Table 4: Summary of gender, hair colour and hair concentrations of amitriptyline (AT), nortriptyline (NT), and corresponding hydroxymetabolites examined in hair bundles and alleles of CYP2D6 and CYP2D6.

No / Gender / Colour / CYP2D6 / CYP2C19 / AT / NT / E10-OHNT / Z10-OHNT / E10-OHAT / Z10-OHAT
f.a. / *4 / *6 / *5 / *3 / f.a. / *2 / *3 / *4 / pg/mg / a.u.+)
1 / m / d-bl / 1 / 1 / 2 / 20400 / 33720 / 8350 / 1230 / 4107 / 1649
2 / m / d-bl / 2 / 2 / 7560 / 19800 / 9720 / 1920 / 3229 / 872
3 / f / d-bl / 1 / 1 / 1 / 1 / 4840 / 13960 / 4250 / 890 / 2550 / 930
4 / m / d-bl / 2 / 1 / 1 / 3500 / 10200 / 4840 / 622 / 1745 / 571
5 / m / Brown / 1 / 1 / 2 / 596 / 2848 / 776 / 136 / 121 / 35
6 / m / Brown / 2 / 2 / 3188 / 9680 / 5440 / 629 / 2665 / 481
7 / f / Blond / 2 / 2 / 5.6 / 13.56 / 10.6 / 1.0 / 2.4 / 0.9
8 / f / d-bl / 2 / 2 / 2796 / 10400 / 1690 / 462 / 555 / 185
9 / m / Brown / 1 / 1 / 2 / 6.16 / 20.2 / 5.5 / 4.7 / 2.6 / 0
10 / f / Brown / 1 / 1 / 1 / 1 / 163.6 / 253.2 / 112 / 25.2 / 88 / 27
11 / f / d-bl / 1 / 1 / 1 / 1 / 175.6 / 668 / 50.2 / 25.6 / 32 / 0
12 / m / Brown / 2 / 2 / 332.8 / 1192 / 454 / 94.6 / 147 / 29
13 / m / Blond / 2 / 2 / 1564 / 6560 / 1070 / 178 / 302 / 75
14 / f / Blond / 2 / 2 / 724 / 2568 / 1140 / 168 / 406 / 85
15 / m / Brown / 2 / 2 / 25160 / 70400 / 7990 / 1930 / 638 / 199
16 / m / d-bl / 2 / 2 / 4800 / 13560 / 3160 / 578 / 641 / 287
17 / f / Blond / 2 / 0 / 2 / 1584 / 944 / 175 / 65 / 544 / 471
18 / m / Blond / 1 / 1 / 2 / 110 / 244 / 30.4 / 7.7 / 16 / 5.7
19 / f / Blond / 2 / 2 / 1300 / 4840 / 831 / 178 / 264 / 72
20 / f / d-bl / 2 / 1 / 1 / 3204 / 7520 / 942 / 233 / 641 / 287
21 / f / Blond / 1 / 1 / 2 / 1.94 / 6.4 / 1.3 / 0 / 0.9 / 0
22 / f / Brown / 2 / 0 / 2 / 3416 / 1680 / 595 / 137 / 1996 / 1026
23 / f / Blond / 1 / 1 / 0 / 2 / 10560 / 12160 / 1740 / 1030 / 3657 / 2904

The abbreviations f.a. signifies the total number of functional alleles encoding the respective enzyme. Dark blond hair colour is marked as d-bl.

+) The quantitative evaluation of hydroxyamitriptyline (in arbitrary units, a.u.) was referred to the relative response factors of hydroxynortriptyline.