Table E-1. Categorization of Clinical Variables Utilized for Univariate Analysis

Yee 1

Table e-1. Categorization of clinical variables utilized for univariate analysis

Category / Variables
Gender / Male, Female
Age (years) / < 45, 46-65, 66- 85, > 86
Race / Caucasian vs. non-Caucasian
Pupillary Light Reflex / Presence vs. Absence
Corneal Reflex / Presence vs. Absence
Cough Reflex / Presence vs. Absence
Breaths At Ventilatory Rate/Apneic / Presence vs. Absence
Motor Response / Presence of extensor/absent motor response vs. Absence
FOUR Scorea(max score=16) / Score of 5-16
FOUR Scorea(max score=16) / Score of 0-4
Intracranial Disease / Presence/Absent of ischemic stroke, intracranial hemorrhage (hemorrhagic conversion, subdural, intraventricular, subarachnoid, intraparenchymal)
Supratentorial Disease Location / Intracranial disease (stroke, hemorrhage) cortical and/or subcortical
Infratentorial Disease Location / Intracranial disease (stroke, hemorrhage) cerebellar and/or pontomedullary
Intracranial Disease Location / 2 or greater lesions present
Midline Shift / Presence vs. Absence; measured in millimeters [measured from septum pellucidum using Q-reads clinical image viewer, version 3.0.1 (Copyright ©Mayo Clinic)]
Effacement of Basilar Cisterns / Presence vs. Absence
Cranial Imaging / Evidence of progressive disease (worsening hemorrhage, infarct volume, edema, midline shift) on 2 consecutive images (CT/MRI)b
Other Neurological Diseases / Prior intracranial/extracranial vascular disease (e.g. carotid stenosis/carotid endarterectomy), intracranial aneurysm +/- SAHc, arteriovenous or other vascular malformations, cerebrovascular disease (prior stroke/TIA), non-cerebrovascular neurologic disease(motor-neuron disease, myasthenia gravis, muscular dystrophy, demyelinating), seizures(on treatment at time of WLSM), recent CNSd infection(meningitis, encephalitis, abscess), prior or recent primary or secondary CNSd malignancy
Cardiac Disease / Recent MIe(significant serum troponin delta trend, consistent ECG or echocardiogram findings), history of CADf (includes bypass, MIe), acute/decompensated CHFg, heart failure with ejection fraction < 35% with or without implantable cardiac defibrillator, prior cardiopulmonary arrest, prior aortic aneurysmal disease, atrial or ventricular arrhythmia(other than non-sustained), complete heart block, valvular heart disease, hypertension, peripheral vascular disease, cardiac malignancy, cardiac infection (e.g. valvular, myocardial)
Pulmonary Disease / Pulmonary infection (tracheobronchitis, pneumonia, abscess, empyema), COPDh, asthma, pulmonary embolism, ARDSi, malignancy, pneumothorax, alveolar hemorrhage, other pulmonary related diseases(sarcoidosis, Wegener’s Granulomatosis)
PFj Ratio (ordinal variable) / < 200
PF j Ratio (ordinal variable) / 201-300
PF j Value (continuous variable) / Calculated PF j ratio value
Oxygenation Index (continuous variable) / Calculated value
Abnormal Blood Gas pH / pH < 7.30 or > 7.50
Abnormal Arterial Blood Gas / PaCO2k > 45 mm Hg or PaO2l < 80 mm Hg
Abnormal A-a Gradient / A-a gradientm > 100
Gastrointestinal Disease / Hepatic failure(infection and non-infectious), GIn bleed, cirrhosis, inflammatory bowel disease, infectious and non-infectious inflammatory(cholecystitis, pancreatitis) disease, GIn perforation, malignancy, other GIn disease(ischemic)
Renal Disease / Current or recent hemodialysis, ARFo(25% decrease in glomerular filtration rate or 0.5 mg/dL rise in serum creatinine from baseline), CKDp(glomerular filtration rate <60mL/min or persistent albuminuria > 3months), malignancy, upper or lower urinary tract infection, other renal disease(renal infarction, transplantation)
Abnormal Serum Sodium / Serum Sodium concentration (mmol/L)q: < 120, 121-134, > 145
Coagulopathy / Presence vs. Absence of disseminated intravascular coagulation, anticoagulation, other causes of thrombocytopenia (platelet count <100,000 cells/microliter) such as idiopathic thrombocytopenic purpura and thrombotic thrombocytopenic purpura
Hypotension / SBPr < 90 mm Hg with or without use of vasopressors
Abnormal Temperature / Temperature < 35oCs or > 38.3oCs
Abnormal Heart Rate / Heart rate <50 beats/minute or >100 beats/minute

aFOUR Score, Full outline of unresponsiveness scale score6; bCT, computed tomography; bMRI, magnetic resonance imaging; cSAH, subarachnoid hemorrhage; dCNS, central nervous system; eMI, myocardial infarction; fCAD, coronary artery disease; gCHF, congestive heart failure; hCOPD, chronic obstructive pulmonary disease; iARDS11, acute respiratory distress syndrome; jPF, partial pressure of arterial oxygenation/fraction of inspired oxygen; kPaCO2, partial pressure of carbon dioxide in arterial blood; lPaO2, partial pressure of oxygen in arterial blood; mA-a gradient, alveolar-arterial oxygenation gradient; nGI, gastrointestinal; oARF, acute renal failure, pCKD, chronic kidney disease; qmmol/L, millimole per liter; rSBP, systolic blood pressure; soC, degrees in Celsius.

Laboratory values, vital signs, neurologic examinations, and cranial imaging were recorded from period nearest to WLSM.