Bridging Safety Pharmacology to China
Abstract Number: 1
BRIDGING SAFETY PHARMACOLOGY TO CHINA
Yi Yang.
Frontage Laboratories, Inc. Princeton, NJ, USA
Abstract Number: 2
NONCLINICAL SAFETY PHARMACOLOGY STUDY SUBMISSION - DATA STANDARDS AND STATISTICAL ANALYSES
Wherly Hoffman, Mary Jeanne Kallman.
Eli Lilly & Company, Greenfield, IN, USA
Abstract Number: 3
PREDICTIVE VALUE OF THE RAT TELEMETRY MODEL FOR PRECLINICAL EVALUATION OF HEMODYNAMIC LIABILITIES: COMPARISON OF HEMODYNAMIC PROFILES OF TWO PRESSOR AGENTS IN RATS, BEAGLE DOGS AND RHESUS MONKEYS
Patrick A. Fanelli, Kimbery Hoagland.
Merck & Co., Inc., West Point, PA, USA
Abstract Number: 4
THE INFLUENCE OF ANTIEPILEPTIC DRUGS ON THE EEG PATTERNS IN EPILEPTIC PATIENTS (CARBAMAZEPINE)
Irma Khachidze.
Beritashvili Institute of Physiology, Tbilisi, Republic of Georgia
Abstract Number: 5
CORRELATION BETWEEN dP/dtmax AND QA INTERVAL, TWO CARDIAC CONTRACTILITY PARAMETERS, IN THE ANESTHETIZED RAT
Jacqueline Ngo.
UCB Pharma, Braine L’Alleud, Belgium
Abstract Number: 6
EFFECT OF VAGOTOMY ON THE CARDIOVASCULAR FUNCTION IN PENTOBARBITAL ANESTHETIZED DOGS
Richard Woltmann, Pierre Morissette.
Merck & Co., Inc., West Point, PA, USA
Abstract Number: 7
FAST, EFFORTLESS AND ACCURATE MEASUREMENT OF GLOMERULAR FILTRATION RATE IN CONSCIOUS MONKEYS
Alain Stricker-Krongrad1, Paul A. Zavorskas1, Carlos Rabito2, Susan Van Tongeren3, John Robb4, Garner T. Haupert Jr.5
1Charles River Laboratories, Shrewsbury, MA, USA;
2Radiology, Massachusetts General Hospital, Boston, MA, USA,
3Boehringer Ingelheim, Ridgefield, CT, USA;
4Appropriate Technology Co. Newburyport, MA,
5Nephrology Division, Medical Services, Massachusetts General Hospital, Boston, MA
Abstract Number: 8
URODYNAMICS TELEMETRY: A TOOL FOR INVESTIGATING THE URINARY BLADDER FUNCTION IN CONSCIOUS CYNOMOLGUS MONKEY
Stéphane Milano1, O. Boucheix1, E. Chalencon1, P. Lege1, C. Bory1, S. Baudet1, C. Botteron1, I. Williamson2, D. Westbrook2, D. Newgreen2.
1MDS Pharma Services, Lyon, France
2Pfizer Inc., Sandwich, UK.
Abstract Number: 9
MOUSE: MORE SENSITIVE THAN RAT OR GUINEA PIG FOR ASSESSING RESPIRATORY DEPRESSANT POTENTIAL OF DRUGS
Sandra Picard.
Porsolt and Partners Pharmacology, Boulogne-Billancourt, France
Abstract Number: 10
THE SMARTPILL FOR GASTROINTESTINAL MONITORING IN DOGS.
Kevin Norton, Helen Penton.
Charles River Laboratories Preclinical Services, Montreal, Quebec, Canada
Abstract Number: 11
SURVEY OF INDUSTRY: IDENTIFYING CONSORTIA PROJECTS ADDRESSING SIGNIFICANT PUBLIC HEALTH CONCERNS
Niels Christian Ganderup.
Ellegaard Göttingen Minipigs, Dalmose, Denmark
Abstract Number: 12
THE GÖTTINGEN MINIPIG IN CARDIOVASCULAR SAFETY PHARMACOLOGY - A CONSORTIA PROJECT PRELIMINARY REPORT
Niels Christian Ganderup.
Ellegaard Göttingen Minipigs, Dalmose, Denmark
Abstract Number: 13
INHIBITION OF COUGH REFLEX INDUCED BY VARIOUS DRUGS IN CONSCIOUS DOGS
Tadashi Tsubouchi.
Dainippon Sumitomo Pharma Co., Ltd, Osaka, Japan
Abstract Number: 14
INTRODUCTION OF FOB AND AMBULATORY ELECTROCARDIOGRAPHY IN THE EXTENDED SINGLE-DOSE TOXICITY STUDY IN RATS
Yasuki Akie.
Fuji Biomedix Co., Ltd., Hokuto-shi, Yamanashi-pref., Japan
Abstract Number: 15
COMPREHENSIVE EVALUATION OF SAFETY PHARMACOLOGY CORE BATTERY FOR MONKEY IN A NOVEL CHAMBER OF WHOLE-BODY PLETHYSMOGRAPHY
K. Sasaki.
Mitsubishi Chemical Safety Institute Ltd., Uto, Kumamoto, Japan
Abstract Number: 16
EFFECTS OF TUBE RESTRAINT ON HEART RATE, BLOOD PRESSURE AND RESPIRATORY PARAMETERS IN RATS
Steven Behringer, Brian M. Roche, Mathew Ellinger, Vedat Yildiz, Alecia Peppers, Jessica Wise, Craig Hassler.
Battelle Memorial Institute, Columbus, OH, USA
Abstract Number: 17
COMPARISON OF RESPIRATORY FUNCTIONAL ASSESSMENT TOOLS USING PNEUMOTACHOGRAPH AND RESPIRATORY INDCUTANCE PLETHYSMOGRAPHY
Kenneth R. Kearney.
WIL Research Laboratories, LLC, Ashland, OH, USA
Abstract Number: 18
EF50: A NON-INVASIVE MEASURE OF BRONCHOCONSTRICTION IN RATS?
Lorna Ewart, Jean-Pierre Valentin.
AstraZeneca R&D Alderley Park, Macclesfield, UK
Abstract Number: 19
PULMONARY FUNCTION IN RATS MONITORED BY BUXCO® WHOLE-BODY PLETHYSMOGRAPHY
David V. Gauvin, Ph.D., Jill A. Dalton, Ph.D., D.A.B.T., Theodore J. Baird, Ph.D.
Safety Pharmacology & Neurobehavioral Sciences,MPI Research, Mattawan, MI,USA
Abstract Number: 20
EVALUATION OF EFFECTS ON RESPIRATION IN CONSCIOUS MARMOSET (CALLITHRIX JACCHUS) USING WHOLE BODY PLETHYSMOGRAPHY
Sola-Puyravel Marie Laure, Champeroux Pascal.
CERB, Baugy, France
Abstract Number: 21
THE USE OF REFERENCE COMPOUNDS IN THE FREELY MOVING RAT PLETHYSMOGRAPHY SYSTEM
Philippa Priestley, A. Esmail
Covance Laboratories Ltd., Harrogate, UK
Abstract Number: 22
BRONCHOCONSTRICTION MODEL DEVELOPMENT - EFFECT OF APNEA ON PULMONARY RESISTANCE IN ANESTHETIZED SPRAGUE-DAWLEY, SPONTANEOUS HYPERTENSIVE, AND WISTAR-KYOTO RATS
Chin-hu Huang.
Pfizer, Inc, Groton, CT, USA
Abstract Number: 23
WHOLE BODY PLETHYSMOGRAPHY VIA IV INFUSIONS, WITHOUT THE NEED FOR SURGICAL PREPARATION
Helen Prior, Jean-Pierre Valentin.
AstraZeneca UK Ltd, Macclesfield, Cheshire, UK
Abstract Number: 24
ASSESSMENT OF THE VARIABLES AFFECTING RODENT RESPIRATORY STUDY DESIGN AND DATA INTERPRETATION
Philip Atterson.
WIL Research Laboratories, LLC, Ashland, OH, USA
Abstract Number: 25
INHALATION SAFETY PHARMACOLOGY IN THE MINIPIG: VALIDATION OF PROCEDURES
Ken Meecham, Stuart Purbrick.
Huntingdon Life Sciences Ltd, Alconbury, Cambs, UK
Abstract Number: 26
EVALUATION OF RESPIRATORY INDUCTIVE PLETHYSMOGRAPHY AS A METHOD FOR MEASURING VENTILATORY PARAMETERS IN CONSCIOUS, NON-RESTRAINED DOGS
Jonathan Renninger, Daniel Schramek and Dennis Murphy.
GlaxoSmithKline, King of Prussia, PA, USA
Abstract Number: 27
EEG TELEMETRY MODELS IN THE RODENT AND NON-HUMAN PRIMATE
Erik DeBoer, Gregory Friedrichs.
Schering-Plough Research Institute, Lafayette NJ, USA
Abstract Number: 28
VIDEO-ELECTROENCEPHALOGRAPHY IN CONSCIOUS MONKEYS USING TELEMETRY AND COMPUTER ANALYSIS: REFINEMENT OF A SAFETY PHARMACOLOGY MODEL
Simon Authier.
LAB Research Inc., Laval, Quebec, Canada
Abstract Number: 29
TELEMETERED ACTIVITY OF THE RESPIRATORY MUSCLES IN THE FERRET: A RELEVANT APPROACH FOR MONITORING THE EMETIC REFLEX
Stéphane Milano1, P. Lege1, E. Chalencon1, V. Roger1, S. Baudet1, E. Rieux2, S. Caradec2, H. Michelau2.
1MDS Pharma Services, Lyon, France
2Data Science International, St Paul, MN, USA.
Abstract Number: 30
PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING FOR THE RESPIRATORY EFFECT OF AMINOPHYLLINE IN RATS
Angela C. Jenkins, Sun Ku Lee, R. Dustan Sarazan.
Covance Laboratories Inc., Madison, WI, USA
Abstract Number: 31
SAFETY PHARMACOLOGICAL STUDIES ON THE AMORPHOUS FORMULATION OF CELECOXIB
Shyam S Sharma.
National Centre for Safety Pharmacology, National Inst. of Pharm. Edu. & Res., S.A.S. Nagar, India
Abstract Number: 32
IN VITRO PHARMACOLOGICAL PROFILES OF KINASE INHIBITORS: COMPARISON WITH OTHER PHARMACEUTICALS
Mike Rolf..
AstraZeneca UK Ltd, Macclesfield, UK
Abstract Number: 33
ROLE OF HYPERBARIC OXYGEN THERAPY ON SURVIVAL AND ENGRAFTMENT OF STEM CELLS IN THE INFARCT HEART
Mahmood Khan, Periannan Kuppusamy, Robert L Hamlin.
The Ohio State University, Columbus, OH, USA
Abstract Number: 34
EFFECTS OF ISOPRENALINE ON HUMAN STEM CELL DERIVED CARDIOMYOCYTES
Simon Bryant,1, Wyllie, C.1, Palmer, R.1, Heal, R.1, Demmon, J.1, Nicol, S.1, Anson, B.2, Rudy-Reil, D.2, Ma, J.2
1VivoMedica (UK) Ltd, Kent, UK
2Cellular Dynamics International Inc, Madison, WI, USA
Abstract Number: 35
A HIGH THROUGHPUT METHOD FOR THE ENUMERATION OF MICROBIAL COLONIES
Thomas Hattier.
Cellular Technology Limited, Shaker Heights, OH, USA
Abstract Number: 36
EFFECTS OF TEGASEROD ON HUMAN ISOLATED SMALL AND LARGE CORONARY ARTERIES
Kathryn Bagot, Mozam Ali, Lee Dawson, Sandy Williams, Bob Sheldrick.
Asterand UK Ltd, Royston, Hertfordshire, UK.
Abstract Number: 37
ALTERNATIVE MECHANISMS OF DRUG-INDUCED QT PROLONGATION: hERG AND BEYOND
Jean-Pierre Valentin.
AstraZeneca UK Ltd, Macclesfield, UK.
Abstract Number: 38
RELEVANCE OF KINETIC PARAMETERS IN hERG-BASED LQT PREDICTION
Julie Cayer.
IPS Therapeutique Inc., Sherbrooke, Quebec, Canada
Abstract Number: 39
TRANSLATION BETWEEN IN VITRO INHIBITION OF THE CARDIAC NAV1.5 CHANNEL AND PRECLINICAL AND CLINICAL QRS WIDENING
Jill V. Steidl, Martin Sanders, Jason Cordes.
Pfizer Inc., Groton CT, USA
Abstract Number: 40
TRANSLATION OF IN VITRO AND IN VIVO EFFECTS ON CARDIAC SODIUM CHANNELS
Doe CP, Ballini E, Cui Y, Stankus G, Graham S, Heath B, McMahon N.
GlaxoSmithKline, The Frythe, Welwyn, Hertfordshire, UK
Abstract Number: 41
EFFECTS OF CA-CHANNEL ANTAGONISTS ON L-TYPE CA CHANNEL IN THE HH-8 CELLS---A TOOL FOR SCREENING OF NEW COMPOUNDS
Wenge Yu.
Mitsubishi Chemical Safety Institute Ltd., Uto, Kumamoto, Japan
Abstract Number: 42
THROMBIN-INDUCED INCREASES IN VASCULAR PERMEABILITY IN PRESSURISED HUMAN SUBCUTANEOUS ARTERIES: A NOVEL OPTICAL METHOD FOR ISOLATED TISSUES
Emma J Moss, Derek Smith, David C Bunton.
Biopta Ltd, Glasgow, UK
Abstract Number: 43
METHOD VALIDATION AND BACKGROUND DATA FOR AN IN VITRO hERG ASSAY.
Helen Penton.
Charles River Laboratories, Preclinical Services Montreal, Quebec, Canada
Abstract Number: 44
CARDIAC CHANNEL PANELTM: A CRITICAL PATH TOOL FOR UNDERSTANDING CARDIAC RISK
Arthur M. Brown.
ChanTest Corporation, Cleveland, OH, USA
Abstract Number: 45
AUTOMATED PATCH CLAMP FOR hERG SAFETY SCREENING
Alison Haythornthwaite, Andrea Brueggemann, Cecilia Farre, Sonja Stoelzle, Claudia Haarmann, Michael George, Niels Fertig.
Nanion Technologies, Munich, Germany
Abstract Number: 46
SCREENING OF hERG BLOCKERS BY AUTOMATED PATCH CLAMP SYSTEM: QPATCH 16
Yong Zhao.
Cerep, Inc, Redmond, WA, USA
Abstract Number: 47
EFFECT OF COMPOUND PLATE COMPOSITION ON MEASUREMENT OF hERG CURRENT IC50 USING PATCHXPRESS
Zun-Li Mo.
Pfizer Inc, St. Louis, MO, USA
Abstract Number: 48
INCIDENCE AND SPECIFICITY OF DRUG-INDUCED TRAFFICKING INHIBITION OF CARDIAC ION CHANNELS
Barbara A. Wible.
ChanTest Corporation, Cleveland, OH, USA
Abstract Number: 49
OVERVIEW OF THE JOINT PHRMA-FDA DIALOGUE SESSION ON ABUSE POTENTIAL ASSESSMENT
Carrie G. Markgraf1, Mary Jeanne Kallman2.
1Schering Plough Research Institute, Lafayette, NJ, USA
2Eli Lilly & Company, Greenfield, IN, USA
Abstract Number: 50
STRATEGY TO REDUCE SEIZURE LIABILITY IN DRUG DISCOVERY
M. Elizabeth Bell, Russell Bialecki.
AstraZeneca, Wilmington, DE, USA
Abstract Number: 51
EVALUATION OF MORPHINE WITHDRAWAL EFFECTS USING TELEMETRY
Paul Moser.
Porsolt & Partners Pharmacology, Boulogne-Billancourt, France
Abstract Number: 52
GLP-COMPLIANT DRUG SELF-ADMINISTRATION IN THE NON-HUMAN PRIMATE
David V. Gauvin, Ph.D., Robert A. Code, B.S., Margaret M. McComb, B.S., Christina D. Selent, B.S., Bryna A. Shannon, B.A., Theodore J. Baird, Ph.D.
Safety Pharmacology & Neurobehavioral Sciences, MPI Research, Matawan, MI, USA
Abstract Number: 53
CORRELATION BETWEEN EJECTION FRACTION AND DP/DT+ IN CONSCIOUS TELEMETERED DOGS DOSED WITH ATENOLOL
Helen Prior, Jean-Pierre Valentin.
AstraZeneca UK Ltd, Cheshire, UK
Abstract Number: 54
USE OF EMBRYONIC STEM CELL DERIVED CARDIOMYOCYTES FOR DETERMINATION OF CARDIAC CYTOTOXICITY
Silke Schwengberg.
Axiogenesis AG, Cologne, Germany
Abstract Number: 55
APEX-TO-BASE DISPERSION IS GREATER THAN TRANSMURAL DISPERSION OF REPOLARIZATION IN AN INTACT ISOLATED RABBIT HEART MODEL
Nicolas Guérard, Martin Traebert, Willi Suter, Bérengère Dumotier.
Novartis Pharma AG, Basel, Switzerland
Abstract Number: 56
DIFFERENCES IN ECG INTERVALS AND RESTITUTION PARAMETERS IN THE CONSCIOUS SLING-TRAINED CANINE MODEL OF SHORT QT SYNDROME
Anusak Kijtawornrat, Robert L. Hamlin.
QTest Labs, LLC/The Ohio State University, Columbus, OH, USA
Abstract Number: 57
APPLICATION OF MAGNETIC RESONANCE IMAGING (MRI) IN A STUDY OF CARDIAC FUNCTION AND MORPHOLOGY IN MICE
Yee H Looi, Bela Patel, Kumar Changani, Kelly Keddie, Jim Ridings, Nick McMahon. GlaxoSmithKline, The Frythe, Welwyn, Hertfordshire, UK
Abstract Number: 58
EVALUATION OF THE PRO-THROMBOTIC EFFECT OF COX-2 INHIBITOR ROFECOXIB IN DOG MODEL OF ARTERIAL THROMBOSIS
Aliaksandr Bulhak.
AstraZeneca R&D Sdertlje, Sweden
Abstract Number: 59
IKS: ANOTHER CARDIOVASCULAR LIABILITY BESIDES hERG, AND USE OF A NOVEL IKS BLOCKER TO SCREEN FOR IKS BLOCKADE
Rob Towart.
Johnson & Johnson PRD, Beerse, Belgium
Abstract Number: 60
A HESI CONSORTIUM APPROACH TO ASSESS THE HUMAN PREDICTIVE VALUE OF NON-CLINICAL REPOLARISATION ASSAYS
Jean-Pierre Valentin, Syril Pettit.
HESI, Washington, DC, USA
Abstract Number: 61
TOLERANCE AND SPONTANEOUS WITHDRAWAL ASSESSMENT IN THE RAT
Anne Maurin, Champeroux Pascal.
CERB, Baugy, France
Abstract Number: 62
EVALUATION OF THE EFFECTS OF OPIATE DEPENDENCY ON CARDIOVASCULAR PARAMETERS IN RATS
Hamid Daneshvar.
WIL Research Laboratories, LLC, Ashland. OH, USA
Abstract Number: 63
CARDIOVASCULAR EFFECTS OF CONTINGENT (ACTIVE) VERSUS NON-CONTINGENT (PASSIVE) COCAINE ADMINISTRATIONS IN CYNOMOLGUS MONKEYS
David V. Gauvin, Ph.D. Robert A. Code, B.S., Margaret M. McComb, B.S., Christina D. Selent, B.S., Bryna A. Shannon, B.A., Theodore J. Baird, Ph.D.
Safety Pharmacology & Neurobehavioral Sciences, MPI Research, Matawan. MI USA
Abstract Number: 64
DETERMINATION OF SEXUAL CYCLE PHASES AND EVALUATION OF OVULATION INHIBITORY ACTIVITY IN THE FEMALE RAT
Champeroux Pascal, Bracq Emmanuel.
CERB, Baugy, France
Abstract Number: 65
CLINICAL INVESTIGATION OF SILYBUN MARIANUM SEED (SILYMARIN) SEED EXTRACT IN TREATMENT OF TYPE-II DIABETIC PATIENTS
Wael Mohamed Yousef.
Pennsylvania State University, State College, PA, USA
Abstract Number: 66
EFFECT OF SOME CALCIUM CHANNEL BLOCKERS IN EXPERIMENTALLY INDUCED DIABETIC NEPHROPATHY IN RATS
Wael Mohamed Yousef.
Pennsylvania State University, State College, PA, USA
Abstract Number: 67
DIETARY-INDUCED INSULIN RESISTANCE IN NON-HUMAN PRIMATES: A MODEL FOR EFFICACY AND SAFETY ASSESSMENTS
Alain Stricker-Krongrad, Joan Flanagan, Sera Murray.
Charles River Laboratories, Shrewsbury, MA,USA
Abstract Number: 68
ELECTRORETINOGRAPHY: COMPARISON OF SINGLE FLASH WITH AVERAGED TRACINGS USING A STANDARDIZED TESTING PROTOCOL FOR DRUG SAFETY EVALUATIONS
Simon Authier.
LAB Research Inc., Laval, Quebec, Canada
Abstract Number: 69
DIFFERENCES IN ELECTROGRAPHIC ICTAL ACTIVITY BETWEEN C57BL/6 AND BALB/C MOUSE STRAINS
M. Elizabeth Bell, Russell Bialecki.
AstraZeneca, Wilmington, DE, USA
Abstract Number: 70
VEHICLE SELECTION IN THE GASTROINTESTINAL TRANSIT SCREEN
Richard Noy.
Covance Laboratories Ltd., Harrogate, UK
Abstract Number: 71
THE EVALUATION OF AN IN VITRO MOTILITY ASSAY FOR ITS POTENTIAL TO PREDICT GASTROINTESTINAL ADVERSE DRUG REACTIONS
Christopher Keating1, Vicente Martinez1, Jean Pierre Valentin1, David Grundy2.
1AstraZeneca, Alderley Park, UK
2University of Sheffield, Sheffield, UK
Abstract Number: 72
PHARMACOLOGICAL COMPARISON OF PERISTALTIC EFFECTS IN RODENTS
Thomas K.Shaughnessy, K.J.Larson, J.S.Polakowski.
Abbott Laboratories, Abbott Park, IL, USA
Abstract Number: 73
EVALUATION OF THE EFFECTS OF DOSAGE AND DOSE VOLUME ON INDICES OF NEOMYCIN OTOTOXICITY IN THE ALBINO GUINEA PIG
Theodore J. Baird, Ph.D1., Rachel L. Tapp, B.S.1, David D. Dolan, Ph.D.2, Richard A. Altschuler, Ph.D.2, Michael Eliel, B.S.1, David V. Gauvin, Ph.D.1
1Safety Pharmacology & Neurobehavioral Sciences,MPI Research, Inc., Matawan, MI,USA
2KHRI, University of Michigan, Ann Arbor, MI, USA
Abstract Number: 74
COMPARISON OF PIGMENTED AND ALBINO GUINEA PIGS FOR USE IN OTOTOXICITY MODELING
Rachel L. Tapp, B.S.1, Michael Eliel, B.S.1, David D. Dolan, Ph.D.2, Richard A. Altschuler, Ph.D.2, David V. Gauvin, Ph.D.1, Theodore J. Baird, Ph.D.1
1Safety Pharmacology & Neurobehavioral Sciences, MPI Research, Mattawan, MI, USA
2KHRI, University of Michigan, Ann Arbor, MI, USA
Abstract Number: 75
EVALUATION OF DOSE, TIME, AND FREQUENCY DEPENDENT OTOTOXIC RESPONSE TO CISPLATIN ADMINISTRATION IN THE ALBINO GUINEA PIG
Theodore J. Baird, Ph.D.1, Jeffrey W-D Foy, Ph.D., D.A.B.T.2, David D. Dolan, Ph.D.3, Theron Wall, B.S.1, Tara Posthumus, B.S.1, Michael Eliel, B.S.1, Rachel L. Tapp, B.S.1, David V. Gauvin, Ph.D.1
1Safety Pharmacology & Neurobehavioral Sciences, MPI Research, Mattawan, MIUSA
2 Quark Pharmaceuticals, Boulder, CO, USA
3KHRI, University of Michigan, Ann Arbor, MI, USA
Abstract Number: 76
A PRIMARY “ICH S7A CNS CORE” NEUROBEHAVIORAL SCREEN FOR EARLY PHASE DRUG DISCOVERY
Donald B Hodges Jr.
Vertex Pharmaceuticals, Cambridge, MA, USA
Abstract Number: 77
EVALUATION OF EFFECT ON CENTRAL NERVOUS SYSTEM BY FOB AND CARIOVASUCULAR SYSTEM BY TELEMETRY FOR CPZ IN DOGS
Kiyotaka Hoshiai.
Kobuchisawa Research Laboratory, Fuji Biomedix, kobuchisawa, Hokuto, Yamanashi, Japan
Abstract Number: 78
SHORT-TERM EEG RECORDING IN CONSCIOUS GÖTTINGEN MINIPIGS AS AN ALTERNATIVE TO NON-HUMAN PRIMATES AND DOGS
Mark Vezina.
Charles River Laboratories Preclinical Services Montreal, Quebec, Canada
Abstract Number: 79
FUNCTIONAL MOTOR ASSESSMENTS ASSOCIATED WITH SKELETAL MUSCLE NECROSIS
Mary Jeanne Kallman, Deah Modlin, Mario Sgro.
Eli Lilly & Co., Greenfield, IN, USA
Abstract Number: 80
CAN LOCOMOTOR SCREENING BE UTILIZED AS A FIRST-TIERED APPROACH FOR PRECLINICAL CNS/NEUROBEHAVIORAL SAFETY TESTING?
James J. Lynch III, Scott W. Mittelstadt
Abbott Laboratories, Abbott Park, IL, USA
Abstract Number: 81
EVALUATION OF PROPOFOL EFFECT IN ALTERING PENTYLENETETRAZOL INDUCED SEIZURE THRESHOLD IN PERIPHERAL INFLAMMATORY MODELS IN RATS
Bikash Medhi, Ajay Prakash, Prasad Byrav D S.
Department of Pharmacology, PGIMER, Chandigarh, India
Abstract Number: 82
ENGINEERED TISSUES: A NOVEL PARADIGM FOR HIGH THROUGHPUT QUANTITATION OF TISSUE BIOLOGICAL AND MECHANICAL TOXICITIES
Vy Lam.
Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, WI, USA
Abstract Number: 83
WHOLE ZEBRAFISH CYTOCHROME P450 MICROPLATE ASSAYS FOR ASSESSING DRUG METABOLISM AND DRUG SAFETY
Chunqi Li.
Phylonix Pharmaceuticals, Inc., Cambridge, MA, USA
Abstract Number: 84
ALTERED CARDIOMYOCYTE Ca2+ HANDLING AS A PREDICTOR OF CARDIOTOXICITY AND ARRHYTHMOGENESIS OF DRUG CANDIDATES
Jian-Yong Qian, Liang Guo.
Hoffmann-La Roche, Inc., NJ, USA
Abstract Number: 85
IN VITRO AND IN VIVO ELECTROPHYSIOLOGICAL CORRELATES IN NICOTINE AND KAINIC ACID-INDUCED SEIZURES
Alison Easter.
AstraZeneca Pharmaceuticals, Wilmington DE, USA
Abstract Number: 86
SAFETY AGAINST MAXIMAL ELECTROSHOCK (MES) INDUCED SEIZURE BY ACONITUM VIOLACEUM
Muhammad Liaquat Raza.
HEJ, ICCBS, Neuropharmacology Unit, University of Karachi, Karachi, Pakistan
Abstract Number: 87
SAFETY AND EFFICACY OF CONCOMITANT USE OF NEWER AND OLDER ANTIEPILEPTIC DRUGS IN TERTIARY CARE CENTRE OF NORTH INDIA: A PROSPECTIVE COHORT STUDY
Ajay Prakash, Bansal D, Medhi B.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Abstract Number: 88
THE COMBINATION OF DSI RAT TELEMETRY AND THE CULEX AUTOMATED BLOOD SAMPLER (ABS) FOR MULTIPARAMETER SAFETY PHARMACOLOGY SCREENING
David Lengel..
AstraZeneca Pharmaceuticals, Wilmington, DE, USA
Abstract Number: 89
NON-INVASIVE BLOOD PRESSURE DETERMINATION IN MACACA FASCICULARIS AND CALLITHRIX JACCHUS BY HIGH DEFINITION OSCILLOMETRY
Barthel Schmelting.
Covance Laboratories, Muenster, Germany
Abstract Number: 90
A CARDIOVASCULAR SAFETY ASSESSMENT PARADIGM FOR THE EARLY IDENTIFICATION OF PROARRHYTHMIC AND TORSADAGENIC COMPOUNDS
Dinah L Misner1, C. Frantz1, E. Meierhenry, M. Fielden, L. Guo2, J. Ly, H. Uppal, D. Rotstein, M. Gralinski3, P. Senese3, M. Albassam, Sushmita Chanda1, Stefan Platz1, and K. Kolaja.
1Roche Palo Alto, Palo Alto, CA; USA,
2Hoffman La-Roche Inc., Nutley, NJ, USA
3CorDynamics Inc., Chicago, IL, USA
Abstract Number: 91
A NOVEL IMPLANTABLE BLOOD PRESSURE TELEMETRY DEVICE; COMPARISON BETWEEN DATA SCIENCES AND TELEMETRY RESEARCH SYSTEMS
Simon Malpas.
Telemetry Research Ltd., Auckland, New Zealand
Abstract Number: 92
NORMAL PREVALENCE OF CARDIAC ARRHYTHMIAS IN 24 H ECG RECORDINGS OF CHRONICALLY TELEMETERED, HEALTHY, FREELY MOVING BEAGLE DOGS
Frank Cools, David Gallacher..
Johnson & Johnson PRD, Beerse, Belgium
Abstract Number: 93
EVALUATION OF TEST ARTICLE-RELATED VENTRICULAR PREMATURE COMPLEXES IN CONSCIOUS TELEMETERED DOGS
Haisong Ju, Xuejun Wu, Jason Payseur, Jon Renninger, Dennis Murphy.
GlaxoSmithKline, King of Prussia, PA, USA
Abstract Number: 94
AN IN VITRO METHOD FOR DETECTING POTENTIAL PROARRHYTHMIC PROPERTIES OF CARDIOMYOCYTES GROWN ON MICROELECTRODE ARRAYS
Simon Bryant, Wyllie, C., Palmer, R., Heal, R., Demmon, J., Nicol, S.