Ist Year M.D., Department of Post Graduate Studies in Dravya Guna

From:

Dr.Shivashankarappa.

Ist Year M.D., Department of Post Graduate Studies in Dravya Guna.

S.J.G. Ayurvedic Medical College & Hospital, Gavimath Campus Koppal-583231, Karnataka.

To:

The Registrar,

Rajiv Gandhi University of Health Sciences Bengaluru, Karnataka.

Through:

The Principal and The Head of the Department of Dravya Guna.

S.J.G. Ayurvedic Medical College & Hospital, Gavimath Campus Koppal-583231, Karnataka.

Respected Sir,

Sub: Regarding the submission of completed Proforma for Registration of subject for Dissertation.

I request you to kindly register the below mentioned subject against my name for the submission of dissertation to the Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka for the partial fulfilment of M.D. (Ayurveda).

Title of the Dissertation:

“A COMPARATIVE STUDY OF JWARAHARA PROPERTIES OF SARIVA( HEMIDESMUS INDICUS R.Br) AND PATHA(CISSAMPELOS PARIERA Linn.) in JWARA”

Here with I am enclosing completedproforma for registration of the subject for dissertation.

Thanking you.

Yours faithfully

Place: Koppal

Date:(Dr. Shivashankarappa)

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

BENGALURU,KARNATAKA.

ANNEXURE II

Proforma for registration of subject for dissertation

6. Brief Review of Intended work:

6.1) Need for study:

Jwara known as the Lord of Diseases is said to be the most painful of all diseases. Its heat destroys the Ojus and afflicts the body, senses and mind.The Vedic mythology (concept mentioned in Tretayuga) states it to originate from Shiva mentioning it as Rudrakopa.

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All definitions of the word Jwara points out to one main point of increase in temperature of the body. In conventional medicine fever is predominant and common symptom of many diseases. Fever is seen as the first warning the body gives in response to any imbalance or infection.A separate chapter in their texts has been written on Pyrexia of unknown origin. Fever is generally due to pathological impact of microbes as well as traumatic and several reasons. This temperature regulation process involves CNS and Circulatory Systems.

MithyaAhar-Vihara vitiates tridosha resulting in vitiation of agni.The resultant Aama (toxin) causes srotavarodha and circulates throughout the body mixed with rasa.This leads to rise in temperature.Jwara not only causes disturbances in the body but also in the mind and sense organs.

The main line of treatment of Jwara should include the following at different stages,

Dipana,Pachana,Jwaraghna or Jwaraharadravyas.Charaka has explained Jwarahara Dashemanidravyas in the treatment of Jwara.These drugs are Sariva,Sharkara,Patha,

Manjistha,Draksha,Pilu,Parushaka,Abhaya,AmlakhiBibhitaki.

Among these the selection of Sariva and Patha in this work depends on two criteria. Sariva and Patha due to their RaktaShodhak properties also act as Antimicrobial and thus plays an important role in SampraptiVighatana by eliminating causes at the root level.Apart from these the main objective is to prevent the complications of Jwara.

6.2) Review of Literature:

Thorough screening of all available classical Ayurvedic texts like Brihatryee1,2,3 and Laghutrayee7,12, modern literatures and pharmacological literatures will be made to generate sufficient literary data for the present study.SarivaPatha are considered under JwaraharaDashemani in Charka sutrasthana fourth chapter.

Previous work done

1. Evaluation of Jwaraghna property of Sariva-An experimental study –A.L.N.Rao Memorial Ayurvedic Medical College Koppa Karnataka in 2002 by Dr. Mahesh T.S.
2. Study of Sariva in detail & its clinical assessment to symptom Kandu-TilakAyurvedaMahavidyalaya, Pune University, Pune College in 1996 by Dr.SnehaR.Majumdar
3. Study on vrana sodhaka karma of sariva-TilakAyurvedaMahavidyalaya, Pune University, Pune College in 2002 by Dr.TilluGirish S.
4. An evaluative study in the market samples of Sarivaw.s.r. to its clinical efficacy in vyanga-Dr.B.K.R.R.govt.Ayurvedic college Hyderabad College in 2004 by Dr.Jaikrishnan K.P.
5. Sariva-Vicharchika par karmukata-A study-ShriAyuurvedaMahavidyalayaNagapur University Nagapura in 1998 by Dr.Sharma D.K.

1. An experimental study on diuretic effect of Patha-Dr.B.K.R.R.Govt.Ayurvedic college A.P.University,Vijayawada in 1997 by Dr.RaoVenugopal
2. An anti- hepatic toxic effect of Indravaruni, KarnjaPatha-An experimental study- A.L.N.Rao Memorial Ayurvedic Medical college Koppa Karnataka in 2002

6.3) Objectives of the study:

1. To evaluate Jwarghna properties of Sariva and Patha in Jwara.

2. Morphological and Pharmacognostical study of Sariva&Patha.

3. Phytochemical analysis of SarivaPatha.

7) Materials & Methods:

7.1) Source of data:

Patients will be selected from post graduation and research centre OPD of S.J.G. Ayurvedic Medical College and Hospital of Koppal by pre-set inclusive and exclusive criteria.

1. Literary Source of data: The literary pertaining to the present study is screened through various Samhita,Nighantus, Ayurvedic Articles, Journals and Websites.
2. The pharmacognostical source of data: Through organoleptic and microscopical study.
3. Phytochemical source of data: By Phytochemical analysis.

7.2) Composition of trial drug:

7.2. a)

7.2. b) Preparation of Medicine:

Drugs are collected and choorna is prepared as per choornaprakarana.

7.3) Method of collection Data: Data collected from morphological, Phytochemical, pharmacognostical and clinical study.

7.3. a) Study design: Patients in each group having basic symptoms of disease and classified respectively to the group.

7.3. b) Sample size & grouping:

Total 30 patients of Jwara will be selected from the OPD of S.J.G. Ayurvedic Medical College & Hospital, Koppal and put into two groups.

Group A (15 ) Patients will receive SarivaChoorna.

Group B (15 ) Patients will receive PathaChoorna.

7.3. c) Exclusive criteria: 1. Age below 5 years

2. Chronic fever (more than 07 days)

3. In diagnosed conditions of chronic diseases 7.3. d) Inclusive criteria: 1. Patient’s age group 5 years above

2. In initial (within 07 days) stage of all types of Jwara

7.3. e) Criteria of Diagnosis:

The symptom logy mentioned in classics and modern texts will be the base of the diagnosis.

7.3. f) Posology: 3 grams of each( SarivaPatha)drug in divided doses a thrice day.

7.3. g) Study duration: Seven days,

Review alternate days.

7.3.h) Follow up: Seven days

7.3.i) Assessment of results:

Subjective and objective parameters and base line

Data before and after treatment, data comparison will be assessed

7.3.j) Subjective parameters:

Jwaralakshanas explained as per classical text as follows

Swedavaroda,Shrama

JadhatwaJalasrava from netra

Santapa,Romanch

SarvangaghrahanaGhurghuratwa of swara

JhrumbhaVaivarnata

BhojanaaruchiShosha of mukha

7.3. k) Objective parameters: Temperature chart records.

7.3. l) Investigations: CBC, ( Widal, MP or RMT if needed), Routine urine test

7.3.m) Data Analyzed by using SPSS-16 verifies software ANOVAs followed Dunne’s test

7.4) Ethical clearance:

Obtained and enclosed.

8) List of References:

1. Charakasamhita of Agnivesa,Revised by Charaka and Drdhabala with the Ayurveda-Dipika commentary of Chakrapanidatta and Hindi Commentary by Pt.KashinathaSastri ,Sootrastana fourth chapter Nidanastana first chapter and chikistastana third chapter.
2. SusrutaSamhita by Dalhana commentary by with the nibandhasangraha commentary of dalhanacharya edited by vaidhyajadvji Acharya-2010,Poorvatantra and Uttaratantra.

1. AstangaHrudaya of Vagbhata with Vidwanmanoranjini Hindi Commentary and Notes by KashinathShastri,Published by Krishnadas Academy-1994 Varanasi, second cp.Nidanastana,page no.75

1. MadhavaNidana of Sri Madhavakara with The MadhukosaSanskrut Commentary by Srivijayaraksita and Srikanthadatta with The Vidyotini Hindi Commentary notes by Sri SudarsanaSastri part-1 Thirtyoneth 2002 Edition, Published by Chaukhambha Sanskrit Bhavan Varanasi-221001 Second chapter page no.92

1. Raj Nighantu of PanditNarahari,Published by Krishnadas Academy Varanasi 1998,Shathanyadi varga,Page no.76-77

1. Kaiyadeva-Nighantuh-Pathyapatya-vibhodhaka-edited and translated by Prof.PriyavatSharma,Published by ChaukhambhaOrientalia Varanasi, Oushadhivarga,page no.125

1. Bhavaprakash of Sri Bhavamisra edited with The Vidyotini Hindi Commentary, Notes and Appendix by Sri BrahmasankaraMisra and Sri RupalalajiVaisya first part nighantu part, Guduchydivarga, page no. 396 and 426 and BhavaprakashMadyamakhandaPrathamaJwaraAdhikara page no.6.

1. Dhanvantari-Nighantuh,edited by Prof.PriyaVratSharma,Published by Chaukhambha Orientalia,Varanasi-2210011 GudoochyadiVarga Page no.28 and 45

1. PriyaNighantu-Author P.V.Sharma published by ChaukambhaSurabharatiPrakashana Varanasi-221001 second edition 1995 Pipplyadivarga,page no.61

1. NighantuAdarsha-Author BapalalG.Vaidya, Published by ChaukambhaBharati Academy Varanasi-2210012 Vol-I second edition, page no-35 Vol-II,page no-23

1. Dravya guna-Vijnana vol.1 and vol.2 by Prof. P.V.Sharma,Published by ChaukhambhaBharati Academy Varanasi page no.798 and 627

1. HaritaSamhita-“Hari” Hindi Vyakhyasahita author Pt. HariprasadTripathi,Published by ChaukhambhaKrishnadasAcademy,Varanasi,TritiyaSthana 2/45,Page no 181

1. Namarupajnanam, Characterization of Medicinal Plants by Proff. PriyabrataSharma,Published by SatyapriyaPrakashan Varanasi 221010 (India),Page no 126, 191

1. The Sabdakalpadruma by Raja RadhakantaDeva,Published by Naga Publishers Delhi 110007 (India),DwitiyaKanda,Page no 551,Trutiya Kanda,Page no 101,Panchma Kanda,Page no 340

1. Some Controversial Drugs In Indian Medicine by Dr. BapalalVaidya,forewarded by P.V.Sharma,Published by ChaukhambhaOrientalia Varanasi 221001,Page no 136,172

1. MateriaMedica of Ayurveda based on Madanpala’sNighantu by VaidyaBhagawan Dash,Published by Health HarmanyPaharganj New Delhi 11005,Page no 32 and 76

1. Database on Medicinal Plants used in Ayurveda, Authors P.C Sharma, M.B.Yelne,T.J.Dennis, Published by Publisher Documentation and Publication division Central Council For Research in Ayurveda and SiddhaJanakpuri New Delhi 110058,Vol I,Page no 394 and VolII,Page no 438

9. Signature of the candidate:

(Dr. Shivashankarappa)

10. Remarks of Guide:

The present study will help the Ayurvedic Practitionersto select the classical Ayurvedic single drugs in their practice to treat simple fevers with confidence and is most worthy and appreciable.

11. Name and Designation (in Block letters)

11.1. Guide :DR.RAGHURAM SHENOY.P.

PROFESSOR

PG DEPT.OF DRAVYAGUNA

11.2. Signature:

11.3. Co-Guide:DR.C.B.INAMDAR.

LECTURER

PG DEPT.OF DRAVYAGUNA

11.4. Signature:

11.5. Head of the department: DR.U.V.SIMHADRI

PROFESSOR HEAD

PG DEPT.OF DRAVYAGUNA

11.6. Signature:

12. Remarks of Chairman and Principal:

The above synopsis is scrutinized by the PG Studies & Research Centre Committee of S.J.G. Ayurvedic Medical College, Koppal & submitted for registration as subject of dissertation at R.G.U.H.S Bengaluru, Karnataka.

(Dr.B.S.Savadi)

Principal/C.M.O

1