Computing Reproducibility Score (RS)

Computing Reproducibility Score (RS)

Here we provide step-by-step instruction on computing RS.

1. Check if the SNP is nonsynonymous or 5’UTR. If “yes”, RS = 2. If SNP is coding synonymous,3’ downstream or non-coding, RS = 1. If SNP is intergenic, 3’ UTR, 5’ upstream, intronic or non-coding intronic, RS =0. Details on the definition of SNP types can be found in the paper by Ullah et al.(Dayem Ullah, Lemoine, & Chelala, 2013).
2. Check minor allele frequency (MAF) among controls. If MAF>0.3 add 1 to RS otherwise add 0.
3. Determine if the SNP is linked to a gene. A SNP is considered linked to a gene when the SNP is located in a gene region or 2 kb flanking regions on either side of the gene. Note that in some cases several genes can be linked to the SNP. If the SNP is not linked any gene, the RS from the step 2 will be the final RS, otherwise go to step 4.
4. Check if at least one of the linked genesis listed in Online Mendelian Inheritance in Men (OMIM) database If the gene is listed in OMIM database add 1 to RS otherwise add 0.
5. Check if the product encoded by at least one linked gene has nuclear localization. Use Gene Ontology component term GO:0005634– nucleus. If gene encoded product shows nuclear localization add 1 to the RS, otherwise add 0. The list of the human genes for GO:0005634 is shown below.
6. Check if the size of each of the linked genes exceeds 800K. If yes, add 0 to RS otherwise add 1. The list of genes with size >800K is shown below.
7. Check if the product encoded by at least one linked gene is a kinase. If yes, add 1 to the RS, otherwise add 0. Use molecular function GO term GO:0016301 – kinase activity. The list of the human genes belonging to this category is shown below.
8. Check if the conservation index (CI) of the protein encoded by at least one linked gene is equal 1 - gene is unique for Homo sapience. If yes, add 1 to RS, otherwise add 0. The list of the human genes with CI=1 can be found below.
9. Check if the product encoded by at least one linked gene is a growth factor. If yes, add 1 to the RS, otherwise add 0. Use molecular function GO term GO:0008038 – growth factor activity. The list of the human genes belonging to this category is shown below.
10. Check if at least one linked gene exhibit tissue specific mode of expression. If yes, add 1 to the RS, otherwise add 0. Use Tissue specific Gene Expression and Regulation (TiGER) database: to identify genes with tissue specific expression. The list of tissue specific genes according to TiGER can be found below.

List of human genes whose products show nuclear localization.

151050, 11073, 54502, 79733, 219541, 83743, 80173, 389549, 340069, 54959, 92312, 644186, 54870, 140733, 340152, 253769, 9840, 3167, 440955, 688, 2188, 3200, 85865, 56903, 3364, 8336, 7258, 197342, 80233, 1647, 122706, 7994, 340120, 23019, 7043, 55814, 647309, 137814, 645836, 645402, 644815, 51754, 3054, 378950, 100131017, 503834, 5546, 728403, 64591, 100288801, 92565, 80142, 344787, 23347, 340784, 343930, 126374, 157848, 503582, 342933, 340260, 339778, 353355, 148198, 138715, 100506888, 6474, 388125, 503835, 139735, 5422, 120237, 100287226, 644168, 730087, 441234, 6597, 22843, 339487, 10629, 8204, 5886, 79003, 26137, 5704, 51747, 5245, 2001, 6776, 10454, 405, 23450, 28970, 2113, 146540, 11260, 2099, 342892, 100130958, 101060200, 344167, 344022, 728386, 442319, 389136, 101928601, 440854, 7652, 55692, 342900, 402569, 57409, 57491, 28973, 114876, 3170, 4174, 5202, 152518, 23581, 100144748, 3020, 8370, 8346, 51727, 10286, 7541, 90993, 64344, 10691, 51447, 7515, 92806, 25978, 201501, 23063, 100128927, 390245, 4691, 9782, 2733, 9918, 22955, 55775, 9355, 3213, 23660, 896, 4212, 11108, 51428, 9874, 4848, 55602, 246243, 6936, 79828, 7514, 339287, 1107, 10051, 1108, 51548, 146713, 1499, 26959, 805, 22903, 7027, 5013, 220042, 6778, 2128, 8428, 9584, 54962, 84498, 345462, 29896, 11011, 4172, 79096, 10296, 2078, 2309, 84364, 728927, 63946, 25828, 654254, 144715, 79616, 1408, 22823, 23081, 8284, 25777, 1879, 2547, 4773, 4775, 10902, 55120, 9971, 7101, 27443, 5423, 39, 324, 80321, 84060, 6189, 4782, 1998, 4857, 8498, 10919, 22828, 1196, 4015, 641, 23369, 4010, 6594, 6847, 391723, 4664, 85446, 4176, 6934, 26512, 6432, 197135, 9612, 100287144, 100287238, 729747, 57018, 100287205, 100287178, 7534, 4784, 5468, 653121, 79618, 8629, 29894, 100287478, 5971, 100287364, 100287513, 100287327, 100287404, 345643, 100287441, 10734, 53335, 6899, 6928, 102723538, 113510, 3980, 116447, 80324, 27301, 4968, 2908, 6683, 10102, 7374, 4913, 23087, 6744, 25998, 6950, 124245, 5079, 11262, 58538, 5108, 100293516, 53371, 27043, 64425, 10250, 57593, 3033, 221178, 647589, 55777, 6949, 8726, 9774, 6342, 5452, 219537, 6195, 10062, 5914, 5916, 6097, 7376, 10002, 2104, 2516, 2494, 3172, 9572, 5467, 8022, 5080, 25806, 7182, 6196, 4862, 54700, 6997, 8091, 5917, 84172, 55110, 23054, 116986, 6601, 686, 4673, 860, 9055, 91133, 29901, 23244, 5017, 54853, 2071, 22938, 23338, 55147, 9079, 996, 51497, 7090, 90120, 7157, 10101, 55291, 55352, 1428, 7181, 7295, 23125, 199, 84250, 6603, 57508, 4301, 23186, 23774, 10179, 11176, 64708, 2966, 1026, 6143, 55651, 2354, 828, 7089, 27335, 200424, 1432, 5581, 5424, 5460, 728361, 8540, 6446, 10212, 11332, 4641, 8773, 10456, 2139, 9049, 421, 6820, 322, 5717, 5718, 5715, 8535, 7485, 6829, 6874, 1676, 5994, 1192, 11060, 406, 2304, 8976, 1112, 10284, 10643, 8634, 10733, 3475, 27333, 4211, 22936, 10384, 10473, 10213, 51042, 607, 23481, 6386, 10199, 10528, 6656, 1654, 8544, 3840, 8789, 11065, 32, 8289, 8099, 23316, 10190, 26330, 11316, 8625, 10106, 9083, 9087, 9973, 1046, 7748, 1856, 1106, 1861, 27348, 8675, 102, 8507, 9536, 8085, 727851, 317, 5609, 10419, 9368, 7015, 1111, 7760, 10681, 10915, 10403, 30000, 11128, 401, 5688, 9447, 571, 8487, 30851, 3551, 6003, 6002, 8520, 8573, 22797, 6790, 1047, 4659, 51582, 10127, 9987, 9044, 23060, 9726, 9866, 23037, 9870, 23350, 9739, 23135, 8864, 9880, 9925, 23148, 80184, 23243, 9745, 1147, 27257, 2533, 4864, 6926, 285, 10066, 3841, 51043, 9533, 5359, 8805, 8312, 6862, 10217, 4093, 10537, 9278, 55922, 3911, 22794, 1193, 6473, 2189, 8473, 247, 8493, 10572, 5890, 10622, 3149, 7161, 8456, 5496, 2175, 6666, 8841, 404281, 332, 10526, 27324, 9123, 10849, 4438, 8974, 2928, 11097, 5433, 9575, 2255, 26257, 8653, 8651, 4097, 5187, 7746, 9127, 4210, 1665, 8731, 23378, 9841, 1406, 5252, 4439, 5414, 5709, 3227, 23543, 6478, 10467, 9183, 9092, 1613, 7041, 9422, 23099, 9907, 23300, 5078, 6885, 9521, 57149, 7757, 4440, 388567, 3199, 284403, 9129, 5612, 9158, 9139, 10465, 6839, 27429, 9314, 11339, 10618, 5889, 9443, 4091, 7516, 27040, 10636, 55806, 10591, 6591, 2307, 5356, 6001, 7756, 4711, 6943, 439, 699, 9184, 81, 30012, 27336, 5565, 63928, 3196, 2029, 8444, 8405, 8636, 11051, 26584, 9136, 9997, 10270, 3420, 10488, 326, 5000, 5885, 6759, 6758, 9282, 6665, 5071, 8467, 23036, 9705, 9891, 9875, 643641, 23295, 66008, 23247, 26048, 9716, 9839, 8888, 23396, 23028, 23239, 26471, 135935, 390874, 5493, 10905, 1747, 7547, 10724, 10174, 10492, 51362, 26953, 1389, 9147, 1149, 2306, 904, 701, 5810, 3717, 7975, 9242, 23633, 29799, 7358, 9404, 1500, 8555, 9595, 8615, 6940, 63931, 9095, 343069, 85236, 10084, 1736, 8721, 23476, 6907, 1515, 4683, 8996, 8732, 9909, 863, 9683, 9475, 9831, 9889, 5253, 9877, 9727, 23066, 9682, 4849, 26039, 26057, 23309, 10049, 4616, 4720, 8882, 347853, 10016, 8468, 56242, 9525, 5626, 5309, 9555, 6451, 100129842, 5195, 1431, 10522, 55660, 8318, 4034, 4094, 8819, 9862, 11104, 2081, 25799, 8856, 11168, 6871, 8464, 2239, 4722, 51053, 3281, 10455, 10656, 27288, 27097, 8815, 23451, 55565, 11193, 8935, 27297, 9252, 10001, 23077, 8928, 9576, 9247, 9099, 10360, 9191, 23020, 8986, 6838, 11033, 27340, 9631, 11169, 6920, 5892, 5064, 9402, 10535, 10248, 10799, 7743, 8666, 5716, 8609, 10269, 10741, 10254, 8812, 9162, 9063, 22826, 10285, 5884, 25822, 10566, 10302, 54440, 26156, 9437, 6792, 9025, 8601, 8817, 1797, 9401, 8725, 9262, 9219, 7398, 51412, 23683, 11076, 8715, 9670, 9878, 23109, 9645, 9913, 23376, 9678, 26043, 9668, 9760, 23353, 24148, 51585, 10725, 5218, 22888, 23030, 22883, 22995, 10614, 27134, 11102, 9133, 51366, 9985, 100861412, 257, 11098, 4821, 57466, 7753, 10073, 7542, 4710, 4947, 7755, 22905, 9406, 11130, 27287, 10112, 25803, 24137, 8930, 6305, 11143, 10912, 3756, 8658, 23582, 7957, 23557, 6496, 10626, 51341, 10569, 10421, 9441, 7546, 9220, 8403, 9530, 5073, 8624, 2778, 23399, 10412, 23466, 51567, 25874, 11279, 25885, 8089, 27107, 23519, 4850, 10617, 10272, 10898, 4772, 2070, 10775, 2103, 23641, 22824, 9991, 90865, 91120, 9204, 9131, 9022, 6615, 11319, 25949, 23492, 9096, 8320, 6911, 9480, 53615, 8940, 11170, 8915, 9421, 9189, 4338, 11200, 86, 9134, 7468, 3939, 6647, 25, 1956, 445, 4938, 12, 1471, 1475, 4609, 7040, 4878, 1409, 3861, 3853, 4000, 335, 348, 4155, 213, 4057, 2495, 4502, 283, 1791, 226, 301, 4613, 3848, 6285, 6406, 10382, 5620, 4489, 4493, 4494, 3315, 6185, 2771, 383, 3690, 6279, 5582, 292, 4353, 3151, 6175, 3725, 661, 7123, 6741, 7020, 5579, 3875, 3856, 1411, 793, 2534, 590, 5925, 5241, 5757, 6280, 6277, 4869, 8970, 7054, 2168, 1059, 5232, 3005, 1420, 1419, 1421, 302, 4490, 154, 1514, 5216, 353, 1508, 3948, 3183, 2067, 6667, 7544, 3303, 4477, 389, 4804, 2735, 6520, 4306, 4313, 6649, 1511, 5160, 1537, 6629, 153, 2249, 3055, 3855, 3868, 3921, 6626, 3233, 3221, 2247, 3215, 6728, 3956, 6678, 307, 1267, 3217, 3223, 3178, 6627, 4070, 142, 240, 7345, 4048, 3015, 8969, 286436, 494551, 29844, 474382, 83740, 100125288, 392197, 392188, 727940, 378949, 342371, 729648, 170067, 146542, 730291, 642623, 54921, 169834, 729288, 100131390, 7316, 728957, 100132396, 100507290, 728410, 441056, 653545, 653548, 728395, 6399, 100861437, 5940, 646817, 2736, 2737, 284459, 342945, 3104, 2738, 3002, 6738, 4605, 367, 49, 3008, 596, 2063, 7025, 4257, 2098, 3329, 5915, 7067, 7068, 1191, 3659, 3309, 1959, 7372, 5162, 3684, 5292, 34, 2260, 7150, 7153, 2539, 7421, 2101, 7356, 3482, 5681, 1019, 6722, 26986, 5111, 291, 293, 3615, 7175, 5744, 5304, 4610, 3001, 6497, 6498, 87, 4625, 6714, 4066, 7520, 1327, 4617, 3234, 4624, 478, 1938, 4495, 3858, 3860, 3852, 7584, 7178, 210, 327, 155, 2963, 3292, 3660, 2224, 5987, 7184, 891, 3212, 3211, 6628, 3416, 5451, 3728, 2114, 673, 2167, 2752, 231, 5880, 4654, 4656, 5224, 55, 7430, 1386, 7347, 8061, 2355, 374, 4830, 51710, 58500, 3096, 5075, 6187, 5896, 6929, 1832, 6118, 2623, 4835, 3014, 286, 1385, 5156, 5532, 4690, 3009, 3007, 3006, 55552, 4255, 1363, 8531, 7543, 7559, 7561, 7562, 7564, 7565, 7566, 7567, 7568, 7569, 7570, 7571, 7572, 7586, 219749, 7587, 7576, 7594, 90075, 7579, 7580, 3310, 7553, 2805, 3726, 3673, 7343, 3219, 3214, 3216, 3727, 11016, 5566, 1051, 5771, 1655, 7494, 3958, 3486, 6688, 5702, 2068, 6129, 6651, 7936, 6139, 466, 467, 5434, 7132, 6737, 7942, 2020, 1459, 6256, 4790, 4688, 10468, 310, 6908, 890, 5455, 5454, 689, 241, 7133, 5367, 7200, 5816, 4437, 4599, 4600, 5689, 3013, 4001, 3202, 602, 825, 6927, 3614, 2312, 5763, 2947, 1465, 4763, 7556, 7128, 6872, 1812, 7416, 5007, 2091, 6192, 43, 7317, 654364, 7391, 2264, 3010, 2261, 3181, 5989, 10309, 794, 867, 3164, 7507, 6917, 5742, 7283, 5479, 6271, 7453, 6188, 4618, 6198, 3716, 5791, 4014, 4163, 4800, 191, 8348, 8263, 5081, 5077, 2624, 2625, 1376, 6240, 7597, 1393, 7026, 1910, 1773, 898, 5430, 1909, 4801, 563, 7528, 3300, 498, 5682, 5683, 5684, 4005, 4004, 6286, 4792, 1786, 11338, 6137, 6275, 3148, 5725, 7538, 6117, 328, 5698, 5686, 5449, 5692, 5693, 7111, 5828, 3235, 3236, 4487, 5594, 1843, 7593, 2073, 5933, 51056, 952, 2960, 2961, 5777, 6870, 1382, 5926, 5927, 7086, 4846, 6317, 5937, 5371, 7297, 1936, 4939, 5161, 4082, 358, 25824, 2644, 894, 7465, 995, 219, 5431, 11151, 6278, 5596, 3232, 3206, 3203, 3204, 3205, 3207, 3224, 3228, 3229, 3237, 3195, 6241, 7072, 3097, 207, 200315, 2810, 6282, 4160, 3344, 2965, 1491, 6133, 1478, 1854, 6274, 3018, 4173, 6470, 2869, 648, 7703, 4843, 4771, 6119, 5984, 5982, 5981, 6146, 2962, 6697, 148, 5743, 147, 6095, 3238, 3239, 102724560, 3857, 4488, 2645, 3667, 178, 4627, 4628, 7078, 1649, 8021, 7913, 1538, 55553, 54345, 6664, 2745, 196, 3849, 2324, 3791, 6932, 402, 403, 373, 5605, 7629, 6124, 4521, 5501, 5438, 6720, 1743, 2879, 6727, 23636, 6935, 6888, 6622, 27316, 672, 8161, 3313, 9775, 3508, 6122, 8125, 2237, 974, 5699, 7428, 5087, 5089, 23521, 10124, 4292, 6774, 5824, 4191, 3600, 5985, 5983, 3397, 2119, 2117, 604, 1069, 2120, 1939, 5997, 5730, 6658, 7318, 8260, 8242, 339, 2617, 5584, 2004, 7112, 6772, 23517, 5291, 2475, 4300, 836, 835, 6232, 7294, 2444, 23310, 23029, 11224, 1030, 1031, 3064, 5048, 4436, 2118, 4100, 4109, 4110, 5902, 10135, 2626, 7080, 7417, 23468, 5599, 5601, 6416, 4288, 5905, 5965, 4839, 546, 7917, 4851, 8870, 5606, 79184, 6125, 6144, 6203, 6204, 4734, 7402, 8826, 4975, 1044, 3400, 653499, 678, 539, 7980, 5990, 5991, 5993, 5305, 6657, 6662, 6258, 5121, 5714, 5273, 7916, 22948, 1453, 7136, 5425, 5829, 9261, 6164, 4891, 5456, 1024, 9801, 501, 997, 1058, 1063, 7319, 3198, 5557, 5558, 379, 10664, 1050, 1052, 5691, 5690, 4171, 58517, 8650, 1195, 5663, 3094, 2272, 9972, 5903, 6000, 5664, 7249, 8859, 6878, 22929, 3981, 1028, 3795, 2776, 3110, 4222, 4223, 2010, 5272, 4601, 2077, 2115, 429, 7275, 1022, 10140, 3141, 9735, 9770, 1025, 5538, 10575, 311, 10914, 8087, 7818, 1845, 7634, 347344, 7637, 1763, 6595, 5023, 675, 3654, 5713, 7321, 6777, 7712, 6990, 7592, 7626, 2334, 5613, 2986, 190, 8277, 3068, 902, 4331, 4751, 4752, 900, 7324, 220988, 5226, 4670, 3838, 22916, 5437, 5439, 3267, 3185, 2957, 2958, 2956, 7692, 7695, 7690, 7693, 7701, 7702, 10181, 10247, 6781, 1609, 3651, 4928, 1482, 10660, 5536, 5347, 11162, 47, 1054, 3984, 3985, 6300, 5602, 754, 5440, 7267, 6525, 1207, 167, 7290, 4287, 7013, 5395, 8565, 5571, 5563, 3306, 5887, 5396, 4901, 5710, 2669, 1434, 7009, 7873, 8028, 4302, 8178, 7862, 840, 842, 839, 132, 103, 1032, 2290, 3169, 3171, 3275, 6396, 9520, 3188, 6612, 5897, 9551, 1749, 1750, 8568, 4150, 8115, 5427, 5024, 3692, 1488, 10123, 8504, 8863, 6663, 145258, 102724334, 53820, 150094, 63977, 30812, 53347, 56683, 10785, 9496, 51282, 51274, 54039, 57122, 83667, 143686, 84695, 338917, 7675, 136319, 3017, 171389, 91662, 126206, 129025, 353274, 84337, 25906, 3646, 339345, 342977, 5531, 345456, 7979, 5687, 6729, 5862, 1163, 5435, 83719, 112755, 9464, 6138, 4116, 2257, 6155, 3670, 5092, 6168, 387, 51126, 5569, 6613, 51569, 10238, 11091, 10204, 3190, 6201, 5499, 5500, 801, 5705, 6202, 6208, 6228, 6222, 6207, 6635, 6636, 6637, 27258, 11157, 6632, 6633, 6634, 694, 5706, 9519, 6130, 5436, 7555, 5516, 388, 6147, 8368, 8347, 5901, 9349, 7322, 6209, 6229, 6230, 6231, 5441, 9978, 6156, 4736, 6135, 6233, 6434, 2770, 5534, 7320, 5520, 6638, 7341, 6500, 1984, 10399, 71, 6827, 4904, 7332, 1915, 10383, 1457, 8968, 1525, 8602, 6047, 10180, 5307, 10557, 10556, 2969, 8396, 6733, 579, 4973, 8900, 8480, 10265, 79190, 50805, 79192, 79191, 11281, 4825, 5591, 1999, 8738, 3430, 4496, 4501, 4925, 6283, 10409, 6492, 29899, 23635, 7110, 64960, 64965, 79366, 84324, 134353, 10907, 10169, 6428, 3021, 390598, 221937, 100381270, 1601, 5310, 7789, 158586, 1947, 8241, 4303, 5935, 54205, 3201, 7019, 3069, 2959, 3222, 1021, 1020, 5813, 2176, 3297, 4791, 2287, 10379, 4193, 27018, 7307, 3642, 6418, 3607, 861, 728137, 4661, 2313, 51350, 8140, 7023, 5394, 5214, 6304, 2130, 5457, 6689, 4952, 5331, 4205, 4207, 6668, 1062, 9493, 4329, 622, 6407, 7596, 320, 6671, 3399, 3024, 3394, 4808, 2692, 5604, 2288, 3000, 6128, 7155, 9586, 5076, 667, 3087, 5453, 1390, 4298, 4297, 1060, 84823, 10153, 344191, 51351, 168374, 7643, 10865, 5970, 51035, 7088, 7091, 2016, 2018, 6742, 1477, 6736, 4084, 7644, 5590, 7704, 9295, 1917, 5580, 6041, 1844, 2019, 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80011, 26287, 56648, 25937, 63978, 59348, 728343, 59351, 3231, 79876, 64077, 342538, 83932, 84232, 79768, 55341, 84225, 55226, 80726, 83447, 84215, 22803, 54472, 79595, 84101, 152006, 84081, 29127, 29070, 23235, 23283, 11059, 90592, 84084, 84105, 51202, 7259, 83591, 55544, 140880, 64412, 116092, 3622, 60529, 81030, 81566, 64682, 55998, 64207, 10621, 64710, 65110, 54830, 85366, 64743, 55040, 80306, 81620, 30844, 57731, 83442, 63973, 64211, 11078, 80314, 7337, 64061, 8548, 53938, 80351, 23394, 64102, 170506, 83881, 28996, 64397, 644524, 55486, 29965, 5411, 26609, 425054, 27086, 79893, 8626, 83892, 140597, 10628, 81542, 7469, 64946, 25930, 55898, 10114, 128866, 79004, 1263, 60485, 56000, 50619, 642636, 23051, 26150, 26168, 26031, 56916, 59336, 59335, 219409, 80345, 253738, 28984, 63925, 63935, 51575, 140836, 85365, 84146, 55127, 63904, 64776, 79724, 79723, 79842, 79101, 79874, 79955, 64376, 84191, 60625, 79177, 80119, 79897, 79991, 79750, 64852, 79041, 79080, 64321, 56919, 65083, 80004, 54828, 79697, 112399, 79818, 55520, 64789, 84154, 64754, 80232, 81550, 64426, 58506, 79973, 79788, 80139, 79943, 84148, 79816, 51808, 64858, 65264, 6598, 79760, 28976, 79706, 79698, 57325, 25926, 64794, 80013, 55893, 1894, 80263, 64768, 90861, 79751, 9477, 93973, 79933, 25904, 80010, 79813, 79797, 57763, 79913, 81875, 54934, 79647, 79840, 79923, 80135, 79727, 64393, 79603, 64769, 80032, 79685, 22877, 54763, 64750, 26019, 57510, 55290, 63967, 57396, 3431, 80237, 27101, 55367, 64121, 2178, 54542, 23598, 57665, 55859, 57407, 55591, 57405, 51616, 56033, 10110, 60489, 64127, 60313, 57332, 59343, 10783, 57727, 57721, 57154, 57703, 54843, 57692, 55167, 55225, 57684, 57680, 57677, 57669, 83439, 56949, 27006, 25855, 57113, 10011, 10017, 51091, 5119, 29098, 56729, 11180, 3166, 58516, 8521, 10363, 51085, 29101, 27434, 58529, 58526, 55734, 56943, 50855, 57820, 10736, 54512, 29089, 51335, 55505, 55644, 55929, 29855, 29117, 55856, 55629, 29079, 55916, 51300, 23414, 85508, 56672, 56676, 64976, 692312, 54586, 23236, 56956, 26508, 57101, 29974, 57142, 1540, 135114, 58490, 54514, 58528, 58524, 5203, 387893, 3619, 56915, 51010, 56924, 56980, 56979, 11105, 93166, 11107, 57050, 1617, 55906, 58491, 9260, 55902, 9188, 56655, 55870, 55509, 4154, 56731, 57054, 56034, 56478, 51547, 128553, 25970, 54107, 54108, 56950, 8086, 54861, 11177, 56606, 11179, 26524, 27148, 29102, 56893, 29907, 27350, 56940, 56902, 58493, 2909, 57047, 56894, 51022, 11186, 728695, 728712, 105, 10210, 55915, 56852, 56998, 9455, 6299, 54014, 64092, 54212, 79019, 11277, 55589, 23047, 29789, 51076, 81847, 10137, 23195, 200350, 346171, 56256, 55794, 55326, 55787, 26010, 55325, 55317, 11194, 25879, 55272, 55257, 55253, 55756, 9440, 55742, 25896, 54496, 55726, 54552, 55723, 55174, 55718, 55153, 55151, 55149, 55145, 51132, 55142, 54475, 140467, 55703, 55131, 55122, 55696, 55090, 54715, 55082, 56271, 54498, 55010, 55663, 55003, 55662, 54998, 54994, 29086, 54982, 54969, 54960, 54957, 54952, 54942, 54937, 54936, 25764, 55646, 54927, 54925, 55588, 23408, 54881, 254394, 9577, 54556, 54807, 54442, 54784, 54780, 55511, 54433, 151987, 10072, 343472, 26574, 54606, 8877, 54386, 51339, 51529, 55813, 51776, 29980, 54069, 9620, 7769, 51755, 57786, 51759, 54458, 4337, 26298, 51741, 50485, 51324, 51704, 10744, 27178, 29841, 29842, 10642, 51514, 26278, 7767, 27430, 26509, 29997, 30845, 30846, 23742, 51517, 30813, 11054, 51734, 23619, 51510, 51503, 29087, 29080, 400569, 51079, 26064, 55810, 55506, 51545, 29843, 30827, 23677, 10362, 51213, 29969, 57658, 55727, 57645, 57205, 57615, 55920, 57606, 57602, 57600, 56647, 51765, 57567, 57563, 53981, 51520, 57547, 55758, 50804, 57540, 54439, 55683, 57520, 57519, 473, 51298, 51222, 8932, 23154, 24144, 3175, 58513, 1789, 100506164, 23595, 10055, 51701, 51438, 9616, 11317, 10891, 4552, 8409, 22953, 1717, 10013, 4234, 6199, 51726, 9604, 51426, 10926, 10933, 50813, 8820, 27129, 51455, 7621, 7620, 390010, 84152, 8427, 55954, 11080, 9263, 23361, 27347, 120, 92999, 222229, 10765, 9337, 25934, 8545, 23761, 26575, 54764, 26297, 10038, 8994, 23264, 6942, 10042, 79159, 9582, 23075, 6945, 51187, 27158, 27125, 6730, 27030, 29978, 7227, 11218, 51460, 26747, 29118, 9569, 29761, 23676, 26502, 55971, 29115, 9969, 22827, 29959, 58478, 29114, 51194, 1602, 10459, 23039, 51193, 7773, 27285, 4595, 29994, 9031, 28999, 51191, 51131, 4152, 51804, 29883, 5361, 23270, 4482, 9205, 84515, 51605, 83699, 56180, 65243, 54206, 346157, 57167, 51174, 27022, 29942, 51164, 29947, 7772, 7733, 29946, 8697, 51434, 29945, 29882, 26353, 26088, 30968, 7768, 7766, 7673, 7638, 27330, 51157, 25819, 51690, 3621, 51163, 10116, 51155, 27005, 26273, 26235, 58155, 23291, 26205, 51154, 23043, 26060, 25833, 143, 29107, 11164, 9994, 22913, 9329, 26271, 26223, 26224, 22806, 22985, 267, 10762, 11244, 55571, 10178, 9529, 25790, 30009, 23567, 29944, 5721, 9344, 7762, 7761, 23040, 23549, 51703, 57509, 27154, 27153, 54617, 57496, 54454, 49854, 57178, 57474, 55689, 57472, 57461, 25831, 25792, 3299, 23624, 22974, 29777, 4674, 28987, 7732, 26993, 23764, 729355, 26228, 29108, 23569, 51343, 10393, 4854, 4646, 5325, 9825, 9757, 8538, 57057, 27247, 27339, 10745, 171024, 11274, 29979, 51684, 666, 51406, 6322, 57447, 23439, 9580, 11201, 9284, 10273, 58533, 11266, 51147, 5719, 11036, 11124, 10450, 9429, 27292, 8914, 8533, 4858, 10885, 8458, 7775, 55968, 8605, 8927, 6314, 5326, 26468, 51592, 23133, 23381, 23067, 23326, 22897, 22887, 23287, 23314, 22858, 8036, 23524, 5036, 9156, 728642, 1501, 6795, 9126, 10014, 10389, 7707, 9107, 51388, 51637, 10856, 9425, 5303, 6941, 10000, 51371, 26240, 51659, 11178, 10855, 27166, 51386, 8607, 10726, 51655, 7419, 27130, 25842, 10224, 27296, 22809, 117178, 22834, 22982, 23379, 745, 22835, 22869, 22890, 22992, 22894, 22909, 27252, 90485, 10172, 113835, 11056, 51082, 8313, 51087, 10746, 23592, 23588, 30062, 9967, 51729, 30818, 10025, 51602, 23568, 51728, 27033, 10910, 51005, 51070, 51072, 221527, 57819, 51631, 51118, 51119, 51013, 51639, 25996, 51018, 51002, 26994, 51645, 51003, 51647, 102157402, 51649, 50810, 11171, 51493, 25793, 25776, 26152, 81628, 27309, 26155, 25873, 25950, 26097, 26108, 25939, 26017, 25966, 11187, 90417, 50945, 9149, 6297, 26013, 7728, 5564, 8690, 8295, 9603, 23132, 9730, 55818, 9904, 9958, 9633, 4017, 7189, 26100, 9894, 81887, 23658, 25804, 50674, 55905, 27254, 171568, 54626, 10586, 7589, 51667, 9150, 11198, 51096, 23626, 51377, 23534, 26517, 23594, 10087, 28227, 9935, 9328, 9330, 1761, 9939, 10600, 9500, 10365, 29915, 29914, 51513, 93621, 29109, 10881, 11213, 25788, 10082, 11166, 10927, 11133, 8926, 25932, 9054, 23741, 23788, 10565, 8379, 10039, 9426, 9085, 91419, 29924, 9960, 23523, 1788, 4940, 7779, 27244, 7539, 8202, 163131, 23473, 11221, 26040, 23383, 26049, 23026, 22882, 22880, 23261, 51750, 6773, 6660, 93349, 84530, 811, 8092, 7529, 5696, 1745, 64067, 7508

List of the genes with the size of the gene region >800K.

7399, 26137, 60412, 2918, 8821, 121256, 1826, 161357, 9910, 5797, 1806, 27328, 56243, 26033, 55016, 25834, 157680, 64067, 257194, 2917, 54212, 22871, 123624, 129684, 344148, 83943, 4745, 9734, 1730, 5101, 1501, 285220, 254827, 55799, 152330, 9229, 26059, 50863, 221935, 57451, 23261, 23245, 65217, 154215, 6660, 5799, 117583, 1010, 10718, 51741, 9378, 253559, 11122, 4978, 3084, 79582, 1496, 40, 137868, 2066, 1012, 6091, 10082, 26053, 1630, 26280, 114788, 80333, 442117, 56899, 1600, 158038, 5592, 53942, 57689, 11141, 5071, 57628, 9863, 2895, 2262, 401145, 84871, 2272, 5144, 54715, 6092, 29119, 53353, 346007, 140733, 1740, 1756, 5789, 26047

List of the human genes belonging to GO category GO:0016301 – kinase activity.

25, 27, 90, 91, 92, 93, 94, 132, 156, 157, 203, 204, 205, 207, 208, 238, 269, 369, 472, 545, 558, 595, 613, 640, 657, 658, 659, 660, 673, 695, 699, 701, 780, 805, 814, 815, 816, 817, 818, 891, 898, 902, 983, 984, 1017, 1018, 1019, 1020, 1021, 1022, 1024, 1025, 1027, 1029, 1111, 1119, 1120, 1147, 1152, 1158, 1160, 1195, 1196, 1198, 1263, 1326, 1432, 1445, 1452, 1453, 1454, 1455, 1456, 1457, 1459, 1460, 1606, 1607, 1608, 1609, 1612, 1613, 1633, 1716, 1760, 1841, 1859, 1944, 1945, 1949, 1956, 1969, 2011, 2041, 2042, 2043, 2044, 2045, 2046, 2047, 2048, 2049, 2050, 2051, 2059, 2064, 2065, 2066, 2068, 2071, 2081, 2185, 2202, 2241, 2242, 2260, 2261, 2263, 2264, 2268, 2321, 2322, 2324, 2444, 2475, 2534, 2580, 2584, 2585, 2645, 2710, 2712, 2868, 2869, 2870, 2872, 2931, 2932, 2965, 2967, 2968, 2984, 2986, 2987, 3000, 3055, 3098, 3099, 3101, 3480, 3482, 3551, 3611, 3643, 3645, 3654, 3656, 3702, 3705, 3706, 3707, 3716, 3717, 3718, 3756, 3757, 3791, 3795, 3815, 3932, 3984, 3985, 4052, 4058, 4067, 4117, 4139, 4140, 4145, 4214, 4215, 4216, 4217, 4233, 4293, 4294, 4296, 4331, 4342, 4356, 4486, 4593, 4598, 4638, 4705, 4750, 4751, 4752, 4830, 4832, 4833, 4881, 4882, 4914, 4915, 4916, 4919, 4920, 4921, 5058, 5062, 5063, 5106, 5127, 5128, 5129, 5156, 5157, 5159, 5163, 5164, 5165, 5166, 5170, 5207, 5208, 5209, 5210, 5211, 5213, 5214, 5218, 5230, 5232, 5255, 5256, 5257, 5260, 5261, 5286, 5287, 5288, 5289, 5290, 5291, 5292, 5293, 5294, 5296, 5297, 5298, 5305, 5313, 5315, 5328, 5347, 5531, 5562, 5563, 5564, 5565, 5566, 5567, 5568, 5571, 5573, 5579, 5580, 5581, 5582, 5583, 5584, 5585, 5586, 5587, 5588, 5590, 5591, 5592, 5593, 5594, 5595, 5596, 5597, 5598, 5599, 5600, 5601, 5602, 5603, 5604, 5605, 5606, 5607, 5608, 5609, 5610, 5613, 5631, 5634, 5649, 5681, 5747, 5753, 5754, 5756, 5832, 5871, 5891, 5894, 5987, 6011, 6041, 6093, 6098, 6102, 6195, 6196, 6197, 6198, 6199, 6259, 6300, 6347, 6352, 6355, 6416, 6446, 6464, 6662, 6714, 6725, 6732, 6733, 6787, 6788, 6789, 6790, 6792, 6793, 6794, 6795, 6850, 6872, 6885, 7006, 7010, 7016, 7042, 7046, 7048, 7049, 7075, 7083, 7084, 7204, 7272, 7294, 7297, 7301, 7371, 7443, 7444, 7465, 7525, 7535, 7786, 7867, 8317, 8382, 8394, 8395, 8396, 8408, 8428, 8444, 8445, 8476, 8491, 8503, 8518, 8525, 8526, 8527, 8536, 8550, 8558, 8566, 8569, 8573, 8575, 8576, 8621, 8711, 8737, 8767, 8780, 8798, 8805, 8812, 8814, 8828, 8829, 8844, 8851, 8859, 8877, 8878, 8895, 8899, 8986, 8997, 8999, 9020, 9024, 9031, 9060, 9061, 9064, 9088, 9113, 9149, 9162, 9175, 9201, 9212, 9238, 9252, 9261, 9262, 9263, 9344, 9448, 9451, 9465, 9475, 9479, 9578, 9625, 9641, 9677, 9706, 9730, 9748, 9807, 9833, 9874, 9891, 9917, 9942, 9943, 10000, 10020, 10087, 10110, 10114, 10155, 10188, 10201, 10221, 10290, 10295, 10298, 10420, 10454, 10461, 10494, 10595, 10641, 10645, 10654, 10733, 10746, 10769, 10783, 10922, 10978, 11011, 11035, 11040, 11113, 11183, 11184, 11200, 11213, 11214, 11284, 11329, 22845, 22848, 22853, 22858, 22868, 22928, 22929, 22983, 22993, 23012, 23031, 23043, 23049, 23097, 23139, 23178, 23235, 23262, 23363, 23387, 23396, 23415, 23416, 23552, 23604, 23617, 23678, 23683, 23729, 25778, 25865, 25989, 26007, 26289, 26353, 26524, 26576, 26750, 27102, 27133, 27148, 27231, 27330, 27347, 28951, 28964, 28996, 29110, 29904, 29922, 29941, 29959, 29993, 30811, 30849, 50488, 50808, 51086, 51135, 51231, 51232, 51265, 51314, 51347, 51447, 51701, 51719, 51727, 51755, 51765, 51776, 53354, 53632, 53834, 53904, 53944, 54101, 54822, 54861, 54875, 54899, 54963, 54986, 55224, 55229, 55277, 55300, 55312, 55351, 55359, 55361, 55437, 55500, 55561, 55577, 55589, 55681, 55728, 55750, 55781, 55872, 56155, 56164, 56848, 56924, 56975, 56997, 57091, 57118, 57143, 57144, 57147, 57172, 57396, 57410, 57538, 57551, 57761, 57787, 60493, 64080, 64122, 64768, 64781, 65018, 65061, 65125, 65220, 65266, 65267, 65268, 65975, 79012, 79072, 79646, 79672, 79675, 79705, 79707, 79834, 79837, 79858, 79877, 79934, 80025, 80122, 80201, 80216, 80271, 80347, 81629, 81788, 83440, 83549, 83694, 83732, 83903, 83931, 83942, 83983, 84033, 84197, 84254, 84446, 84451, 84630, 84930, 85366, 85442, 85443, 85481, 90956, 91419, 91461, 91807, 92335, 92597, 93627, 112858, 114783, 115701, 117283, 118672, 120892, 122011, 122481, 123688, 124923, 126520, 127933, 129607, 130399, 131096, 131890, 132158, 133686, 136332, 138429, 138474, 139189, 139728, 140469, 140609, 140803, 140901, 146057, 146850, 147746, 149420, 150094, 152110, 157285, 158067, 160851, 166614, 166929, 167359, 169436, 197258, 197259, 200576, 202374, 203054, 203447, 204851, 221264, 221823, 225689, 253430, 255239, 255324, 255967, 256356, 260425, 282974, 283106, 283209, 283455, 283629, 284086, 284656, 285220, 340156, 340371, 341676, 344387, 347736, 375298, 375449, 388228, 389840, 414328, 415116, 440275, 494551, 548596, 646643, 654364, 728642, 100130827, 100526835, 100533105, 102157402

List of the human genes with conservation index (CI) = 1.

2220, 2306, 2850, 3049, 4150, 5553, 7141, 7423, 7554, 7739, 8605, 10443, 10626, 11086, 14761, 17188, 17301, 19074, 21958, 22340, 22702, 24839, 25959, 27295, 29923, 51287, 51686, 53814, 54544, 54841, 54848, 55663, 55891, 57275, 58826, 65275, 66477, 66816, 68185, 69573, 74175, 77669, 83591, 84833, 89796, 113917, 114108, 132625, 171069, 215690, 216635, 232889, 235041, 243833, 244486, 246229, 269870, 288416, 313504, 381695, 417298, 456350, 461639, 465961, 469052, 473087, 475850, 485539, 486075, 489518, 490238, 492228, 499214, 544763, 568734, 609386, 618325, 691810, 691813, 745632, 767586

List of the human genes from GO category GO:0008038 – growth factor activity.

183, 258, 265, 268, 374, 627, 649, 650, 651, 652, 653, 654, 655, 656, 685, 1270, 1435, 1437, 1839, 1950, 2069, 2147, 2202, 2246, 2247, 2248, 2249, 2250, 2251, 2252, 2253, 2254, 2255, 2256, 2257, 2258, 2259, 2277, 2657, 2658, 2660, 2661, 2662, 2668, 2671, 2764, 2896, 2919, 3068, 3082, 3479, 3481, 3558, 3562, 3565, 3567, 3574, 3578, 3586, 3589, 3592, 3593, 3623, 3624, 3625, 3626, 3714, 3952, 3976, 4192, 4254, 4693, 4803, 4838, 4856, 4902, 4908, 4909, 5008, 5154, 5155, 5473, 5623, 5764, 5967, 6320, 6387, 7031, 7040, 7042, 7043, 7044, 7060, 7422, 7423, 7424, 7425, 7873, 8074, 8190, 8200, 8817, 8822, 8823, 8909, 9048, 9135, 9210, 9518, 9535, 9542, 9573, 9965, 10220, 10637, 10675, 10718, 11162, 23529, 26281, 26291, 27006, 27302, 27329, 29937, 29948, 50810, 51293, 51816, 56034, 56287, 79874, 80310, 83729, 84432, 90070, 145957, 146433, 151449, 255324, 346389, 353500, 392255, 441549

List of the genes with tissue specific gene expression pattern according to Gene Expression and Regulation (TiGER) database:

1, 2, 10, 12, 13, 18, 21, 24, 25, 26, 29, 32, 36, 40, 48, 55, 56, 58, 70, 72, 88, 89, 92, 93, 101, 102, 108, 114, 116, 117, 119, 124, 125, 126, 127, 130, 131, 133, 135, 136, 140, 141, 146, 147, 148, 173, 174, 175, 176, 177, 178, 183, 185, 187, 189, 190, 197, 199, 203, 205, 212, 213, 215, 216, 218, 221, 222, 226, 229, 231, 240, 241, 244, 245, 247, 250, 259, 267, 270, 272, 276, 277, 278, 279, 280, 283, 284, 286, 292, 302, 306, 309, 312, 313, 314, 316, 318, 325, 330, 332, 335, 336, 338, 339, 341, 343, 344, 345, 346, 350, 354, 359, 360, 361, 362, 364, 366, 367, 368, 369, 374, 375, 378, 379, 382, 383, 388, 390, 391, 395, 397, 399, 401, 407, 409, 412, 415, 416, 419, 429, 430, 432, 433, 434, 443, 445, 462, 478, 486, 488, 489, 493, 498, 509, 513, 515, 521, 522, 535, 545, 547, 552, 558, 560, 563, 566, 567, 570, 573, 575, 576, 577, 580, 586, 587, 597, 604, 608, 629, 631, 633, 634, 635, 638, 639, 640, 641, 643, 646, 649, 650, 652, 654, 656, 658, 660, 665, 668, 669, 671, 675, 676, 678, 683, 685, 688, 695, 699, 712, 713, 714, 715, 717, 718, 720, 721, 722, 725, 726, 727, 728, 729, 730, 731, 732, 733, 735, 747, 752, 758, 759, 760, 761, 768, 778, 779, 781, 790, 793, 799, 800, 801, 805, 808, 810, 811, 814, 815, 817, 820, 822, 823, 825, 826, 827, 830, 838, 842, 843, 845, 846, 847, 857, 862, 864, 866, 874, 881, 883, 885, 896, 898, 911, 913, 916, 919, 920, 921, 922, 924, 926, 930, 931, 932, 933, 939, 944, 946, 947, 948, 951, 952, 956, 957, 958, 962, 963, 967, 969, 970, 971, 972, 973, 974, 976, 978, 983, 989, 990, 996, 1000, 1001, 1002, 1003, 1004, 1005, 1009, 1012, 1013, 1014, 1015, 1016, 1017, 1019, 1022, 1028, 1029, 1032, 1033, 1038, 1041, 1043, 1044, 1045, 1047, 1048, 1050, 1052, 1056, 1058, 1062, 1063, 1066, 1068, 1070, 1071, 1073, 1080, 1081, 1082, 1084, 1087, 1088, 1101, 1106, 1109, 1111, 1113, 1114, 1116, 1117, 1118, 1128, 1130, 1134, 1136, 1137, 1149, 1154, 1158, 1160, 1178, 1179, 1182, 1186, 1188, 1193, 1195, 1207, 1208, 1209, 1236, 1238, 1244, 1258, 1259, 1264, 1269, 1272, 1277, 1278, 1280, 1285, 1286, 1288, 1289, 1290, 1291, 1292, 1293, 1294, 1295, 1296, 1297, 1299, 1300, 1301, 1302, 1303, 1305, 1308, 1310, 1311, 1312, 1329, 1339, 1345, 1346, 1350, 1357, 1358, 1359, 1360, 1361, 1363, 1365, 1369, 1373, 1374, 1378, 1379, 1380, 1381, 1382, 1387, 1389, 1392, 1401, 1404, 1406, 1408, 1409, 1410, 1411, 1412, 1413, 1414, 1415, 1417, 1420, 1421, 1427, 1429, 1432, 1436, 1437, 1438, 1439, 1440, 1441, 1442, 1443, 1444, 1457, 1459, 1462, 1463, 1464, 1465, 1469, 1474, 1475, 1476, 1482, 1489, 1490, 1491, 1501, 1504, 1506, 1509, 1510, 1511, 1515, 1520, 1521, 1525, 1528, 1536, 1548, 1549, 1551, 1555, 1558, 1559, 1562, 1565, 1571, 1573, 1576, 1577, 1580, 1581, 1583, 1584, 1586, 1588, 1589, 1591, 1594, 1595, 1606, 1607, 1608, 1609, 1610, 1612, 1617, 1618, 1621, 1629, 1630, 1633, 1634, 1638, 1643, 1644, 1645, 1646, 1653, 1666, 1667, 1668, 1670, 1672, 1674, 1675, 1677, 1678, 1717, 1718, 1730, 1731, 1733, 1735, 1747, 1748, 1755, 1757, 1761, 1763, 1767, 1769, 1770, 1775, 1776, 1786, 1787, 1788, 1793, 1794, 1798, 1800, 1803, 1805, 1807, 1808, 1811, 1813, 1815, 1819, 1820, 1821, 1824, 1825, 1828, 1829, 1830, 1832, 1833, 1834, 1840, 1846, 1848, 1852, 1859, 1869, 1875, 1879, 1880, 1901, 1902, 1908, 1909, 1915, 1938, 1939, 1950, 1959, 1962, 1967, 1968, 1977, 1991, 1992, 1993, 1995, 1996, 1997, 2000, 2001, 2006, 2010, 2012, 2014, 2016, 2017, 2018, 2027, 2028, 2033, 2037, 2038, 2045, 2049, 2053, 2066, 2067, 2070, 2072, 2078, 2099, 2103, 2116, 2117, 2123, 2124, 2128, 2134, 2139, 2147, 2150, 2151, 2152, 2153, 2158, 2160, 2161, 2162, 2165, 2166, 2167, 2168, 2172, 2175, 2177, 2185, 2187, 2189, 2192, 2193, 2196, 2199, 2200, 2201, 2202, 2204, 2205, 2206, 2207, 2208, 2212, 2213, 2214, 2215, 2217, 2219, 2232, 2239, 2243, 2244, 2247, 2255, 2256, 2258, 2259, 2264, 2266, 2267, 2268, 2273, 2275, 2290, 2295, 2296, 2304, 2307, 2313, 2315, 2318, 2321, 2322, 2323, 2324, 2326, 2327, 2328, 2329, 2330, 2331, 2334, 2335, 2346, 2348, 2350, 2352, 2353, 2356, 2357, 2359, 2444, 2483, 2487, 2494, 2495, 2515, 2516, 2520, 2524, 2525, 2526, 2528, 2533, 2535, 2538, 2543, 2548, 2550, 2554, 2557, 2558, 2559, 2563, 2565, 2568, 2569, 2572, 2574, 2576, 2579, 2585, 2591, 2592, 2593, 2595, 2596, 2597, 2619, 2624, 2625, 2626, 2627, 2628, 2632, 2634, 2638, 2641, 2647, 2650, 2653, 2662, 2670, 2672, 2674, 2676, 2688, 2689, 2690, 2694, 2696, 2697, 2701, 2705, 2706, 2707, 2712, 2719, 2729, 2731, 2735, 2762, 2764, 2769, 2778, 2779, 2780, 2784, 2785, 2788, 2793, 2803, 2813, 2819, 2823, 2824, 2825, 2828, 2840, 2847, 2849, 2859, 2863, 2868, 2869, 2875, 2877, 2878, 2887, 2888, 2890, 2893, 2898, 2901, 2902, 2903, 2911, 2912, 2913, 2915, 2918, 2920, 2922, 2923, 2934, 2937, 2938, 2939, 2940, 2947, 2967, 2978, 2979, 2984, 2993, 2994, 2998, 3000, 3001, 3015, 3026, 3034, 3037, 3039, 3040, 3042, 3043, 3045, 3046, 3047, 3048, 3050, 3053, 3055, 3059, 3061, 3065, 3070, 3071, 3074, 3075, 3078, 3080, 3081, 3082, 3084, 3094, 3101, 3107, 3110, 3111, 3112, 3113, 3115, 3118, 3119, 3120, 3122, 3123, 3125, 3126, 3127, 3133, 3134, 3135, 3140, 3142, 3158, 3162, 3164, 3166, 3169, 3170, 3171, 3172, 3174, 3176, 3177, 3183, 3196, 3200, 3204, 3205, 3207, 3209, 3214, 3216, 3218, 3219, 3221, 3222, 3223, 3225, 3226, 3227, 3229, 3231, 3232, 3233, 3234, 3235, 3236, 3240, 3241, 3242, 3248, 3249, 3250, 3263, 3265, 3270, 3273, 3281, 3283, 3290, 3291, 3292, 3293, 3294, 3303, 3304, 3306, 3316, 3321, 3340, 3344, 3346, 3347, 3358, 3359, 3371, 3373, 3375, 3381, 3383, 3385, 3394, 3396, 3416, 3419, 3422, 3431, 3459, 3479, 3481, 3484, 3485, 3487, 3489, 3490, 3491, 3512, 3543, 3547, 3549, 3553, 3557, 3560, 3561, 3569, 3570, 3575, 3576, 3587, 3589, 3598, 3603, 3606, 3609, 3612, 3617, 3620, 3622, 3626, 3627, 3630, 3633, 3635, 3640, 3641, 3642, 3646, 3651, 3659, 3660, 3662, 3663, 3664, 3669, 3670, 3671, 3674, 3678, 3680, 3683, 3684, 3685, 3687, 3689, 3690, 3694, 3695, 3697, 3698, 3699, 3700, 3702, 3707, 3713, 3717, 3718, 3730, 3737, 3739, 3741, 3745, 3747, 3750, 3754, 3758, 3761, 3762, 3770, 3772, 3773, 3779, 3780, 3781, 3782, 3784, 3785, 3787, 3788, 3792, 3795, 3800, 3814, 3815, 3816, 3817, 3818, 3822, 3823, 3827, 3838, 3840, 3841, 3842, 3848, 3850, 3851, 3852, 3853, 3854, 3855, 3858, 3859, 3860, 3861, 3866, 3868, 3872, 3882, 3885, 3887, 3892, 3897, 3898, 3903, 3904, 3909, 3910, 3912, 3914, 3916, 3918, 3921, 3929, 3930, 3931, 3932, 3933, 3934, 3936, 3937, 3948, 3950, 3955, 3959, 3960, 3963, 3975, 3980, 3982, 3987, 3990, 3996, 4004, 4005, 4010, 4015, 4016, 4023, 4025, 4033, 4034, 4036, 4038, 4041, 4043, 4046, 4050, 4051, 4052, 4053, 4054, 4055, 4057, 4062, 4063, 4064, 4065, 4066, 4067, 4068, 4069, 4074, 4077, 4081, 4085, 4087, 4092, 4094, 4099, 4101, 4102, 4103, 4104, 4105, 4107, 4109, 4110, 4111, 4112, 4113, 4116, 4117, 4121, 4125, 4128, 4133, 4141, 4143, 4145, 4146, 4148, 4149, 4151, 4157, 4162, 4166, 4168, 4171, 4173, 4184, 4185, 4194, 4207, 4213, 4221, 4222, 4223, 4224, 4225, 4232, 4237, 4241, 4242, 4246, 4250, 4254, 4257, 4258, 4261, 4282, 4283, 4284, 4285, 4286, 4287, 4288, 4291, 4297, 4303, 4308, 4311, 4312, 4313, 4314, 4318, 4319, 4320, 4321, 4322, 4323, 4326, 4329, 4332, 4336, 4340, 4353, 4359, 4360, 4363, 4430, 4435, 4438, 4440, 4477, 4478, 4481, 4485, 4486, 4487, 4488, 4489, 4495, 4496, 4501, 4504, 4534, 4542, 4547, 4571, 4582, 4583, 4584, 4585, 4586, 4588, 4589, 4593, 4602, 4603, 4604, 4606, 4607, 4609, 4610, 4618, 4619, 4620, 4621, 4624, 4625, 4627, 4629, 4632, 4633, 4634, 4635, 4640, 4648, 4650, 4653, 4654, 4660, 4666, 4670, 4675, 4680, 4688, 4689, 4693, 4694, 4695, 4696, 4698, 4701, 4702, 4703, 4709, 4710, 4711, 4717, 4723, 4724, 4733, 4734, 4736, 4741, 4744, 4745, 4747, 4750, 4751, 4753, 4760, 4772, 4773, 4778, 4780, 4801, 4804, 4807, 4811, 4815, 4821, 4824, 4828, 4833, 4837, 4838, 4842, 4843, 4852, 4857, 4861, 4867, 4869, 4878, 4879, 4881, 4883, 4884, 4885, 4892, 4900, 4901, 4907, 4921, 4922, 4923, 4935, 4940, 4948, 4958, 4973, 4978, 4983, 4990, 5002, 5003, 5004, 5005, 5010, 5015, 5017, 5018, 5021, 5023, 5026, 5027, 5031, 5042, 5045, 5046, 5047, 5049, 5051, 5052, 5053, 5055, 5058, 5063, 5068, 5069, 5071, 5076, 5077, 5079, 5080, 5090, 5092, 5096, 5100, 5101, 5104, 5105, 5118, 5121, 5122, 5126, 5128, 5130, 5138, 5139, 5145, 5148, 5149, 5152, 5155, 5157, 5163, 5166, 5167, 5169, 5170, 5173, 5174, 5179, 5187, 5199, 5202, 5205, 5212, 5222, 5224, 5225, 5228, 5232, 5233, 5265, 5266, 5267, 5268, 5272, 5276, 5284, 5290, 5292, 5293, 5294, 5304, 5305, 5307, 5308, 5309, 5313, 5314, 5317, 5318, 5319, 5320, 5322, 5327, 5330, 5336, 5340, 5341, 5342, 5345, 5346, 5348, 5349, 5350, 5354, 5355, 5358, 5359, 5360, 5367, 5368, 5375, 5376, 5396, 5406, 5407, 5408, 5409, 5413, 5424, 5429, 5430, 5431, 5433, 5440, 5444, 5446, 5450, 5451, 5452, 5453, 5454, 5455, 5457, 5465, 5470, 5473, 5479, 5502, 5506, 5507, 5522, 5530, 5535, 5539, 5552, 5553, 5554, 5555, 5563, 5569, 5570, 5577, 5579, 5581, 5582, 5585, 5590, 5594, 5613, 5618, 5619, 5620, 5621, 5624, 5625, 5630, 5641, 5644, 5645, 5646, 5650, 5653, 5655, 5663, 5664, 5669, 5670, 5671, 5672, 5673, 5675, 5676, 5678, 5680, 5685, 5687, 5688, 5689, 5698, 5714, 5723, 5728, 5729, 5730, 5731, 5732, 5733, 5734, 5737, 5738, 5740, 5742, 5743, 5744, 5753, 5768, 5777, 5778, 5787, 5788, 5790, 5791, 5793, 5794, 5795, 5801, 5803, 5806, 5814, 5816, 5818, 5820, 5827, 5828, 5831, 5833, 5836, 5837, 5858, 5871, 5880, 5896, 5897, 5898, 5911, 5913, 5921, 5926, 5929, 5932, 5947, 5949, 5950, 5957, 5959, 5961, 5966, 5967, 5968, 5971, 5972, 5984, 5988, 5990, 5992, 5994, 5995, 5996, 6003, 6005, 6006, 6007, 6008, 6009, 6010, 6013, 6014, 6017, 6036, 6037, 6038, 6047, 6091, 6094, 6096, 6101, 6121, 6123, 6124, 6139, 6143, 6150, 6156, 6166, 6167, 6168, 6169, 6170, 6171, 6183, 6195, 6203, 6204, 6205, 6206, 6210, 6222, 6232, 6235, 6236, 6241, 6252, 6261, 6262, 6271, 6273, 6274, 6275, 6277, 6278, 6279, 6280, 6281, 6282, 6283, 6285, 6286, 6287, 6288, 6289, 6291, 6295, 6299, 6300, 6304, 6305, 6314, 6317, 6318, 6319, 6320, 6327, 6329, 6340, 6341, 6342, 6344, 6349, 6351, 6362, 6363, 6364, 6366, 6370, 6372, 6373, 6374, 6387, 6392, 6397, 6399, 6402, 6404, 6405, 6406, 6407, 6414, 6422, 6425, 6428, 6431, 6439, 6440, 6441, 6442, 6443, 6444, 6445, 6447, 6450, 6451, 6452, 6457, 6472, 6474, 6476, 6480, 6484, 6490, 6492, 6493, 6495, 6496, 6503, 6504, 6505, 6506, 6512, 6514, 6515, 6518, 6519, 6521, 6522, 6523, 6524, 6529, 6530, 6531, 6532, 6533, 6538, 6540, 6543, 6546, 6549, 6554, 6555, 6557, 6558, 6559, 6561, 6563, 6568, 6569, 6570, 6575, 6580, 6581, 6582, 6585, 6586, 6588, 6590, 6610, 6613, 6614, 6616, 6618, 6620, 6622, 6623, 6649, 6653, 6654, 6656, 6658, 6659, 6663, 6670, 6675, 6677, 6688, 6689, 6690, 6691, 6692, 6694, 6696, 6698, 6699, 6700, 6707, 6708, 6710, 6711, 6716, 6718, 6725, 6726, 6738, 6741, 6742, 6750, 6751, 6752, 6756, 6757, 6760, 6767, 6768, 6774, 6779, 6781, 6783, 6789, 6793, 6804, 6810, 6813, 6819, 6820, 6822, 6832, 6833, 6840, 6843, 6846, 6847, 6850, 6853, 6854, 6855, 6856, 6857, 6860, 6861, 6862, 6865, 6866, 6868, 6891, 6898, 6899, 6900, 6906, 6910, 6913, 6917, 6920, 6923, 6925, 6926, 6928, 6929, 6932, 6934, 6935, 6949, 6954, 6991, 6997, 6998, 6999, 7001, 7006, 7011, 7014, 7015, 7018, 7021, 7025, 7026, 7027, 7031, 7032, 7033, 7035, 7036, 7037, 7038, 7040, 7042, 7045, 7047, 7051, 7052, 7053, 7054, 7057, 7058, 7060, 7069, 7078, 7080, 7087, 7094, 7097, 7098, 7103, 7104, 7106, 7113, 7122, 7124, 7125, 7133, 7134, 7135, 7136, 7137, 7138, 7139, 7140, 7141, 7143, 7149, 7150, 7162, 7166, 7168, 7169, 7172, 7174, 7175, 7179, 7180, 7186, 7200, 7216, 7227, 7251, 7253, 7263, 7272, 7273, 7275, 7276, 7277, 7278, 7287, 7290, 7293, 7294, 7299, 7305, 7306, 7318, 7323, 7326, 7336, 7348, 7349, 7351, 7352, 7356, 7363, 7364, 7365, 7369, 7371, 7380, 7381, 7398, 7399, 7405, 7408, 7409, 7410, 7412, 7423, 7425, 7429, 7432, 7436, 7439, 7443, 7448, 7450, 7454, 7456, 7462, 7468, 7472, 7473, 7475, 7477, 7483, 7485, 7490, 7504, 7512, 7518, 7535, 7544, 7549, 7552, 7584, 7639, 7693, 7704, 7718, 7726, 7727, 7739, 7756, 7776, 7780, 7781, 7782, 7805, 7818, 7827, 7837, 7841, 7849, 7851, 7857, 7862, 7866, 7867, 7869, 7884, 7915, 7942, 7975, 7976, 7978, 7980, 7984, 7988, 8000, 8001, 8013, 8022, 8029, 8036, 8038, 8048, 8061, 8076, 8091, 8092, 8099, 8115, 8128, 8131, 8140, 8148, 8161, 8178, 8190, 8200, 8214, 8218, 8233, 8277, 8284, 8288, 8291, 8294, 8302, 8312, 8313, 8324, 8326, 8328, 8339, 8347, 8351, 8354, 8356, 8357, 8362, 8363, 8364, 8368, 8382, 8398, 8404, 8406, 8407, 8419, 8424, 8427, 8431, 8436, 8437, 8440, 8444, 8451, 8458, 8459, 8468, 8470, 8473, 8482, 8483, 8487, 8495, 8500, 8503, 8506, 8507, 8513, 8514, 8515, 8516, 8519, 8521, 8529, 8530, 8531, 8532, 8534, 8538, 8542, 8549, 8553, 8557, 8559, 8570, 8572, 8575, 8581, 8603, 8604, 8608, 8612, 8620, 8622, 8626, 8630, 8632, 8635, 8638, 8643, 8644, 8645, 8646, 8649, 8651, 8654, 8655, 8671, 8673, 8676, 8688, 8698, 8706, 8731, 8736, 8744, 8749, 8751, 8764, 8767, 8771, 8778, 8787, 8788, 8789, 8793, 8794, 8795, 8797, 8800, 8807, 8808, 8809, 8817, 8821, 8825, 8828, 8831, 8837, 8838, 8839, 8843, 8848, 8852, 8854, 8856, 8857, 8858, 8859, 8864, 8870, 8874, 8875, 8876, 8877, 8884, 8886, 8891, 8895, 8900, 8904, 8908, 8909, 8911, 8932, 8934, 8935, 8941, 8942, 8971, 8972, 8975, 8986, 8988, 8992, 8997, 8999, 9019, 9021, 9022, 9027, 9032, 9045, 9050, 9058, 9063, 9068, 9071, 9073, 9074, 9075, 9076, 9077, 9084, 9086, 9095, 9098, 9099, 9103, 9104, 9113, 9120, 9122, 9126, 9127, 9138, 9142, 9143, 9149, 9152, 9154, 9156, 9169, 9172, 9173, 9175, 9180, 9187, 9194, 9196, 9211, 9214, 9227, 9242, 9244, 9245, 9258, 9262, 9267, 9271, 9283, 9308, 9311, 9315, 9319, 9325, 9332, 9334, 9337, 9340, 9341, 9349, 9351, 9353, 9355, 9356, 9360, 9361, 9362, 9363, 9365, 9369, 9370, 9376, 9381, 9388, 9398, 9402, 9404, 9415, 9419, 9427, 9439, 9447, 9448, 9450, 9451, 9452, 9453, 9457, 9463, 9464, 9465, 9466, 9469, 9473, 9476, 9477, 9493, 9497, 9498, 9499, 9502, 9506, 9509, 9514, 9518, 9519, 9522, 9535, 9543, 9547, 9551, 9554, 9555, 9563, 9568, 9576, 9583, 9585, 9588, 9589, 9595, 9616, 9618, 9622, 9623, 9626, 9628, 9631, 9633, 9635, 9641, 9646, 9659, 9665, 9669, 9679, 9681, 9683, 9687, 9698, 9703, 9711, 9715, 9721, 9727, 9734, 9737, 9750, 9753, 9754, 9759, 9768, 9770, 9789, 9790, 9796, 9806, 9808, 9819, 9829, 9834, 9836, 9839, 9843, 9844, 9846, 9848, 9858, 9859, 9862, 9878, 9881, 9890, 9891, 9906, 9914, 9933, 9934, 9935, 9936, 9937, 9938, 9940, 9947, 9953, 9962, 9963, 9968, 9970, 9971, 9976, 9980, 9982, 10002, 10008, 10010, 10044, 10048, 10050, 10051, 10054, 10056, 10058, 10060, 10062, 10071, 10075, 10077, 10081, 10083, 10092, 10094, 10103, 10106, 10107, 10110, 10111, 10116, 10124, 10125, 10127, 10136, 10140, 10147, 10148, 10149, 10157, 10158, 10163, 10171, 10175, 10179, 10195, 10199, 10200, 10202, 10205, 10207, 10215, 10216, 10218, 10219, 10223, 10229, 10230, 10231, 10232, 10234, 10235, 10247, 10249, 10253, 10257, 10265, 10272, 10276, 10282, 10286, 10297, 10312, 10320, 10321, 10324, 10326, 10331, 10332, 10333, 10344, 10346, 10347, 10349, 10350, 10361, 10362, 10368, 10369, 10379, 10380, 10381, 10382, 10388, 10389, 10395, 10397, 10400, 10403, 10406, 10409, 10417, 10418, 10434, 10438, 10439, 10440, 10445, 10451, 10457, 10463, 10468, 10473, 10474, 10480, 10481, 10485, 10493, 10499, 10501, 10512, 10514, 10517, 10522, 10525, 10529, 10533, 10536, 10537, 10551, 10558, 10562, 10563, 10566, 10567, 10568, 10578, 10579, 10580, 10584, 10587, 10589, 10590, 10591, 10595, 10598, 10599, 10603, 10607, 10611, 10614, 10620, 10622, 10628, 10630, 10631, 10632, 10633, 10635, 10637, 10643, 10653, 10654, 10655, 10659, 10663, 10665, 10673, 10675, 10686, 10693, 10699, 10712, 10716, 10718, 10721, 10724, 10734, 10736, 10747, 10750, 10753, 10755, 10761, 10773, 10786, 10791, 10794, 10800, 10801, 10804, 10807, 10815, 10838, 10840, 10841, 10842, 10846, 10850, 10855, 10857, 10858, 10859, 10863, 10864, 10866, 10867, 10874, 10875, 10878, 10879, 10880, 10881, 10882, 10884, 10886, 10888, 10891, 10892, 10893, 10894, 10897, 10900, 10902, 10905, 10908, 10911, 10913, 10923, 10926, 10927, 10928, 10930, 10935, 10942, 10943, 10944, 10951, 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