International Cardiovascular Infection Symposium Monday 26 March
1 ICI/SGM Symposium Dublin March 2012
International cardiovascular infection symposium– Monday 26 March 2012Session 1: Scientific evidence and History
Chair : Prof. Howard Jenkinson (University of Bristol, UK)
09:00 / Infection and cardiovascular disease - the early findings
Prof. Kimi Mattilla, HelsinkiUniversityHospital, Helsinki, Finland
09.30 / Epidemiological evidence
Prof. Lise Lund Haheim, University of Oslo, Oslo, Norway
10.00 / Impact of sub-inhibitory antibiotic concentrations on the plasminogen binding ability on viridans group streptococci
Dr. Sue Lang, GlasgowCaledonianUniversity, Glasgow, Scotland
10.15 / Refreshments and Exhibition
Session 2: Models of Disease
Chair : Dr. Steve Kerrigan (RoyalCollege of Surgeons in Ireland, Ireland)
10.45 / Imaging of platelets in real time in vivo
Dr. Neena Kalia, University of Birmingham, England, UK
11.15 / Animal models of disease / infective endocarditis
Prof. Paul Sullam, University of California San Francisco, San Francisco, USA
11.45 / Platelet Polymorphisms in Infective Endocarditis
Dr.Suthri Daga, University of Edinburgh, Scotland, UK
12.10 / SGM Prize Medal Lecture
Julian Davies, University of British Columbia, Canada
13.00 / Lunch and exhibition
Session 3: Infection in the cardiovascular system – Streptococci
Chair : Prof. Philip Moreillon (University of Lausanne, Switzerland)
14.00 / Streptococciand surface proteins
Prof. Todd Kitten, VirginaCommonwealthUniversity, Richmond, USA
14.30
14:45 / Viridans Bacterium Streptococcus gordonii mimics the actions of fibrinogen by expression of GPIIbIIIa binding motifs.
Dr. Helen Petersen, UCL, Eastman Dental Institute, London, UK
A critical role for platelet FcRIIa in Streptococcus oralis induced platelet activation.
Ms. Thea Tilley, RoyalCollege of Surgeons in Ireland, Dublin, Ireland
15.00 / The facultative pathogen Streptococcus pneumoniae induces exocytosis mechanisms of human lung endothelium
Dr. Simone Bergman, Helmoltz Centre for Infection, Braunschweig, Germany
15.15 / Refreshments and Exhibition
Chair / Session 4: Infection in the cardiovascular system – Staphylococci
Chair : Dr. Oonagh Shannon (Lund University, Sweden)
15.45 / Staphylococci and surface proteins
Prof. Tim FosterTrinity College Dublin, Ireland
16.15 / Using a dynamic shear based system to investigate the interactions between S. aureus and platelets
Dr. Steve Kerrigan,Royal College of Surgeons in Ireland, Dublin, Ireland
16.45 / Iron regulated surface determinant B (IsdB) of S. aureus directly interacts with integrins promoting adhesion and invasion of mammalian cells.
Ms. Marta Zapotoczna, TrinityCollegeDublin, Ireland
17.00 / Session ends
Tuesday 27 March
Infection & the cardiovascular system – Tuesday 27 March 2012Chair / Session 5: Infection in the cardiovascular system – Other micro-organisms
Chair :Prof. Kimi Mattilla (Helsinki University Hospital, Finland)
09:00 / Platelet other microorganisms interactions
Dr. Oonagh Shannon,LundUniversity, Lund, Sweden
09.30
09:45 / Staphylococcus lugdunensis, an unusual Staphylococcus
Mr. Simon Heilbronner, TrinityCollegeDublin, Ireland
SNP genotyping of chromosomally integrated Human Herpesvirus 6 in patients with acquired cardiomyopathies and heart failure symptoms
Mr. Dirk Lassner, Institute of Cardiac Diagnostics and Therapy, Berlin, Germany
10.00 / CD36 is a platelet receptor for bacterial pathogens.
Dr. Jennifer Mitchell, UniversityCollegeDublin, Dublin, Ireland
10.15 / Refreshments and Exhibition
Session 6: Current treatments & novel drug targets
Chair : Prof. Paul Sullam (University of CaliforniaSan Francisco, USA)
10.45 / Current treatment and management for Infective Endocarditis
Prof. Philip MoreillonUniversity of Lausanne, Switzerland
11.15 / Novel drug targets for the treatment of Infective Endocarditis and bloodstream infection
Dr. Dermot Cox, Royal College of Surgeons in Ireland, Dublin, Ireland
11.45 / Does Positron Emission Tomography have a role to play in the diagnosis of infective endocarditis and its associated complications?
Professor John Moore, BelfastCityHospital, Belfast, Northern Ireland.
12.00 / Marjory Stephenson Prize Lecture TBC
13.00 / Lunch and exhibition
Session 7 : Open presentations
Chair :
14.00 / Staphylococcus aureus lipoteichoic acid raises platelet cAMP levels via interactions with the PAF receptor, inhibiting their activation.
Ms. Amie Waller, University of Reading, Reading, UK
14.15 / FcγRIIA phosphorylation as a common mechanism of bacterial-mediated platelet activation
Dr. Monica Arman, University of Birmingham, Brimingham, UK
14.30 / The role of platelet-neutrophil complexes in inflammation & infection
Sinéad Hurley, LundUniversity, Lund, Sweden
14.45 / Von Willebrand factor fibers mediate luminal S. aureus adhesion to intact endothelial cell layer under shear stress
Ms. Karin Pappelbaum, Medical Faculty Mannheim, Heidlberg, Germany
15.00 / Staphylococcus aureus lipoteichoic acid interacts with the human membrane receptor CD36 on the surface of platelets
Ms. Alyson Murray, UniversityCollegeDublin, Dublin, Ireland
15.15 / The role of Staphylococcus aureus wall teichoic acid in potentiating activation of human platelets
Dr. Simon Clarke, University of Reading, Reading, UK
15.30 / Refreshments and Exhibition
Session 8: Framework Presentation & General Discussion
Chair : Dr. Dermot Cox (RoyalCollege of Surgeons in Ireland, Ireland)
16.00 / Presentation from FP call
16.30 / Group Discussion: Possibility of European Network or Consortium FP7 or FP8.
17.30 / Session ends