Supplementary file 3.
Results of all cardiac phenotypes and calcineurin polymorphisms for which at least one P value <0.05 was reached (i.e., at pre-exercise, 50W, 100W, 150W or pos-exercise recovery) for the interaction (genotype*training) effect. Note: those P values for which statistical significance remained after correction for mass significance are also shown in Table 3 of the manuscript.
Table 1. Stroke volume index (ml/m2) according to PPP3CA rs10516472genotypes
N / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
AA / 87 / 48.7±7.6 / 51.5±7.6 / 0.569
AG / 14 / 47.3±5.8 / 51.2±8.8
50W
AA / 87 / 60.1±7.7 / 62.8±9.7 / 0.660
AG / 14 / 60.5±5.9 / 62.1±4.8
100W
AA / 87 / 72.3±9.1 / 72.7±8.7 / 0.155
AG / 14 / 74.4±6.9 / 71.7±5.9
150W
AA / 87 / 79.1±10.2 / 79.0±8.2 / 0.111
AG / 14 / 74.9±14.5 / 79.3±6.5
Post-exercise recovery
AA / 87 / 54.8±10.0 / 54.8±8.2 / 0.014
AG / 14 / 52.5±3.7 / 59.3±10.2
Table 2. Cardiac output index (l/m2) according to PPP3CA rs3804357 genotypes
n / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
AA / 6 / 3.6±0.6 / 3.1±0.1 / 0.138
AC / 40 / 3.2±0.6 / 3.4±0.9
CC / 56 / 3.2±0.7 / 3.23±0.71
50W
AA / 6 / 6.6±0.9 / 5.4±0.5 / 0.044
AC / 40 / 6.4±0.9 / 6.1±1.0
CC / 56 / 6.4±1.2 / 6.1±1.0
100W
AA / 6 / 9.9±1.8 / 8.2±1.2 / 0.119
AC / 40 / 9.1±1.4 / 8.4±1.3
CC / 56 / 9.1±1.5 / 8.6±1.4
150W
AA / 6 / 11.2±1.1 / 9.9±0.8 / 0.618
AC / 40 / 12.0±2.0 / 11.4±1.6
CC / 56 / 11.7±1.8 / 11.1±1.5
Recovery post-exercise
AA / 6 / 4.7±0.7 / 4.7±0.8 / 0.216
AC / 40 / 4.8±1.0 / 4.3±1.1
CC / 56 / 4.7±1.0 / 4.5±1.0
Table 3. Stroke volume index (ml/m2) according to PPP3CA rs2044041 genotypes
n / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
AA / 1 / 43.3 / 44.7 / 0.123
AT / 27 / 48.2±6.6 / 52.7±6.8
TT / 74 / 48.7±7.7 / 51.0±8.1
50W
AA / 1 / 57.3 / 57.4 / 0.026
AT / 27 / 61.1±7.7 / 66.3±12.3
TT / 74 / 59.8±7.4 / 61.2±7.3
100W
AA / 1 / 74.6 / 71.6 / 0.443
AT / 27 / 73.6±9.0 / 74.6±8.2
TT / 74 / 72.1±8.7 / 71.8±8.5
150W
AA / 1 / 79.8 / 78.4 / 0.747
AT / 27 / 80.4±10.8 / 80.4±6.9
TT / 74 / 77.8±10.9 / 78.6±8.4
Recovery post-exercise
AA / 1 / 51.4 / 59.1 / 0.568
AT / 27 / 54.1±6.6 / 54.0±9.2
TT / 74 / 54.6±10.5 / 55.7±8.5
Table 4. Stroke volume index (ml/m2) according to PPP3CA rs931870 genotypes
N / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
CC / 7 / 47.6±10.1 / 47.1±12.0 / 0.138
CG / 41 / 50.4±8.3 / 52.8±7.0
GG / 47 / 47.3±6.0 / 51.5±7.6
50W
CC / 7 / 56.0±10.2 / 59.3±7.1 / 0.973
CG / 41 / 61.5±8.1 / 64.0±12.0
GG / 47 / 60.1±6.6 / 62.7±6.6
100W
CC / 7 / 70.2±11.6 / 68.1±9.5 / 0.721
CG / 41 / 73.9±9.8 / 73.9±10.3
GG / 47 / 72.6±7.6 / 72.7±6.2
150W
CC / 7 / 80.0±13.2 / 73.1±8.1 / 0.022
CG / 41 / 80.6±10.8 / 79.8±9.4
GG / 47 / 77.6±11.0 / 80.2±6.4
Recovery post-exercise
CC / 7 / 53.4±9.6 / 52.3±6.1 / 0.677
CG / 41 / 55.7±9.7 / 57.3±11.0
GG / 47 / 53.7±9.6 / 53.9±6.7
Table 5. Stroke volume index (ml/m2) according to PPP3CC rs1879793 genotypes
n / Pre-training / Post-training / P interaction(genotype*
training)
Pre-exercise
CC / 13 / 49.8±5.3 / 51.9±3.8 / 0.803
CT / 33 / 47.8±7.5 / 51.2±8.8
TT / 50 / 49.3±7.8 / 52.1±8.0
50W
CC / 13 / 62.1±6.2 / 63.4±5.1 / 0.122
CT / 33 / 59.2±7.4 / 63.8±12.2
TT / 50 / 60.8±7.6 / 61.9±7.8
100W
CC / 13 / 72.9±5.9 / 75.9±7.7 / 0.179
CT / 33 / 71.5±7.8 / 71.1±7.4
TT / 50 / 73.9±9.8 / 71.8±9.1
150W
CC / 13 / 78.7±10.1 / 81.3±5.3 / 0.486
CT / 33 / 78.8±11.5 / 77.8±6.6
TT / 50 / 79.2±10.7 / 88.0±9.2
Recovery post-exercise
CC / 13 / 53.1±6.4 / 60.8±6.7 / 0.001
CT / 33 / 51.6±8.1 / 54.9±9.3
TT / 50 / 56.8±10.6 / 54.8±8.5
Table 6. Stroke volume index (ml/m2) according to PPP3CC rs1075534 genotypes
Genotype / n / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
AA / 18 / 49.8±6.5 / 51.9±6.3 / 0.749
AG / 42 / 47.9±8.1 / 51.3±9.7
GG / 42 / 49.4±7.1 / 51.3±6.3
50W
AA / 18 / 62.7±6.6 / 62.6±6.4 / 0.051
AG / 42 / 59.1±7.7 / 63.7±11.0
GG / 42 / 60.0±7.5 / 61.6±8.3
100W
AA / 18 / 74.7±8.2 / 74.0±8.9 / 0.888
AG / 42 / 72.2±9.1 / 72.3±7.1
GG / 42 / 72.0±8.9 / 72.2±9.3
150W
AA / 18 / 77.9±9.8 / 79.9±6.1 / 0.590
AG / 42 / 78.4±11.9 / 78.8±7.5
GG / 42 / 78.2±10.4 / 79.0±9.2
Recovery post-exercise
AA / 18 / 53.4±7.4 / 57.9±7.4 / 0.003
AG / 42 / 52.2±8.5 / 55.2±9.8
GG / 42 / 57.0±10.5 / 54.2±7.9
Table 7. Cardiac output index (ml/m2) according to PPP3CC rs1075534 genotypes
Genotype / n / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
AA / 18 / 3.4±0.6 / 3.3±0.8 / 0.618
AG / 42 / 3.2±0.6 / 3.3±0.9
GG / 42 / 3.2±0.7 / 3.3±0.7
50W
AA / 18 / 6.8±1.1 / 6.1±1.1 / 0.723
AG / 42 / 6.2±1.0 / 6.2±1.0
GG / 42 / 6.3±1.1 / 6.1±1.0
100W
AA / 18 / 9.5±1.30 / 8.6±1.5 / 0.582
AG / 42 / 9.1±1.4 / 8.5±1.3
GG / 42 / 9.1±1.5 / 8.4±1.3
150W
AA / 18 / 11.7±1.7 / 11.3±1.4 / 0.855
AG / 42 / 11.7±1.8 / 11.1±1.6
GG / 42 / 11.9±1.7 / 11.2±1.6
Recovery post-exercise
AA / 18 / 4.8±1.0 / 4.9±1.1 / 0.007
AG / 42 / 4.4±0.8 / 4.3±1.1
GG / 42 / 5.0±1.0 / 4.3±1.0
Table 8. Stroke volume index (ml/m2) according to PPP3CC rs7430 genotypes
Genotype / n / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
CC / 46 / 48.8±8.0 / 51.7±8.5 / 0.852
CG / 43 / 47.6±7.4 / 51.0±7.7
GG / 12 / 50.3±5.1 / 52.6±4.4
50W
CC / 46 / 60.1±7.9 / 62.80±11.4 / 0.824
CG / 43 / 59.7±7.3 / 62.3±7.2
GG / 12 / 62.2±6.6 / 63.4±5.6
100W
CC / 46 / 72.8±10.2 / 72.2±9.7 / 0.755
CG / 43 / 71.7±7.5 / 72.3±6.9
GG / 12 / 75.1±7.2 / 75.3±7.6
150W
CC / 46 / 77.9±11.1 / 79.6±10.0 / 0.463
CG / 43 / 79.0±10.7 / 78.2±6.3
GG / 12 / 80.3±11.3 / 80.6±4.5
Recovery post-exercise
CC / 46 / 55.8±9.3 / 54.6±9.6 / 0.002
CG / 43 / 53.5±10.4 / 54.2±5.7
GG / 12 / 53.0±5.1 / 62.9±11.3
Table 9. Stroke volume index (ml/m2) according to PPP3CC rs2461483 genotypes
Genotype / n / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
CC / 17 / 48.4±6.6 / 51.2±7.7 / 0.877
CT / 41 / 48.1±6.9 / 51.5±7.0
TT / 43 / 48.6±8.1 / 51.2±8.4
50W
CC / 17 / 60.6±7.3 / 62.6±8.5 / 0.954
CT / 41 / 59.7±7.2 / 62.3±6.5
TT / 43 / 60.3±8.0 / 62.9±11.5
100W
CC / 17 / 73.8±7.0 / 72.9±9.4 / 0.336
CT / 41 / 71.5±7.6 / 72.9±6.5
TT / 43 / 72.93±10.50 / 72.09±9.63
150W
CC / 17 / 79.8±10.5 / 80.3±4.7 / 0.517
CT / 41 / 78.7±11.2 / 77.9±6.6
TT / 43 / 78.3±10.8 / 79.8±10.1
Recovery post-exercise
CC / 17 / 51.8±7.0 / 59.5±11.4 / 0.003
CT / 41 / 53.5±10.3 / 53.9±7.2
TT / 43 / 56.3±9.3 / 55.0±8.5
Table 10. Stroke volume index (ml/m2) according to PPP3CC rs10108011 genotypes
Genotype / N / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
AA / 57 / 48.6±7.5 / 51.1±7.8 / 0.487
AG / 36 / 47.3±7.4 / 51.2±8.2
GG / 8 / 51.4±5.8 / 53.4±3.8
50W
AA / 57 / 60.2±7.5 / 62.6±10.6 / 0.807
AG / 36 / 59.3±7.6 / 62.3±7.5
GG / 8 / 62.8±7.7 / 63.8±6.3
100W
AA / 57 / 73.1±9.6 / 72.2±9.1 / 0.193
AG / 36 / 71.4±8.1 / 71.8±7.2
GG / 8 / 73.8±6.9 / 77.8±7.5
150W
AA / 57 / 78.5±10.7 / 79.6±9.2 / 0.450
AG / 36 / 79.1±10.8 / 78.0±6.7
GG / 8 / 78.3±12.8 / 80.4±4.6
Recovery post-exercise
AA / 57 / 56.5±10.2 / 54.7±8.4 / 0.003
AG / 36 / 51.6±8.1 / 55.1±9.3
GG / 8 / 52.6±5.8 / 60.3±7.7
Table 11. Ejection fraction (%) according to PPP3R2 rs1407877 genotypes
Genotype / N / Pre-training / Post-training / P interaction(genotype*training)
Pre-exercise
5 / 72.6±2.8 / 73.3±1.9 / 0.461
32 / 70.5±4.0 / 71.99±3.6
59 / 70.5±3.3 / 71.1±4.1
50W
AA / 5 / 71.2±1.9 / 76.9±2.1 / 0.007
GA / 32 / 73.3±4.6 / 74.5±4.4
GG / 59 / 74.7±3.7 / 74.5±4.0
100W
5 / 79.2±1.4 / 80.2±2.3 / 0.270
32 / 77.3±3.7 / 77.1±4.1
59 / 77.4±3.7 / 76.9±3.9
150W
5 / 79.2±1.4 / 80.0±1.7 / 0.219
32 / 77.8±3.8 / 78.6±3.6
59 / 78.9±3.0 / 78.7±2.8
Recovery post-exercise
5 / 73.5±4.3 / 79.0±7.8 / 0.012
32 / 71.5±3.7 / 72.8±3.5
59 / 73.1±3.9 / 73.1±3.1