BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Evan D. Morris / POSITION TITLE
Assoc. Professor
eRA COMMONS USER NAME
emorris
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION / DEGREE
(if applicable) / YEAR(s) / FIELD OF STUDY
Massachusetts Institute of Technology / BS / 1983 / Chemical Engineering
Massachusetts Institute of Technology / BS / 1983 / Biology
Case Western Reserve Univ., Cleveland, OH / MS / 1988 / Biomedical Engineering
Case Western Reserve Univ., Cleveland, OH / PhD / 1991 / Biomedical Engineering
Mass. General Hospital/Harvard Medical School / Post Doc / 1992-95 / Radiological Sciences
National Institute on Drug Abuse, NIH / Sr. Staff Fel. / 1995-98 / Brain Imaging
A. Positions and Honors
Positions
1983-1989 Research Asst., Cleveland Clinic Foundation., Atherosclerosis & Thrombosis Dept., Cleveland
1990-1992 Imaging Processing Engineer, Psychiatry Dept. University Hospitals, Cleveland
1992-1995 Research Fellow, Div. of Radiological Sciences, Massachusetts General Hospital, Boston
1995-1998 Senior Staff Fellow, Brain Imaging Center, National Institute on Drug Abuse, NIH, Baltimore
1998-2001 Senior Software Developer, Sensor Systems Inc., Sterling, VA
2001-2009 Assistant Professor, Biomedical Engineering, Radiology, and Medical Neurobiology; Assistant Professor (adjunct), Psychiatry. Indiana University School of Medicine/IUPUI, Indianapolis
2003-2009 Assistant Professor, Biomedical Engineering (adjunct) Purdue University. W Lafayette, IN
2004-2009 Member of the Graduate Faculty, Indiana University
2004-2009 Primary Investigator, Stark Neurosciences Institute
2009-present Assoc Prof Radiology, Psychiatry and Biomedical Engineering, Yale University School of Medicine, Co-Director of Imaging, Yale PET Center
Honors
1983-1990 NIH-NRSA pre-doctoral fellow, Cleveland Clinic Foundation
1990 IEEE EMBS Student Paper Finalist, Annual Meeting, Philadelphia
1992-1995 NIH-NRSA post-doctoral fellow, Massachusetts General Hospital
1995 NIDA Scientific Director’s Award
Ad Hoc Manuscript Reviewer: Journal of Nuclear Medicine, PNAS, Psychopharmacology, Nuclear Medicine and Biology, Physics in Medicine Biology, NeuroImage. IEEE Trans Med Imag, Annals of Biomed Eng, Medical Physics
Ad Hoc Associate Editor: Medical Physics; Ad Hoc Grant Reviewer: NIDA ISTART program;
Member of International Organizing Committee: Neuroreceptor Mapping, Vancouver, 2004; Copenhagen, 2006. Pittsburgh, 2008
Section Editor, Functional Imaging, Encyclopedia of Systems Biology
B. Peer-reviewed publications
1. Klibanov, A.M., B.N. Alberti, E.D. Morris, L.M. Felshin. Enzymatic removal of toxic phenols and anilines from waste waters. J. Appl. Bioch. 1980, 3.
2. Klibanov, A.M. and E.D. Morris. Horseradish peroxidase for the removal of carcinogenic aromatic amines from water. Enz. Microb Tech. 1981, 3
3. Saidel, G.M., E.D. Morris, G.M. Chisolm. Transport of macromolecules in arterial wall in vivo: a mathematical model and analytical solutions. Bull. Math. Biol. 1987, 49(2):153-169.
4. Morris, E.D., G.M. Saidel, G.M. Chisolm. Optimal design of experiments to estimate LDL transport parameters in arterial wall. Modeling Methodology Forum of Am. J. Physiol. 1991, 261 (Heart Circ. Phys. 30) H929-H949.
5. Semple, W.E., P. Goyer, R. McCormick, E. Morris, B. Compton, G. Muswick, D. Nelson, B. Donovan, G. Leisure, M. Berridge, F. Miraldi, S. C. Schulz. Preliminary Report: Brain Blood Flow using PET in Patients with Posttraumatic Stress Disorder and Substance-Abuse Histories. Biological Psychiatry. 1993, 34(1-2):115-118.
6. Fisher, R.E., E.D. Morris, N.M. Alpert, A.J. Fischman. In Vivo Imaging of Neuromodulatory Synaptic Transmission Using PET: A Review of Relevant Neurophysiology. Human Brain Mapping. 1995, 3:24-34.
7. Morris, E.D., R.E. Fisher, N.M. Alpert, S.L. Rauch, A.J. Fischman. In Vivo Imaging of Neuromodulation Using Positron Emission Tomography: Optimal Ligand Characteristics and Task Length for Detection of Activation. Human Brain Mapping. 1995, 3:35-55.
8. Semple, W.E., P.F. Goyer, R. McCormick, B. Compton-Toth, E. Morris, B. Donovan, G. Muswick, D. Nelson, M.L. Garnett, J. Sharkoff, G. Leisure, F. Miraldi, S.C. Schulz. Attention and Regional Cerebral Blood Flow in Posttraumatic Stress Disorder Patients with Substance Abuse Histories. Psych Res.Neuroimaging. 1996, 67:17-28.
9. Goyer, P.F., M.S. Berridge, E.D. Morris, W.E. Semple, B.A. Compton-Toth, S.C. Schulz, D.F. Wong, F. Miraldi, H.Y. Meltzer. PET Measurement of Neuroreceptor Occupancy by Typical and Atypical Neuroleptics. J Nucl Med. 1996, 37(7):1122-1126.
10. Alpert, N.M., D. Berdichevsky, Z. Levin, E.D. Morris, A.J. Fischman. Improved Methods for Image Registration. NeuroImage. 1996, 3(1): 10-18.
11. Morris, E.D., N.M. Alpert, A.J. Fischman. Comparison of Two Compartmental Models for Describing Receptor Ligand Kinetics and Receptor Availability in Multiple Injection PET Studies. J Cereb Blood Flow & Metab. 1996, 16:841-853.
12. Morris, E.D., J.W. Babich, N.M. Alpert, A.A. Bonab, E. Livni, S. Weise, H. Hsu, B.T. Christian, B.K. Madras, A.J. Fischman. Quantification of Dopamine Transporter Density in Monkeys by Dynamic PET Imaging of Multiple Injections of 11C-CFT. Synapse. 1996, 24:262-272.
13. Morris, E.D., S.I. Chefer, M.A. Lane, R.F. Muzic, Jr., D.R. Wong, R.F. Dannals, J.A. Matochik, A.A. Bonab, V.L. Villemagne, S.J. Grant, D.K. Ingram, G.S. Roth, E.D. London. Loss of D2 Receptor Binding with Age in Rhesus Monkeys: Importance of Correction for Differences in Striatal Size. J Cereb Blood Flow & Metab. 1999, 19:218-229.
14. Matochik, J.D., S.I. Chefer, M.A. Lane, R.I. Woolf, E.D. Morris, D.K. Ingram, G.S. Roth, E.D. London. Age-Related Decline in Striatal Volume in Monkeys as Measured by Magnetic Resonance Imaging. Neurobiol of Aging. 2000, 21:591-598.
15. Christian, B.T., T. Narayanan, B. Shi, E.D. Morris, J. Mantil, J. Mukherjee. Measuring the In Vivo Binding Parameters of [18F]-Fallypride in Monkeys Using a PET Multiple-Injection Protocol. J Cereb Blood Flow & Metab. 2004, 24(3):309-22.
16. Yoder, K.K., G.D. Hutchins, E.D. Morris, C. Wang, A. Shekhar. Dopamine Transporter Density In Schizophrenic Subjects With and Without Tardive Dyskinesia. Schizophrenia Research. 2004, 71:371-375.
17. Yoder, K.K., C. Wang, E.D. Morris. Change in Binding Potential as a Quantitative Index of Neurotransmitter Release is Highly Sensitive to Relative Timing and Kinetics of Both the Tracer and the Endogenous Ligand. J Nucl Med. 2004, 45(5):903-911.
18. Kamasak, M., C.A. Bouman, E.D. Morris, K. Sauer. Direct Reconstruction of Kinetic Parameter Images from Dynamic PET Data. IEEE Trans Med Imag. 2005, 24:636-650.
19. Yoder, K.K., D. Kareken, R. Seyoum, S. O'Connor, C. Wang, Q.H. Zheng, B. Mock, E.D. Morris. Dopamine D2 receptor availability is associated with subjective responses to alcohol. Alc Clin Exp Res. 2005, 29(6):965–970.
20. James, J.R., K.K. Yoder, O. Osuntokun, A. Kalnin, A. Bruno, E.D. Morris. A supervised method for calculating perfusion / diffusion mismatch volume in acute ischemic stroke. Comp Biol Med. 2005, 36(11):1268-87.
21. Morris, E.D., K.K. Yoder, C. Wang, M.D. Normandin, Q.-H-. Zheng, B. Mock, R.F. Muzic, J.C. Froehlich. ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release Molec Imag. 2005, 4(4):473-489.
22. Morris, E.D., and Yoder, K.K. PET Displacement Sensitivity: Predicting Binding Potential Change for PET Tracers Based on their Kinetic Characteristics J Cereb Blood Flow and Metab. 2007, 27(3):606-17 [Epub 2006 Jun 21].
23. Innis, R.B., V.J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R.N. Gunn, J. Holden, S. Houle, S.C. Huang, M. Ichise, H. Iida, H. Ito, Y Kimura, R.A. Koeppe, G.M. Knudsen, J. Knuuti, A.A. Lammertsma, M. Laruelle, J. Logan, R.P. Maguire, M.A. Mintun, E.D. Morris, R. Parsey, J.C. Price, M. Slifstein, V. Sossi, T. Suhara, J.R. Votaw, D.F. Wong, R.E. Carson. Consensus nomenclature for in vivo imaging of reversibly-binding radioligands. J Cereb Blood Flow and Metab. 2007, 27, 1533–1539.
24. Constantinescu, C.C., C.A. Bouman, E.D. Morris. Nonparametric Extraction of Transient Changes in Neurotransmitter Concentration from Dynamic PET Data. IEEE Trans Med Imag. 2007, 26(3) 359-373.
25. Yoder, K.K., C.C. Constantinescu, D.A. Kareken, M.N. Normandin, T.N. Cheng, S.J. O'Connor, E.D. Morris. Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study. Alc Clin Exp Res. 2007, 31(6):965-73 [Epub 2007 Apr 11].
26. Normandin, M.D., and E.D. Morris. Estimating neurotransmitter kinetics with ntPET: A simulation study of temporal precision and effects of biased data. Neuroimage. 2008, 39(3):1162-79 [Epub 2007 Oct 5].
27. Yoder, K.K., C.C. Constantinescu, M.D. Normandin, T.E. Cheng, S.J. O’Connor, D.A. Kareken, E.D. Morris. What were they thinking? Cognitive states may influence [11C]raclopride binding potential in the striatum. Neurosci Lett. 2008, 430(1):38-42 [Epub 2007 Dec 3].
28. Morris, E.D., M.D. Normandin, W.K. Schiffer. Initial comparison of ntPET with microdialysis measurements of methamphetamine induced dopamine release in rats. Support for estimation of dopamine curves from PET data. Mol Imaging Biol. 2008,10(2):67-73 [Epub 2008 Jan 4].
29. Constantinescu, C.C., K.K. Yoder, D.A. Kareken, C.A. Bouman, S.J. O'Connor, M.D. Normandin, E.D. Morris. Estimation from PET data of transient changes in dopamine concentration induced by alcohol: Support for a non-parametric signal estimation method. Phys Med Biol. 2008, 53: 1353-1367.
30. Yoder, K.K., E.D. Morris, C.C. Constantinescu, T.E. Cheng, M.D. Normandin, S.J. O’Connor, D.A. Kareken. What You See Isn’t What You Get: Alcohol Cues, Alcohol Administration, Prediction Error, and Human Striatal Dopamine. Alc Clin Exp Res. 2009, 33(1) pp 1–11 [Epub 2008 Oct 31].
31. Cheng, T.E., K.K. Yoder, M.D. Normandin, S.L Risacher, A. Converse, J. Hampel, M.A. Miller, E.D. Morris. A rat head holder for simultaneous scanning of two rats in small animal PET scanners: Design, construction, feasibility testing and kinetic validation. J Neurosci Meth. 2009, 176(1):24-33.
32. E.D. Morris, C.C. Constantinescu, J.M. Sullivan, M.D. Normandin, L.A. Christopher. Noninvasive Visualization of Human Dopamine Dynamics from PET Images. Neuroimage 2010. Jan 4. [Epub ahead of print]
2. Case Reports, Technical Notes, Letters
1. Morris, E.D., A.A. Bonab, N.M. Alpert, A.J. Fischman, B.K. Madras, B.T. Christian. Letter (responding to Logan et al, Synapse, 1997). Concentration of Dopamine Transporters: To Bmax or Not to Bmax. Synapse. 1999, 32(2):136-140.
3. Reviews, Chapters, Books
1. Morris, E.D., R.F. Muzic, B.T. Christian, C.J. Endres, R.E. Fisher. Modeling of PET/SPECT Receptor Images. In Functional Neuroimaging in Child Psychiatry, ed. M. Ernst and J. Rumsey. Cambridge University Press, Cambridge, UK, 2000, pp. 27-44.
2. Morris, E.D., B.T. Christian, K.K. Yoder, R.F. Muzic. Invited Review. Estimation of Local Receptor Density B' max and Other Parameter via Multiple-Injection PET Experiments. In Methods in Enzymology, Imaging in Biological Research Part A, ed. P.M. Conn, 2004, 385:184-213.
3. Morris, E.D., C.J. Endres, K. Schmidt, B.T. Christian, R.F. Muzic, R.E. Fisher. Kinetic Modeling in PET. In Emission Tomography: The Fundamentals of PET and SPECT, ed. M. Wernick and N. Aarsvold. Academic Press. Amsterdam, Netherlands, 2004, pp. 499-540.
4. Morris, E.D., B.T. Christian, K.K. Yoder, R.F. Muzic. Estimation of Local Receptor Density B' max and Other Parameter via Multiple-Injection PET Experiments. Chapter7 in Essential Bioimaging Methods, ed. P.M. Conn, Elsevier, 2009.
5. Conference Publications (selected)
1. Morris, E.D., R.E. Fisher, S.L. Rauch, A.J. Fischman, N.M. Alpert. PET Imaging of Neuromodulation: Designing Experiments to Detect Endogenous Transmitter Release. In Quantification of Brain Function Using PET, ed. T. Jones, V. Cunningham, R. Meyers, D. Bailey. Academic Press, 1996, pp. 425-433.
2. Morris, E.D., A.J. Fischman, N.M. Alpert. Analyzing PET Receptor Studies of Multiple Injections of Varying Specific Activities: Proper Modeling of Unlabeled Ligand in Blood and Tissue. In Quantification of Brain Function Using PET, ed. T. Jones, V. Cunningham, R. Meyers, D. Bailey. Academic Press, 1996, pp. 249-256.
3. Morris, E.D., S.I. Chefer, E.D. London. Limitations of Binding Potential as a Measure of Receptor Function. A Two-Point Correction for the Effects of Mass. In Quantitative Functional Brain Imaging with Positron Emission Tomography, ed. R.E. Carson, M.E. Daube-Witherspoon, P. Herscovitch. Academic Press, 1998, pp. 407-414.
4. Kamasak, M., C.A. Bouman, E.D. Morris, K. Sauer. Direct Reconstruction of Kinetic Parameter Images from Dynamic PET Data. In Proceedings of the 37th Asilomar Conference on Signals, Systems, and Computers, 2003 pp. 1-5.
5. James, J.R., O. Osuntokun, K. Yoder, A. Bruno, E.D. Morris. A Supervised Method for Calculation of Perfusion/Diffusion Mismatch Volume in Acute Stroke. In Proceedings of the IEEE International Symposium on Biomedical Imaging (ISBI), 2004, pp. 1295-1298.
6. Kamasak, M.E., C.A. Bouman, E.D. Morris, K. Sauer. Parametric reconstruction of kinetic {PET} data with plasma function estimation. In Proc. of SPIE Conf. on Electronic Imaging: Computational Imaging, 2005, 5674:293-305.
7. Kamasak, M.E., C.A. Bouman, E.D. Morris, K. Sauer. Reconstruction of kinetic parameter images directly from dynamic {PET} sinograms. In Proc. of SPIE Conf. on Medical Imaging: Image Processing,2005, vol. 5747.
8. Morris, E.D., M.E. Kamasak, B.T. Christian, T.E. Cheng, C.A. Bouman. Visualizing all the fits: Evaluating the quality and precision of parametric images created from direct reconstruction of PET sinogram data. In Proceedings of the IEEE International Symposium on Biomedical Imaging, 2006.
9. Normandin, M.D., and E.D. Morris. Two variants of the ntPET model for the recovery of timing information related to changes in endogenous neurotransmitters using dynamic PET. Proceedings: Engineering in Medicine and Biology Conference. Annual Meeting, New York. 2006, pp. 2005-2008.
C. Research Support
Ongoing
NIH (4/1/09 – 3/31/14)
Title: “Dopaminergic Function in Alcoholism” (R01 AA017661)
Morris Role on project: Grant funds awarded after Dr Morris left IU. Role being renegotiated
(PI – Kareken)
NIH (6/1/08-5/30/10)
“Dopamine, Prediction Error, and Human Alcohol Consumption.” (R21 AA016901-01A1)
Morris Role on grant: Grant funds awarded after Dr Morris left IU. Role being renegotiated
(PI - Yoder)
Completed (last 3 years)
NIH (3/1/06 – 2/28/09)
“Temporal Response of Dopamine to Alcohol Imaged via PET“ (R21 AA015077)
Morris Role on grant: Principal Investigator