Supplementary Table1 Comparison of the prevalence between complete cases and imputations
Pre-imputation(complete cases 1027) / Post imputation (n=1566)Mean(SD)
Age at SOLAR II / 21.7(0.74) / 21.8(0.74)
Age at ISAAC Phase II / 9.6(0.53) / 9.6(0.54)
N (%)
Sex(Female) / 601(58.5) / 921(58.8)
Centre (Munich) / 491(47.8) / 753(48.1)
SES (high)* / 617(60.1) / 928(59.3)
Educational level (high)** / 680(66.2) / 1003(64.0)
Smoking at the time of hire(current)¶ / 340(33.1) / 523(33.4)
Parental history of (yes)
AD / 192(18.7) / 320(20.4)
AR / 372(36.2) / 597(38.1)
Asthma / 115(11.2) / 182(11.6)
Asthma symptoms at ISAAC Phase II(yes) / 110(10.7) / 177(11.3)
AR symptoms at ISAAC Phase II(yes) / 148(14.4) / 230(14.7)
AD at ISAAC Phase II(yes) / 100(9.7) / 162(10.3)
AD at SOLAR I(yes) / 118(11.5) / 187(11.9)
Pre-hire-onset AD (yes) / 128(12.5) / 207(13.2)
Occupational exposure(high-risk) / 246(24.0) / 396(25.3)
Positive SPT / 249(24.2) / 388(24.8)
Received job counselling / 108(10.5) / 159(10.2)
AD=Atopic dermatitis, AR=Allergic rhinitis, SD=Standard deviation, SES=Socioeconomic status, SPT=Skin prick test
*High SES is defined as at least one parent with ≥12 years of schooling
**High level of education means having qualified for university entrance
¶Current smoker was deemed as smoked≥ 20 packs of cigarettes in a lifetime, or≥ one cigarettes per day or one cigar per week for a year
Supplementary Table 2 Comparison of the prevalence between complete cases and imputations for subjects who ever worked in high-risk jobs
Mean(SD)
Age at baseline / 9.6(0.53) / 9.6(0.54)
Age at SOLAR II / 21.7(0.73) / 21.8(0.72)
N (%)
Sex(Female) / 424(68.3) / 427(68.1)
Centre(Munich) / 281(45.2) / 284(45.3)
SES (high)* / 366(58.9) / 373(59.5)
Educational level (high)** / 385(62.0) / 389(62.0)
Smoking status¶ at time of hire
Non-smoker / 70(11.3) / 71(11.3)
Current smoker / 257(41,4) / 263(41.9)
Parental history of (yes)
AD / 108(17.4) / 127(20.3)
AR / 229(36.9) / 252(40.2)
AD status (yes) / 76(12.2) / 80(12.8)
Preventive measures (yes) / 525 / 530(84.5)
Positive SPT / 114(18.4) / 144(23.0)
Received job counselling / 84(13.5) / 84(13.4)
AD=Atopic dermatitis, AR=Allergic rhinitis, SD=Standard deviation, SES=Socioeconomic status, SPT=Skin prick test
*High SES is defined as at least one parent with ≥12 years of schooling
**High level of education means having qualified for university entrance
¶Non-current smoker was deemed as smoked≥ 20 packs of cigarettes in a lifetime, or≥ one cigarettes per day or one cigar per week for a year but was not smoking within the last month; Current smoker was identical with non-current smoker but smoked in the last month
Supplementary Table 3 Descriptions of the study population of vocational training in high-risk occupations (234 complete cases)
No / Yes
Subjects (n) / 234 / 27 / 207
Mean±(SD)
Age at ISAAC Phase II / 9.6±0.57 / 9.7±0.53 / 9.6±0.57 / 0.15*
Age at SOLAR II / 21.9±0.73 / 22.0±0.7 / 21.9±0.73 / 0.22*
N (%)
Sex (Female) / 174(74.4) / 15(55.6) / 159(76.8) / 0.03
Study location (Munich) / 75(32.1) / 6(22.2) / 69(33.3) / 0.35
SES (High)** / 100(42.7) / 8(29.6) / 92(44.4) / 0.19
Educational level (High)§ / 75(32.1) / 12(44.4) / 63(30.4) / 0.23
Smoking status¶ at the age of hire / 0.40†
Never/Irregular / 89(38.0) / 8(29.6) / 81(39.1)
Non-smoker / 28(12.0) / 2(7.4) / 26(12.6)
Current smoker / 116(49.6) / 17(63.0) / 99(47.8)
Parental history of:
AD / 42(17.9) / 2(7.4) / 40(19.3) / 0.12†
Allergic rhinitis / 83(35.5) / 6(22.2) / 77(37.2) / 0.10
AD status (yes) / 30(12.8) / 2(7.4) / 28(13.5) / 0.54†
Positive SPT / 54(23.1) / 7 (25.9) / 47(22.7) / 0.96
Received job counselling / 57(24.4) / 5(18.5) / 52(25.1) / 0.61
AD=Atopic dermatitis, AR=Allergic rhinitis, SD=Standard deviation, SES=Socioeconomic status, SPT=Skin prick test
*P-value is Mann-Whitney U test
†P-value from Fisher’s exact test
**High SES was defined as at least one parent with ≥12 years of schooling
§High education level was defined as having qualified for university entrance
¶Never/irregular smoker was deemed as smoked< 20 packs of cigarettes in a lifetime, or< one cigarette per day or one cigar per week for a year; Non-current smoker was deemed as smoked≥ 20 packs of cigarettes in a lifetime, or≥ one cigarettes per day or one cigar per week for a year but was not smoking within the last month; Current smoker was identical with non-current smoker but smoked in the last month
Supplementary Table 4 Associations between subjects with AD in high-risk jobs and preventive measure usage among vocational trainees (n=234)
Preventive measure usageOR (95% CI) / Multivariate OR (95% CI)
Sex (Female) / 2.65(1.14-6.04) / 3.63(1.41-9.51)
Study location (Munich) / 1.75(0.71-4.95)
SES (high)* / 1.93(0.84-4.87)
Education level (high)** / 0.65(0.25-1.28)
Parental history of
AD / 3.26(0.91-20.88) / 3.25(0.81-22.2)
AR / 2.42(0.98-6.88) / 1.69(0.60-5.54)
Subject with AD (yes) / 1.36(0.84-2.20) / 1.26(0.31-8.56)
Positive SPT / 0.87(0.35-2.35)
Received job counselling / 1.48(0.57-4.58) / 2.04(0.68-7.68)
AD=Atopic dermatitis, AR=Allergic rhinitis, OR=Odds ratio, CI=Confidence interval, SES=Socioeconomic status, SPT=Skin prick test
*High SES is defined as at least one parent with ≥12 years of schooling
**High level of education means having qualified for university entrance
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