Table e-1. Specificities, sensitivities and likelihood ratios at cut-offs for 85% sensitivity for AD dementia, including confidence intervals
Biomarker / Age group / Cross-sectional cohort(AD dementia and controls) / Longitudinal cohort
(MCI patients)
Specificity (controls) / LR+ / LR- / Specificity (SMCI/MCI-other) / Sensitivity (MCI-AD) / LR+ / LR-
Aβ42 / ≤ 64 years / 82
(74-88) / 4.9
(4.4-5.4) / 0.13
(0.07-0.2) / 77
(70-83) / 75
(63-85) / 3.2
(2.8-3.8) / 0.33
(0.2-0.5)
65-74 years / 82
(73-88) / 4.6
(4.1-5.1) / 0.18
(0.1-0.3) / 56
(49-63) / 84
(76-91) / 1.9
(1.7-2.2) / 0.28
(0.2-0.4)
≥ 75 years / 73
(60-84) / 3.2
(2.7-3.7) / 0.19
(0.1-0.3) / 60
(50-69) / 83
(74-90) / 2.1
(1.7-2.5) / 0.29
(0.2-0.5)
T-tau / ≤ 64 years / 74
(65-81) / 3.3
(2.9-3.7) / 0.20
(0.1-0.3) / 65
(57-72) / 81
(70-90) / 2.3
(2.0-2.7) / 0.29
(0.2-0.5)
65-74 years / 53
(43-62) / 1.8
(1.5-2.2) / 0.28
(0.2-0.4) / 49
(42-56) / 91
(84-96) / 1.8
(1.5-2.1) / 0.19
(0.1-0.3)
≥ 75 years / 61
(47-74) / 2.2
(1.8-2.7) / 0.24
(0.1-0.4) / 46
(36-56) / 83
(74-90) / 1.5
(1.2-1.9) / 0.38
(0.2-0.6)
P-tau / ≤ 64 years / 67
(58-75) / 2.6
(2.2-3.0) / 0.22
(0.1-0.3) / 55
(47-63) / 73
(61-84) / 1.6
(1.3-2.0) / 0.48
(0.3-0.8)
65-74 years / 46
(37-56) / 1.6
(1.3-1.9) / 0.31
(0.2-0.5) / 44
(37-51) / 90
(83-95) / 1.6
(1.3-1.9) / 0.23
(0.1-0.4)
≥ 75 yrs / 37
(25-51) / 1.4
(1.0-1.9) / 0.40
(0.3-0.6) / 30
(22-40) / 84
(75-90) / 1.2
(0.9-1.6) / 0.54
(0.3-0.9)
Combination / ≤ 64 yrs / 95
(90-98) / 18
(17-20) / 0.14
(0.06-0.3) / 86
(80-91) / 77
(64-86) / 5.5
(4.8-6.4) / 0.27
(0.2-0.5)
65-74 yrs / 83
(75-89) / 5.1
(4.7-5.7) / 0.16
(0.09-0.3) / 65
(58-71) / 86
(78-92) / 2.4
(2.1-2.8) / 0.21
(0.1-0.4)
≥ 75 yrs / 80
(67-89) / 4.3
(3.7-4.9) / 0.16
(0.09-0.3) / 61
(51-70) / 83
(74-90) / 2.1
(1.8-2.5) / 0.29
(0.2-0.5)
All measurements are calculated at the 85% sensitivity cut-off value for AD dementia. Data within brackets are 95% confidence intervals. AD, Alzheimer’s disease; MCI, mild cognitive impairment.