ESACT-UK 20th Annual Scientific Meeting Programme (version 2)
Wednesday 6th January 2010
9.30Registration desk opens
10.30-10.35ESACT-UK meeting introduction
10.35-12.00Session 1- Cell Culture Biotechnology
(Sponsored by BD)
Chair: Nick Amiss
10.35-11.15Keynote speaker – Animal Cell Culture Technology over the last 20 years
Ian Freshney, Honorary Senior Research Fellow in the Centre for Oncology & Applied Pharmacology, Division of Cancer Sciences and Molecular Pathology, Glasgow University
11.15-11.55Keynote speaker - State of the bioprocessing industry in the UK
Mark Bustard, bioProcessUK
11.55-12.30Keynote speaker – Therapeutic protein production; past perspective and future prospects
John Birch, Lonza
12.30-13.30Lunch
13.30-16.00Session 2 – Fermentation Technology
Chair: Julian Hanak
13.30-14.00Mixing Issues in Animal Cell Culture Bioreactors; Possible Implications for Stem Cell Culture
Alvin Nienow, University of Birmingham
14.00-14.30 Cell culture in miniature bioreactors: Engineering characterisation, scale-up and impact on primary recovery
Gary Lye, University College London
14.30-15.00Study of Alternating Tangential Flow filtration for perfusion and harvest in Chinese Hamster Ovary cells cultivation
Veronique Chotteau, Stockholm University
New Fermentation Technology From The Trade
15.00-15.15New Automated Cell Culture System: 6 parallel fed batch cultures with live cell imaging
Sharon Brownlow, Applikon Biotechnology
15.15-15.30High Throughput Process Development Technologies: Successful Implementation and Application to Process Improvement
JonathanH. Dempsey, Invitrogen
15.30-15.45The Development of a Single-Use 3L Bench-top Stirred-tank Bioreactor
Guy Matthews, Millipore
15.45-16.00Utilization of Cyclonic Technology for Re-Usable and Disposable Perfusion Bioreactors
John Moys, Sartorius Stedim
16.00-16.30 Tea/coffee, trade stands and poster viewing
16.30-18.00Session 3 –Student Session
Chair: Julian Hanak
16.30-16.45Improving CHO cell Productivity. The Pursuit of Happiness
Laura Bailey, University of Manchester
16.45-17.00The process of N-glycosylation in CHO cells can be manipulated for the production of desirable monoclonal antibody glycoforms
Rhian Grainger, University of Sheffield
17.00-17.15Molecular painting by numbers: Looking at CHO cell chromosomes
Leo Choi, University of Manchester
17.15-17.30A Comparison of Alternative Host CHO Cell Lines
Zoe Towler, University of Kent
17.30-18.00Poster flashes
Rational feed design based on metabolite profiling of mammalian cell lines
Arfa Maqsood, University of Manchester
Use of SIFT-MS for the on-line monitoring of stem cell production in stirred-tank bioreactors
Tom Chippendale, Keele University
A systematic examination of phenotypic heterogeneity in CHO cells
Clare Lovelady, University of Sheffield
Automation of human embryonic stem cell culture
Gayatri Ramasamy, Loughborough University
Enhancing recombinant mRNA translation via microRNA interactions with the 3'-UTR for improved recombinant protein yield
Elizabeth Sayer, University of Kent
Developing scalable and standardised manufacturing methods for human mesenchymal stem cells
Qasim Rafiq, Loughborough University
18.00-18.15ESACT-UK Annual General Meeting
18.15-19.30 Posters, trade stands and networking
A coach will be provided for transportation between Holywell and Burleigh Court at 19.30
20.00ESACT-UK society dinner and after-dinner quiz
Thursday 7th January 2010
7.30-8.45Breakfast
A coach will be provided for transportation between Burleigh Court and Holywell at 8.45
9.10-10.10Session 4 - Developments in Antibody and Therapeutic Protein Bioprocessing
Chair: John Davis
9.10-9.40Determination of Post-Transcriptional Limitations on Recombinant Antibody Production
Emma Mead, University of Kent
9.40-10.10Practical challenge and innovative solution: natural consummation or enforced annulment in therapeutic bioprocessing?
Andy Lyddiatt, Lyddallan Consultancy
10.10-11.00Tea/coffee, trade stands and poster viewing
11.00-13.10Session 5 – Regenerative Medicine Bioprocessing
(Sponsored by IChemE BESG)
Chair: Chris. J. Hewitt
11.00-11.10Introduction to regenerative medicine bioprocessing
Chris. J. Hewitt, Loughborough University
11.10-11.40The biochemical engineering challenges of embryonic stem cell processes
Farlan Veraitch, University College London
11.40-12.10Towards scale-up of tissue engineering systems by using an iterative approach to scaffold and bioreactor design
Marrianne Ellis, University of Bath
12.10-12.40In-vitro expansion of stem and progenitor cells
Mohamed Al-Rubeai, University College Dublin
12.40-13.10Automated manufacture of stem cells for regenerative medicine applications
Robert Thomas, Loughborough University
13.10-14.15Lunch
14.15-15.45Session 6 – Cell Based Bioactivity Testing
Chair: Joanna Long
14.15-14.45Cell-based alternatives: Getting to replacement
Nirmala Bhogal, FRAME, Nottingham
14.45-15.15Cell Culture Methods as Alternatives to Animal Testing – Advances and Challenges
Carol Barker, XCellR8 Ltd, Manchester
15.15-15.45Enabling and Delivering High Quality, Reproducible Cell-Based Assays; Impact of Frozen Cell Technology
Danuta Mossakowska, GlaxoSmithKline
15.45-16.15Award of prizes and close of meeting