Table S4: Spearman´s Rho correlation analysis of chemokine expression (CCL2, CCL8, CCL12), chemokine receptor expression (CCR2), pathology and serum cytokines (TNFα, IFNγ)

GI Tract / Serum IFNγ / Serum TNF / CCR2 / Pathology
r2 / p value / r2 / p value / r2 / p value / r2 / p value
Week 1 / CCL2 / 0.594 / 0.015 / 0.865 / <0.001** / 0.425 / 0.114 / 0.349 / 0.203
CCL8 / 0.632 / 0.009** / 0.794 / <0.001** / 0.236 / 0.398 / 0.270 / 0.330
CCL12 / -0.088 / 0.745 / 0.244 / 0.362 / 0.225 / 0.420 / -0.283 / 0.307
CCR2 / --- / --- / --- / --- / --- / --- / 0.374 / 0.188
Week 2 / CCL2 / 0.550 / 0.027* / 0.529 / 0.035* / -0.107 / 0.704 / 0.885 / 0.002**
CCL8 / 0.402 / 0.137 / 0.714 / 0.003** / -0.266 / 0.358 / 0.868 / 0.005**
CCL12 / 0.283 / 0.289 / 0.588 / 0.017* / 0.114 / 0.685 / 0.570 / 0.109
CCR2 / --- / --- / --- / --- / --- / --- / 0.034 / 0.931
Week 3 / CCL2 / -0.041 / 0.865 / 0.789 / <0.001** / 0.207 / 0.409 / 0.548 / 0.012*
CCL8 / -0.219 / 0.383 / 0.686 / 0.002 / 0.050 / 0.854 / 0.391 / 0.109
CCL12 / 0.153 / 0.520 / 0.338 / 0.145 / 0.236 / 0.345 / 0.293 / 0.210
CCR2 / --- / --- / --- / --- / --- / --- / 0.118 / 0.641
Week 6 / CCL2 / 0.233 / 0.323 / 0.050 / 0.835 / 0.783 / <0.001** / 0.534 / 0.022*
CCL8 / 0.123 / 0.605 / 0.189 / 0.424 / 0.857 / <0.001** / 0.545 / 0.019*
CCL12 / 0.209 / 0.376 / -0.036 / 0.880 / 0.761 / <0.001** / 0.280 / 0.261
CCR2 / --- / --- / --- / --- / --- / --- / 0.326 / 0.186
Lung / Serum IFNγ / Serum TNF / CCR2 / Pathology
r2 / p value / r2 / p value / r2 / p value / r2 / p value
Week 1 / CCL2 / 0.768 / 0.001** / 0.835 / <0.001** / 0.247 / 0.356 / 0.327 / 0.253
CCL8 / 0.650 / 0.006** / 0.791 / <0.001** / 0.365 / 0.165 / 0.255 / 0.379
CCL12 / 0.718 / 0.003** / 0.661 / 0.007** / 0.221 / 0.428 / 0.180 / 0.557
CCR2 / --- / --- / --- / --- / --- / --- / 0.008 / 0.979
Week 2 / CCL2 / 0.747 / <0.001** / 0.258 / 0.301 / 0.465 / 0.052 / 0.633 / 0.067
CCL8 / 0.578 / 0.012* / 0.728 / 0.001** / 0.185 / 0.463 / 0.735 / 0.024*
CCL12 / 0.700 / 0.001** / 0.425 / 0.078 / 0.480 / 0.044* / 0.675 / 0.046*
CCR2 / --- / --- / --- / --- / --- / --- / 0.496 / 0.175
Week 3 / CCL2 / 0.160 / 0.500 / 0.185 / 0.435 / 0.169 / 0.563 / 0.173 / 0.464
CCL8 / 0.469 / 0.037* / 0.571 / 0.008** / 0.666 / 0.009** / 0.471 / 0.036*
CCL12 / 0.502 / 0.056 / 0.404 / 0.136 / 0.576 / 0.082 / 0.432 / 0.108
CCR2 / --- / --- / --- / --- / --- / --- / 0.784 / 0.001**
Week 6 / CCL2 / -0.624 / 0.003** / 0.602 / 0.005** / 0.394 / 0.086 / 0.110 / 0.653
CCL8 / -0.301 / 0.198 / 0.880 / <0.001** / 0.429 / 0.059 / 0.556 / 0.013*
CCL12 / -0.253 / 0.311 / 0.785 / <0.001** / 0.554 / 0.017* / 0.637 / 0.004**
CCR2 / --- / --- / --- / --- / --- / --- / 0.434 / 0.064
Liver / Serum IFNγ / Serum TNF / CCR2 / Pathology
r2 / p value / r2 / p value / r2 / p value / r2 / p value
Week 1 / CCL2 / 0.635 / 0.008** / 0.676 / 0.004** / 0.471 / 0.076 / 0.172 / 0.541
CCL8 / 0.729 / 0.001** / 0.715 / 0.002** / 0.514 / 0.050* / 0.166 / 0.554
CCL12 / 0.762 / 0.001** / 0.538 / 0.031* / 0.582 / 0.023* / 0.329 / 0.231
CCR2 / --- / --- / --- / --- / --- / --- / 0.414 / 0.141
Week 2 / CCL2 / 0.445 / 0.073 / 0.712 / 0.001** / 0.801 / <0.001** / 0.481 / 0.190
CCL8 / 0.414 / 0.111 / 0.861 / <0.001** / 0.756 / 0.001** / 0.439 / 0.237
CCL12 / 0.591 / 0.012* / 0.758 / <0.001** / 0.946 / <0.001** / 0.515 / 0.156
CCR2 / --- / --- / --- / --- / --- / --- / 0.515 / 0.156
Week 3 / CCL2 / 0.381 / 0.097 / 0.662 / 0.001** / 0.818 / <0.001** / 0.756 / <0.001*
CCL8 / -0.004 / 0.986 / 0.728 / <0.001** / 0.815 / <0.001** / 0.878 / <0.001**
CCL12 / 0.517 / 0.023* / 0.658 / 0.002** / 0.780 / 0.001** / 0.694 / 0.001**
CCR2 / --- / --- / --- / --- / --- / --- / 0.730 / 0.002**
Week 6 / CCL2 / -0.621 / 0.003** / 0.629 / 0.003** / 0.626 / 0.004** / 0.670 / 0.002**
CCL8 / -0.614 / 0.004** / 0.662 / 0.001** / 0.444 / 0.057 / 0.597 / 0.007**
CCL12 / -0.420 / 0.066 / 0.609 / 0.004** / 0.604 / 0.006** / 0.719 / 0.001**
CCR2 / --- / --- / --- / --- / --- / --- / 0.391 / 0.109
Skin/Tongue / Serum IFNγ / Serum TNF / CCR2 / Pathology
r2 / p value / r2 / p value / r2 / p value / r2 / p value
Week 1 / CCL2 / 0.762 / 0.001** / 0.606 / 0.013* / 0.447 / 0.083 / 0.855 / <0.001**
CCL8 / 0.810 / 0.015* / 0.690 / 0.058 / 0.833 / 0.010* / 0.815 / 0.025*
CCL12 / 0.441 / 0.087 / 0.047 / 0.863 / 0.888 / <0.001** / 0.508 / 0.076
CCR2 / --- / --- / --- / --- / --- / --- / 0.508 / 0.076
Week 2 / CCL2 / 0.663 / 0.004** / 0.630 / 0.007** / 0.644 / 0.007** / 0.354 / 0.349
CCL8 / 0.617 / 0.006** / 0.147 / 0.562 / 0.003 / 0.991 / 0.565 / 0.113
CCL12 / 0.608 / 0.007** / 0.103 / 0.683 / 0.076 / 0.778 / 0.540 / 0.133
CCR2 / --- / --- / --- / --- / --- / --- / 0.557 / 0.119
Week 3 / CCL2 / 0.525 / 0.017* / 0.705 / 0.001** / 0.692 / 0.001** / 0.759 / <0.001**
CCL8 / 0.020 / 0.932 / 0.812 / <0.001** / 0.844 / <0.001** / 0.363 / 0.116
CCL12 / 0.747 / <0.001** / 0.392 / 0.087 / 0.537 / 0.015* / 0.837 / <0.001**
CCR2 / --- / --- / --- / --- / --- / --- / 0.570 / 0.009**
Week 6 / CCL2 / 0.811 / <0.001** / -0.454 / 0.051 / 0.779 / <0.001** / 0.071 / 0.772
CCL8 / 0.857 / <0.001** / -0.392 / 0.087 / 0.695 / 0.001** / 0.047 / 0.845
CCL12 / 0.846 / <0.001** / 0.136 / 0.630 / 0.851 / <0.001** / 0.532 / 0.041*
CCR2 / --- / --- / --- / --- / --- / --- / 0.153 / 0.543