Article title: Hepatic expression of the GH/JAK/STAT/IGF pathway, Acute Phase Response signalling and Complement System are affected in mouse offspring by pre- and early postnatal exposure to maternal high protein diet
Journal name: European Journal of Nutrition
Author names: Jens Vanselow, Marzena Kucia, Martina Langhammer, Dirk Koczan, Charlotte Rehfeldt and Cornelia C. Metges
Corresponding author:Cornelia C. Metges, Leibniz-Institut für Nutztierbiologie (FBN), Forschungsbereich Ernährungsphysiologie, e-mail:
Online Resource 1. Offspring hepatic transcriptsa that were affected by high protein diet of dams during pregnancy and/or lactation.
Probe Set IDb / Gene ID / Symbol / Title / HPHP (FC)c / CHP (FC)c / Pathwaysd1 / 1428694_at / 75957 / 5033413D16Rik / RIKEN cDNA 5033413D16 gene / 2.4 / 2.3
2 / 1440671_at / 320235 / A130012E19Rik / RIKEN cDNA A130012E19 gene / 2.1 / 1.5
3 / 1438895_at / 109200 / A430102J17Rik / RIKEN cDNA A430102J17 gene / 1.8 / 1.7
4 / 1416468_at / 11668 / Aldh1a1 / aldehyde dehydrogenase family 1. subfamily A1 / -1.7 / -2.1 / 4.7.9.10.11.12
5 / 1443516_at / 20239 / Atxn2 / Ataxin 2 / 2.2 / 2.3
6 / 1428012_at / 230558 / C8a / complement component 8. alpha polypeptide / -1.5 / -1.5 / 1
7 / 1448364_at / 12452 / Ccng2 / cyclin G2 / 1.9 / 1.5
8 / 1432352_at / 67974 / Ccny / cyclin Y / 2.0 / 2.2
9 / 1417649_at / 12577 / Cdkn1c / cyclin-dependent kinase inhibitor 1C (P57) / 1.9 / 1.8 / 6
10 / 1435275_at / 333182 / Cox6b2 / cytochrome c oxidase subunit VIb polypeptide 2 / 1.9 / 2.1
11 / 1426243_at / 107869 / Cth / cystathionase (cystathionine gamma-lyase) / 1.5 / 1.4 / 9
12 / 1418989_at / 13034 / Ctse / cathepsin E / -2.5 / -2.1
13 / 1425365_a_at / 68444 / Cyp2d13 / cytochrome P450. family 2. subfamily d. polypeptide 13 / -2.3 / -2.8 / 4.9.12
14 / 1431803_at / 68444 / Cyp2d13 / cytochrome P450. family 2. subfamily d. polypeptide 13 / -1.9 / -1.9 / 4.9.12
15 / 1417531_at / 13109 / Cyp2j5 / cytochrome P450. family 2. subfamily j. polypeptide 5 / -1.7 / -1.7 / 4.9.12
16 / 1417532_at / 13109 / Cyp2j5 / cytochrome P450. family 2. subfamily j. polypeptide 5 / -1.6 / -1.8 / 4.9.12
17 / 1438788_at / 28022 / D5Wsu152e / DNA segment. Chr 5.WayneStateUniversity 152. expressed / 2.1 / 1.9
18 / 1436733_at / 272031 / E130309F12Rik / RIKEN cDNA E130309F12 gene / 2.2 / 2.2
19 / 1451600_s_at / 382053 / Es31 / esterase 31 / -2.4 / -2.3
20 / 1457896_at / 26381 / Esrrg / estrogen-related receptor gamma / 2.7 / 3.2
21 / 1435245_at / 216456 / Gls2 / glutaminase 2 (liver. mitochondrial) / 2.0 / 1.4 / 9
22 / 1449848_at / 14675 / Gna14 / guanine nucleotide binding protein. alpha 14 / -1.8 / -2.0
23 / 1446550_at / 14852 / Gspt1 / G1 to S phase transition 1 / 2.4 / 2.2
24 / 1436643_x_at / 66438 / Hamp2 / hepcidin antimicrobial peptide 2 / 2.1 / -16.8 / 1
25 / 1424252_at / 50926 / Hnrpdl / heterogeneous nuclear ribonucleoprotein D-like / 1.6 / 1.3
26 / 1450011_at / 56348 / Hsd17b12 / hydroxysteroid (17-beta) dehydrogenase 12 / -1.3 / -1.4
27 / 1418238_at / 56357 / Ivd / isovaleryl coenzyme A dehydrogenase / 1.4 / 1.3 / 4.9
28 / 1417835_at / 17836 / Mug1 / murinoglobulin 1 / -1.8 / -1.7
29 / 1427631_x_at / 17842 / Mup3 / major urinary protein 3 / -2.9 / -2.1
30 / 1424893_at / 83431 / Ndel1 / nuclear distribution gene E-like homolog 1 (A. nidulans) / 1.9 / 2.0
31 / 1454295_at / 268903 / Nrip1 / nuclear receptor interacting protein 1 / 3.3 / 2.9 / 6.10.12
32 / 1440037_at / 18514 / Pbx1 / pre B-cell leukemia transcription factor 1 / 2.0 / 2.4 / 6
33 / 1436194_at / 77619 / Prelid2 / PRELI domain containing 2 / 3.7 / 2.7
34 / 1456074_at / 70061 / Sdr9c7 / short chain dehydrogenase/reductase family 9C. member 7 / -1.5 / -1.9 / 10
35 / 1434442_at / 52331 / Stbd1 / starch binding domain 1 / -1.6 / -1.8
36 / 1423033_at / 16430 / Stt3a / STT3. subunit of the oligosaccharyltransferase complex. homolog A / -1.4 / -1.7
37 / 1435893_at / 22359 / Vldlr / very low density lipoprotein receptor / 1.8 / 1.8 / 10
38 / 1438714_at / 22680 / Zfp207 / zinc finger protein 207 / 1.7 / 1.7
39 / 1436933_at / RIKEN full-length enriched library. clone:E030012B08 / 2.5 / 2.6
40 / 1441539_at / --- / 2.8 / 3.2
41 / 1441556_at / Transcribed locus / 2.1 / 2.2
42 / 1442946_at / --- / 3.1 / 2.9
43 / 1443231_at / Transcribed locus / 2.0 / 2.2
44 / 1443491_at / RIKEN full-length enriched library. clone:A330048C19 / 2.8 / 2.6
45 / 1443521_at / --- / 2.0 / 2.4
46 / 1445689_at / Transcribed locus / 3.0 / 2.2
47 / 1447071_at / --- / 2.6 / 3.2
48 / 1424695_at / 67017 / 2010011I20Rik / RIKEN cDNA 2010011I20 gene / -1.3
49 / 1460464_at / 381820 / 2700089E24Rik / RIKEN cDNA 2700089E24 gene / -1.4
50 / 1418625_s_at / 378954 / Gapdh / glyceraldehyde-3-phosphate dehydrogenase / 1.4 / 7
51 / 1429810_at / 78757 / 4921505C17Rik / RIKEN cDNA 4921505C17 gene / 1.9
52 / 1426655_a_at / 75007 / 4930504E06Rik / RIKEN cDNA 4930504E06 gene / -1.4
53 / 1438321_x_at / 75007 / 4930504E06Rik / RIKEN cDNA 4930504E06 gene / -1.4
54 / 1429899_at / 70524 / 5730414N17Rik / RIKEN cDNA 5730414N17 gene / -1.6
55 / 1430585_at / 77068 / 5930436O19Rik / RIKEN cDNA 5930436O19 gene / 2.2
56 / 1427425_at / 77670 / 9130208E07Rik / RIKEN cDNA 9130208E07 gene / 1.9
57 / 1424312_at / 72674 / Adipor1 / adiponectin receptor 1 / 1.8
58 / 1418833_at / 11611 / Agxt / alanine-glyoxylate aminotransferase / 1.6 / 9
59 / 1431406_at / 71760 / Agxt2l1 / alanine-glyoxylate aminotransferase 2-like 1 / 1.5
60 / 1452975_at / 71760 / Agxt2l1 / alanine-glyoxylate aminotransferase 2-like 1 / 2.1
61 / 1437923_at / 106885 / AI314760 / expressed sequence AI314760 / 2.6
62 / 1424400_a_at / 107747 / Aldh1l1 / aldehyde dehydrogenase 1 family. member L1 / 1.4 / 7.9.12
63 / 1417828_at / 11833 / Aqp8 / aquaporin 8 / -2.4
64 / 1423194_at / 11855 / Arhgap5 / Rho GTPase activating protein 5 / -1.8
65 / 1450896_at / 11855 / Arhgap5 / Rho GTPase activating protein 5 / -2.2
66 / 1416239_at / 11898 / Ass1 / argininosuccinate synthetase 1 / 1.4 / 9
67 / 1442367_at / 320940 / Atp11c / Atpase. class VI. type 11C / -1.7
68 / 1423890_x_at / 11931 / Atp1b1 / ATPase. Na+/K+ transporting. beta 1 polypeptide / 1.7
69 / 1438035_at / 381110 / AW061290 / expressed sequence AW061290 / -2.1
70 / 1425646_at / 225994 / BC016495 / cDNA sequence BC016495 / -1.7
71 / 1423839_a_at / 218490 / Btf3 / basic transcription factor 3 / -1.4
72 / 1457464_at / 403342 / C130015C19 / hypothetical LOC403342 / 2.1
73 / 1457508_at / 320358 / C430003N24Rik / RIKEN cDNA C430003N24 gene / 2.1
74 / 1451635_at / 319800 / C730048C13Rik / RIKEN cDNA D630002G06 gene / 1.4
75 / 1440513_at / 97540 / C80258 / expressed sequence C80258 / 2.8
76 / 1450876_at / 12628 / Cfh / complement component factor h / -2.1 / 1
77 / 1442277_at / 12660 / Chka / choline kinase alpha / 2.2 / 4.9
78 / 1455901_at / 212862 / Chpt1 / choline phosphotransferase 1 / -2.0 / 4
79 / 1436390_a_at / 229725 / Clcc1 / chloride channel CLIC-like 1 / -1.7
80 / 1433782_at / 64945 / Cldn12 / claudin 12 / -1.4
81 / 1417417_a_at / 12861 / Cox6a1 / cytochrome c oxidase. subunit VI a. polypeptide 1 / 1.4
82 / 1422492_at / 12892 / Cpox / coproporphyrinogen oxidase / -2.0
83 / 1436631_at / 12385 / Ctnna1 / catenin (cadherin associated protein). alpha 1 / 2.4
84 / 1417017_at / 13074 / Cyp17a1 / cytochrome P450. family 17. subfamily a. polypeptide 1 / 1.8
85 / 1455457_at / 404195 / Cyp2c54 / cytochrome P450. family 2. subfamily c. polypeptide 54 / -3.0
86 / 1457034_at / 218850 / D14Abb1e / DNA segment. Chr 14. Abbott 1 expressed / -2.3
87 / 1417103_at / 13202 / Ddt / D-dopachrome tautomerase / 1.4 / 9
88 / 1449443_at / 67460 / Decr1 / 2.4-dienoyl CoA reductase 1. mitochondrial / -1.4
89 / 1441788_s_at / 108025 / Dkc1 / dyskeratosis congenita 1. dyskerin homolog (human) / -1.5
90 / 1419162_s_at / 1E+08 / Dnajc3a / DnaJ (Hsp40) homolog. subfamily C. member 3A / -1.4
91 / 1416018_at / 13486 / Dr1 / down-regulator of transcription 1 / -1.5
92 / 1448830_at / 19252 / Dusp1 / dual specificity phosphatase 1 / 2.0 / 5.6.10
93 / 1425705_a_at / 67475 / Ero1lb / ERO1-like beta (S. cerevisiae) / -2.0
94 / 1418438_at / 14079 / Fabp2 / fatty acid binding protein 2. intestinal / -1.7
95 / 1426593_a_at / 71999 / Fbxo22 / F-box protein 22 / -1.6
96 / 1450869_at / 14164 / Fgf1 / fibroblast growth factor 1 / -1.7
97 / 1439189_at / 329679 / Fnip2 / folliculin interacting protein 2 / -1.6
98 / 1423100_at / 14281 / Fos / FBJ osteosarcoma oncogene / 3.0 / 1.6.8.10.12.13
99 / 1421365_at / 14313 / Fst / follistatin / 2.4
100 / 1434458_at / 14313 / Fst / follistatin / 2.3
101 / 1439050_at / 14630 / Gclm / glutamate-cysteine ligase. modifier subunit / -1.7
102 / 1455981_at / 1E+08 / Gm16409 / ribosomal protein S6 / -1.5
103 / 1436270_at / 626571 / Gm6685 / predicted gene. EG626571 / -1.3
104 / 1417422_at / 14711 / Gnmt / glycine N-methyltransferase / 1.5 / 9
105 / 1450970_at / 14718 / Got1 / glutamate oxaloacetate transaminase 1. soluble / 1.7 / 4.9
106 / 1439566_at / 243385 / Gprin3 / GPRIN family member 3 / -1.9
107 / 1452823_at / 76263 / Gstk1 / glutathione S-transferase kappa 1 / 1.5 / 4.12
108 / 1423891_at / 103140 / Gstt3 / glutathione S-transferase. theta 3 / 1.9 / 12
109 / 1428361_x_at / 15122 / Hba-a1 / hemoglobin alpha. adult chain 1 / 1.3
110 / 1452757_s_at / 15122 / Hba-a1 / hemoglobin alpha. adult chain 1 / 1.4
111 / 1451229_at / 232232 / Hdac11 / histone deacetylase 11 / -1.4 / 2
112 / 1449080_at / 15182 / Hdac2 / histone deacetylase 2 / -1.5 / 2
113 / 1434736_at / 217082 / Hlf / hepatic leukemia factor / -1.4
114 / 1437526_x_at / 74326 / Hnrpr / heterogeneous nuclear ribonucleoprotein R / -1.8
115 / 1421011_at / 114664 / Hsd17b11 / hydroxysteroid (17-beta) dehydrogenase 11 / -2.0
116 / 1438040_a_at / 22027 / Hsp90b1 / heat shock protein 90kDa beta (Grp94). member 1 / -1.6
117 / 1431182_at / 15481 / Hspa8 / heat shock protein 8 / 2.5 / 5.6
118 / 1443252_at / 218215 / Ibrdc2 / IBR domain containing 2 / 2.3
119 / 1423062_at / 16009 / Igfbp3 / insulin-like growth factor binding protein 3 / -1.5 / 8.10
120 / 1458268_s_at / 16009 / Igfbp3 / insulin-like growth factor binding protein 3 / -1.5 / 8.10
121 / 1436420_a_at / 75751 / Ipo4 / importin 4 / -1.4
122 / 1418629_a_at / 20218 / Khdrbs1 / KH domain containing. RNA binding. signal transduction ass. 1 / -1.3
123 / 1436968_x_at / 75785 / Klhl24 / kelch-like 24 (Drosophila) / -2.0
124 / 1439441_x_at / 50523 / Lats2 / large tumor suppressor 2 / -1.7
125 / 1455240_x_at / 1E+08 / LOC100042687 / similar to CG32602-PA / -3.6
126 / 1439263_at / LOC14210 / hypothetical LOC14210 / -2.7
127 / 1458690_at / 57438 / March7 / membrane-associated ring finger (C3HC4) 7 / 2.3
128 / 1433576_at / 232087 / Mat2a / methionine adenosyltransferase II. alpha / -1.3 / 9
129 / 1423960_at / 14792 / Mboat5 / membrane bound O-acyltransferase domain containing 5 / -1.2
130 / 1448172_at / 17449 / Mdh1 / malate dehydrogenase 1. NAD (soluble) / 1.5 / 11
131 / 1453836_a_at / 23945 / Mgll / monoglyceride lipase / -1.4 / 4
132 / 1430969_at / 56428 / Mtch2 / mitochondrial carrier homolog 2 (C. elegans) / 1.7
133 / 1418024_at / 74838 / Narg1 / NMDA receptor-regulated gene 1 / -1.5
134 / 1428410_at / 72117 / Nat13 / N-acetyltransferase 13 / -1.6
135 / 1434056_a_at / 230075 / Ndufb6 / NADH dehydrogenase (ubiquinone) 1 beta subcomplex. 6 / -1.5
136 / 1439805_at / 54446 / Nfat5 / nuclear factor of activated T-cells 5 / 2.3
137 / 1425392_a_at / 12355 / Nr1i3 / nuclear receptor subfamily 1. group I. member 3 / -1.6 / 10.12
138 / 1457635_s_at / 14815 / Nr3c1 / nuclear receptor subfamily 3. group C. member 1 / -1.7 / 1.6.10.13
139 / 1449140_at / 52653 / Nudcd2 / NudC domain containing 2 / -1.4
140 / 1453139_at / 67993 / Nudt12 / nudix (nucleoside diphosphate linked moiety X)-type motif 12 / -2.2
141 / 1416452_at / 18242 / Oat / ornithine aminotransferase / 1.5 / 9
142 / 1437711_x_at / 18263 / Odc1 / ornithine decarboxylase. structural 1 / -1.9 / 9
143 / AFFX-PyruCarbMur/L09192_MB_at / 18563 / Pcx / pyruvate carboxylase / -1.4 / 9.11
144 / 1442700_at / 18578 / Pde4b / phosphodiesterase 4B. cAMP specific / 2.7
145 / 1423423_at / 14827 / Pdia3 / protein disulfide isomerase associated 3 / -1.2 / 4.5.9
146 / 1416497_at / 12304 / Pdia4 / protein disulfide isomerase associated 4 / -1.8
147 / 1423747_a_at / 228026 / Pdk1 / pyruvate dehydrogenase kinase. isoenzyme 1 / -1.9 / 13
148 / 1422861_s_at / 56376 / Pdlim5 / PDZ and LIM domain 5 / -1.8
149 / 1417864_at / 18655 / Pgk1 / phosphoglycerate kinase 1 / 1.3 / 7
150 / 1425514_at / 18708 / Pik3r1 / phosphatidylinositol 3-kinase. regulatory subunit. polypeptide 1 / -1.4 / 1.5.6.8.10.12.13
151 / 1437100_x_at / 223775 / Pim3 / proviral integration site 3 / 1.4
152 / 1417785_at / 85031 / Pla1a / phospholipase A1 member A / 2.2 / 4
153 / 1437751_at / 19017 / Ppargc1a / peroxisome proliferative activated receptor. gamma. coactivator 1 α / 1.7
154 / 1433540_x_at / 19046 / Ppp1cb / protein phosphatase 1. catalytic subunit. beta isoform / -1.8
155 / 1416166_a_at / 53381 / Prdx4 / peroxiredoxin 4 / -2.0
156 / 1419700_a_at / 19126 / Prom1 / prominin 1 / 3.6
157 / 1437894_at / 19130 / Prox1 / prospero-related homeobox 1 / -1.7
158 / 1435391_at / 381626 / Prr8 / proline rich 8 / 1.8
159 / 1438984_x_at / 19172 / Psmb4 / proteasome (prosome. macropain) subunit. beta type 4 / -1.9
160 / 1438390_s_at / 30939 / Pttg1 / pituitary tumor-transforming 1 / 2.0
161 / 1456726_x_at / 97541 / Qars / glutaminyl-tRNA synthetase / -1.4 / 9
162 / 1455938_x_at / 19357 / Rad21 / RAD21 homolog (S. pombe) / -1.8
163 / 1456918_at / 77300 / Raph1 / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 / 3.6
164 / 1426037_a_at / 19734 / Rgs16 / regulator of G-protein signaling 16 / -1.8
165 / 1434872_x_at / 67281 / Rpl37 / ribosomal protein L37 / -1.3
166 / 1428657_at / 68750 / Rreb1 / ras responsive element binding protein 1 / -2.0
167 / 1448964_at / 12309 / S100g / S100 calcium binding protein G / 6.1
168 / 1418206_at / 64136 / Sdf2l1 / stromal cell-derived factor 2-like 1 / -1.8
169 / 1424744_at / 231691 / Sds / serine dehydratase / 1.6 / 4.9
170 / 1418565_at / 66870 / Serbp1 / Serpine1 mRNA binding protein 1 / -1.8
171 / 1435887_at / 380780 / Serpina11 / serine peptidase inhibitor. clade A. member 11 / -1.6
172 / 1451513_x_at / 20700 / Serpina1a / serine peptidase inhibitor. clade A. member 1a / 1.5 / 1
173 / 1448506_at / 12401 / Serpina6 / serine (or cysteine) peptidase inhibitor. clade A. member 6 / 1.6
174 / 1420821_at / 81535 / Sgpp1 / sphingosine-1-phosphate phosphatase 1 / -1.5
175 / 1423149_at / 21402 / Skp1a / S-phase kinase-associated protein 1A / -1.6 / 2
176 / 1434996_at / 73132 / Slc25a16 / solute carrier family 25. member 16 / -1.8
177 / 1423621_a_at / 11416 / Slc33a1 / solute carrier family 33 (acetyl-CoA transporter). member 1 / -2.1
178 / 1429649_at / 229782 / Slc35a3 / solute carrier family 35. member 3 / -1.7
179 / 1427826_a_at / 28253 / Slco1b2 / solute carrier organic anion transporter family. member 1b2 / -1.8
180 / 1457522_at / 68734 / Smek1 / SMEK homolog 1. suppressor of mek1 (Dictyostelium) / 1.8
181 / 1460722_at / 223920 / Soat2 / sterol O-acyltransferase 2 / -1.5
182 / 1435492_at / 54607 / Socs6 / suppressor of cytokine signaling 6 / -2.4 / 1.8.13
183 / 1427345_a_at / 20887 / Sult1a1 / sulfotransferase family 1A. phenol-preferring. member 1 / 1.4 / 9.12
184 / 1452007_at / 20955 / Sybl1 / synaptobrevin like 1 / -2.1
185 / 1451557_at / 234724 / Tat / tyrosine aminotransferase / 1.6 / 6.9
186 / 1417370_at / 21786 / Tff3 / trefoil factor 3. intestinal / 2.0
187 / 1457357_at / 24086 / Tlk2 / tousled-like kinase 2 (Arabidopsis) / 1.8
188 / 1423295_at / 68059 / Tm9sf2 / transmembrane 9 superfamily member 2 / -2.1
189 / 1416447_at / 69981 / Tmem30a / transmembrane protein 30A / -1.6
190 / 1426628_at / 234463 / Tmem34 / transmembrane protein 34 / -1.3
191 / 1415908_at / 22110 / Tspyl1 / testis-specific protein. Y-encoded-like 1 / -1.9
192 / 1424493_s_at / 105887 / Ugt3a1 / UDP glycosyltransferases 3 family. polypeptide A1 / -2.1
193 / 1438258_at / 22359 / Vldlr / very low density lipoprotein receptor / 2.5
194 / 1420723_at / 26464 / Vnn3 / vanin 3 / -1.5
195 / 1448418_s_at / 28199 / Wdr23 / WD repeat domain 23 / 1.3
196 / 1431960_at / 80707 / Wwox / WW domain-containing oxidoreductase / 2.5
197 / 1434298_at / 24136 / Zeb2 / zinc finger E-box binding homeobox 2 / -2.4
198 / 1440977_at / RIKEN full-length enriched library. clone:A130071G05 / 2.0
199 / 1442014_at / Transcribed locus / 2.2
200 / 1442097_at / RIKEN full-length enriched library. clone:D630011L08 / -3.4
201 / 1444130_at / Transcribed locus / 2.2
202 / 1445042_at / --- / 5.4
203 / 1445349_at / RIKEN full-length enriched library. clone:E030049A20 / -3.5
204 / 1446201_at / RIKEN full-length enriched library. clone:E130116B10 / 2.5
205 / 1452426_x_at / --- / -3.8
206 / 1457944_at / RIKEN full-length enriched library. clone:F830029F03 / 2.6
207 / 1442992_at / 403343 / 130004C03 / hypothetical LOC403343 / 2.6
208 / 1436424_at / 72012 / 1600020E01Rik / RIKEN cDNA 1600020E01 gene / 1.6
209 / 1437019_at / 69134 / 2200001I15Rik / RIKEN cDNA 2200001I15 gene / -1.6
210 / 1429822_at / 70828 / 4633401B06Rik / RIKEN cDNA 4633401B06 gene / 1.8
211 / 1456706_at / 108962 / 4833441D16Rik / RIKEN cDNA 4833441D16 gene / 3.3
212 / 1447937_a_at / 108816 / 4933409K07Rik / RIKEN cDNA 4933409K07 gene / 3.4
213 / 1430414_at / 76016 / 5730406G12Rik / RIKEN cDNA 5730406G12 gene / 2.5
214 / 1438667_at / 319613 / 5730410E15Rik / RIKEN cDNA 5730410E15 gene / 1.8
215 / 1433242_at / 76012 / 5830415B17Rik / RIKEN cDNA 5830415B17 gene / 2.2
216 / 1440163_at / 77715 / 6030490B17Rik / RIKEN cDNA 6030490B17 gene / 2.3
217 / 1441688_at / 319654 / 6430537I21Rik / RIKEN cDNA 6430537I21 gene / 3.3
218 / 1430191_at / 71603 / 9130004J05Rik / RIKEN cDNA 9130004J05 gene / 2.5
219 / 1441779_at / 77393 / 9530006C21Rik / RIKEN cDNA 9530006C21 gene / 2.0
220 / 1454364_at / 77439 / 9530025L08Rik / RIKEN cDNA 9530025L08 gene / 2.3
221 / 1460121_at / 399612 / 9630010G10Rik / RIKEN cDNA 9630010G10 gene / 2.5
222 / 1443088_at / 319589 / 9930031P18Rik / RIKEN cDNA 9930031P18 gene / 2.1
223 / 1442358_at / 101447 / AA409587 / expressed sequence AA409587 / 2.1
224 / 1457111_at / 103570 / AA415038 / expressed sequence AA415038 / 1.9
225 / 1456081_a_at / 78894 / Aacs / acetoacetyl-CoA synthetase / -2.6
226 / 1418148_at / 57742 / Abhd1 / abhydrolase domain containing 1 / -1.8
227 / 1429883_at / 56456 / Actl6a / actin-like 6A / 1.5
228 / 1438816_at / 226747 / Ahctf1 / AT hook containing transcription factor 1 / 2.0
229 / 1450387_s_at / 11639 / Ak3l1 / adenylate kinase 3 alpha-like 1 / -1.5
230 / 1423556_at / 11997 / Akr1b7 / aldo-keto reductase family 1. member B7 / 2.9 / 7.11
231 / 1432007_s_at / 11772 / Ap2a2 / adaptor protein complex AP-2. alpha 2 subunit / 1.7
232 / 1431429_a_at / 11861 / Arl4a / ADP-ribosylation factor-like 4A / 1.5
233 / 1425099_a_at / 11865 / Arntl / aryl hydrocarbon receptor nuclear translocator-like / 2.2 / 3
234 / 1440586_at / 97874 / B430203I24Rik / RIKEN cDNA B430203I24 gene / 2.1
235 / 1448595_a_at / 19716 / Bex1 / brain expressed gene 1 / 2.8
236 / 1418025_at / 20893 / Bhlhb2 / basic helix-loop-helix domain containing. class B2 / -1.6
237 / 1417009_at / 50909 / C1r / complement component 1. r subcomponent / -1.4 / 1
238 / 1458942_at / 30910 / C230037E05Rik / RIKEN cDNA C230037E05 gene / 4.9
239 / 1418037_at / 12269 / C4bp / complement component 4 binding protein / -1.3
240 / 1427472_a_at / 110382 / C8b / complement component 8. beta subunit / -1.5 / 1
241 / 1425814_a_at / 54598 / Calcrl / calcitonin receptor-like / -1.5
242 / 1449486_at / 12623 / Ces1 / carboxylesterase 1 / -1.6 / 12
243 / 1427428_at / 75863 / Clec4g / C-type lectin domain family 4. member g / -1.4
244 / 1418660_at / 12753 / Clock / circadian locomoter output cycles kaput / 1.9 / 3.10
245 / 1423447_at / 270166 / Clpx / caseinolytic peptidase X (E.coli) / 1.5
246 / 1439342_at / 270166 / Clpx / Caseinolytic peptidase X (E.coli) / 3.0
247 / 1439094_at / 67300 / Cltc / clathrin. heavy polypeptide (Hc) / 1.8
248 / 1428043_a_at / 12763 / Cmah / cytidine monophospho-N-acetylneuraminic acid hydroxylase / -2.0
249 / 1436039_at / 12763 / Cmah / cytidine monophospho-N-acetylneuraminic acid hydroxylase / -1.6
250 / 1449183_at / 12846 / Comt / catechol-O-methyltransferase / -1.3
251 / 1438831_at / 69131 / Crkrs / Cdc2-related kinase. arginine/serine-rich / 2.3
252 / 1447500_at / 13048 / Cux2 / cut-like homeobox 2 / 3.2
253 / 1418652_at / 17329 / Cxcl9 / chemokine (C-X-C motif) ligand 9 / -1.8
254 / 1421363_at / 13098 / Cyp2c39 / cytochrome P450. family 2. subfamily c. polypeptide 39 / -1.5 / 4.9.10.12
255 / 1421741_at / 13114 / Cyp3a16 / cytochrome P450. family 3. subfamily a. polypeptide 16 / 1.8
256 / 1424943_at / 666168 / Cyp4a31 / cytochrome P450. family 4. subfamily a. polypeptide 31 / 2.0
257 / 1455134_at / 242474 / D730040F13Rik / RIKEN cDNA D730040F13 gene / 1.5
258 / 1418174_at / 13170 / Dbp / D site albumin promoter binding protein / -2.7
259 / 1438211_s_at / 13170 / Dbp / D site albumin promoter binding protein / -2.8
260 / 1417441_at / 30045 / Dnajc12 / DnaJ (Hsp40) homolog. subfamily C. member 12 / 1.8
261 / 1436186_at / 108961 / E2f8 / E2F transcription factor 8 / -1.5
262 / 1423695_at / 108687 / Edem2 / ER degradation enhancer. mannosidase alpha-like 2 / -1.3
263 / 1447939_a_at / 545605 / EG545605 / predicted gene. EG545605 / 2.9
264 / 1418059_at / 170757 / Eltd1 / EGF. latrophilin seven transmembrane domain containing 1 / -1.5
265 / 1441233_at / Predicted gene. ENSMUSG00000073237 / 1.8
266 / 1435476_a_at / 14130 / Fcgr2b / Fc receptor. IgG. low affinity IIb / -1.5
267 / 1435477_s_at / 14130 / Fcgr2b / Fc receptor. IgG. low affinity IIb / -1.5
268 / 1419146_a_at / 103988 / Gck / glucokinase / -3.0 / 7
269 / 1426235_a_at / 14645 / Glul / glutamate-ammonia ligase (glutamine synthetase) / -1.4 / 9
270 / 1420385_at / 14675 / Gna14 / guanine nucleotide binding protein. alpha 14 / -2.2
271 / 1447791_s_at / 14675 / Gna14 / guanine nucleotide binding protein. alpha 14 / -2.4
272 / 1446861_at / 75612 / Gns / glucosamine (N-acetyl)-6-sulfatase / 2.0
273 / 1421041_s_at / 14857 / Gsta1 / glutathione S-transferase. alpha 1 (Ya) / 2.1
274 / 1421040_a_at / 14858 / Gsta2 / glutathione S-transferase. alpha 2 (Yc2) / 2.3
275 / 1428124_at / 74197 / Gtf2e1 / general transcription factor II E. polypeptide 1 (alpha subunit) / 1.6 / 6
276 / 1448194_a_at / 14955 / H19 / H19 fetal liver mRNA / 2.2
277 / 1449047_at / 56794 / Hacl1 / 2-hydroxyacyl-CoA lyase 1 / 1.3
278 / 1426645_at / 15519 / Hsp90aa1 / heat shock protein 90kDa alpha (cytosolic). class A member 1 / -1.6 / 6.10.12
279 / 1437497_a_at / 15519 / Hsp90aa1 / heat shock protein 90kDa alpha (cytosolic). class A member 1 / -1.7
280 / 1423555_a_at / 99899 / Ifi44 / interferon-induced protein 44 / -1.7
281 / 1423584_at / 29817 / Igfbp7 / insulin-like growth factor binding protein 7 / -1.2 / 8
282 / 1443969_at / 384783 / Irs2 / insulin receptor substrate 2 / 1.9 / 8
283 / 1421322_a_at / 16391 / Isgf3g / interferon dependent positive acting transcription factor 3 gamma / -1.6
284 / 1449001_at / 56357 / Ivd / isovaleryl coenzyme A dehydrogenase / 1.4
285 / 1425644_at / 16847 / Lepr / leptin receptor / 1.8
286 / 1442258_at / 66887 / Lonp2 / lon peptidase 2. peroxisomal / 1.9
287 / 1425673_at / 210126 / Lpp / LIM domain containing preferred translocation partner in lipoma / 2.2
288 / 1451255_at / 54135 / Lsr / lipolysis stimulated lipoprotein receptor / -1.5
289 / 1453304_s_at / 17069 / Ly6e / lymphocyte antigen 6 complex. locus E / -1.7
290 / 1437045_at / 26419 / Mapk8 / mitogen activated protein kinase 8 / 1.8 / 1.6.8.10.12
291 / 1441100_at / 103537 / Mbtd1 / mbt domain containing 1 / 1.8
292 / 1416632_at / 17436 / Mod1 / malic enzyme. supernatant / -1.8
293 / 1430307_a_at / 17436 / Mod1 / malic enzyme. supernatant / -1.7
294 / 1428167_a_at / 68481 / Mpzl1 / myelin protein zero-like 1 / 1.7
295 / 1428168_at / 68481 / Mpzl1 / myelin protein zero-like 1 / 1.8
296 / 1434807_s_at / 382793 / Mtx3 / metaxin 3 / 1.9
297 / 1448854_s_at / 17837 / Mug2 / murinoglobulin 2 / -2.0
298 / 1418932_at / 18030 / Nfil3 / nuclear factor. interleukin 3. regulated / 1.6
299 / 1448944_at / 18186 / Nrp1 / neuropilin 1 / -1.5
300 / 1453187_at / 433904 / Ociad2 / OCIA domain containing 2 / -1.6
301 / 1425125_at / 18302 / Oit3 / oncoprotein induced transcript 3 / -1.8
302 / 1424733_at / 140795 / P2ry14 / purinergic receptor P2Y. G-protein coupled. 14 / 1.5
303 / 1417273_at / 27273 / Pdk4 / pyruvate dehydrogenase kinase. isoenzyme 4 / 2.0
304 / 1424671_at / 72287 / Plekhf1 / pleckstrin homology domain containing. family F member 1 / -1.8
305 / 1456395_at / 19017 / Ppargc1a / peroxisome proliferative activated receptor. gamma. coactivator 1 α / 2.2 / 6.10.12
306 / 1428923_at / 76487 / Ppp1r3g / protein phosphatase 1. regulatory (inhibitor) subunit 3G / 2.2
307 / 1456072_at / 243725 / Ppp1r9a / protein phosphatase 1. regulatory (inhibitor) subunit 9A / 1.6
308 / 1456531_x_at / 28000 / Prpf19 / PRP19/PSO4 pre-mRNA processing factor 19 homolog / -1.3
309 / 1445729_at / 23997 / Psmd13 / Proteasome (prosome. macropain) 26S subunit. non-ATPase. 13 / 1.8
310 / 1439687_at / 68365 / Rab14 / RAB14. member RAS oncogene family / 2.0
311 / 1438055_at / 109222 / Rarres1 / retinoic acid receptor responder (tazarotene induced) 1 / -1.7
312 / 1440223_at / 19654 / Rbm6 / RNA binding motif protein 6 / 1.8
313 / 1419319_at / 20211 / Saa4 / serum amyloid A 4 / -1.8 / 1
314 / 1437503_a_at / 66940 / Scotin / scotin gene / -1.2
315 / 1423130_a_at / 20384 / Sfrs5 / splicing factor. arginine/serine-rich 5 (SRp40. HRS) / 1.3
316 / 1445933_at / 57138 / Slc12a5 / solute carrier family 12. member 5 / 2.2
317 / 1449844_at / 28248 / Slco1a1 / solute carrier organic anion transporter family. member 1a1 / -4.4
318 / 1437180_at / 67797 / Snrnp48 / small nuclear ribonucleoprotein 48 (U11/U12) / 1.6
319 / 1418789_at / 268534 / Sntg2 / syntrophin. gamma 2 / -1.9
320 / 1452125_at / 230753 / Thrap3 / thyroid hormone receptor associated protein 3 / 1.8
321 / 1422973_a_at / 21835 / Thrsp / thyroid hormone responsive SPOT14 homolog (Rattus) / -3.1 / 10
322 / 1424737_at / 21835 / Thrsp / thyroid hormone responsive SPOT14 homolog (Rattus) / -2.2 / 10
323 / 1455698_at / 69276 / Tloc1 / translocation protein 1 / -1.6
324 / 1455128_x_at / 233833 / Tnrc6a / trinucleotide repeat containing 6a / 1.6
325 / 1442886_at / 101214 / Tra2a / transformer 2 alpha homolog (Drosophila) / 1.8
326 / 1452646_at / 68728 / Trp53inp2 / transformation related protein 53 inducible nuclear protein 2 / -1.4
327 / 1430043_at / 72795 / Ttc19 / tetratricopeptide repeat domain 19 / 2.5
328 / 1417900_a_at / 22359 / Vldlr / very low density lipoprotein receptor / 1.7
329 / 1446365_at / 53611 / Vti1a / vesicle transport through interaction with t-SNAREs homolog 1A / 2.0
330 / 1438234_at / 226757 / Wdr26 / WD repeat domain 26 / 1.9
331 / 1416773_at / 22390 / Wee1 / wee 1 homolog (S. pombe) / -1.7
332 / 1415689_s_at / 72739 / Zkscan3 / zinc finger with KRAB and SCAN domains 3 / 1.3
333 / 1445543_at / 219105 / Zmym5 / zinc finger. MYM-type 5 / 1.9
334 / 1435579_at / 2.5
335 / 1436145_at / 2.4
336 / 1437162_at / Transcribed locus / 2.3
337 / 1437599_at / 2.0
338 / 1438864_at / --- / 1.8
339 / 1438906_at / 2.1
340 / 1439233_at / Transcribed locus / 1.8
341 / 1439652_at / --- / 2.5
342 / 1439722_at / --- / 2.1
343 / 1439857_at / Transcribed locus / 1.9
344 / 1440365_at / --- / 2.0
345 / 1440563_at / 2.2
346 / 1440579_at / 2.2
347 / 1440892_at / --- / 2.1
348 / 1442049_at / Transcribed locus / 1.5
349 / 1442126_at / Transcribed locus / 2.3
350 / 1442509_at / 2.3
351 / 1442760_x_at / --- / 2.1
352 / 1443037_at / 2.7
353 / 1443048_at / --- / 2.8
354 / 1443109_at / --- / 3.2
355 / 1443489_at / --- / 2.5
356 / 1443526_at / 2.1
357 / 1443905_at / 2.7
358 / 1444045_at / Transcribed locus / 2.1
359 / 1444258_at / Transcribed locus / 2.6
360 / 1444337_at / 2.4
361 / 1444349_at / --- / 1.9
362 / 1444406_at / Transcribed locus / 2.0
363 / 1444458_at / --- / 1.8
364 / 1445377_at / 2.2
365 / 1445512_at / --- / 2.6
366 / 1445612_at / 2.9
367 / 1446130_at / --- / 1.9
368 / 1446921_at / Transcribed locus / 2.6
369 / 1447408_at / --- / 2.1
370 / 1447951_at / 2.3
371 / 1456547_at / --- / 2.8
372 / 1456655_at / 1.8
373 / 1456717_at / --- / 3.0
374 / 1456979_at / 2.1
375 / 1457324_at / Transcribed locus / 2.8
376 / 1457338_at / --- / 2.1
377 / 1458077_at / 2.9
378 / 1458296_at / Transcribed locus / 2.5
379 / 1458460_at / --- / 4.7
380 / 1458566_at / Transcribed locus / 2.8
381 / 1458661_at / --- / 2.0
382 / 1458974_at / Transcribed locus / 2.1
383 / 1459635_at / --- / 2.3
aTranscripts were identified by differential microarray analysis at d21 comparing the control diet group (CC) with the CHP diet group (control diet during gestation and high protein diet during lactation) and the HPHP diet group (high protein diet during gestation and lactation);b ID-numbers of mouse gene specificities on Affymetrix MOE430_2.0 expression array;cFC, fold change of transcript abundance in CHP and HPHP vs. CC; d Pathways combined from significantly affected IPA (Ingenuitiy Pathway Analysis tool) Canonical Pathways (see Fig. 1): 1 Acute Response/Complement. 2 Cell Cycle. 3 Circadian Rhythm. 4 Fatty Acid Metabolism. 5 Aldosterone Signalling. 6 Glucocorticoid Signalling. 7 Hexose Metabolism. 8 GH/JAK/STAT/IGFSignalling. 9 Protein/Amino Acid Metabolism. 10 PX/RX/FX/RA/PPARSignalling. 11 Pyruvate Metabolism. 12 Xenobiotic Metabolism. 13 Prolactin Signalling