Table 4S: Differentially expressed genes (absolute fold change ≥ 2.0 and p-value ≤ 0.05) between space (S) and ground (G) groups containing a potential or recognized binding site for MEF2. Genes related to muscle metabolism are in bold.

Gene Symbol / Gene Title / Fold change (S/G) / P-Value
Ankrd23 / ankyrin repeat domain 23 / 3.10 / 0.0043
Arrdc3 / arrestin domain containing 3 / 2.17 / 0.0056
Asb2 / ankyrin repeat and SOCS box-containing 2 / 3.58 / 0.0015
Asb4 / ankyrin repeat and SOCS box-containing 4 / 2.32 / 0.010
Asb15 / ankyrin repeat and SOCS box-containing 15 / 2.74 / 0.014
Asph / aspartate-beta-hydroxylase / 3.03 / 0.0012
Atf3 / activating transcription factor 3 / 2.00 / 0.0063
Atl2 / atlastin GTPase 2 / 2.00 / 0.0063
Banp / BTG3 associated nuclear protein / -2.30 / 0.047
Capn3 / calpain 3 / 2.03 / 0.0019
Casq1 / calsequestrin 1 / 2.50 / 0.011
Cav3 / caveolin 3 / 2.26 / 0.0067
Cktm2 / creatine kinase, mitochondrial 2 / 3.30 / 0.0002
Cox6a2 / cytochrome c oxidase, subunit VI a, polypeptide 2 / 2.13 / 0.0077
Cpt1b / carnitine palmitoyltransferase 1b, muscle / 2.19 / 0.00496
Csrp3 / cysteine and glycine-rich protein 3 / 2.08 / 0.015
Ctgf / connective tissue growth factor / 2.65 / 0.0018
Des / Desmin / 2.06 / 0.0063
Eno3 / enolase 3, beta muscle / 2.49 / 0.0014
Esr1 / estrogen receptor 1 (alpha) / -2.05 / 0.028
Fam134b / family with sequence similarity 134, member B / 2.04 / 0.0045
Fitm1 / fat storage-inducing transmembrane protein 1 / 2.51 / 0.0075
Hbp1 / high mobility group box transcription factor 1 / 3.34 / 0.014
Hfe2 / hairy and enhancer of split 1 (Drosophila) / 2.08 / 0.013
Hist1h1c / histone cluster 1, H1c / 2.34 / 0.0014
Hoxb6 / homeo box B6 / -2.22 / 0.016
Hrc / histidine rich calcium binding protein / 2.06 / 0.030
Ip6k2 / inositol hexaphosphate kinase 2 / 2.01 / 0.0054
Kbtbd5 / kelch repeat and BTB (POZ) domain containing 5 / 2.17 / 0.020
Kbtbd10 / kelch repeat and BTB (POZ) domain containing 10 / 3.39 / 0.00063
Kcnn1 / potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 / 3.01 / 0.018
Kcnq5 / potassium voltage-gated channel, subfamily Q, member 5 / 2.72 / 0.0094
Mb / Myoglobin / 3.16 / 0.00016
Mef2c / myocyte enhancer factor 2C / 2.06 / 0.0012
Mybpc2 / myosin binding protein C, fast-type / 2.23 / 0.019
Myf6 / myogenic factor 6 / 2.22 / 0.0046
Myog / Myogenin / 2.13 / 0.026
Myom2 / myomesin 2 / 3.69 / 0.00025
Myoz2 / myozenin 2 / 2.78 / 0.0079
Ndrg2 / N-myc downstream regulated gene 2 / 2.78 / 0.00071
Neb / nebulin / 2.48 / 0.0065
Nfil3 / nuclear factor, interleukin 3, regulated / 2.73 / 0.0077
Nr4a1 / nuclear receptor subfamily 4, group A, member 1 / 2.20 / 0.016
Obscn / obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF / 2.99 / 0.0071
Pacsin3 / protein kinase C and casein kinase substrate in neurons 3 / 2.48 / 0.00002
Pgam2 / phosphoglycerate mutase 2 / 2.94 / 0.0012
Phka2 / phosphorylase kinase alpha 2 / 2.04 / 0.042
Ptpro / protein tyrosine phosphatase, receptor type, O / -2.11 / 0.025
Scn4b / sodium channel, type IV, beta / 2.47 / 0.024
Sgcg / sarcoglycan, gamma (dystrophin-associated glycoprotein) / 2.00 / 0.011
Slc8a3 / solute carrier family 8 (sodium/calcium exchanger), member 3 / 2.24 / 0.012
Slc25a4 / solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 / 2.02 / 0.0003
Slco2a1 / Solute carrier organic anion transporter family, member 2a1 / 3.34 / 0.011
Smyd1 / SET and MYND domain containing 1 / 2.37 / 0.020
Sox5 / SRY-box containing gene 5 / 2.11 / 0.040
Stc1 / stanniocalcin 1 / 2.11 / 0.025
Synpo2l / synaptopodin 2-like / 2.56 / 0.0024
Tlk2 / tousled-like kinase 2 (Arabidopsis) / 2.25 / 0.010
Tmod4 / tropomodulin 4 / 2.37 / 0.0003
Tnni2 / troponin I, skeletal, fast 2 / 2.14 / 0.012
Tpm2 / tropomyosin 2, beta / 2.24 / 0.042
Tpp2 / tripeptidyl peptidase II / 2.30 / 0.0026
Trdn / triadin / 2.26 / 0.0048
Ttn / titin / 2.30 / 0.010
Wac / WW domain containing adaptor with coiled-coil / 2.06 / 0.011
Xirp1 / xin actin-binding repeat containing 1 / 2.87 / 0.042