 491-501.

25Schroecksnadel K, Winkler C, Werner ER, Sarcletti M, Romani N, Ebner S et al. Interferon-gamma-mediated pathways and in vitro PBMC proliferation in HIV-infected patients. Biol Chem 2009; 390: 115-23.

26Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J 1997; 16: 5894-903.

27Vitale G, Caraglia M, van Koetsveld PM, Maroni P, Marra M, Colao A et al. Potential role of type I interferons in the treatment of pituitary adenomas. Rev Endocr Metab Disord 2009; 10: 125-33.

28van Koetsveld PM, Vitale G, de Herder WW, Feelders RA, van der Wansem K, Waaijers M et al. Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth. J Clin Endocrinol Metab 2006; 91: 4537-43.

29Takane H, Ohdo S, Yamada T, Koyanagi S, Yukawa E, Higuchi S. Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells. Life Sci 2001; 68: 1449-55.

30Bogdan C, Mattner J, Schleicher U. The role of type I interferons in non-viral infections. Immunol Rev 2004; 202: 33-48.

31Ding L, Shevach EM. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J Immunol 1992; 148: 3133-9.

32Huys L, Van Hauwermeiren F, Dejager L, Dejonckheere E, Lienenklaus S, Weiss S et al. Type I interferon drives tumor necrosis factor-induced lethal shock. J Exp Med 2009; 206: 1873-82.

33Doyle SE, Schreckhise H, Khuu-Duong K, Henderson K, Rosler R, Storey H et al. Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes. Hepatology 2006; 44: 896-906.

34Yerkovich ST, Rigby PJ, Fournier PA, Olynyk JK, Yeoh GC. Kupffer cell cytokines interleukin-1beta and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes. Int J Biochem Cell Biol 2004; 36: 1462-72.

35Negrotto S, De Giusti CJ, Lapponi MJ, Etulain J, Rivadeneyra L, Pozner RG et al. Expression and functionality of type I interferon receptor in the megakaryocytic lineage. J Thromb Haemost 2011; 9: 2477-85.

36Gimeno MJ, Pascual G, Garcia-Honduvilla N, Prieto A, Alvarez de Mon M, Bellon JM et al. Modulatory role of IL10 in endothelial cell damage and platelet adhesion. Histol Histopathol 2003; 18: 695-702.

37Zurney J, Howard KE, Sherry B. Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses. J Virol 2007; 81: 13668-80.

38Moroguchi A, Ishimura K, Okano K, Wakabayashi H, Maeba T, Maeta H. Interleukin-10 suppresses proliferation and remodeling of extracellular matrix of cultured human skin fibroblasts. Eur Surg Res 2004; 36: 39-44.

39Aldebert D, Lamkhioued B, Desaint C, Gounni AS, Goldman M, Capron A et al. Eosinophils express a functional receptor for interferon alpha: inhibitory role of interferon alpha on the release of mediators. Blood 1996; 87: 2354-60.

40Dajotoy T, Andersson P, Bjartell A, Lofdahl CG, Tapper H, Egesten A. Human eosinophils produce the T cell-attracting chemokines MIG and IP-10 upon stimulation with IFN-gamma. J Leukoc Biol 2004; 76: 685-91.

41Pekarek V, Srinivas S, Eskdale J, Gallagher G. Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. Genes Immun 2007; 8: 177-80.

42Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J et al. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 2008; 28: 675-86.

43Rivera A, Jarolim P, Brugnara C. Modulation of Gardos channel activity by cytokines in sickle erythrocytes. Blood 2002; 99: 357-603.

44Tohyama M, Dai X, Sayama K, Yamasaki K, Shirakata Y, Hanakawa Y et al. dsRNA-mediated innate immunity of epidermal keratinocytes. Biochem Biophys Res Commun 2005; 335: 505-11.

45Gueniche A, Viac J, Charveron M, Schmitt D. Effect of gamma-interferon on IL-1 alpha, beta and receptor antagonist production by normal human keratinocytes. Exp Dermatol 1994; 3: 113-8.

46Michel G, Mirmohammadsadegh A, Olasz E, Jarzebska-Deussen B, Muschen A, Kemeny L et al. Demonstration and functional analysis of IL-10 receptors in human epidermal cells: decreased expression in psoriatic skin, down-modulation by IL-8, and up-regulation by an antipsoriatic glucocorticosteroid in normal cultured keratinocytes. J Immunol 1997; 159: 6291-7.

47Truchet S, Wietzerbin J, Debey P. Mouse oocytes and preimplantation embryos bear the two sub-units of interferon-gamma receptor. Mol Reprod Dev 2001; 60: 319-30.

48Mordstein M, Neugebauer E, Ditt V, Jessen B, Rieger T, Falcone V et al. Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. J Virol 2010; 84: 5670-7.

49Donnelly RP, Sheikh F, Kotenko SV, Dickensheets H. The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. J Leukoc Biol 2004; 76: 314-21.

50Sheikh F, Baurin VV, Lewis-Antes A, Shah NK, Smirnov SV, Anantha S et al. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. J Immunol 2004; 172: 2006-10.

51Walter J, Honsek SD, Illes S, Wellen JM, Hartung HP, Rose CR et al. A new role for interferon gamma in neural stem/precursor cell dysregulation. Mol Neurodegener 2011; 6: 18.

52Zhai Y, Qiao B, Gao F, Shen X, Vardanian A, Busuttil RW et al. Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion. Hepatology 2008; 47: 199-206.

53Meissner NN, Swain S, Tighe M, Harmsen A. Role of type I IFNs in pulmonary complications of Pneumocystis murina infection. J Immunol 2005; 174: 5462-71.

54Chowdhury SR, King DE, Willing BP, Band MR, Beever JE, Lane AB et al. Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets. BMC Genomics 2007; 8: 215.

55Ragimbeau J, Dondi E, Alcover A, Eid P, Uze G, Pellegrini S. The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression. Embo J 2003; 22: 537-47.

56Piganis RA, de Weerd NA, Gould JA, Schindler CW, Mansell A, Nicholson SE et al. Suppressor of cytokine signaling (SOCS)1 inhibits type I interferon (IFN) signaling via the IFNAR1 associated tyrosine kinase, Tyk2. J Biol Chem 2011; 286: 33811-8.

57Kumar KG, Krolewski JJ, Fuchs SY. Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. J Biol Chem 2004; 279: 46614-20.

58Kumar KG, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs SY. SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J 2003; 22: 5480-90.

59Marijanovic Z, Ragimbeau J, van der Heyden J, Uze G, Pellegrini S. Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2. Biochem J 2007; 407: 141-51.

60Severa M, Remoli ME, Giacomini E, Ragimbeau J, Lande R, Uze G et al. Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression. J Leukoc Biol 2006; 79: 1286-94.

61Bhattacharya S, Zheng H, Tzimas C, Carroll M, Baker DP, Fuchs SY. Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNalpha via accelerating the degradation of its receptor. Blood 2011; 118: 4179-87.

62Bhattacharya S, Qian J, Tzimas C, Baker DP, Koumenis C, Diehl JA et al. Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor. J Biol Chem 2011; 286: 22069-76.

63Zheng H, Qian J, Varghese B, Baker DP, Fuchs S. Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2. Mol Cell Biol 2011; 31: 710-20.

64Skrenta H, Yang Y, Pestka S, Fathman CG. Ligand-independent down-regulation of IFN-gamma receptor 1 following TCR engagement. J Immunol 2000; 164: 3506-11.

65Claudinon J, Monier MN, Lamaze C. Interfering with interferon receptor sorting and trafficking: impact on signaling. Biochimie 2007; 89: 735-43.

66Curry H, Alvarez GR, Zwilling BS, Lafuse WP. Toll-like receptor 2 stimulation decreases IFN-gamma receptor expression in mouse RAW264.7 macrophages. J Interferon Cytokine Res 2004; 24: 699-710.

67Ray M, Gam AA, Boykins RA, Kenney RT. Inhibition of interferon-gamma signaling by Leishmania donovani. J Infect Dis 2000; 181: 1121-8.

68Kierszenbaum F, Mejia Lopez H, Tanner MK, Sztein MB. Trypanosoma cruzi-induced decrease in the level of interferon-gamma receptor expression by resting and activated human blood lymphocytes. Parasite Immunol 1995; 17: 207-14.

69Rayamajhi M, Humann J, Kearney S, Hill KK, Lenz LL. Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infections. Virulence 2010; 1: 418-22.

70Rayamajhi M, Humann J, Penheiter K, Andreasen K, Lenz LL. Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma. J Exp Med 2010; 207: 327-37.

71Liu BS, Janssen HL, Boonstra A. IL-29 and IFNalpha differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNgamma receptor expression. Blood 2011; 117: 2385-95.