1. Documentation of the Searches

DATA SUPPLEMENT

1. Documentation of the Searches

1.1 MEDLINE

• Search date: May 24th, 2011
• Databases: Ovid MEDLINE(R) Daily Update <May 20, 2011> AND Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) <1948 to Present>

1.2 EMBASE

• Search date: May 24th, 2011
• Database: Embase Classic+Embase <1947 to 2011 May 20>

1.3 Science Citation Index

• Search date: May 24th, 2011
• Database: Science Citation Index

1.4 BIOSIS

• Search date: May 24th, 2011
• Database: BIOSIS Previews <1993 to 2011 Week 24>
  

1.5 Cited Reference Search

• Search date: July 10th, 2011
• Database: Cited Reference Search, – Web of Science

Total after deleting duplicates: 201 (69 duplicates)

1.6 Cochrane library

• Search date: July 10th, 2011
• Database: Cochrane library
• Search query: Neoplastic cells, circulating (MeSH term)
• Evaluated abstract of: 2 Cochrane Reviews, 6 other reviews, 287 clinical trials, 3 technology assessments, 1 economic evaluation
• Relevant papers not found in Medline/Embase/Biosis/Science Citation Index searches: None

1.7 International Clinical Trials Registry Platform – WHO

• Search date: July 10th, 2011
• Database: International Clinical Trials Registry Platform – WHO
• Search query: Circulating tumor cells
• Evaluated abstracts: 33 clinical trials
• Relevant papers not found in Medline/Embase/Biosis/Science Citation Index searches: None

2. Excluded studies

3. Assessment of publication bias

Publication bias was assessed with funnel plots.

Funnel Plot Analysis on Overall Survival

Funnel Plot Analysis on Progression Free Survival

4. Additional study characteristics

REFERENCES

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