Kawanishi et al. (2005) remarked that curcumin, like many antioxidants, can be a "double-edged sword" where in the test tube, anti-cancer and antioxidant effects may be seen in addition to pro-oxidant effects. Carcinogenic effects are inferred from interference with the p53tumor suppressor pathway, an important factor in human colon cancer. Carcinogenic and LD50 tests in mice and rats, however, have failed to establish a relationship between tumorogenesis and administration of curcumin in turmeric oleoresin at >98% concentrations.
In animal studies, hair loss (alopecia) and lowering of blood pressure have been reported.
Clinical studies in humans with high doses (2–12 grams) of curcumin have shown few side effects, with some subjects reporting mild nausea or diarrhea. More recently, curcumin was found to alter iron metabolism by chelating iron and suppressing the protein hepcidin, potentially causing iron deficiency in susceptible patients.
- ^Kawanishi, S; Oikawa, S; Murata, M; (2005). "Evaluation for safety of antioxidant chemopreventive agents". Antioxidants & Redox Signaling7 (11-12): 1728–39. doi:10.1089/ars.2005.7.1728. PMID 16356133.
- ^Moos PJ; Edes K; Mullally JE; Fitzpatrick FA (2004). "Curcumin impairs tumor suppressor p53 function in colon cancer cells". Carcinogenesis25 (9): 1611–7. doi:10.1093/carcin/bgh163. PMID 15090465.
- ^ Lois Swirsky Gold. Turmeric (>98% curcurmin). Carcinogenic Potency Database Project. Last updated 3 Apr 2006. Last accessed 4 Jan 2007. 
- ^ National Institutes of Health 
- ^Hsu CH, Cheng AL (2007). "Clinical studies with curcumin". Adv. Exp. Med. Biol.595: 471–80. doi:10.1007/978-0-387-46401-5_21. PMID 17569225.
- ^Jiao Y, Wilkinson J, Di X, et al (January 2009). "Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator". Blood113 (2): 462–9. doi:10.1182/blood-2008-05-155952. PMID 18815282.
Worlds Healthiest Foods - "Six hundred and eighty-eight studies, more than 400 of them published within the last four years, confirm Curcumin's remarkable anticarcinogenic, anti-inflammatory, and antioxidant properties. Within the last year, interest in Curcumin's potential as a neuroprotective agent have been rising."
Science Daily, April 27 2009 - "Everyday foods, beverages, and spices contain healthful compounds that help us fight harmful inflammation. And, in doing that, these phytochemicals may also reduce our risk of diseases associated with chronic inflammation, including cancer and diabetes."
Washington Post - "Medical researchers are becoming increasingly convinced that the most primitive part of the immune system (inflammation), may play a crucial role in some of the most devastating afflictions of modern humans, including heart disease, cancer, diabetes and possibly Alzheimer's."
Amount: 500 milligrams per capsule of 95% standardized Curcumin. The suggested serving size is one (1) to four (4) capsules daily with meals, potentially offsetting the inflammatory response process that occurs during ingestion and digestion.
500mg or 1000 mg per day