Supplementary material: SPPE-D-10-00161

Online Resource 1: Pairwise comparisons of anxiety, depressive disorder & comorbid anxiety/depression recent DSM-IV disorders (previous 12-months) by 21-year empirical and DSM-oriented Achenbach scales OR(95%CI)
YASR scalesa
empirical &
DSM-oriented / Anxiety disorder
only bc (371 cases) / Depressive disorder
only de (128 cases) / Comorbid anxiety & depressive disorder (112 cases)
Reference =
Anxiety disorders onlye / Reference =
Depressive disorders onlyc
OR / 95% CI / OR / 95% CI / OR / 95% CI / OR / 95% CI
Internalising / 0.7 / 0.4-1.1 / 1.4 / 0.9-2.4 / 3.9 / 2.5-6.2 / 2.7 / 1.5-4.8
Affective problems / 0.5 / 0.3-0.8 / 2.1 / 1.3-3.3 / 5.9 / 3.7-9.4 / 2.9 / 1.7-4.9
Lengua depressive scale / 0.5 / 0.3-0.8 / 2.0 / 1.2-3.3 / 5.3 / 3.3-8.4 / 2.6 / 1.5-4.5
Anxiety problems / 1.0 / 0.6-1.7 / 1.0 / 0.6-1.6 / 2.7 / 1.7-4.2 / 2.7 / 1.5-4.8
Lengua anxiety scale / 0.8 / 0.6-1.3 / 1.0 / 0.6-1.6 / 2.9 / 1.9-4.5 / 2.7 / 1.5-4.8
Kendall Anxiety / 0.9 / 0.5-1.5 / 1.1 / 0.7-1.9 / 3.1 / 2.0-4.9 / 2.8 / 1.5-4.9
Ferdinand Anxiety / 0.7 / 0.5-1.2 / 1.4 / 0.9-2.1 / 3.3 / 2.1-5.1 / 2.4 / 1.4-4.2
Ferdinand GAD / 0.8 / 0.5-1.2 / 1.3 / 0.8-2.2 / 4.8 / 3.0-7.5 / 3.5 / 2.0-6.2

a.  YASR: Young Adult Self-report

b.  GAD, PTSD, panic and/or phobic disorders

c.  Reference group = Depressive disorders only

d.  MDD and/or Dysthymia disorders

e.  Reference group = Anxiety disorders only

Kaeleen Dingle 5

Online Resource 2: Removal of early onset (onset <16 years of age) by empirical and DSM-oriented Achenbach scales OR(95%CI)
YASR scales empirical & DSM-oriented
Depressive scales / Total sample
(Depressive disorders=240) / Removal of 144 cases with reported onset of depression before
16 years of age
OR / 95% CI / OR / 95% CI
Internalising / 6.9 / 5.0-9.5 / 5.8 / 4.0-8.4
Affective problems
(Achenbach et al 2003, 2005) / 8.2 / 6.1-11.1 / 6.9 / 4.9-9.8
Lengua depressive scale (et al 2001) / 9.1 / 6.7-12.5 / 8.4 / 5.8-12.1
Total sample
(Anxiety disorders=486) / Removal of 371 cases with reported onset of anxiety before
16 years of age
Anxiety Scales / OR / 95% CI / OR / 95% CI
Internalising / 5.1 / 3.8-6.7 / 4.2 / 2.2-7.9
Anxiety problems
(Achenbach et al 2003, 2005) / 4.7 / 3.7-6.2 / 3.6 / 1.9-6.7
Lengua anxiety scale (et al 2001) / 4.1 / 3.2-5.2 / 3.6 / 2.0-6.4
Kendall Anxiety (et al 2007) / 4.5 / 3.5-5.9 / 4.4 / 2.4-8.2
Ferdinand Anxiety (2007) / 4.2 / 3.3-5.4 / 3.1 / 1.6-5.7
Ferdinand GAD (2007) / 5.5 / 4.2-7.1 / 4.9 / 2.7-9.0
Online Resource 3: Sensitivity and specificity (percentages) of 12-month DSM-IV GAD & phobic disorder and YASR
21-year empirical &
DSM-oriented YASR scales / Cases on
YASR / Congruent cases with DSM-IV / Sensitivitya / Specificityb / PPVc / NPVd
Internalising / 220 / 92 / 25.2 / 94.3 / 40.4 / 88.0
Anxiety
(Achenbach et al 2003) / 265 / 103 / 28.4 / 91.9 / 37.1 / 88.4
Lengua anxiety scale
(et al 2001) / 328 / 121 / 33.3 / 89.5 / 34.9 / 88.8
Kendall Anxiety
(et al 2007) / 241 / 99 / 27.3 / 92.8 / 39.0 / 88.3
Ferdinand Anxiety
(2007) / 289 / 112 / 30.9 / 91.2 / 37.1 / 88.7
Ferdinand GAD
(2007) / 251 / 112 / 30.9 / 92.8 / 42.1 / 88.8

a.  The proportion of people with DSM-IV anxiety who were cases on the 21-yr YASR scale.

b.  The proportion of people with a negative DSM-IV anxiety who had a negative screening test.

c.  Positive predictive value the proportion of cases on the 21-yr YASR that subsequently met the DSM-IV criteria for anxiety.

d.  Negative predictive value the proportion of cases that were negative on the 21-yr YASR and subsequently did not met the DSM-IV criteria for anxiety.

Online Resource 4: Concordance of DSM-IV GAD & phobic disorders by 21-year YASR on empirical and DSM-oriented scales OR and AUC(95%CI), N=2551
12-month DSM-IV GAD & phobic disorder
(366 cases, 14.4% overall prevalence)
Concurrent measure (21-year YASRa) / OR / 95% CI / AUCb / 95% CI
Internalising / 5.0 / 3.7-6.7 / 0.72 / 0.69-0.75
Anxiety (Achenbach et al 2003, 2005) / 4.5 / 3.4-5.9 / 0.71 / 0.68-0.74
Lengua anxiety scale (et al 2001) / 4.3 / 3.3-5.5 / 0.70 / 0.67-0.73
Kendall Anxiety (et al 2007) / 4.8 / 3.6-6.4 / 0.73 / 0.71-0.76
Ferdinand Anxiety (2007) / 4.6 / 3.5-6.0 / 0.72 / 0.69-0.75
Ferdinand GAD (2007) / 5.8 / 4.4-7.6 / 0.74 / 0.71-0.76

a.  YASR: Young Adult Self-report

b.  Area under the curve

Kaeleen Dingle 5

Online Resource 5: Sensitivity analyses, removal of items not in the 2003 ASR or YSR Achenbach scales: sensitivity and specificity & concordance of recent
DSM-IV disorders OR and AUC (95%CI)
12-month DSM-IV depressive disordera (N=240)
DSM-oriented YASR scales with substituted items removed / YASR
Cases / DSM-IV cases / YASR & DSM-IV disorder / Sensb / Specc / PPVd / NPVe / OR / 95% CI / AUCf / 95% CI
Lengua depressive scale
‘I have trouble sitting still’ removed / 306 / 236 / 106 / 44.9 / 91.9 / 34.6 / 94.6 / 8.5 / 6.3-11.3 / 0.80 / 0.77-0.83
12-month DSM-IV anxiety disorderg (N=486)
Achenbach Anxiety scale
‘I worry about my job or school work’ removed / 410 / 481 / 179 / 37.2 / 88.7 / 43.7 / 85.6 / 4.6 / 3.7-5.8 / 0.74 / 0.72-0.76
Lengua anxiety
‘I worry about my job or school work’ removed / 322 / 481 / 147 / 30.6 / 91.4 / 45.7 / 84.7 / 4.7 / 3.6-6.0 / 0.73 / 0.70-0.75
Kendall Anxiety
‘I worry about my job or school work’ removed / 246 / 481 / 119 / 24.7 / 93.7 / 48.4 / 84.0 / 4.9 / 3.7-6.4 / 0.75 / 0.73-0.78
Ferdinand Anxiety
‘I worry about my job or school work’ removed / 292 / 481 / 137 / 28.5 / 92.4 / 46.9 / 84.5 / 4.8 / 3.7-6.2 / 0.73 / 0.71-0.76
Ferdinand GAD
‘I have trouble sitting still’ removed / 269 / 481 / 133 / 27.7 / 93.3 / 49.4 / 84.5 / 5.3 / 4.1-6.9 / 0.75 / 0.72-0.77
Ferdinand GAD
‘I worry about my job or school work’ removed / 260 / 481 / 135 / 28.1 / 93.8 / 51.9 / 84.6 / 6.0 / 4.5-7.8 / 0.75 / 0.73-0.77

a.  MDD and/or Dysthymia disorders

b.  Sensitivity: The proportion of people with DSM-IV lifetime depression who were cases on the 21-year YASR scale.

c.  Specificity: The proportion of people with a negative DSM-IV lifetime depression who had a negative screening test.

d.  Positive predictive value the proportion of cases on the 21-year YASR scale that subsequently met the DSM-IV criteria for recent depression.

e.  Negative predictive value the proportion of cases that were negative on the 21-year YASR scale and subsequently did not met the DSM-IV criteria for recent depression.

f.  Area under the curve

g.  GAD, PTSD, panic and/or phobic disorders

Kaeleen Dingle 5