CURRICULUM VITAE
Edwin John Weeber, Ph.D.
Personal Data
Address Vanderbilt University Medical Center
Department of Molecular Physiology and Biophysics
Robinson Research Building #754
Nashville TN. 37213-0615
Phone Office: (615) 343-1312
Lab: (615) 343-1311
Lab URL www.mc.vanderbilt.edu/root/vumc.php?site=weeber&doc=6448
Education
1993 B.S., Biology, University of New Mexico, Department of Biology,
Albuquerque, NM.
1998 Ph.D., Neuroscience, University of New Mexico, College of Medicine, Department of Neuroscience, Albuquerque, NM.
Professional Experience
Post Doctoral Training
1999-2002 Post-doctoral Fellow, Laboratory of Dr. J D Sweatt, Division of Neuroscience, Baylor College of Medicine, Houston, Texas.
Academic Appointments
2001-2002 Research Instructor,
Division of Neuroscience, Baylor College of Medicine, Houston, TX.
2002-2003 Assistant Professor,
Division of Neuroscience, Baylor College of Medicine, Houston, TX.
2004-Present Assistant Professor,
Department of Molecular Physiology and Biophysics, John F. Kennedy Center for Research in Human Development, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville TN.
2005-Present Joint appointment, Department of Pharmacology, Vanderbilt University Medical Center, Nashville TN
Awards and Honors
2004 National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Scientist Award
2003 American Federation for Aging Research (AFAR) Award
2003 Cynthia and George Mitchell Awards in Dementia Research
2000 Travel Award, American College of Neuropsychopharmacology / Puerto Rico
1999-2002 NINDS, Post-doctoral Supplemental Grant for Underrepresented Minorities
1997-1998 Minority Biomedical Research Sciences (MBRS) Pre-doctoral Fellowship
1994-1995 Patricia Harris Minority Pre-doctoral Fellowship Award
1993-1994 Research Improvements for Minority Institutions (RIMI) Pre-doctoral Fellowship
Trainees
Graduate Students
2004-Present Kimberly Korwek, B.A.; Hiram College
2005-Present Richard Gustin, B.S. University of Miami
2006-Present Nicole Speed, B.S. SUNY, Albany
Undergraduate Students
2004-2005 Courtney Young, Summer Neuroscience Apprentice Program (SNAP)
2005-2006 Karen Harris, Savannah State., Initiative for Minority Student Development (IMSD)
Other Trainees
2002-2003 Grace Cortez-Jackson, M.D. Baylor College of Medicine. MD research Track Program.
Current position: Resident in Pathology, UTMB.
2005-Present Lisa Zhao, B.S.; UCLA, Med Scholar Program
Post Doctoral Fellows
2004-Present Shenfeng Qiu, Ph.D. University of California, Riverside, CA.
2006 Jessica Banko, Ph.D. Baylor College of Medicine, Houston, TX.
Current position: Assistant Director for Sponsored Research,
Vanderbilt University, Nashville, TN
PH.D. Dissertation Committees Graduated
Nicholas Trotta Dept. of Biological Sciences, Vanderbilt University Ph.D. 2005
Jennifer Edl Dept. of Pharmacology, Vanderbilt University
Jana Shirey Dept. of Pharmacology, Vanderbilt University
Liza Nikandrova Dept. of Mol. Phys., Vanderbilt University
Ashleigh Long Biological Sciences, Vanderbilt University
Heather Gosnell Dept. of Mol. Phys., Vanderbilt University
Angela Shields Dept. of Mol. Phys., Vanderbilt University
Elizabeth Haldeman Neuroscience, Vanderbilt University
Mica Bergman Neuroscience, Vanderbilt University
Adeola Pratt Neuroscience, Vanderbilt University
Teaching Experience
Undergraduate
1997 Laboratory Instructor, Microbiology (352), University of New Mexico
1996 Lecturer, Microbiology (350), University of New Mexico
1996-1997 Laboratory Instructor, Microbiology (238), University of New Mexico
Graduate
2006 Coordinator Graduate Student Seminar Series
2005-2006 Instructor, Neuroscience Foundations (325), Vanderbilt University Medical Center
2005-2006 Course Director, Graduate Tutorials (MPB324), Vanderbilt University Medical Center
2005-2006 Lecturer, Cellular and Molecular Neuroscience (345), Vanderbilt University Medical Center
2004-2006 Lecturer, Systems and Integrative Neuroscience (340), Vanderbilt University Medical Center
2004 Lecturer, Molecular Mechanisms of Learning and Memory, Baylor College of Medicine
Professional Membership
American Academy for the Advancement of Science (AAAS)
American Society for Neurochemistry (ASN)
Molecular and Cellular Cognition Society
Society for Neuroscience (SFN)
Society for the Advancement of Chicanos and Native Americans in Science (SACNAS)
National Scientific Participation
Editorial Board: Molecular Neurodegeneration
Editorial Board: International Archives of Bioscience
NINDS Special Study Section grant reviewer
UK Medical Research Council (MRC) grant reviewer
U.S. Civilian Research and Development Foundation (CRDF) grant reviewer
Alzheimer’s Disease Research Grants Program grant reviewer
Manuscript Referee for:
· Brain Research
· Behavioral Brain Research
· Current Opinion in Neuroscience
· EMBO
· Hippocampus
· Journal of Comparative Neurology
· Journal of Neurochemistry
· Journal of Neurophysiology
· Journal of Neuroscience
· Journal of Neuroscience Methods
· Journal of Neuroscience Research
· Journal of Physiology
· Learning and Memory
· Molecular and Cellular Biology
· Nature Neuroscience Reviews
· Neuroscience and Biobehavioral Reviews
· Neuropsychopharmacology
· Neurobiology of Learning and Memory
· Pharmacology, Biochemistry and Behavior
· Psychopharmacology
· Synapse
Presentations:
2000 “Disregulation of CamKII in Angelman Human Mental Retardation Syndrome”
Society for Neuroscience National Conference, New Orleans, LA.
2001 “Modulation of Synaptic Function by Omega 3 Fatty Acids”
Society for Neuroscience National Conference, San Diego, CA.
2003 “Angelman Human Mental Retardation Syndrome: From Mouse Models to Molecular Mechanisms” The Gladstone Institute of Neurological Disease, San Francisco, CA.
“The Emerging Role of Lipoprotein Receptors in Synaptic Function and Memory Processes” Vanderbilt University, Nashville, TN.
“Lipoprotein receptors: Insights into the Memory Loss and Pathology Associated with Alzheimer’s Disease” Learning and Memory Conference, Cold Spring Harbor, NY.
“ApoER2 and VLDLR Receptors in Hippocampal Function and Memory Formation”
UTSW at Dallas, Dallas, TX.
“ApoE Receptors and Human Cognition: A Missing Piece of the Alzheimer’s Disease Puzzle?” The Huffington Center on Aging, Baylor College of Medicine, Houston, TX.
“Reelin Receptors, Synaptic Function and Schizophrenia”
Maryland Psychiatric Research Center, Baltimore MD.
2004 “ApoE in Alzheimer’s Disease”
3rd annual Alzheimer’s Disease Consortium, League City, TX.
“Discrete Reelin Signaling Involves Differential Splicing and Direct Coupling to NMDA Receptors” Spring Hippocampal Research Conference, Grand Cayman, BWI
“ApoE and Alzheimer’s Disease” Minisymposium, Society for Neuroscience National Conference, San Diego, CA.
2005 “Consequences of Diminished Reelin Signaling on Adult Synaptic Transmission and Plasticity”, Spring Hippocampal Conference, Sedona, AZ
2006 “The Role of Reelin in Synaptic Function and Dysfunction; a Matter of Development, or Signaling?” NIH/NIEHS, Raleigh, NC.
“Reelin signaling and Schizophrenia; from mouse models to molecular mechanisms.”
University of New Mexico, Albuquerque, NM.
“Alterations in CaMKII Phosphorylation can Rescue the Cognitive and Synaptic Plasticity Defects in a Mouse Model for Angelman Syndrome Human” Epigenetics & Neural Developmental Disorders conference, Washington D.C.
"Reelin, cognition and schizophrenia: Uncovering the truth about the ‘axons of evil’"
Georgetown University, Washington, D.C.
Research Support:
Prior Support:
1999-2001 Research Supplement for underrepresented minorities. Parent Grant: NINDS, “Regulation of Neuronal Excitability” (1 PO NS37444-01A1) Post Doctoral Research
2003-2004 Cynthia and George Mitchell Awards in Dementia Research (PI: E.J. Weeber)
“The Relationship between APP and Apolipoprotein Receptors in Adult Hippocampal Function”
7/03-6/05 American Federation for Aging Research
“The Role of ApoE Receptors in Hippocampal-Dependent Synaptic Function”
7/04-6/06 National Alliance for Research on Schizophrenia and Depression (NARSAD)
“Reelin-dependent alterations in Schizophrenia”
Current Support:
7/04-6/09 National Institutes on Aging 1 R01 AG022574-01 A1
“Mechanisms of Reelin signaling in the Adult Hippocampus”
Publications: 1-37
1. A. M. Allan, E. J. Weeber, D. D. Savage, and K. K. Caldwell, "Effects of prenatal ethanol exposure on phospholipase C-beta 1 and phospholipase A2 in hippocampus and medial frontal cortex of adult rat offspring," Alcohol Clin Exp Res 21(8), 1534-1541 (1997).
2. E. J. Weeber, C. M. Atkins, J. C. Selcher, A. W. Varga, B. Mirnikjoo, R. Paylor, M. Leitges, and J. D. Sweatt, "A role for the beta isoform of protein kinase C in fear conditioning," J Neurosci 20(16), 5906-5914 (2000).
3. K. T. Dineley, E. J. Weeber, C. Atkins, J. P. Adams, A. E. Anderson, and J. D. Sweatt, "Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination," J Neurochem 77(4), 961-971 (2001).
4. B. Mirnikjoo, S. E. Brown, H. F. Kim, L. B. Marangell, J. D. Sweatt, and E. J. Weeber, "Protein kinase inhibition by omega-3 fatty acids," J Biol Chem 276(14), 10888-10896 (2001).
5. H. F. Seung Kim, E. J. Weeber, J. D. Sweatt, A. L. Stoll, and L. B. Marangell, "Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro," Mol Psychiatry 6(2), 246-248 (2001).
6. E. J. Weeber, D. D. Savage, R. J. Sutherland, and K. K. Caldwell, "Fear conditioning-induced alterations of phospholipase C-beta1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex," Neurobiol Learn Mem 76(2), 151-182 (2001).
7. Y. Gu, K. L. McIlwain, E. J. Weeber, T. Yamagata, B. Xu, B. A. Antalffy, C. Reyes, L. Yuva-Paylor, D. Armstrong, H. Zoghbi, J. D. Sweatt, R. Paylor, and D. L. Nelson, "Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice," J Neurosci 22(7), 2753-2763 (2002).
8. J. M. Levenson, E. J. Weeber, J. D. Sweatt, and A. Eskin, "Glutamate uptake in synaptic plasticity: from mollusc to mammal," Curr Mol Med 2(7), 593-603 (2002).
9. J. Levenson, E. Weeber, J. C. Selcher, L. S. Kategaya, J. D. Sweatt, and A. Eskin, "Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake," Nat Neurosci 5(2), 155-161 (2002).
10. J. C. Selcher, E. J. Weeber, A. W. Varga, J. D. Sweatt, and M. Swank, "Protein kinase signal transduction cascades in mammalian associative conditioning," Neuroscientist 8(2), 122-131 (2002).
11. K. Watase, E. J. Weeber, B. Xu, B. Antalffy, L. Yuva-Paylor, K. Hashimoto, M. Kano, R. Atkinson, Y. Sun, D. L. Armstrong, J. D. Sweatt, H. T. Orr, R. Paylor, and H. Y. Zoghbi, "A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration," Neuron 34(6), 905-919 (2002).
12. E. J. Weeber, J. M. Levenson, and J. D. Sweatt, "Molecular genetics of human cognition," Mol Interv 2(6), 376-391, 339 (2002).
13. E. J. Weeber, U. Beffert, C. Jones, J. M. Christian, E. Forster, J. D. Sweatt, and J. Herz, "Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning," J Biol Chem 277(42), 39944-39952 (2002).
14. E. J. Weeber, M. Levy, M. J. Sampson, K. Anflous, D. L. Armstrong, S. E. Brown, J. D. Sweatt, and W. J. Craigen, "The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity," J Biol Chem 277(21), 18891-18897 (2002).
15. E. J. Weeber and J. D. Sweatt, "Molecular neurobiology of human cognition," Neuron 33(6), 845-848 (2002).
16. C. S. Chan, E. J. Weeber, S. Kurup, J. D. Sweatt, and R. L. Davis, "Integrin requirement for hippocampal synaptic plasticity and spatial memory," J Neurosci 23(18), 7107-7116 (2003).
17. T. J. Hendricks, D. V. Fyodorov, L. J. Wegman, N. B. Lelutiu, E. A. Pehek, B. Yamamoto, J. Silver, E. J. Weeber, J. D. Sweatt, and E. S. Deneris, "Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior," Neuron 37(2), 233-247 (2003).
18. J. C. Selcher, E. J. Weeber, J. Christian, T. Nekrasova, G. E. Landreth, and J. D. Sweatt, "A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1," Learn Mem 10(1), 26-39 (2003).
19. J. D. Sweatt, E. J. Weeber, and P. J. Lombroso, "Genetics of childhood disorders: LI. Learning and memory, Part 4: Human cognitive disorders and the ras/ERK/CREB pathway," J Am Acad Child Adolesc Psychiatry 42(6), 741-744 (2003).
20. J. D. Sweatt and E. J. Weeber, "Genetics of childhood disorders: LII. Learning and memory, part 5: human cognitive disorders and the ras/ERK/CREB pathway," J Am Acad Child Adolesc Psychiatry 42(7), 873-876 (2003).
21. E. J. Weeber, Y. H. Jiang, Y. Elgersma, A. W. Varga, Y. Carrasquillo, S. E. Brown, J. M. Christian, B. Mirnikjoo, A. Silva, A. L. Beaudet, and J. D. Sweatt, "Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome," J Neurosci 23(7), 2634-2644 (2003).
22. S. Y. Yoo, M. E. Pennesi, E. J. Weeber, B. Xu, R. Atkinson, S. Chen, D. L. Armstrong, S. M. Wu, J. D. Sweatt, and H. Y. Zoghbi, "SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity," Neuron 37(3), 383-401 (2003).
23. U. Beffert, E. J. Weeber, G. Morfini, J. Ko, S. T. Brady, L. H. Tsai, J. D. Sweatt, and J. Herz, "Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission," J Neurosci 24(8), 1897-1906 (2004).
24. P. Marschang, J. Brich, E. J. Weeber, J. D. Sweatt, J. M. Shelton, J. A. Richardson, R. E. Hammer, and J. Herz, "Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1," Mol Cell Biol 24(9), 3782-3793 (2004).
25. P. May, A. Rohlmann, H. H. Bock, K. Zurhove, J. D. Marth, E. D. Schomburg, J. L. Noebels, U. Beffert, J. D. Sweatt, E. J. Weeber, and J. Herz, "Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice," Mol Cell Biol 24(20), 8872-8883 (2004).
26. P. Opal, J. J. Garcia, A. E. McCall, B. Xu, E. J. Weeber, J. D. Sweatt, H. T. Orr, and H. Y. Zoghbi, "Generation and characterization of LANP/pp32 null mice," Mol Cell Biol 24(8), 3140-3149 (2004).
27. V. Strasser, D. Fasching, C. Hauser, H. Mayer, H. H. Bock, T. Hiesberger, J. Herz, E. J. Weeber, J. D. Sweatt, A. Pramatarova, B. Howell, W. J. Schneider, and J. Nimpf, "Receptor clustering is involved in Reelin signaling," Mol Cell Biol 24(3), 1378-1386 (2004).
28. E. J. Weeber and K. K. Caldwell, "Delay fear conditioning modifies phospholipase C-beta 1a signaling in the hippocampus and frontal cortex," Pharmacol Biochem Behav 78(1), 155-164 (2004).
29. U. Beffert, E. J. Weeber, A. Durudas, S. Qiu, I. Masiulis, J. D. Sweatt, W. P. Li, G. Adelmann, M. Frotscher, R. E. Hammer, and J. Herz, "Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2," Neuron 47(4), 567-579 (2005).
30. M. Sinagra, D. Verrier, D. Frankova, K. M. Korwek, J. Blahos, E. J. Weeber, O. J. Manzoni, and P. Chavis, "Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro," J Neurosci 25(26), 6127-6136 (2005).
31. U. Beffert, A. Durudas, E. J. Weeber, P. C. Stolt, K. M. Giehl, J. D. Sweatt, R. E. Hammer, and J. Herz, "Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity," J Neurosci 26(7), 2041-2052 (2006).
32. C. S. Chan, E. J. Weeber, L. Zong, E. Fuchs, J. D. Sweatt, and R. L. Davis, "Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory," J Neurosci 26(1), 223-232 (2006).