CHEMISTRY 109 – 6M

GENERAL, ORGANIC AND BIOLOGICAL CHEMISTRY

SPRING 2016

Instructor: Duane Smith, Jr., Ph.D., M.B.A.Course section: CHEM 109-6M

Office: BEA 134Room: BEA 104

Office Hours: MWF 10:45 a.m.-12:45 p.m.MeetingTime: 12:55 - 1:50 a.m. (MWF)

TR 10:30 a.m. - 12:30 p.m.

(or as arranged)

Phone: (985) 448-4165Email:

COURSE DESCRIPTION: CHEM 109. General, Organic and Biological Chemistry.for Nursing330.Prerequisite: Non-developmental Math placement. Emphasis is on broad aspects of general, organic, and biochemistry necessary for the comprehension of biological processes occurring within the human body. (40.0599)

PRE-/CO-REQUISITE: Non-developmental Math placement

REQUIRED TEXT: General, Organic, and Biological Chemistry, 3rd edition by Frost and Deal (ISBN 978-0-13-446669-9, ISBN-10: 0-13-446669-1) plus Mastering Chemistry (ISBN 978-0-312706195)

RECOMMENDED: A course website has been set up on the Nicholls MoodleTM server: . At this website, you will find a copy of this syllabus, the course calendar, a discussion forum, Internet resources, and online quizzes.

COURSE GOAL: Students will gain critical thinking skills and process skills necessary to analyze and solve problems in their chosen careers. Students will gain an appreciation of chemistry, its universal nature, its role in the molecules of life.

GENERAL EDUCATION STUDENT LEARNING OUTCOMES

CHEM 109 , a course specifically designed for nursing students, fulfills three hours of general education requirements in the area of the natural sciences and is thus designed to enable students to meet the following broad outcome for all the natural sciences.

Goal:Upon completion of the undergraduate curriculum, students will be able to comprehend and to apply the basic principles of science and methods of scientific inquiry.

For further explanation of the learning objectives associated with this goal, go to

STUDENT OUTCOME OBJECTIVES: This one semester course is designed to introduce students to the general principles of chemistry geared to the allied health major including organic chemistry and biochemistry. The principles fall into the four main areas of:

  1. Measurement and Mathematical Concepts (MMC)
  2. Molecular Structures (MS)
  3. Solution and Acid/Base Chemistry (ABC)
  4. Biochemistry (BC)

Thefollowing learning outcomes represent what the student should be able to understand as the course moves along. Upon successful completion of this course, the student should be able to meet these learning outcomes.

LEARNING OUTCOME:

  1. Classify different forms of matter. Distinguish physical and chemical properties. Identify and describe the properties of metals and nonmetals (MS).
  2. Measuring items and applying rules for significant figures correctly (MMC).
  3. Convert English to metric units of measurement, and vice-versa. Perform simple dosage calculations through unit conversions (MMC).
  4. Explain the basic relationships of gas pressure, temperature, volume, and amount. Apply Boyle’s Law and Charles’ Law (MMC).
  5. Identify the number of subatomic particles present in atoms and ions. Distinguish between isotopes and ions by the number of subatomic particles present. Distinguish Mass Number from Atomic Mass (MS).
  6. Identify specific charges on ions. Distinguish and name ionic and binary covalent compounds. Identify the number of valence electrons in the main group elements (MS).
  7. Determine the molecular shapes of carbon, nitrogen, and oxygen in a covalent compound. Determine the polarity of the covalent bond and a covalent compound (MS).
  8. Distinguish representatives of organic compounds (including Lewis, condensed, skeletal, 3-D ball, and stick structures). Define structural isomer (MS).
  9. Recognize organic families and hydrocarbon functional groups (MS).
  10. Distinguish isomers of organic compounds as structural, cis/trans, enatiomers, and diastereomers. Identify chiral centers in organic molecules (MS).
  11. Identify a carbohydrate by its molecular formula and functional groups. Distinguish the simple sugars by structure and function (BC).
  12. Determine the ring structure of a linear monosaccharide. Recognize and name a glycosidic linkage. Identify the products of the following reactions for carbohydrates: condensation, hydrolysis, oxidation and reduction. Describe what is a reducing sugar (BC).
  13. Describe the structure and function of complex carbohydrates, and identify the corresponding glycosidic linkages (BC).
  14. Draw fatty acid salts in water, a “micelle”. Describe the difference between a saturated versus an unsaturated fatty acid. Draw a triglyceride, and identify its functional groups. Distinguish between a fat and an oil.
  15. Distinguish the structural differences between a triglyceride and a phospholipid. Identify the function of phospholipids. Draw a phospholipid bilayer (BC).
  16. Determine the direction of the flow of water across a membrane in osmosis and diffusion (ABC). Distinguish the three main mechanisms of transport across a biological membrane (BC).
  17. Distinguish between a solution and a suspension. Distinguish solutions as electrolyte, non-electrolyte, or weak electrolyte (ABC).
  18. Calculate the concentration of a solution. Describe how you would make an aqueous solution of a known concentration using a solid solute or concentrated stock solution (ABC).
  19. Identify and learn how to name the strong acids and bases. Identify an acid, base, conjugate acid and conjugate base. Write conjugate acid-base reactions. Write a balanced neutralization reaction (ABC).
  20. Predict the strength of a weak acid from its Ka, or the pKa. Determine the acidity of a solution from the pH scale. Calculate the pH of a solution from its hydronium ion concentration and vice-versa (ABC).
  21. Explain how buffering works, and the components that make up a buffer. Apply LeChatelier’s principle to the bicarbonate buffer system (ABC).
  22. Determine the predominant species present in aqueous solution for the functional groups amine and carboxylic acid, found in amino acids, at a given pH (BC).
  23. Draw the general structure of an amino acid in zwitterion form. Identify the functional groups: amide, thiol, aromatic, and disulfide. Classify the amino acids by R- group polarity and charge (BC).
  24. Describe the levels of structure and various functions of proteins (BC).
  25. Establish whether a chemical reaction is exothermic or endothermic, by using a reaction free energy diagram. Apply the factors that affect enzyme activity to a given situation. Distinguish between competitive and noncompetitive types of inhibition (BC).
  26. Identify parts of a nucleotide and a nucleic acid. Distinguish purines and pyrimidines. Identify the structure and function of the nucleic acids DNA and RNA. Provide the complementary strand for a given strand of DNA showing the 5’ and 3’ ends (BC).

COURSE REQUIREMENTS:

  1. Required written work:
  2. Homework assignments (20%)
  3. Exams (80%)
  4. Activities
  5. Cooperative group discussions
  6. Quizzes

METHOD OF EVALUATION:

Grades will be based on a 10-point grading scale.

90 – 100A

80 – 89B

70 – 79C

60 – 69D

< 60F

*Grades will be based on the average of four exams plus the Final with the option of dropping the lowest grade, excluding the final exam, and account for 80% of your final grade. Homework assignments will be made throughout the semester and will account for 20% of the total grade value. This grading policy may be amended due to any unforeseen changes in schedule.

MAKE-UP POLICY: If a student misses a class, he or she is still responsible for the material covered during that class period. If a student misses an exam, a makeup will not be given unless the student notifies the instructor in advance of his or her absence. If no advance notice is given, the student must provide documentation as to the reason for having been absent, such as death of a close family friend (death notice), illness (doctor’s bill), or court appearance (summons).

ATTENDANCE POLICY: Absences amounting to the equivalent of 10% of class time, whether consecutive or not, is grounds for the student being dropped from the course. You are expected to be present, prepared, and alert at all sessions.

ACADEMIC HONESTY POLICY: Any student found cheating will be subject to the penalties as stated in the Student Code of Conduct Handbook; including, but not limited to, a score of zero on an exam, expulsion from the class, and/or expulsion from the University.

SEMESTER WITHDRAWALS:

The responsibility for withdrawing from the course, if you decide not to continue, lie completely with the student. Failure to drop a course by the final deadline will result in your receiving a grade of “F”. The last day to drop the course with a “W” is Friday, March 24, 2017.

DISABILITIES POLICY: If you have a documented disability that requires assistance, you will need to register with the Office of Disability Services for coordination of your academic accommodations. The Office of Disability Services is located in Peltier Hall, Room 100-A. The phone number is (985) 448-4430 (TDD 449-7002).

ACADEMIC GRIEVANCES: The proper procedure for filing a grade appeal or grievances related to other academic matters is listed in Section 5 of the Code of Student Conduct and at the following link:

CONTINUED LEARNING FOLLOWING AN EXTREME EMERGENCY: In order to make continued learning possible following an extreme emergency, students are responsible for:

  • reading regular emergency notification on the NSU website;
  • knowing how to use and access Moodle (or university designated electronic delivery system);
  • being familiar with emergency guidelines;
  • evacuating with textbooks and other course materials;
  • knowing their Moodle (or designated system) student login and password;
  • contacting faculty regarding their intentions for completing the course.

Faculty are responsible for:

  • development in the use of the Moodle (or designated) software;
  • having a plan for continuing their courses using only Moodle and email;
  • continuing their course in whatever way suits the completion of the course best, and being creative in the continuation of these courses;
  • making adjustments or compensations to a student’s progress in special programs with labs, clinical sequences or the like, only in the immediate semester following the emergency.

NO CELL PHONES OR AUDIBLE BEEPERS WILL BE ALLOWED IN CLASS. Be sure that these devices are turned off or on silent mode as you enter the classroom. These devices are a distraction to the instructor as well as your classmates. If there is an emergency and you need to respond please let the instructor know of this before the class starts.

THIS SYLLABUS, IN NO WAY, IS TO BE MISCONSTRUED AS A CONTRACT, AND MAY BE AMENDED BY THE INSTRUCTOR AS DEEMED NECESSARY.

OUTLINE OF TOPICS

CHAPTER(S)POINTS

1.Chemistry: It’s all About “Stuff’

2. Atoms and Radioactivity

3. Compounds

EXAM 1 (Friday, Feb. 10)100

4. Introduction to Organic Compounds

5. Chemical Reactions

6. Carbohydrates

EXAM 2 (Wednesday, Mar. 8)100

7.Intermolecular Forces

8. Solution Chemistry

9. Acids, Bases, and Buffers in the Body

LAST DAY TO DROP WITH ‘W’ GRADE IS FRIDAY, MARCH 24, 2017

EXAM 3 (Friday, Mar. 31)100

  1. Proteins

11. Nucleic Acids

12.Food as Fuel – A Metabolic Overview

EXAM 4 (Wednesday, May 3)100

FINAL EXAM (Fri., May 5)100

TOTAL POINTS500*

*Note: Able to drop lowest exam score excluding Final Exam. Everyone MUST take the Final Exam. Average exam score will constitute 80% of the final grade. Homework constitutes 20% of the final grade.

Monday – Wednesday – Friday

Date / Topic / Date / Topic / Date / Topic
Jan. 16 / Martin Luther King Holiday / Jan. 18 / Scientific Inquiry / Jan. 20 / Chapter 1. Matter
Metric Units, Prefixes, Conversions, Significant Figures
Jan. 23 / Chapter 1. Classification of Matter; Gases, Solids and Liquids; Elements; Compounds; Periodic Table / Jan. 25 / Chapter 1. How matter Changes: Physical vs Chemical changes / Jan. 27 / Chapter 2. Atoms and their Basic Components, Atomic Number, Atomic mass
Jan. 30 / Chapter 2. Isotopes, Atomic Mass, The Mole concept (counting atoms) / Feb. 1 / Chapter 2. Radioactivity and Radioisotopes, Nuclear Equations and Radioactive Decay / Feb. 3 / Chapter 2. Radiation Units and Half-Lives, Medical Applications
Feb. 6 / Chapter 3. COMPOUNDS: The Octet Rule Ionic Compounds, Names / Feb. 8 / Chapter 3. Covalent Compounds, Names; Polarity / Feb. 10 / EXAM 1
Chapters 1,2,3
Feb. 13 / Chapter 4. Intro to Organic: Alkanes, Structures / Feb. 15 / Chapter 4. Functional Groups / Feb. 17 / Chapter 5. Chemical Reactions: Thermodynamics
Feb. 20 / Chapter 5. Chemical Reactions: Kinetics, Types / Feb. 22 / Chapter 5. Chemical Reactions: Oxidation – Reduction, Addition / Feb. 24 / Chapter 6. CHOs: Monosaccharides, oxidation-reduction, ring structures
Feb. 27 / Lundi Gras/Mardi Gras / Mar. 1 / Ash Wednesday / Mar. 3 / Chapter 6: Modified sugars, Disaccharides, Artificial Sweetners, Polysaccharides
Mar. 6 / Chapter 6: Modified sugars, Disaccharides, Artificial Sweetners, Polysaccharides / Mar. 8 / EXAM 2
Chapters 4,5,6 / Mar. 10 / Chapter 7. Intermolecular Forces and Changes of State, Fats and Oils, Melting
Mar. 13 / Chapter 7. Intermolecular Forces and Changes of State, Fats and Oils, Melting / Mar. 15 / Chapter 7. Cell Membranes, Phospholipids and Cholesterol / Mar. 17 / Chapter 8. Solubility, Elecrolytes, Concentrations, Dilutions
Mar. 20 / Chapter 8. Solubility, Elecrolytes, Concentrations, Dilutions / Mar. 22 / Chapter 8. Osmosis and Diffusion, Transport Across Cell Membranes / Mar. 24 / Chapter 9. Acids and Bases: Definitions, Strong vs. Weak, Equilibrium
Mar. 27 / Chapter 9. pH and pH Scale, Autoionization of Water / Mar. 29 / Chapter 9. Buffers: Maintaining physiological pH, amino acids / Mar. 31 / EXAM 3
Chapters 7,8,9
Apr. 3 / Chapter 10. Proteins: Amino Acids, Classification, Separation / Apr. 5 / Chapter 10. Three Dimensional Structure, Denaturation / Apr. 7 / Chapter 10. Enzymes: Substrate interaction, Thermodynamics
Apr. 10 / Chapter 10. Factors that Affect Enzyme Activity: Substrate, pH, Temp, etc. / Apr. 12 / Chapter 11. Nucleic Acids: Components: DNA, RNA, Protein Synthesis / Apr. 14 / GOOD FRIDAY
Apr. 17 / EASTER BREAK / Apr. 19 / EASTER BREAK / Apr. 21 / EASTER BREAK
Apr. 24 / Chapter 11. The Genetic Code, Protein Synthesis / Apr. 26 / Chapter 11. Mutations, Viruses, Recombinant DNA Technology / Apr. 28 / Chapter 12. Overview of Metabolism: Catabolism, Anabolism
May 1 / Chapter 12. Glycolysis, The Citric Acid Cycle, ATP Production / May 3 / EXAM 4
Chapters 10,11,12 / May 5 / FINALS
CHEM 109-6M
10:30am – 12:30 pm
May 8 / FINALS / May 10 / FINALS / May 11
(THURSDAY)
Grades Due 9:00 am