Supplementary Table 3.Univariate and multivariate analyses of the relationships between PD-L1 protein expression and other patient characteristics.

Factors / 5% cut-off / 1% cut-off
Univariate analysis / Multivariate analysis** / Multivariate analysis*** / Univariate analysis / Multivariate analysis** / Multivariate analysis***
OR (95%CI) / OR (95%CI) / OR (95%CI) / OR (95%CI) / OR (95%CI) / OR (95%CI)
P / P / P / P / P / P
Age (years) / ≥ 70 / 1.02 (0.63–1.64) / 0.91 (0.60–1.36)
< 70 / 0.9511 / 0.6292
Sex / Male / 2.53 (1.55–4.23) / 1.76 (1.17–2.65)
Female / 0.0002 / 0.0064
Smoking status / Smoker / 4.13 (2.46–7.16) / 2.31 (1.28–4.25) / 2.10 (1.40–3.18)
Never-smoker / < 0.0001 / 0.0056 / 0.0004
Grade / ≥ G2 / 11.73 (5.97–25.85) / 15.58 (5.24–67.03) / 7.04 (3.28–16.54) / 5.78 (3.67–9.29) / 4.78 (3.00–7.76) / 5.08 (3.10–8.48)
G1 / < 0.0001 / < 0.0001 / < 0.0001 / < 0.0001 / < 0.0001 / < 0.0001
Stage / ≥ II / 2.32 (1.40–3.82) / 2.34 (1.50–3.66) / 1.90 (1.11–3.25)
Ⅰ / 0.0012 / 0.0002 / 0.0184
pl / Present / 2.82 (1.67–4.72) / 2.08 (1.30–3.32)
Absent / 0.0001 / 0.0023
ly / Present / 0.86 (0.41–1.68) / 0.37 (0.16–0.81) / 0.94 (0.52–1.66) / 0.37 (0.19–0.72)
Absent / 0.6667 / 0.0126 / 0.8324 / 0.0033
v / Present / 4.34 (2.63–7.19) / 1.94 (1.04–3.65) / 2.85 (1.83–4.44)
Absent / < 0.0001 / 0.037 / < 0.0001
Histological subtype / Micropapillary/solid / 17.83 (7.32–50.16) / 12.06 (1.98–232.57) / 6.06 (2.36–17.74) / 12.78 (4.79–44.30) / 6.40 (2.35–22.44) / 6.13 (2.19–21.96)
Others / < 0.0001 / 0.0048 / 0.0001 / < 0.0001 / 0.0001 / 0.0003
Surgical procedure / ≥ Lobectomy / 1.12 (0.65–2.02) / 1.16 (0.72–1.89)
Sublobar resection / 0.6919 / 0.5396
EGFR* / Wild-type / 4.57 (2.10–11.11) / 2.46 (1.03–6.39) / ー / 2.56 (1.41–4.78) / ー
Mutant / < 0.0001 / 0.0426 / 0.0018

*: casesin which data were available.

**: multivariate analysis adjusted by all factors.

***: multivariate analysis adjusted by all factors except EGFR status.

pl: pleural invasion, ly: lymphatic invasion, v: vascular invasion, EGFR: epidermal growth factor receptor gene, PD-L1: programmed death-ligand 1, OR: odds ratio, CI: confidence interval

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