ONLINE SUPPLEMENTAL DATA

Table E-1: Mayo Fluctuations Scale: Percentage of normal controls and patients with item endorsement

MAYO FLUCTUATIONS SCALE / Normal
n=200
%yes / * / AD
n=70
%yes / * / DLB
n=70
%yes / * / X2
AD vs
DLB
1. Have there been abrupt changes in the patient's thinking or
mental state? / 1.5 / 24.3 / 37.1 / 2.14
2. Are there changes in his/her abilities that fluctuate (come and go)? / 6.0 / 72.9 / 87.1 / 3.61
3. Does the patient have difficulty focusing attention? / 2.0 / 58.6 / 78.6 / 5.60
4. Is he or she easily distractible? / 2.5 / 52.9 / 64.3 / 1.44
5. Does the patient have trouble keeping track of what is said? / 6.0 / 65.7 / 77.1 / 1.72
6. Are there times when the patient's flow of ideas seem
disorganized, unclear or not logical? / 3.5 / 58.6 / 85.7 / 11.50
7. Are there times when he or she unpredictably switches from
subject to subject when speaking? / 4.5 / 32.9 / 51.4 / 4.22
8. How often is the patient drowsy and lethargic during the day,
despite getting enough sleep the night before?
a) All the time or several times a day* b) Once a day or less / 6.5 / 27.1 / 72.9 / 27.50
9. How much time does the patient spend sleeping during the day
(before 7:00pm)? a) 2 hours or more* b) Less than 2 hours / 7.0 / 27.1 / 67.1 / 20.90
10. During the day, does the patient get confused to the point of being
unaware of what is going on around him/her? / 1.0 / 17.1 / 32.9 / 3.80
11. Does the patient stare into space for long periods of time? / 1.0 / 12.9 / 34.3 / 7.77
12. Does he/she seem blank, zoned out or switched off at times? / 0.5 / 31.4 / 50.0 / 4.26
13. Does the patient have thinking problems on some days BUT not
on other days? / 4.5 / 61.4 / 70.0 / 0.79
14. Does the patient have daytime thinking problems that come and
go, or that fluctuate from being poor to fairly good? / 1.5 / 62.9 / 77.1 / 2.75
15. Are there times when the patient cannot figure out how to do a
task, BUT LATER can figure it out easily? If Yes, please
describe. / 5.0 / 61.4 / 67.1 / 0.00
16. Does he/she have thinking problems that are worst in the evening? / 0.0 / 24.3 / 25.7 / 1.49
17. Which best describes the patient's ability to concentrate or focus
attention during the day?
a. usually good b. usually fair c. usually poor
d. varies from poor to good* / 0.0 / 17.1 / 27.1 / 0.35
18. Which best describes the patient's ability to remember recent
information?
a. usually good b. usually fair c. usually poor
d. varies from poor to good* / 2.0 / 27.1 / 21.4 / 1.30
19. When the patient hears what is said, which best describes his/her
ability to understand it?
a. usually good b. usually fair c. usually poor
d. varies from poor to good* / 1.0 / 21.7 / 12.9

Items 1-7, 10-16 responses include yes, no, don’t know.

%yes = affirmative response to yes/no items

* = affirmative response to specified items

 = p < 0.01 for AD vs. DLB comparisons with Yates' continuity correction used for dichotomous items