1106, either, cat: 13
EVALUATION OF PLATELET INDICES AND COUNT IN ISCHEMIC HEART DISEASE PATIENTS COMPARED TO NORMAL POPULATION
N Mesbah Ardakani , M Saravi, Sh Shafahi, M Sharbatdaran, K HajianBabol
University of Medical Science, Babol, Iran
BACKGROUND & OBJECTIVE: Atherosclerosis and its complications are a major cause of ischemic heart diseases. Platelets play an important role in initiation of atherosclerosis lesions and coronary thrombus formation. Large platelets are shown to be hemostatically more active. Evaluation of platelets volume parameters as an index of their activity could be useful in prediction and differentiation of coronary events. This study evaluates platelets volume indices in IHD patients.METHODS : A population of 200 patients with chest pain were distributed in three groups according to clinical manifestation and standard diagnostic criteria. 50 patients with unstable angina , 50 patients with chronic stable angina and hundred patients with non cardiac chest pain as normal population were included. Venous blood samples of subjects were drawn and collected in K3 EDTA. Platelet indices and count were assayed within 1 to 3 hours after sampling by a Sysmex KX21 autoanalayser. Data were gathered and compared with SPSS 10.FINDINGS: Patients with unstable angina had a significant higher MPV (10.7 ± 0.23 fl ) , PDW and PLCR than those in chronic stable angina and normal group . MPV in chronic stable angina patients( 10.1 ± 0.2 fl ) was higher than normal population (9.5 ± 0.1 fl) but platelet count and other indices were not statistically different. Platelets count in unstable angina was significantly lower than chronic stable angina and normal group. There were no sex or age differences in MPV amounts in normal population group.COCLUSION : Platelet volume indices are increased in unstable angina probably because of platelet activation and a compensatory volume enhancement . Platelets count reduction in this condition results from platelets consumption . These changes in platelets count and volume could differentiate unstable angina patients from chronic stable patients and normal individuals. KEY WORDS: PLATELET DISTRIBUTION WIDTH(PDW), PLATELET LARGE CELL RATIO(PLCR), MEAN PLATELET VOLUME(MPV), UNSTABLE ANGINA, CHRONIC STABLE ANGINA.