Supplementary Data 1: Reviews of the Reported Studies of the Inner Ear Lesions in Children

Supplementary Data 1: Previous studies of inner ear lesions in children born with congenital cytomegalovirus infection or postnatally acquired cytomegalovirus infection

Author / Age-
Disease / Side/
Child / Cochlea / Organ of Corti / Spiral ganglion / Stria vascularis / Saccule / Utricule / Semicircular canals / Endolymphatic
sac
Myers and Stool (68) / 3 w
CID / Bilateral / Hydrops: Apical
Scala media
IBC: RM / No IBC / No IBC / IBC: marginal cells, cystic / Hydrops / Hydrops / Membrane distension
IBC: NS
Davis (69) / 6 w
CID / Bilateral / IBC: RM / No IBC / No IBC / IBC
Microcyst / IBC: Ep
Davis (77) / Premature
CID
Death at 3 w / Bilateral / RM Collapse / IBC: NS, NN / No IBC / IBC: NS, NN / IBC: NS, NN / IBC: NS, NN
Stagno (77) / 3children
CID / N°1 / N / N / N / N / N / N / N
N°2 & 3 / IBC: RM
Inflammation: mild / IBC: NS / IBC: neurons / IBC / Edema
Inflammation / Edema and inflammation / Edema
Inflammation
Davis (81) / 1 m
CID / Bilateral / Autolysis
IBC in basal turn of spiral ligt and RM / Autolysis
OHC present / No IBC / N / Abnorotoconia
Macular collapse
IBC: macula / Abnorotoconia, Decreased neural density
IBC / Hair cell loss
Strauss (85) / 27 PW
CID hypotrophic / Bilateral / N / N / N / N / N / N / N
Davis (87) / 5 m
CID
ABR: N / Bilateral / N / N / N / N / N / N
Rarey (93) / LBW
Mental retardation
Microcephaly
Death at 14 y / Bilateral / Basal hydrops, collapse of RM, extracellular calcification / Absence of sensory and nonsensory cells / Ganglion cell loss / Strial atrophy / Hydrops; neurosensory degeneration
Calcifications / Calcification
Bachor E (00) / 3 y
Leukemia
CMV Septicemia / Left / IBC: RM / Round cell infiltration
Loss of nerve cells (1/3) / IBC / IBC: saccular membrane / IBC: NS of crista
Right / Autolysis IHC and OHC loss / 80% cell loss basal turn
Congestion Inflammation / Moderate dilation / IBC in dark cells of crux commune / IBC in dense cells of NS / Dark cells: aqueduct and
sac

ABR, auditory brain response; CID, cytomegalic inclusion disease; Ep, epithelium; IBC, cytomegalic cells with inclusion bodies; IHC, inner hair cells; ligt, ligament; m, month(s); N, normal; NN, nonneuronal cells; NS, nonsensory epithelium; OHC, outer hair cells; PW, postconceptional weeks; RM, Reissner’s membrane; y, years; w, week(s).