SOCIETY FOR RESEARCH INTO HYDROCEPHALUS AND SPINA BIFIDA

51st Annual Meeting

Heidelberg, Germany

Final Programme

Wednesday 27th June

17.30: Annual Business Meeting Ancient Aula, University Platz, Heidelberg.

19.00: Welcome Reception, Ancient Aula.

Thursday 28th June 2007

08.45 /

Introduction: Welcome to Heidelberg

09.00 – 10.30 / Scientific Session 1: Chronic Hydrocephalus
Chaired by Hugh Richards and Miles Johnston
09.00 /

Paper 1

/ VEGF-R2+ activation in the caudate: an adaptive angiogenic response to hypoxia in chronic hydrocephalus?
Abhishek Deshpande, Stephen M. Dombrowski, Mark G. Luciano
09.15 /

Paper 2

/ Does NPH equal ischaemia?
Gerald Silverberg, Conrad Johanson, John Duncan, Thomas Brinker, Stephanie Slone, Arthur Messier, Sarah Soltman, Petra Klinge
09.30 /

Paper 3

/ Opposite changes in cerebellar vs. cortical blood brain barrier (BBB) expression in aged and hydrocephalic rats.
Petra M Klinge, Arthur Messier, Anna Heile, Mohsen Nouri, Conrad E Johanson, John A Duncan, Thomas Brinker, Gerald D Silverberg
09.45 /

Paper 4

/ Shunting in AD increases ventricular CSF protein levels.
Tom Saul, Dawn McGuire, Martha Mayo, Jere Fellmann, Joan Carvalho, Gerald D. Silverberg, Jonathan Williams
10.00 /

Paper 5

/ Ultrastructural study of the permeability of in-vitro and ex-vivo human models of human arachnoid granulation CSF outflow pathway.
Deborah M. Grzybowski, David W. Holman, Shelley A. Glimcher, Steven E. Katz
10.15 /

Paper 6

/ Hydrocephalus in primary craniosynostosis.
Hartmut Collman, Christian Schropp, Jürgen Krauss, Niels Soerensen
10.30 / Coffee
11.00 – 12.30 / Scientific Session2: Spina Bifida
Chaired by Carole Sobkowiak and David Shurtleff
11.00 /

Paper 7

/ Reliability of the MRI diagnosis of the Chiari type2 malformation.
Reinier Mullaart, Niels Geerdink, Ton van der Vliet
11.15 /

Paper 8

/ Pathogenesis of cerebral malformations in perinatal spina bifida aperta.
Olga A. de Wit, Wilfred F. den Dunnen, Krystyna M. Sollie, Oebele F. Brouwer, Deborah A. Sival
11.30 /

Paper 9

/ Cystatin C: a potentially useful marker for identifying individuals with spina bifida and early renal insufficiency.
Eric Levey, Susan Demetrides, Yegappan Lakshmanan
11.45 /

Paper 10

/ Muscle echogenicity is increased in fetuses with spina bifida aperta.
Renate J Verbeek, Johannes H vd Hoeven, Natasha M Maurits, Krystyna M Sollie, Arend F Bos, Oebele F Brouwer, Wilfred F den Dunnen, Deborah A Sival
12.00 /

Paper 11

/ Complete tendon transfer and inverse lambrinudi arthrodesis. A new developed operative treatment for paralytic pes calcaneus in spina bifida.
Wolfram Wenz
12.15 / Paper 12 / Current prevalence of latex sensitization in children with spina bifida with use of latex precautions.
Eric Levey, Susan Demetrides, Robert Hamilton, N. Franklin Adkinson
12.30 / Lunch

Thursday afternoon and evening: Society Outing

Friday 29th June 2007
08.30 – 10.30 / Scientific Session 3: Bowel and Urodynamic Function
Chaired by Debra Sival and Margareta Dahl
08.30 /

Paper 13

/ Early start to therapy preserves kidney function in spina bifida patients
Pieter Dik, Aart Klijn, Jan van Gool, Teau de Jong-de Vos van Steenwijk, Tom de Jong
08.45 / Paper 14 / Does long term intravesical oxybutynin treatment of hyperreflexic neurogenic bladder result in bladder auto-augmentation?
Udo Rolle, Christian Geyer, Thomas Lehnert, Margit Weißer, Holger Till
09.00 /

Paper 15

/ Whose bowel is it anyway? A short case study illustrating the practical difficulties resulting from a childhood procedure that impinge upon an adult with spina bifida attempting to live independently.
Lissa Wright
09.15 / Paper 16 / Auto-augmentation: ought it to be done?
Suzanne Lawther, David Marshall, Alan Bailie, Stephen Brown
09.30 / Paper 17 / Bowel and bladder continence among children with spina bifida: a retrospective study.
Michelle Campbell, Susan Demetrides, Elaine Stashinko, Valerie Rogers,
Keith Slifer, Yeggepan Lakshmanan, T. Andrew Zabel. Eric Levey
09.45 / Paper 18 / Outcome on renal and bladder function in children with spina bifida in a standardised follow-up programme.
Peter Wide, Gunilla Gladh, Sven Mattsson
10.00 / Paper 19 / Independence in the toilet activity in children with myelomeningocele.
Marie Donlau, Tor-Björn Falkner, Gunilla Gladh, Sven Mattsson
10.15 /

Paper 20

/ Simple clinical and bedside urodynamic evaluation is sufficient for successful management decisions in spina bifida patients with urinary incontinence and the machine urodynamics are not necessary.
Anant Bangar, Santosh Karmarkar
10.30 / Coffee
11.00 – 12.30 / Scientific Session 4: Hydrocephalus Pathology
Chaired by Hazel Jones and Mark Luciano
11.00 /

Paper 21

/ Hyperdynamic pulsatile flow and ventricular dilation in experimental communicating hydrocephalus.
Mark E. Wagshul, Jie Li, Helene Benveniste, Michael R. Egnor, E. Mark Haacke, Shams Rashid, Yimin Shen, Marion E. Walker, Ma Yu, James P. McAllister
11.15 / Paper 22 / Mechanism of obliteration of Sylvius aqueduct in the H-Tx rat.
A.R. Ortloff, E.M. Rodríguez
11.30 /

Paper 23

/ Anti-Reissner’s fibre and anti-p73 co - expression in the subcommissural organ of the mice and rats with spontaneously hydrocephalus.
Agustín Castañeyra-Perdomo, Ibrahim González-Marrero, Paloma Fernández-Rodriguez, Teresa A. Ruiz-Mayor, Leandro Castañeyra-Ruiz, Juan M. González-Toledo, Agustín Castañeyra-Ruiz, Lidia Ruiz-Mayor, Emilia M. Carmona-Calero
11.45 / Paper 24 / Lack of formation of Reissner fiber leads to hydrocephalus.
S. Rodríguez, L.F. Bátiz, A.R. Ortloff, K. Vío, R.I. Muñoz, L.M. DeGraff, J.P. Graves, D.J. Stumpo, P.J. Blackshear, D.C. Zeldin, J. Goto, T. Tezuka, T. Yamamoto, E.M. Rodríguez
12.00 / Paper 25 / p73 isoforms expression in the cerebrospinal fluid and circumventricular organs of BPH mice and SHR rats.
Emilia M. Carmona-Calero, Ibrahim González-Marrero, Paloma Fernández-Rodriguez, Juan M González-Toledo, Leandro Castañeyra-Ruiz, Agustín Castañeyra-Ruiz, Lidia Ruiz-Mayor, Agustín Castañeyra-Perdomo
12.15 / Paper 26 / Postnatal ependymogenesis occuring in wild-type hyh mice increases significantly in hydrocephalic hyh mice.
Luis Federico Bátiz, Antonio J. Jiménez, Toledo C, José Manuel Pérez-Fígares, Esteban M. Rodríguez
12.30 / Lunch
14.00 – 15.15 / Scientific Session 5: Shunts
Chaired by Ray Fitzgerald and Jerry Silverberg
14.00 /

Paper 27

/ Antibiotics for eradication of propionibacterium acnes biofilms.
Waheed Ashraf, Bryar Nuradeen, Roger Bayston
14.15 / Paper 28 / Conservative management of cerebrospinal fluid shunt infections.
Amy Cheney, Anthony Avellino, Sharon Duguay, David Shurtleff
14.30 / Paper 29 / Are adjustable valves effective? Data from the UK Shunt Registry.
Hugh Richards, Helen Seeley, John Pickard
14.45 / Paper 30 / Limits and options for electronic devices for the treatment of hydrocephalus.
Christoph Miethke
15.00 / Paper 31 / Changing definition of non-responsiveness to shunting - the influence of valve-adjustability.
Christian Sprung, Annegret Zech, Hans-Georg Schlosser
15.15 / Tea
15.45-16.45 / Scientific Session 5: Shunts continued
Chaired by Conrad Johanson and Petra Klinge
15.45 /

Paper 32

/ 23 hydrocephalus valves tested over 367-514 days.
D Biedermann, J Ludwig, A Aschoff
16.00 /

Paper 33

/ Latex sensitisation in hydrocephalic patients with and without spina bifida.
Reinhold Cremer, Mehrsad Klemm
16.15 / Paper 34 / Gravitational valves. Personal 27 year experience in 420 patients.
A Aschoff, R Wirtz, B Hashemi, P Kremer, A Unterberg, M Halatsch
16.30 / Paper 35 / Interaction between hydrocephalus shunt and pressure waves.
Z.Czosnyka, M.Czosnyka, G.Petrella, HK Richards, JD Pickard
16.45 – 17.35 / Poster Discussion
Chaired by Stephen Brown and Zofia Czosnyka
16.45 /

Poster 1

/ BWM+, a B-Wave Monitor plus P-Wave analysis
Stefanie Jetzki, Michael Kiefer, Regina Eymann, Marian Walter, Steffen Leonhardt
16.52 / Poster 2 / Vertical extension device for automatic adjustment of EVD-drip chambers or ICP-transducers.
G Karpel-Massler, F Wittmann, A Aschoff
16.59 / Poster 3 / Independence and perceived quality of life in young adults with myelomeningocele. Function, needs and recommendations for what to do.
Simone Norrlin, Margareta Strinnholm, Ann Butler, Eva Stagling, Monica Bergh, Erika Rönnblom, Gunnar Ahlsten, Margareta Dahl
17.06 / Poster 4 / Anterior encephalocele: staged reconstruction.
H. Dutta
17.13 /

Poster 5

/ Long-term experiences (max. 22 years) with 38 antisiphon devices.
A Aschoff, D Biedermann, J Ludwig, A El Tayeh, N Biedermann, A Piotrowicz, P Kremer
17.20 / Poster 6 / Controversies about adjustable shunts.
Christoph Miethke
17.27 / Poster 7 / Analysis of 120 cases of treatment of spina bifida and neural damage through complete release of pression of sacrum nerve.
Hongxia Zhang, Weiguang Zhang
17.35- 17.50 / Casey Holter Essay Prize Winner
Introduced by Ray Fitzgerald
Friday Evening: annual dinner
Saturday 30th June 2007
09.00 – 10.30 / Scientific Session 6: Psychosocial Issues
Chaired by Rosemary Batchelor and Eric Levey
09.00 /

Paper 36

/ Early puberty in boys with myelomeningocele. Risk factors for early puberty.
M. Dahl, G. Ahlsten, J. Gustafsson, L. A. Proos, T. Tuvemo
09.15 / Paper 37 / Neurological bypass for sensory innervation of the penis in patients with spina bifida.
P.Dik, ML Overgoor, M. Kon, TPVM de Jong
09.30 / Paper 38 / Psychosocial adaptation and cognitive functioning in young male adults with myelomeningocele.
Jan Stubberud, Gunnar Riemer, Pål-Erik Plaum, Karen Grimsrud
09.45 / Paper 39 / Global assessment of function in adolescents with myelomeningocele
M Dahl, S Norrlin, M Strinnholm, A Butler, G Ahlsten
10.00 / Paper 40 / Continence and dryness in spina bifida patients at school age.
Pieter Dik, Sarah van Loopik, Aart Klijn, Rafal Chrzan, Tom de Jong
10.15 /

Paper 41

/ Shunting in AD slows progression of the dementia.
Tom Saul, Dawn McGuire, Martha Mayo, Jere Fellmann, Joan Carvalho, Gerald D. Silverberg, Jonathan Williams
10.30 / Coffee
11.00 – 12.15 / Scientific Session 7: Hydrocephalus and CSF
Chaired by Roger Strachan and Esteban Rodriguez
11.00 /

Paper 42

/ Lymphatic cerebrospinal fluid absorption is impaired in a kaolin-induced hydrocephalus model in the rat.
Gurjit Nagra, Jie Li, James P McAllister II, Janet Miller, Mark Wagshul, Miles Johnston
11.15 / Paper 43 / The role of vitamin A and its CSF metabolites in supporting a novel mechanism of idiopathic intracranial hypertension.
Steven E. Katz, Deborah M. Grzybowski, Marc R. Criden, J. Garret Mouser
11.30 / Paper 44 / Enhanced expression of the LRP-1 transporter at the blood-CSF interface in chronic hydrocephalus.
Conrad E. Johanson, Petra M. Klinge, Sarah Soltman, Stephanie Flaherty, Arthur Messier, John A. Duncan III, Edward G. Stopa and Gerald D. Silverberg
11.45 / Paper 45 / Prospective evaluation of selected cytokines for hydrocephalus surgery.
Christian Geyer, Gerd Graefe, Anke Pauer, Katrin Bauer, Udo Rolle, Roman Metzger, Holger Till, Ulrich Sack
12.00 / Paper 46 / GLP-1 secreting encapsulated human mesenchymal stem cells for neuroprotection.
Anna Heile, Steffen Baltes, Petra M. Klinge,Christine Wallrapp, Thomas Brinker
12.15 /

Paper 47

/ High pressure hydrocephalus in neonates is associated with increased CSF concentrations of interleukin-18 and interferon gamma.
Axel Heep, Ursula Felderhoff-Mueser, Arie Bos, Eelco Hoving, Carlo Schaller, Deborah Sival
12.30 / Closing Remarks
12.45 / Invitation to Providence
Johanson / Silverberg / Duncan
13.00 / End

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