Supplemental Figure S1. Aligned ATPaseb flanking exon (A) and intron (B) sequences from two Musculista senhousia specimens (labeled “Msen”), and representative taxa from the NCBI database. Alignment was done with MAFFT v. 6.240, using the E-INS-i setting with a gap-opening value of 1.0. Accession numbers for reference sequences follow the taxon name; Drosophila = D. melanogaster. Only the entries for Haliotis spp. included intron sequence data, all others were cDNA sequences. Highlighted regions are where primers anneal; the grey bar indicates where the intron occurs; intron sequences were excised and are given in section B.

(A) Exon sequence flanking the ATPaseb intron

Mytilus_edulis_AY580269 CGT GAA GGA AAT GAC TTG TAC CAT GAA ATG ATC ACA TCT AAA

Modiolus_americanus_AY580264 CGT GAA GGA AAT GAC TTG TAC CAT GAA ATG ATC ACA TCT AAA

Drosophila_BT120330 CGT GAG GGA AAC GAT TTA TAC AAT GAG ATG ATC GAG GGT GGT

Haliotis_rubra_3_AY043198 ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???

Haliotis_conicopora_1_AY043200 ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???

Haliotis_laevigata_2_AY043204 ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???

Msen_06DWA6 ??? ??? ??? ??? ??? ??? TAC CAT GAG ATG ATC ACC TCA AAA

Msen_06COR10 ??? ??? ??? ??? ??? ??? ??? CAT GAG ATG ATC ACA TCA AAA

Mytilus_edulis_AY580269 GTT ATT AGC TTG ACA GAC GAC ACG TCC AAG GTA TCT TTG

Modiolus_americanus_AY580264 GTC ATC AGT TTA ACA GAT GAC ACA TCA AAG GTA TCC CTT

Drosophila_BT120330 GTT ATT TCA CTA AAG GAC AAG ACC TCA AAG GTG GCT CTC

Haliotis_rubra_3_AY043198 ??? ??? ??? ??? ??? ??? ??? ACC TCC AAG GTT TCT CTG

Haliotis_conicopora_1_AY043200 ??? ??? ??? ??? ??? ??? ??? ACC TCC AAG GTT TCT CTG

Haliotis_laevigata_2_AY043204 ??? ??? ??? ??? ??? ??? ??? ACC TCC AAG GTT TCT CTG

Msen_06DWA6 GTC ATC AGC TTG ACA GAC GAT ACG TCT AAG GTA TCG CTT

Msen_06COR10 GTC ATY AGC TTG ACA GAC GAT ACA TCT AAG GTA TCG CTT

Mytilus_edulis_AY580269 GTA TAT GGA CAG ATG AAT GAG CCC CCA GGA GCA CGT GCC CG

Modiolus_americanus_AY580264 GTA TAT GGA CAA ATG AAT GAA CCA CCA GGA GCA CGT GCC CG

Drosophila_BT120330 GTA TAT GGG CAA ATG AAC GAG CCG CCA GGT GCT CGT GCC CG

Haliotis_rubra_3_AY043198 GTA TAC GGT CAG ATG AAC GAA CC? ??? ??? ??? ??? ??? ??

Haliotis_conicopora_1_AY043200 GTA TAC GGT CAG ATG AAC GAA CC? ??? ??? ??? ??? ??? ??

Haliotis_laevigata_2_AY043204 GTA TAC GGT CAG ATG AAC GAA CC? ??? ??? ??? ??? ??? ??

Msen_06DWA6 GTA TAC GGA CAA ATG AAC GAA CCG CCA GGT GCT CGT GCC CG

Msen_06COR10 GTA TAC GGA CAA ATG AAC GAA CC? ??? ??? ??? ??? ??? ??

(B) ATPaseb intron sequences

H_rubra ------agcactg--tgttt------tgtttcttrattcacacactagtacacaactatg

H_conicopora ------agcactg--tgttt------tgtttcttgattcacacactagtacacaactatg

H_laevigata ------agcacc---tgttt------tgtttcttgattcatrcactagtacacaactatg

Msen_06DWA6 ctgtaaaatgttgaatgtttatcatctgttaattgttcaaattaccga-aaaaaagttat

Msen_06COR10 ctgtgaaatgttgaatgtttatcatctgtaaattgttcaaactaccaa-aaaaaacctta

H_rubra aataatg---gataatacatacctgcttt------

H_conicopora aataatg---gataatacatacctgcttt------

H_laevigata aataatg---gataatacatacctgcttt------

Msen_06DWA6 tatggtgtcagaagatttatgaatgattttcatgaata------ttgtcacttctgtaat

Msen_06COR10 aatgatg---aaaagtatatacatgtatatcaaaattacaacattaatcacccttacctt

H_rubra ------

H_conicopora ------

H_laevigata ------

Msen_06DWA6 ttaagag------ggac------agatgttgcaataaa

Msen_06COR10 taaatagattgccttgaaatactggtaacttttaggactgccttgaaatactagtatgaa

H_rubra ------

H_conicopora ------

H_laevigata ------

Msen_06DWA6 tgatgaaaagaatatattttt------atactagagggaagc

Msen_06COR10 -ggtcagaactatattttgttggtaacttttaggactgccttgaaatactagaatgaagg

H_rubra ------ttctaagaaaatga------

H_conicopora ------ttctaagaaaatga------

H_laevigata ------ttctaagaaaataa------

Msen_06DWA6 tcagaactatattttgttggtaacttataagaaagcaaaaaattgttggaatggaattaa

Msen_06COR10 ttagaactatattttgttggwaayttttaggacagcaaaagattgttggaatggaattta

H_rubra ----agagcattaac------atgattaa

H_conicopora ----agagcattaac------atgattaa

H_laevigata ----agagcattaac------atgattaa

Msen_06DWA6 aaccaaagtattagttggccaaaaactatcaaacttgcttgattttctaaaaatgaccaa

Msen_06COR10 aaccaaagtattagttggccaaaaactatcaatcttgcttgttttctaaagaatgacaaa

H_rubra cat------ggtcctttt------

H_conicopora cat------ggtcctttt------

H_laevigata cat------ggtcctttt------

Msen_06DWA6 tattcacagttctacttgtgttcttcacaatcaaaaacctttattctaacttttaatgac

Msen_06COR10 tccc-----acctacttgtgttcttaacaatcaaaaatcttttttctaacttttaatgac

H_rubra ------caggta

H_conicopora ------caggta

H_laevigata ------caggta

Msen_06DWA6 tacaatgtacttcaaacaattttgacaggta

Msen_06COR10 ------tactacaaacaattttgacaggta