Non-Occupational Post-Exposure Prophylaxis (Npep) Infographic

Non-occupational Post-Exposure Prophylaxis (nPEP) Infographic

What is PEP?
PEP is the use of antiretroviral drugs after a single high-risk eventto prevent HIV seroconversion

Sexual HIV Acquiring Risks
Unprotected (no condom and no PrEP) vaginal assault or intercourse with known PLWH or someone of unknown status
Unprotected rectal assault or intercourse with known PLWH or someone of unknown status

Common Reasons Providers Give for Not Prescribing PEP
Concern of drug side effects
Concern of drug resistance: there is a potential risk of drug resistance with poor PEP adherence and HIV exposure

Perception of “Low-risk” exposure including providers in lower-prevalence communities
No or limited health insurance
Lack of knowledge of PEP guidelines

Key Concepts
Evaluate persons rapidly for PEP when care is sought ≤72 hours after a potential exposure that presents a substantial risk for HIV acquisition
Early initiation of PEP is essential (i.e., as soon as possible after the exposure but not later than 72 hours after the exposure)
Do an HIV test before initiating PEP (if rapid testing not possible, send blood to lab and initiate PEP immediately – follow-up with results and patient asap stopping PEP only if test result is confirmed positive)
All persons offered PEP should be prescribed a 28-day course of a 3-drug antiretroviral regimen, and given the first dose ON SITE ASAP after the exposure
Adherence to recommended dosing for 28 days without interruption is essential
Providers should emphasize that severe adverse effects are rare from PEP, but review possible side effects and reinforce limitedness of such effects
Follow-up is important for additional counseling and monitoring

Post-Exposure Prophylaxis Hotline (PEPline):

888-HIV-4911 (888-448-4911)from9:00 AM - 9:00 PM ET, 7 days/week