Table S5: Summary of LOH rates following exposure to stress conditions.

Temperature stress
Strain / URA3 / Chr1 / LOH2 rate/cell division3
location / 30°C / SD (±) / 39°C / SD (±) / Fold change
no stress / in LOH rate
YJB9318 / GAL1 / 1L / 2.6E-06 / 2.6E-07 / 5.0E-06 / 7.5E-08 / 2
YJB10136 / CLB2 / 2L / 6.9E-06 / 2.0E-06 / 1.0E-05 / 3.2E-06 / 1
YJB9984 / MYO1 / 5L / 1.6E-07 / 8.6E-09 / 5.2E-07 / 2.8E-07 / 3
YJB9834 / INT1 / 5R / 1.8E-06 / 1.1E-06 / 7.1E-05 / 2.1E-05 / 40
YJB10597 / BUD7 / 5R / 3.0E-07 / 2.4E-08 / 2.0E-06 / 2.3E-07 / 7
YJB10146 / BUD3 / 7L / 7.8E-06 / 6.1E-07 / 7.0E-06 / 2.1E-07 / 1
H2O2 stress
Strain / LOH rate/cell division
URA3 / Chr / 30°C / SD (±) / 0.4 mM / SD (±) / Fold change
location / no stress / in LOH rate
YJB9318 / GAL1 / 1L / 5.7E-06 / 7.0E-07 / 1.7E-05 / 5.0E-06 / 3
YJB10136 / CLB2 / 2L / 2.7E-06 / 5.2E-07 / 3.1E-05 / 8.0E-06 / 12
YJB9984 / MYO1 / 5L / 7.8E-06 / 5.0E-06 / 2.1E-05 / 9.1E-06 / 3
YJB9834 / INT1 / 5R / 8.6E-08 / 2.9E-08 / 6.2E-06 / 4.2E-06 / 72
YJB10597 / BUD7 / 5R / 6.0E-06 / 6.5E-07 / 4.0E-05 / 1.7E-05 / 7
YJB10146 / BUD3 / 7L / 3.0E-06 / 6.9E-07 / 1.6E-05 / 2.4E-06 / 5
Fluconazole stress
Strain / LOH rate/cell division
URA3 / Chr / 30°C / SD (±) / 1 μg/ml / SD (±) / Fold change
location / no stress / in LOH rate
YJB9318 / GAL1 / 1L / 2.7E-06 / 1.1E-06 / 2.4E-05 / 1.4E-05 / 9
YJB10136 / CLB2 / 2L / 4.1E-06 / 8.9E-07 / 4.6E-05 / 8.4E-06 / 11
YJB9984 / MYO1 / 5L / 7.2E-07 / 3.5E-07 / 9.8E-06 / 6.8E-06 / 14
YJB9834 / INT1 / 5R / 2.5E-06 / 2.3E-06 / 7.3E-04 / 8.7E-04 / 285
YJB10597 / BUD7 / 5R / 3.0E-06 / 1.2E-06 / 1.6E-05 / 3.8E-06 / 6
YJB10146 / BUD3 / 7L / 2.7E-06 / 4.2E-07 / 3.1E-05 / 4.8E-06 / 12

1 chromosome

2 loss of heterozygosity

3 LOH rate represents average of at least 2 fluctuation analyses per strain.