Supplementary File Sensitivity Analyses to Evaluate Robustness of Findings

Supplementary File – Sensitivity Analyses to Evaluate Robustness of Findings

Table 1. Time trends in readmission and mortality after patient discharge from ICU among the study group, a comparison of unadjusted data and adjusted data.

Abbreviations: CI; confidence interval

Figure 1. Trends in unadjusted patient outcomes over time*†

A. Readmission to ICU within 72 hours of discharge

B. Mortality within 14 days of discharge from ICU

* Data are provided by quarter. Bars indicate the unadjusted proportion of events per quarter; dashed horizontal lines the overall unadjusted means; the black dashed lines the quarter in which the critical care transition program was implemented.

† Patients discharged within 3 months of program implementation (study quarter 0) were excluded from analysis to allow for a period of institutional adjustment prior to evaluation.

Figure 2. Trends in adjusted patient outcomes over time for study hospitals - interrupted time series analysis of adjusted event rates and associated 95% confidence intervals*†

A. Readmission to ICU within 72 hours of discharge

B. Mortality within 14 days of discharge from ICU

* Data are provided by quarter. The solid lines indicate the adjusted proportion of events (red) and associated 95% upper (purple) and lower (green) confidence limit. The broken lines indicate the adjusted overall mean (red) and associated 95% upper (purple) and lower (green) confidence limits.

† Patients discharged within 3 months of program implementation (study quarter 0) were excluded from analysis to allow for a period of institutional adjustment prior to evaluation.

Table 2. Time trends in readmission and mortality after patient discharge from ICU using different approaches to model the peri-intervention period

Abbreviations: CI; confidence interval