Table S1. Sampling structure of carriage and invasive bacterial cultures

Parti-cipant / Sample ID / Origin / Date duea / Date collecteda / Methicillin sensitivityb / spa type / No. colonies prepared for sequencing / No. successfully sequenced / Sample groupc
P / N0 / Nasal / 0 / 0 / MSSA / t4714 / 0 / - / -
P / N1 / Nasal / 30 / 56d / MSSA / t4714 / 12 / 11 / ENC
P / N2 / Nasal / 60 / 56d / MSSA / t4714 / 12 / 9 / ENC
P / N4 / Nasal / 120 / 126 / MSSA / t4714 / 12 / 8 / ENC
P / N6 / Nasal / 180 / 183 / MSSA / t4714 / 12 / 7 / ENC
P / N8 / Nasal / 240 / 242 / MSSA / t4714 / 12 / 10 / ENC
P / N10 / Nasal / 300 / 303 / n.g. / - / - / - / -
P / N12 / Nasal / 360 / 358 / MSSA / t4714 / 12 / 12 / LNC
P / N15 / Nasal / n/ae / 450 / n.g. / - / - / - / -
P / B15 / Blood / n/ae / 450 / MSSAf / t4714 / 12 / 11 / LBC
Q / Q0 / Nasal / 0 / 0 / MSSA / t164 / 0 / - / -
Q / Q1 / Nasal / 30 / 32 / MSSA / t164 / 0 / - / -
Q / Q2 / Nasal / 60 / 60 / MSSA / t164 / 12 / 12g / Q
Q / Q4 / Nasal / 120 / 118 / MSSA / t164 / 12 / 10g / Q
R / R0 / Nasal / 0 / 0 / MSSA / t012 / 0 / - / -
R / R1 / Nasal / 30 / 22 / MSSA / t012 / 0 / - / -
R / R2 / Nasal / 60 / 59 / MSSA / t012 / 12 / 11g / R
R / R4 / Nasal / 120 / 114 / MSSA / t012 / 12 / 11g / R
R / R6 / Nasal / 180 / 190 / n.g. / - / - / - / -
R / R8 / Nasal / 240 / 239 / MSSA / t012 / 12 / 11 / R
R / R10 / Nasal / 300 / 309 / MSSA / t012 / 12 / 11 / R
R / R12 / Nasal / 360 / 354 / MSSA / t012 / 12 / 10 / R
R / R14 / Nasal / 420 / 418 / MSSA / t012 / 12 / 9 / R
R / R16 / Nasal / 480 / n.r.h / - / - / - / - / -
R / R18 / Nasal / 540 / 552 / MSSA / t012 / 12 / 6 / R
R / R20 / Nasal / 600 / 599 / MSSA / t012 / 12 / 10 / R
R / R22 / Nasal / 660 / 667 / n.g. / - / - / - / -
R / R24 / Nasal / 720 / 725 / n.g. / - / - / - / -
R / R26 / Nasal / 780 / 782 / n.g. / - / - / - / -
R / R28 / Nasal / 840 / 848 / n.g. / - / - / - / -
R / R30 / Nasal / 900 / 900 / n.g. / - / - / - / -
R / R32 / Nasal / 960 / 963 / n.g. / - / - / - / -

a Days since enrolment in the carriage study

b MSSA: methicillin sensitive Staphylococcus aureus. n.g.: no growth

c For participant P, ENC: nasal swabs collected prior to drug intervention. LNC: nasal swabs collected after drug intervention. LBC: blood cultures.

d Participant P self-administered swabs N1 and N2 on the same date

e Collected during hospitalization

f Extended sensitivity testing of the blood culture B15 showed the organism was sensitive to flucloxacillin, rifampicin, erythromycin, ciprofloxacin and resistant to penicillin G and trimethoprim.

g These colonies were sequenced on the Illumina GAIIx platform.

h n.r.: not returned.