Autoregulation of Cyclic AMP in Vascular Smooth Muscle: a Role for Adenosine Receptors M

PHARMACOLOGY

November 2002Volume 62Number 5 0026-895X

PERSPECTIVES

Autoregulation of Cyclic AMP in Vascular Smooth Muscle: A Role for Adenosine Receptors M

Joel Linden969

Dancing with Different Partners: Protein Kinase A Phosphorylation of Seven Membrane-Spanning Receptors Regulates Their G Protein-Coupling Specificity <§>

Robert J. Lefkowitz, Kristen L. Pierce, and Louis M. Luttrell971

ARTICLES

Reduction of Hypoxia-Induced Transcription through the Repression of Hypoxia-Inducible Factor-la/ Aryl Hydrocarbon Receptor Nuclear Translocator DNA Binding by the 90-kDa Heat-Shock Protein Inhibitor Radicicol

Eunseon Hur, Hong-Hee Kim, Su Mi Choi, Jin Hee Kim, Sujin Tim, Ho Jeong Kwon,
Youngyeon Choi, Dae Kyong Kim, Mi-Ock Lee, and Hyunsung Park975

Localization of Adenylyl Cyclase Isoforms and G Protein-Coupled Receptors in Vascular Smooth Muscle Cells: Expression in Caveolin-Rich and Noncaveolin Domains

Rennolds S. Ostrom, Xiaoqiu Liu, Brian P. Head, Caroline Gregorian, Tammy M. Seasholtz, and
Paul A. Insel983

Mice with Partial Deficiency of c-Jun Show Attenuation of Methamphetamine-Induced Neuronal

Apoptosis

Xiaolin Deng, Subramaniam Jayanihi, Bruce Ladenheim, Irina N. Krasnova, and Jean Lud Cadet 993

Phosphatidylinositol 3-Kinase Regulates Nuclear Translocation of NF-E2-Related Factor 2 through
Actin Rearrangement in Response to Oxidative Stress
Keon Wook Kang, Seung Jin Lee, Jeong Weon Park, and Sang Geon Kim1001

Haptenation of Sulfonamide Reactive Metabolites to Cellular Proteins

Tarang Manchanda, David Hess, Lianna Dale, Stephen G. Ferguson, Michael J. Rieder1011

The Mutant Androgen Receptor T877A Mediates the Proliferative but Not the Cytotoxic Dose-
Dependent Effects of Genistein and Quercetin on Human LNCaP Prostate Cancer Cells
Marcello Maggiolini, Adele Vivacqua, Amalia Carpino, Daniela Bonofiglio, Giovanna Fasanella,
Michele Salerno, Didier Picard, and Sebastiano Ando1027

Modulation of the Hydrophobic Domain of Polymyxin B Nonapeptide: Effect on Outer-Membrane
Permeabilization and Lipopolysaccharide Neutralization
Haim Tsubery, Itzhak Ofek, Sofia Cohen, Miriam Eisenstein, and Mati Fridkin1036

Activation of the Mitogen-Activated Protein Kinase (ERK1/2) Signaling Pathway by Cyclic AMP

Potentiates the Neuroprotective Effect of the Neurotransmitter Noradrenaline on Dopaminergic

Neurons

Jean-Denis Troadec, Marc Marten, Sophie Mourlevat, Thomas Debeir, Merle Ruberg,

Francis Colpaert, and Patrick P. Michel1043

Novel Antagonists of Alcohol Inhibition of Ll-Mediated Cell Adhesion: Multiple Mechanisms of Action

Michael F. Wilkemeyer, Carrie E. Menkari, and Michael E. Charness1053

Cytochrome P450 CYPlAl Accumulates in the Cytosol of Kidney and Brain and Is Activated by Heme

Half Peter Meyer, Michael Pb'dvinec, and Urs A. Meyer1061

Inhibition of CTP:Phosphocholine Cytidylyltransferase by C2-Ceramide and Its Relationship to

Apoptosis

Belen Ramos, Mohammed El Mouedden, Enrique Claro, and Suzanne Jackowski1068

Stereospecific Activation of Cardiac ATP-Sensitive K' Channels by Epoxyeicosatrienoic Acids: A
Structural Determinant Study
Tong Lu, Mike VanRollins, and Hon-Chi Lee1076

Evaluation of Muscarinic Agonist-Induced Analgesia in Muscarinic Acetylcholine Receptor Knockout

Mice

Alokesh Duttaroy, Jesus Gomeza, Jai-Wei Gan, Nasir Siddiqui, Anthony S. Basile,

W. Dean Harman, Philip L. Smith, Christian C. Felder, Allan I. Levey, and Jilrgen Wess1084

j32-Adrenergic Receptor Lacking the Cyclic AMP-Dependent Protein Kinase Consensus Sites Fully

Activates Extracellular Signal-Regulated Kinase 1/2 in Human Embryonic Kidney 293 Cells: Lack

of Evidence for Gs/Gi Switching.

Jacqueline Friedman, Bonita Babu, and Richard B. Clark1094

Pharmacophore Definition and Three-Dimensional Quantitative Structure-Activity Relationship Study on Structurally Diverse Prostacyclin Receptor Agonists

Friederike Stoll, Sven Liesener, Thomas Hohlfeld, Karsten Schror, Philip L. Fuchs, and
Hans-Dieter Holtje1103

Interleukin-1/3 Induces MUC2 and MUC5AC Synthesis through Cyclooxygenase-2 in NCI-H292 Cells
Yong-Dae Kim, Eun-Jin Kwon, Dae-Won Park, Si-Youn Song, Seok-Keun Yoon, and
Suk-Hwan Baek1112

Association of NR3A with the AT-Methyl-d-aspartate Receptor NR1 and NR2 Subunits

Hana A. Al-Hallaq, Bryan R. Jarabek, Zhanyan Fu, Stefano Vicini, Barry B. Wolfe, and

Robert P. Yasuda1119

Interaction of the Metal Chelator 2,3-Dimercapto-l-propanesulfonate with the Rabbit Multispecific Organic Anion Transporter 1 (rbOATl)

A. Bahn, M. Knabe, Y. Hagos, M. Rodiger, S. Godehardt, D. S. Graber-Neufeld, K. K. Evans,
G. Burckhardt, and S. H. Wright1128

Signaling Pathway from the Human Adenosine A3 Receptor Expressed in Chinese Hamster Ovary
Cells to the Extracellular Signal-Regulated Kinase 1/2
Gunnar Schulte and Bertil B. Fredholm1137

Cyclooxygenase-2 Acts as an Endogenous Brake on Endothelin-1 Release by Human Pulmonary Artery
Smooth Muscle Cells: Implications for Pulmonary Hypertension
Stephen J. Wort, Mandy Woods, Timothy D. Warner, Timothy W. Evans, and Jane A. Mitchell1147

The Copper Transporter CTR1 Regulates Cisplatin Uptake in Saccharomyces cerevisiae

Xinjian Lin, Tsuyoshi Okuda, Alison Holzer, and Stephen B. Howell1154

Inhibition of the Multidrug Resistance Protein 1 (MKP1) by Peptidomimetic Glutathione-Conjugate
Analogs
Danny Burg, Peter Wielinga, Noam Zelcer, Tohru Saeki, Gerard J. Mulder, and Piet Borst1160

] Regulation of the A3 Adenosine Receptor Gene in Vascular Smooth Muscle Cells: Role of a cAMP and
GATA Element
R. Yaar, L. M. Cataldo, A. Tzatsos, C. E. Francis, Z. Zhao, and K Ravid1167

Squalestatin 1-Inducible Expression of Rat CYP2B: Evidence That an Endogenous Isoprenoid Is an
Activator of the Constitutive Androstane Receptor
Thomas A. Kocarek and Nancy A. Mercer-Haines1177

Purinergic P2X2 Receptor Desensitization Depends on Coupling between Ectodomain and C-Terminal Domain

Mu-Lan He, Taka-aki Koshimizu, Melanija Tomic, and Stanko S. Stojilkovic1187

Identification of Transdominant-Negative Genetic Suppressor Elements Derived from hMSH2 That Mediate Resistance to 6-Thioguanine

Maida M. de las Alas, Gerrit Los, Xinjian Lin, Buran Kurdi-Haidar, Gerald Manorek, and
Stephen B. Howell1198

Peroxisome Proliferator-Activated Receptor-y Is a Target of Nonsteroidal Anti-Inflammatory Drugs
Mediating Cyclooxygenase-Independent Inhibition of Lung Cancer Cell Growth
Marilee Wick, Greg Hurteau, Christina Dessev, Daniel Chan, Mark W. Geraci, Robert A. Winn,
Lynn E. Heasley, and Raphael A. Nemenoff1207

DNA Binding and Topoisomerase I Poisoning Activities of Novel Disaccharide Indolocarbazoles
Michael Facompre, Carolina Carrasco, Pierre Colson, Claude Houssier, John D. Chisholm,
David L. Van Vranken, and Christian Bailly1215

Inhibition of Na+ Current by Imipramine and Related Compounds: Different Binding Kinetics as an
Inactivation Stabilizer and as an Open Channel Blocker
Ya-Chin Yang, and Chung-Chin Kuo1228

Evidence for the Locations of Distinct Steroid and Vinca Alkaloid Interaction Domains within the
Murine mdrlb P-Glycoprotein
Donald J. Gruol, Miranda N. King, and Martin E. Kuehne1238

Quantitation of the P2Y} Receptor with a High Affinity Radiolabeled Antagonist

Gary L. Waldo, James Corbitt, Jose L. Boyer, Gnana Ravi, Hak Sung Kim, Xiao-duo Ji,

James Lacy, Kenneth A. Jacobson, and T. Kendall Harden1249

Correction to: "The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and

pancuronium"1258

Correction to: "Activation of the mitogen activated protein kinase extracellular signal-regulated kinase
1 and 2 by the nitric oxide— cGMP-cGMP-dependent protein kinase axis regulates the expression
of matrix metalloproteinase 13 in vascular endothelial cells"1259