Genes Activated in Liver After LPS Treatment
Table 3
Genes up-regulated in p8+/+ liver after LPS
Fold induction
Protein synthesis, transport and modification
proteasome subunit MECL1 (‡)10.1
heat shock protein 862.6
proteasome subunit (lmp7)4.4
ALANYL-TRNA SYNTHETASE2.6
Signaling
JAB5.8
guanine nucleotide dissociation stimulator for a ras-related GTPase6.0
cytoplasmic phosphotyrosine phosphatase4.5
musculus intracellular calcium-binding protein (MRP8)6.0
intracellular calcium-binding protein (MRP14)3.9
GTPase IGTP4.7
ras-GTPase-activating protein SH3-domain binding protein (G3BP)2.0
suppressor of cytokine signalling-2 (SOCS-2)2.5
suppressor of cytokine signalling-3 (SOCS-3)11.1
SERINE/THREONINE PROTEIN KINASE5.2
interferon-inducible protein homologue4.9
ADENOSINE KINASE2.1
TRA14.2
ARF42.3
T-cell specific protein3.8
mothers-against-dpp-related-13.2
myristoylated alanine-rich C-kinase substrate (MARCKS)3.1
Secreted factors
alpha-1 type IV collagen (Col4a-1)3.5
alpha-2 type IV collagen5.7
serum amyloid A protein5.0
plasminogen activator inhibitor (PAI-1)22.7
monokine induced by gamma interferon (MIG)62.3
interferon-gamma inducible protein (mag-1)21.0
spi2 proteinase inhibitor (spi2/eb4)2.0
presenilin-15.9
IFN-gamma induced (Mg11)2.4
B615.0
adrenomedullin precursor2.7
follistatin-like protein2.0
CHYMOTRYPSIN-LIKE PROTEASE CTRL-1 PRECURSOR4.0
PAP homologous protein2.9
collagen a1 XIX chain2.0
fibroblast growth factor2.3
secretory protein containing thrombospondin motifs4.7
endothelial monocyte-activating polypeptide I5.9
fragment for kappa-immunoglobulin4.3
prolactin-like protein G precursor2.5
gamma-casein2.6
alpha-1 acid glycoprotein (Agp-1B)2.7
cryptdin (Defcr)2.2
Cytoskeletal proteins
cytokeratin endo A2.5
endo B cytokeratin2.9
alpha-tubulin isotype M-alpha-14.7
calpactin I light chain (p11)2.8
alpha-tropomyosin slow13.8
Transcriptional factors and RNA processing
X box binding protein-1 (XBP-1)6.2
gut-enriched Kruppel-like factor GKLF3.8
transcription factor junB (junB)11.1
NUCLEAR RNA HELICASE3.1
apurinic/apyrimidinic endonuclease (Apex)2.2
CArG-binding factor-A2.2
growth factor-induced protein (zif/268)2.2
DNA-DAMAGE-REPAIR/TOLERATION PROTEIN DRT111 PRECURSOR2.4
homeobox protein Pitx32.6
transcription factor PBX3b (PBX3b)3.6
DNA polymerase alpha catalytic subunit p1802.5
homeobox protein (cdx 4)2.6
homeobox HOX8.1 (Msx2)3.2
zinc finger protein (Sna)3.5
NFIL3/E4BP4 transcription factor5.3
helix-loop-helix factor HES-13.9
myocyte nuclear factor (MNF)3.3
interferon consensus sequence binding protein2.0
recombination protein RAD52 homolog2.5
WW domain binding protein 52.1
SON PROTEIN2.0
valosin-containing protein2.3
hypoxia-inducible factor 1 alpha (Hif1a)5.9
U2af1-rs22.9
HAM13.6
mATF42.1
interferon regulatory factor 7 (mirf7)4.3
Apoptotic-related proteins
BTG12.1
Membrane and transporters proteins
interleukin-1 receptor8.0
MHC class I Q8/9d cell surface antigen2.0
chemokine rantes (Scya5)10.0
interleukin-4 receptor (secreted form)3.7
MAJOR VAULT PROTEIN12.2
CD63/ME4917.9
mkf-12.6
Glvr-16.4
adipose differentiation related protein (ADFP)2.0
Sca-2 precursor5.6
Lisch76.5
lymphocyte diffentiation antigen CD38 homologue2.4
retinoic acid receptor gamma2.7
sodium-calcium exchanger (NCX1)2.2
chemokine receptor4.5
CGRP-receptor component protein2.0
ATP-sensitive inwardly rectifying K channel2.8
cystic fibrosis transmembrane conductance regulator (CFTR)3.0
ATP receptor (P2u)2.1
Cytosolic enzymes and detoxification factors
transglutaminase (TGase)16.3
UDP-galactose transporter related isozyme 12.1
tumor-induced 32 kD protein (p32) (heme oxygenase)4.3
tryptophan hydroxylase (Tph)4.3
carbonic anhydrase IV5.2
Growth-related proteins
Gadd457.0
p21 (Waf1)4.9
TIS2110.9
cyclin B12.4
‡ Underlined genes are also up-regulated in liver from p8-/- mice
Table 4
Genes down-regulated in p8+/+ liver after LPS
Fold repression
Protein synthesis, transport and modification
heat shock protein 105 kDa alpha2.1
zeta-crystallin6.7
mannosyl-oligosaccharide alpha-1,2-mannosidase2.3
co-chaperonin cofactor A2.1
chaperonin 102.7
delta proteasome subunit2.2
alpha-D-mannosidase (Man2b1)9.0
26S proteasome subunit 4 ATPase2.1
translation initiation factor (Eif4g2)2.3
beta proteasome subunit (Lmp3)2.5
ribosomal protein S26 (RPS26)2.5
ribosomal protein L8 (RPL8)2.2
heat shock 70 protein (Hsc70)2.6
ribosomal protein S52.7
ribosomal protein L214.1
t-complex polypeptide 1A (Tcp-1a)2.5
eps152.7
SKD1 protein2.8
maternal-embryonic 3 (Mem3)4.3
heat-responsive protein (HRP12)2.8
PHAS-II3.1
L23 mitochondrial-related protein (L23mrp)7.7
MITOCHONDRIAL 60S RIBOSOMAL PROTEIN L32.8
Signaling
antioxidant protein 2 (AOP2) (†)4.1
Selenium-binding liver protein5.1
Wnt-5b2.2
house-keeping protein2.4
Max interacting protein 1 alternatively spliced long form (Mxi1)3.4
mSTI13.0
senescence marker protein-30 (SMP30)6.9
38 kDa Mov34 isologue4.4
BS4 peptide4.1
manic fringe precursor7.4
beta1-syntrophin (SNTB1)3.7
SERINE/THREONINE PROTEIN KINASE2.8
epidermal growth factor receptor-binding protein12.7
guanine nucleotide exchange factor delta subunit (JGR1)3.5
retinoid X receptor interacting protein (RIP14-1No.6)6.8
glycosyl-phosphatidyl-inositol-anchored protein homolog8.6
adenylyl cyclase type 95.3
MAP kinase kinase 6c3.0
phosphatidylethanolamine binding protein2.0
selenophosphate synthetase 26.1
SH2 containing inositol-5-phosphatase (Ship)8.4
protein phosphatase 1cgamma (PP1cgamma)3.5
putative SH3-containing protein SH3P122.5
SH3-containing protein SH3P22.7
protein phosphatase 2A Balpha3 regulatory subunit5.8
protein kinase C inhibitor (mPKCI)3.4
FK506-binding protein 25 homolog (mFKBP25)3.0
MEK kinase 4a (MEKK4a)6.1
protein phosphatase 1 binding protein PTG7.9
retinally abundant regulator of G-protein signaling mRGS-r (RGS-r)2.6
eph-related receptor tyrosine kinase (Mek4)2.1
Dgcr6 protein (Dgcr6)5.3
HS-1-associating protein HAX-1L (mHAX-1s)2.0
lefty gene.5.2
Secreted factors
heparin cofactor II precursor (HCII)6.7
D-dopachrome tautomerase (Ddt)2.0
serine protease hepsin2.0
monoglyceride lipase5.4
Zn-alpha2-glycoprotein2.3
IGIF precursor polypeptide3.1
cystatin C3.7
prolidase (pep4)7.0
coagulation factor VIII2.7
complement factor H-related protein4.2
complement component C5S (pro-C5)2.1
plasma kallikrein (PK)6.7
C10-like chemokine10.4
complement factor I2.5
coagulation factor VII4.3
murinoglobulin (MUG3)2.0
Cytoskeletal proteins
fibroglycan (syndecan-2)3.0
p116Rip2.1
beta III spectrin (Spnb3)5.6
ALPHA-ACTININ 1, CYTOSKELETAL ISOFORM2.4
fast fiber troponin I3.8
neural cadherin (N-cadherin)3.1
desmocollin type 2 (DSC2)4.1
Transcriptional factors and RNA processing
BAP-135 homolog (Diws1t)5.2
zinc finger protein (Zfx)2.0
Rep-3 protein2.1
deleted in split hand/split foot 1 homolog (Dss1)2.4
Supt4h2.3
CCR4 protein4.6
NNP-1 (NNP-1)5.7
embryonic ectoderm development protein (eed)2.6
RecA-like protein (mREC2)4.3
orphan nuclear hormone receptor isoform mCAR221.7
homeobox containing protein (Hox-B3 [2.7])6.8
orphan nuclear receptor RVR2.7
adenine nucleotide translocase-2 (Ant2)2.7
albumin gene D-Box binding protein6.2
muscle-specific transcriptional activator alpha-NAC gp220 (Naca)2.7
zinc finger protein (Zfp64)2.9
11-zinc-finger transcription factor (CTCF)4.4
telomerase protein-12.8
nuclear receptor co-repressor2.4
DNA binding protein NFI-B (NfiB)3.2
Apoptotic-related proteins
bcl-2 binding protein BAG-14.5
EAT/MCL-12.5
TDAG51 (TDAG51)8.0
PS-2short8.5
defender against death 1 protein (DAD1)2.6
Membrane and transporters proteins
multidrug resistance protein18.2
microsomal triglyceride transfer protein3.2
asialoglycoprotein receptor (MHL-1)10.9
NPC1 (Npc1)2.4
retinol binding protein (RBP)2.3
peroxisomal PTS2 receptor3.9
CD13/aminopeptidase N3.9
plasma membrane protein syntaxin-42.3
IL-6 receptor11.9
liver-type glucose transporter protein30.2
FATTY ACID-BINDING PROTEIN2.1
serotonin transporter2.2
Fc receptor2.8
neuropeptide Y-Y1 receptor3.1
plasma-cell membrane glycoprotein PC-13.4
receptor for advanced glycosylation end products (RAGE)9.4
parathyroid hormone/parathyroid hormone related-peptide receptor (PTHR)3.7
high affinity IgG receptor (Fc-gammaRI)3.7
erythrocyte membrane protein band 4.2 (mur42)2.1
polymeric immunoglobulin receptor2.8
mannose-binding protein C (Mbl2)3.0
scavenger receptor class B type I (mSR-BI)2.6
transmembrane transporter (Lx1)21.3
putative transmembrane receptor (frizzled 4)3.5
aquaporin-4 (Aqp4)2.3
Kupffer cell receptor3.3
reduced folate carrier (RFC1)5.3
peroxisome membrane protein PEX24.8
L6 antigen3.0
Fabpi2.8
TR2 (mTR2)2.4
Cytosolic enzymes and detoxification factors
GLYCINE DEHYDROGENASE3.9
carnitine acetyltransferase2.3
TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE2.4
amine N-sulfotransferase (SULT-N)3.3
sulfotransferase-related protein (SULT-X2)7.8
alanine:glyoxylate aminotransferase (Agxt1)20.4
very-long-chain acyl-CoA synthetase (VLCS)3.0
4-hydroxyphenylpyruvate dioxygenase2.1
estradiol 17-beta-dehydrogenase (A-specific)6.5
catalase3.6
hydroxysteroid sulfotransferase (mSTa2)4.0
branched chain alpha ketoacid decarboxylase E1a subunit2.1
ornithine transcarbamylase2.0
adh-1 gene encoding alcohol dehydrogenase (ADH)5.4
malate dehydrogenase2.2
aldehyde dehydrogenase II3.3
fumarylacetoacetate hydrolase (Fah)3.2
alcohol dehydrogenase-B2 (Adh-2)2.3
thioether S-methyltransferase40.3
glucose-6-phosphatase10.8
sorbitol dehydrogenase precursor16.0
homogentisate 1,2-dioxygenase (HGO)19.0
flavin-containing monooxygenase 330.5
flavin-containing monooxygenase 1 (FMO1)13.7
flavin-containing monooxygenase 5 (FMO5)9.2
cytochrome P-4504.4
cytochrome P450 monooxygenase (CYP2J5)6.9
adrenodoxin3.1
glutathione synthetase type A12.0
AGT2 PRECURSOR (alanine-glyoxylate aminotransferase 2)3.6
housekeeping-type protein (MER5)2.6
paraoxonase (Pon)3.4
rhodanese (Tst)2.5
ancient ubiquitous 46 kDa protein AUP1 precursor (Aup1) CDP-diacylglycerol synthase3.9
DIHYDROPTERIDINE REDUCTASE3.6
CHLORDECONE REDUCTASE3.3
GLYCINE CLEAVAGE SYSTEM H PROTEIN PRECURSOR5.4
A-GLUCOSIDASE I4.6
GALACTOKINASE2.5
putative lysophosphatidic acid acyltransferase4.8
testosterone 15-alpha-hydroxylase mRNA type I3.3
glutathione S-transferase class mu (GST5-5)6.7
ferrochelatase3.0
adenylosuccinate synthetase2.6
cathepsin H prepropeptide (ctsH)2.6
uroporphyrinogen III synthase6.8
glutaryl-CoA dehydrogenase3.3
phosphatidylethanolamine-N-methyltransferase 22.6
adenosine kinase3.9
uroporphyrinogen decarboxylase5.3
galactose-1-phosphate uridyltransferase (GALT)5.4
liver glutathione transferase theta class type 219.1
type 1 deiodinase (DIO1)2.9
isocitrate dehydrogenase4.1
liver arginase2.2
ornithine decarboxylase antizyme3.1
carbonic anhydrase III (CAIII)3.3
transaldolase5.8
dihydrolipoamide dehydrogenase (Dld)4.7
sepiapterin reductase4.7
glutathione-S-transferase3.1
glutamate-cysteine ligase catalytic subunit (GLCLC)5.3
preprodipeptidyl peptidase I5.5
NAD(+) ADP-RIBOSYLTRANSFERASE4.0
SUCCINYL-COA LIGASE2.1
2,4-DIENOYL-3-hydroxyacyl CoA dehydrogenase3.0
pyruvate dehydrogenase (pdha-1)4.9
cytochrome P-450 naphthalene hydroxylase4.7
medium-chain acyl-CoA dehydrogenase2.7
long-chain acyl-CoA dehydrogenase2.2
voltage dependent anion channel 23.2
3-hydroxy-3-methylglutaryl-CoA lyase (Hmgcl)2.5
COA REDUCTASE2.9
cytochrome P450 monooxygenase (CYP2J6)4.2
mitochondrial transcription factor A2.2
mitochondrial ATP synthase coupling factor 62.8
Thioredoxin12.3
alpha-methylacyl-CoA racemase3.5
cytochrome c oxidase subunit VIII-H precursor (COX8H)2.8
Growth-related proteins
retinoblastoma-related protein Rb2/p1304.9
p53 responsive (EI24)5.0
growth-arrest-specific (gas2) protein2.0
retinoblastoma-binding protein (mRbAp48)2.6
elav G homolog (MelG)2.9
Csa-192.0
oligodendrocyte-specific protein2.3
Max interacting protein 1 alternatively spliced long form (Mxi1)2.2
p1072.0
Evi-52.6
t-BOP (Bop)6.3
mutated in multiple advanced cancers protein (MMAC1)2.3
acid labile subunit (ALS)6.3
CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 22.0
hepatoma-derived growth factor3.8
fibroblast growth factor2.1
Cdk-inhibitor p57KIP2 (KIP2)3.6
† Underlined genes are also down-regulated in liver from p8-/- mice