Supplementary Table 1 Significance values for within genotype comparisons of morphological properties

NT / TG
Early vs. Advanced* / Early vs. TG intact* / Early vs. TG atrophic*
Apical
Length (µm)
Total / ns / ns / < 0.001
Proximal / 0.02 / ns / < 0.001
Middle / ns / ns / ns
Distal / ns / < 0.001
Nodes (#)
Total / ns / 0.048 / 0.002
Proximal / 0.022 / ns / 0.007
Middle / ns / ns / ns
Distal / ns / 0.013 / 0.007
Basal
Length (µm)
Total / ns / ns / ns
Proximal / ns / ns / ns
Middle / ns / ns / ns
Distal / ns / ns / ns
Nodes (#)
Total / ns / ns / ns
Proximal / ns / ns / ns
Middle / ns / ns / ns
Distal / ns / ns / ns
Soma
Volume (µm3) / ns / ns / ns
Spines
Density (#/µm) / < 0.001 / < 0.001 / < 0.001
% Composition
Mushroom / ns / 0.001 / 0.004
Stubby / ns / ns / ns
Thin / ns / ns / ns
Filopodia / 0.013 / < 0.001 / < 0.001

*Fisher’s LSD test

ns, not significant

n: early- 23 NT, 18 TG neurons; advanced- 34 NT, 15 TGintact, 21 TGatrophic neurons


Supplementary Table 2 Significance values for within genotype comparisons of electrophysiological properties

NT / TG
Early vs. Advanced* / Early vs. TG intact* / Early vs. TG atrophic*
Passive
Resting Potential (mV) / ns / ns / ns
Input Resistance (MW) / ns / 0.014 / ns
Time Constant (ms) / ns / ns / ns
Action Potential
Rheobase (pA) / ns / ns / ns
Threshold (mV) / ns / ns / ns
Amplitude (mV) / ns / ns / ns
Sag Amplitude (mV) / ns / ns / ns
Firing Rate (Hz)
+30 pA Current Step / ns / ns / ns
+80 pA Current Step / ns / ns / ns
+130 pA Current Step / ns / ns / ns
+180 pA Current Step / ns / ns / 0.013
+230 pA Current Step / ns / ns / 0.006
+280 pA Current Step / ns / ns / 0.003
+330 pA Current Step / ns / ns / 0.001
+380 pA Current Step / ns / ns / 0.001
sEPSC
Frequency (Hz) / ns / ns / ns
Amplitude (pA) / ns / 0.001 / ns
Rise Time (ms) / ns / ns / ns
Decay Time (ms) / ns / ns / ns

*Fisher’s LSD test

ns, not significant

n: early- 23 NT, 18 TG neurons; advanced- 34 NT, 15 TGintact, 21 TGatrophic neurons