European Journal
of Clinical Pharmacology
Volume 64 ■ Number 5 • May 2008
CLINICAL TRIAL
Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil
D.-H. Choi ■ W.-G. Shin ■ J.-S. Choi 445
SPECIAL ARTICLE
A nurse-led intervention for identification of drug-related problems
M, Bergqvist ■ J. Ulfvarson ■ E. Andersen Karlsson ■ C von Bahr 451
PHARMACODYNAMICS
The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects
J.M. Kovarik ■ M. Lu ■ G.-J. Riviere ■ I. Barbet ■ S. Maton ■ D.R. Goldwater ■ R.L. Schmouder 457
PHARMACOGENETICS
The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements
A. Gaedigk ■ C. Coetsee 465
Further evidence for the association between 5-HT2C receptor gene polymorphisms and extra pyramid a I side effects in male schizophrenic patients
A. Gunes ■ M.-L Dahl ■ E. Spina ■ M.G. Scordo 477
Serum concentrations of venlafaxine and its metabolites O-desmethylvenlafaxine and W-des methyl venlafaxine in heterozygous carriers of the CYP2D6*3, *4 or *5 allele
M. Hermann • M. Hendset ■ K. Fosaas ■ M. Hjerpset ■ H. Refsum 483
Estimation of the area under the concentration-time curve of racemic lansoprazole by using limited plasma concentration of lansoprazole enantiomers
T. Niioka -M. Miura -T. Uno ■ N. Yasui-Furukori ■ M. Hayakari T.Tateishi • T.Suzuki 503
Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo
MJ. Karjaiainen ■ PJ. Neuvonen ■ J.T. Backman 511
Modelling ocular pharmacokinetics of fluorescein administered as lyophilisate or conventional eye drops
K. Abduljalil ■ M. Diestelhorst ■ 0. Doroshyenko ■ A. Lux ■ A. Steinfeld • S. Dinslage ■ R. Suverkrup ■ U. Fuhr 521
PHARMACOEPIDEMIOLOGY AND PRESCRIPTION
The association between antidepressant use and disturbances in glucose homeostasis: evidence from spontaneous reports
HJ. Derijks ■ R.H.B. Meyboom ■ E.R. Heerdink ■ F.H.P. De Koning R. Janknegt ■ M. Lindquist ■ A.C.G. Egberts 531
Ten years after the Dutch public health campaign on folic acid: the continuing challenge
H.E.K. de Walle ■ L.T.W. de Jong-van den Berg 539
Predictors of orphan drug approval in the European Union
H.E. Heemstra ■ R.L de Vrueh ■ S. van Weely ■ H.A. Buller ■ H.G.M. Leufkens 545
LETTER TO THE EDITOR
Detection of the pharmaceutical agent glaucine as a recreational drug
P.I. Dargan ■ J. Button ■ L Hawkins ■ J.R.H. Archer ■ H. Ovaska ■ S. Lidder ■ J. Ramsey ■ D.W. Holt ■ D.M. Wood 553
PHARMACOKINETICS AND DISPOSITION
Interindividual variability of oral sumatriptan pharmacokinetics and of clinical response in migraine patients
A. Ferrari ■ D. Pinetti ■ A. Bertolini ■ C. Coccia ■ E. Sternieri
Early pharmacokinetics of nasal fentanyl: is there a significant arterio-venous difference?
K. Moksnes ■ O.M. Fredheim ■ P. Klepstad ■ S. Kaasa ■ A. Angelsen-T. Nilsen -0. Dale 497
489
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