Supplemental Data. Wolfenstetter Et Al. (2012). Plant Cell 10.1105/Tpc.111.090415

Supplemental Data. Wolfenstetter et al. (2012). Plant Cell 10.1105/tpc.111.090415

Supplemental Data Set 1

19 1320

Hs AP3-D1 ------M ALKMVKGSID RMFDKNLQDL VRGIRNHKED ---EAKYISQ

Hs AP3-D2 ------M ALKMVKGSID RMFDKNLQDL VRGIRNHKED ---EAKYISQ

Hs AP3-B1 -----MSSNS FPYNEQSGGG EATELGQEAT STISPSGAFG ---LFSSDLK

Hs AP3-B2 ------MSAA PAYSEDKGG- -SAGPGEPEY GHDPASG--G ---IFSSDYK

At AP4-B ------MAPPAASQRY PSPSQPSGKS ---EVSDLKT

Hs AP4-B1 ------MPYLGSE------DVVKE

At4g11380 ------MSGHDS KYFSTTK------KG

At4g23460 ------MSGHDS KYFSTTK------KG

Hs AP2-B1 ------MT--DS KYFTTNK------KG

Hs AP1-B1 ------MT--DS KYFTTTK------KG

Sc AP1-B ------MPPLDKRIK KFLKDSIRIA ---PKISGKG

At COP-B1 ------MDKSST MLVHYDKG------TPA

At COP-B2 ------MDKSST MLVHYDKG------TPA

Sc AP3-D2 MTSLYAPGAE DIRQRLRPFG FFFEKSLKDL IKGIRSHNET PEKLDQFFKQ

Sc AP3-B ------MV DSIHRIASAL DTAKVITREA AAVATSKLGE SSYTYYSQNI

Sc AP2-B ------MSDQKV FARYKAN------EIVT

At AP3-B ------

At AP1-G1 ----MEQLKT IGRELAMGSQ GGFGQSKEFL DLVKSIGEAR SKAEEDRIVL

Sc AP1-G1 ------MGSSLR SFIKDVRGAK TLADERAIIT

CIDEIKQELK QDNIAVKANA VCKLTYLQML ---GYDISWA AFNIIEVMSA

KNEDLKQMLE SNKDSAKLDA MKRIVGMIAK ---GKNASEL FPAVVKNVAS

RHDDLKEMLD TNKDSLKLEA MKRIVAMIAR ---GKNASDL FPAVVKNVAC

QLRQLAGSRA PGVDDSKRDL YKKVISYMTI ---GIDVSSV FGEMVMCSAT

LKKALCNPHI QADRLRYRNV IQRVIRYMTQ ---GLDMSGV FMEMVKASAT

EIPELKEELN SQYKDKRKDA VKKVIAAMTV ---GKDVSSL FTDVVNCMQT

EIFELKAELN NEKKEKRKEA VKKVIAAMTV ---GKDVSSL FPDVVNCMQT

EIFELKAELN SDKKEKKKEA VKKVIASMTV ---GKDVSAL FPDVVNCMQT

ELSELRTGLV SQYPQTRKDA IKKTIQQMTL ---GKDVSSL FPDVLKNIAT

VANEIKEALE GNDVEAKVDA MKKAIMLLLN ---GETIPQL FITIIRYVLP

VLSECREEVN SPDLNSKTNA VLKLTYLEMY ---GFDMAWC NFHILEVMSS

NPQQLVTLLN SRNSREVRDA MKRIISIMAS DDDSIDVQLY FADVVKNITT

DLQHFGVKKF KSNITRRKNA LRKIIANLVL G-NYGEMSVL FSELLKFWQI

-MAGIRLHVI APLALAAVSK CARDPAVYVR ----RCAANA LPKLHDLRLE

SEVDILKRRL LEPDIPKRKM KEYIIRLVYI EMLGHDASFG YIYAVKMTHD

KQSAKIRTKL RDDHLPHEKR RVNIQKLLYL YILGEKTHFG QVESINLIAS

-SKFTFKRIG YLAASQSFHE GTD-----VI MLTTNQIRKD LSSP---SQY

-KNIEIKKLV YVYLVRYAEE QQD-----LA LLSISTFQRA LKDP---NQL

-KNIEVKKLV YVYLVRYAEE QQD-----LA LLSISTFQRG LKDP---NQL

-SDIVLKKMC YLYVGNYAKG NPD-----LS LLTINFLQRD CKDE---DPM

-VDIVQKKLV YLYMCTYAPL KPD-----LA LLAINTLCKD CSDP---NPM

-ENLELKKLV YLYLINYAKS QPD-----LA ILAVNTFVKD SQDP---NPL

-DNLELKKLV YLYLMNYAKS QPD-----MA IMAVNSFVKD CEDP---NPL

-DNLELKKLV YLYLMNYAKS QPD-----MA IMAVNTFVKD CEDP---NPL

-IDVEQKKLV YLYVMNYAET HPE-----LC ILAVNTFITD AQDP---NPL

SEDHTIQKLL LLYLELIEKT DSKGKVLPEM ILICQNLRNN LQHP---NEY

-NKLQQKRVG YLAASQSFYK DSD-----IL MLATNLLKKD LKYDGNNDVV

-NDTKVKRLI HLYLLRFAEN DPN-----LT LLSINSLQKS LSDS---NSE

EDDLEVKRIC HEYIRVIGAL KPQ-----QA REALPFIMDD FKSR---DEK

EHASAIEELV GILLNDHSPG VVG------AAAAAFTSI CPNN----FK

-DNLLLKRTG YLAVTLFLNE DHD-----LI ILIVNTIQKD LRSD---NYL

-DDFVDKRLG YLAATLLLDE SED-----LL TLLTNMLNND LHHP---NKY

DTGVALTGLS CFVTPDLAR- --DLANDIMT LMS-HTKPYI RKKA------

DTGVALTGLS CFVTPDLAR- --DLANDIMT LMS-HTKPYI RKKAVLIMYK

IRASALRVLS SIRVPIIVP- --IMMLAIKE ASA-DLSPYV RKNAA-----

IRASALRVLS SIRVPIIVP- --IMMLAIKE AAS-DMSPYV RKTAA-----

IRGLALRSLC SLRVPNLVE- --YLVGPLGS GLK-DNNSYV RTIAV-----

VRGLALRSMC SLRMPGVQE- --YIQQPILN GLR-DKASYV RRVAV-----

IRALAVRTMG CIRVDKITE- --YLCDPLQK CLK-DDDPYV RKTAA-----

IRALAVRTMG CIRVDKITE- --YLCEPLRK CLK-DEDPYV RKTAA-----

IRCMAIRTMS MIRVDKILE- --YIETPLRR TLH-DDNAYV RKTAV-----

IRGVTLRFLC RMKETEIVE- --PLTPSVLQ NLE-HRHPFV RRNAI-----

KVGIALSGLS TIITPSLAR- --DIADDLFT MLN-STRPYI RKKAIT----

LRCFALSALS DMKMSSLAP- --IILHTVKK LVT-DPSAMV RGEVA-----

LQIMALRTLV LVPVKELSD- --QAFDCIIS LVN-HKSPPE QVTRT-----

LIGKNYKKLC QILPDVEEWG QILLIGTLLR YVV-ARHG-L VRES------

VVCAALNAIC RLINEETIP- --AVLPQVVE LLN-HQKEAV RKKAI-----

AVSLALTSLG FLSSPELAR- --DLYPDVEN IIKNSRDPFL LKKAL-----

------

VFLKYPESLR PAFPRLKEKL EDPDPGVQSA AVNVICELAR RNPKNYLSLA

------

------KLIEP LTNLIHSTSA

PLFFKLMTSS TNNWVLIKII KLFGALTPLE PRLGKKLIEP LTNLIHSTSA

------HAIQK LYSLDPE--Q

------HAIPK LYSLDSD--Q

------TGVLK LYHISPSTCI

------LGCAK MHNLHGDSEV

------ICVAK LFDINAELVE

------VCVAK LHDINAQMVE

------VCVAK LHDINAQLVE

------ICVAK LFQLNKDLCV

------LAIMS IYKLPQGDQL

------LAIMS IYKLPHGDQL

------AL FKVFLQYPEA

------LAIIK LYRAGKN-DY

------AIYAL LDLDEIDHER

------LMLSI HGTNSNGFCE

------MAL HRFHRKSPSS

------QCAAK LIFKDVSLLE

MSLLYECVNT VIAV-LISLS SGMPNHSASI QLCVQKLRIL IE-DSDQNLK

KEMLIEVIEK LLK--DKSTL VAGSVVMAFE EVCPD------RI

KDQLIEVIEK LLA--DKTTL VAGSVVMAFE EVCPE------RI

DADFPATLKS LMLH-DSDAQ VVANCLSALQ EIWSLEASHS EE-ACREKES

DGALVNELYS LLR--DQDPI VVVNCLRSLE EILKQEG------GV

DRGFLEALKD LIS--DNNPM VVANAVAALA EIQE--NSSS P------IF

DRGFLEALKD LIS--DNNPM VVANAVAALA EIQE--NSTS P------IF

DQGFLDSLRD LIA--DSNPM VVANAVAALS EISES-HPNS N------LL

DQGFLDTLKD LIS--DSNPM VVANAVAALS EIAES-HPSS N------LL

ELGVVEDLVN ALD--DSNPL VIANATAALI EIHNMDMDAV D------LS

FVDAPEMIEK VLST-EQDPS AKRNAFLMLF TCAEE------

LRDNFDKFVS KLD--DDDIS VVSAAVSVIC ELSKK------NPQ

HEELLDILKE LMA--DTDPK VISCAVLAYK ECYAD------HL

VLGLSSILHD IVKAQSSSPE VIVAALHTLY SIHEKNANME P------F

KDGLGRDLTL DKEDGGKSDS FDVNLVSLVS KCYIQ------

VSHLVSNFRK RLCD--NDPG VMGATLCPLF DLISEDVNSY KD-LVSSFVS

IFNIEDITKI LSSHSICTHG VLLGVTKIIQ SILLIGLNRK KDEDEDEDGI

YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA LDLLYG----

DLIHKNYRKL CNLLVDVEEW GQVVIIHMLT RYARTQFVSP WKEGDELEDN

DLIHKNYRKL CNLLIDVEEW GQVVIISMLT RYARTQFLSP TQNESLLEEN

LLSKPVIYYF LNRIKEFNEW AQCLILELAV KYV------

VINKPIAHHL LNRMSKLDQW GQAEVLNFLL RYQ------

EINSTTLTKL LTALNECTEW GQVFILDALS KYK------

EINSTILTKL LTALNECTEW GQVFILDALS RYK------

DLNPQNINKL LTALNECTEW GQIFILDCLS NYN------

DLNPQSINKL LTALNECTEW GQIFILDCLA NYM------

SLIQSHVSQF LLALNECTEW ARIIILGTLS EYS------

----RAVNYL LSNVDKVSDW NESLQMVVLE LIR------

PFIQLSPLLY EILVTIDNNW IIIRLLKLFT NLS------

ELLHGHFRRY CRIIKQLDSW SQSYLIELLI KYCKQYLPKP TVVDKS----

RIPLELAFDM LELLPELNEW NKATVLEVLT TSV------

------GPDEYL SRSSCTDTVS SAF------

ILKQVTERRL PKSYDYHQMP APFIQIKLLK IMALLG------

DYSNDILSPL SLLLRDFFIR LENMNSKNIE PGYDVQGICD PFLQCEIIYT

-----MVSKK NLMEIVKKLM THVDKAEGTT YRDELLTKII DICSQSNYQY

G-KNFYESDD DQKEKTDKK------KK PYTMDPDHRL LIRNTKPLLQ

AEKAFYGSEE DEAKGAGSEE TAAAAAPSRK PYVMDPDHRL LLRNTKPLLQ

------PSDS NDIFDIMNL------LEDRL QHANGAVVLA

------PRSE EELFDILNL------LDSFL KSSSPGVVMG

------AADP REAENIVER------VTPRL QHANCAVVLS

------ASDP REAENIVER------VTPRL QHANCAVVLS

------PKDD REAQSICER------VTPRL SHANSAVVLS

------AKDS LEAQDIIDR------VTAHL QHVNPAVVLA

---SVCKTKP AEKGKYIKI------IISLL SATSSAVIYE

------QVEP KLRAKLLPK------ILELME STVATSVIYE

------SEGS PRSCPLPDKY NEIEYPSYEV VNDPDLDLFL QSLNCLIYSS

-----VPQHY LDTHEMIEL------ALPYL QQVNTYVVLN

------DT KETTSIAHN------EDVKI LLQCTSPLLW

------SGD KNASDIMSMV ------LGDLF RKCDSSTNIG

LKLYFQVGEL LNSNNVLDYK DN------FCDLLT RIATNTDSTK

ITNFEWYISI LVELTRLEGT RHGHLIAAQM LDVAIRVKAI --RKFAVSQM

SRNAAVVMAV AQLYWHISPK SEAGIISKSL VRLLRSNREV --QYIVLQNI

SRSAAVVMAV AQLYFHLAPK AEVGVIAKAL VRLLRSHSEV --QYVVLQNV

TVKVFLQLTL SMTD--VHQQ VYERIKSPLL TLVSSGSPEQ --SYAILSHL

ATKLFLILAK MFPH--VQTD VLVRVKGPLL AACSSESREL --CFVALCHV

AVKMILQQME LITS-TDVIR NLCKKMAPPL VTLLSAEPEI --QYVALRNI

AVKVLMKFLE LLPKDSDYYN MLLKKLAPPL VTLLSGEPEV --QYVALRNI

AVKVLMKFME MLSKDLDYYG TLLKKLAPPL VTLLSAEPEL --QYVALRNI

TIKVIVRNLP QIEY--SSNS LIMKRLSSAF VSLMSTPPEM --QYVALKNI

CAGTLVSLSS APTAIRAAAN TYCQLLLS------QSDNNV --KLILLDRL

SVNCIVKGNM LEED---DFE TAMACLERLH TFCDSQDPNL --RYISCILF

NPTVILSCCN ALYQLASPLQ MKNTKFIEAL VRTVTMTENQ GNKEMLLQAI

SLKFIMYLLN YVDV---IKE TLAEKLSNSV IALLDKPPEL --QFLVLRNV

SNNSAVVLAA AGVQWIMAPL EDVKKIVKPL LFLLRSSSAS --KYVVLCNI

--NAILYECI RCISCILPNP KLLEAAADAI SKFLKSDSHN -LKYMGIDGL

NSGQAILYET VKTIFSLDLN QPLRVLGINI LAKFLAGKDN NTKYVSLNTL

SALLDSA-HL LASSTQRNGI CEVLYAAAWI CGEFSEHLQE PHHTLEAMLR

ATMSIQR-KG MFEPYLKSFY VRSTDP-TMI KTLKLEILTN LANEANIST-

ATMSIKR-RG MFEPYLKSFY IRSTDP-TQI KILKLEVLTN LANETNIPT-

HLLVVRA-PF IFAADYKHFY CQYNEP-SYV KKLKLEMLTA VANESNTYE-

RQILHSL-PG HFSSHYKKFF CSYSEP-HYI KLQKVEVLCE LVNDENVQQ-

NLIVQKR-PT ILAHEIKVFF CKYNDP-IYV KMEKLEIMIK LASDRNIDQ-

NLIVQKR-PE ILKQEIKVFF VKYNDP-IYV KLEKLDIMIR LASQANIAQ-

NLIVQKR-PE ILKHEMKVFF VKYNDP-IYV KLEKLDIMIR LASQANIAQ-

RIILEKY-PE LLTKELRIFY VKFNDP-LYV KLEKIDILVR LVDPSNLKQC

YELKTLH-RD IMVELIIDVL RALSSPNLDI RRKTLDISLD LITHHNINEV

YELKTLH-RD IMVELIIDVL RALSSPNLDI RRKTLDIALD LITHHNINEV

YKIGKIN-TD FISRFDQLII RLLSDVDVSI RSKAIELVEG IVDEDNLKA-

HFLSILD-QT LFLPYTKKFY VFPKDP-IVA SIWKIQILST LINESNVKE-

ILLLLSRESS LLRLDISYFF IEYNDP-IYI KDTKLECLYL LANKETLPR-

LVFAKAV-PS LFAPHFENFF ICSSDA-YQV KAYKLEMLSL IATTSSIAS-

GRLIKIS-PD IAEQHQLAVI DCLEDPDDTL KRKTFELLYK MTKSSNVEVI

LKVVPQE-PT AVQRHRKFIS HCLQDTDVSI RMRALELSFA ILDDSNLVE-

-PRVTTLPGH IQAVYVQNVV KLYASILQQK EQAGEAEGAQ AVTQLMVDRL

--LLREFQTY VK----SQDK QFAAATIQTI GRCATNILEV T--DTCLNGL

--VLREFQTY IR----SMDK DFVAATIQAI GRCATNIGRV R--DTCLNGL

--IVTELCEY AA----NVDI AIARESIRAV GKIALQQYDV N---AIVDRL

--VLEELRGY CT----DVSA DFAQAAIFAI GGIARTYTDQ -----CVQIL

--VLLEFKEY AT----EVDV DFVRKAVRAI GRCAIKLERA --AERCISVL

--VLAELKEY AT----EVDV DFVRKAVRAI GRCAIKVEQS --AERCVSTL

TLLLTELKEY AM----EYEP EFVSRAIQAL SQLGIKYAQE SFVSKVLDIL

VQMLKKEVVK TQSGELEKNG EYRQMLIQAI HACAVKFPEV A--STVVHLL

-IVQTLMKQF VD---EDVVI LQTGSIVYEK SKRIPIIIPE NYKIKMVNVI

--IFKELKYY VAS--AHFPE NVVIMAVKSL SRCGQLSTSW E--SHVMKWL

--ILEELEQY AT----DIDI QMSRKSVRAI GNLAVKLDED S-VHDCVAVL

--ILREFEDY IK----DPDR RFAADTVAAI GLCAKRLMTI P--TTCLDGL

VDRMIDYMIS IN------DN HYKTEIASRC VELAEQFAPS N--QWFIQIM

--LVNELMKF LAKQDEDSKD LIIYTIDHLI DTFDTRVVKD E--SWKLDVF

PQFVQSADLE VQERASC------ILQL VKHIQKLQAK DVPVAEEVSA

VCLLSNRDEI VVAES------VVVI KKLLQMQPAQ HGEIIKHMAK

VQLLSNRDEL VVAES------VVVI KKLLQMQPAQ HGEIIKHLAK

LQFLEMEKDY VTAET------LVLV KDLLRKYPQW SHDCISVVGG

TELLGLRQEH ITTVV------VQTF RDLVWLCPQC TEAVCQALPG

LELIKIKVNY VVQEA------IIVI KDIFRRYPNT YESIIATLCE

LDLIQTKVNY VVQEA------IVVI RDIFRKYPNK YESIIATLCE

LDLIQTKVNY VVQEA------IVVI KDIFRKYPNK YESVIATLCE

LELLERQD-T IKDDC------CISL CDLLRHCP-G NDKMAKQVCA

MDFLGDSNVA SALDV------VVFV REIIETNPKL RVSIITRLLD

ISICSADNYS SVNDFEW------YNAVIM DLAMLCQDIS DKSLGSKIGE

IDHMESHNLS ASVLDAY------VNVI RMLVQKNPTK HLRIIFKLAD

LDLLEFGVDY VVQEI------ISVF RNILRKYPNN FKANVTELVK

LALVRQESFA GDFESADGEA GVLVQAVMSI QTMIERDPLR HEKVLIQLFR

NKVFEHAGDL VNIKVAHN------LMRLIA EGFGEDDDDA DSKLRLSAVE

FNILKLVGSF INYEKIN------DILII INNTSQLSDK SEFLRKMLTI

LFAGELNPVA PK-AQKKVPV PEGLDLDAWI --NEPLSDSE SEDERPRAVF

LLDSITVP------VARA SILWLIGENC --ERVPKIAP DVLRKMAKSF

LTDNIQVP------MARA SILWLIGEYC --EHVPRIAP DVLRKMAKSF

ISSKNIQEP------KAKA ALIWMLGEYA --QDMS-DAP YVLENLIENW

CEEN-IQDS------EGKQ ALIWLLGVHG --ERIP-NAP YVLEDFVENV

SLDTLDEP------EAKA SMIWIIGEYA --ERID-NAD ELLESFLENF

NLDSLDEP------DARA AMIWIVGEYA --ERID-NAD ELLESFLEGF

NLDSLDEP------EARA AMIWIVGEYA --ERID-NAD ELLESFLEGF

VFNTWSNPEV LL-QSDIAKC NYVWLLGQHP --NNFS-DLE SKINIFIENF

TFYQIRAG------KVCP CALWIIGEYC --LSLS-EVE SGISTITQCL

QFRNLMIKVP SMREVTIANI IKLISNDNIN --KQLPTVLR ECIWCLGEFS

LLTVQTSLAD ------NARA GIVWLFGEIA --SIEFKICP DVLRRLIQNF

HTEVVQEP------ESKN AMIWIITQYS --DVIP-NYL ELFRVFSSNM

SLDSIKVA------AARA TIIWMVGVYC SLGHIIPRML TTITKYLAWS

SYLQLISEPK LP---SLFLQ VISWVLGEYG TADGKYSASY ISGKLCDVAD

SLNGTSAEIS EE--NIGWQL VLIWCIGEYG ------D LVLNEGNKNG

HEEEQRRPKH RPSEADEEEL ARRREAR-KQ EQANNPFYI- -KSSPSPQKR

TSED-DLVKL QILNLGAKLY LTNSKQ---T KLLTQYILN- -LGKYDQNYD

TAEE-DIVKL QVINLAAKLY LTNSKQ---T KLLTQYVLS- -LAKYDQNYD

EEEHSAEVRL HLLTAAMKCF FKRAPE--TQ KALGTALAA- -GIAD-FHQD

KSETFPAVKM ELLTALLRLF LSRPAE--CQ DMLGRLLYY- -CIEEEKDMA

PEEP-AQVQL QLLTATVKLF LKKPTEG-PQ QMIQVVLNN- -ATVETDNPD

HDES-TQVQL TLLTAIVKLF LKKPSE--TQ ELVQQVLSL- -ATQDSDNPD

HDES-TQVQL QLLTAIVKLF LKKPTE--TQ ELVQQVLSL- -ATQDSDNPD

VQEE-ALTQM SLLMTIVRLH ATLTGS---- -MLQSVLEL- -ATQQTHELD

GELPFYSVSE ESEPTETSKK IQPTSSA-MV SSRKPVILA- -DGTYATQSA

TLVENGNDLI KIMTENISYY SHSVQEV-LI LALVKVFSN- -WCNNFQEDK

SNEG-PETRC QILVLSAKLL SYDIDN---- -FKQAQVTG- -SEENNQNPP

FSET-LEVQF SILNSAIKFF IRSPTKE-TE ELCMDLLKG- -CIDHENNPD

FKSEASETKL QILNTIAKVL ISAEAGD-FH MLKRIVVYVF ELGEYDLSYD

AYSSDETVKG YAVSALMKIY AFEIASGRKV DVLPECQSLI EELLASHSTD

ADIINESSIT DYLLTLQELY TATNLKIINY ILTAALKLS------VRFH

YQDTPGVEHI PVVQIDLSVP LKVPGLPMSD QYVKLEEERR HRQKLEKDKR

IRDRTRFIRQ LIVP-NVKSG ALSKYAKKIF LAQKPAPLLE SPFKDRDHFQ

IRDRARFTRQ LIVP-SEQGG ALSRHAKKLF LAPKPAPVLE SSFKDRDHFQ

VHDRALFYYR VLQY--DVHV AERVVSPPKQ AVSVFADTQS SEIKDRVFDE

VRDRGLFYYR LLLV--GIDE VKRILCSPK------SDPTL GLLEDPAERP

LRDRAYIYWR LLST--DPEA AKDVVLAEKP VISDDSNQLD PSLLDELLTN

LRDRAYIYWR LLST--DPEA AKDVVLAEKP VITDDSNQLD PSLLDELLAN

LRDRGYIYWR LLST--DPVT AKEVVLSEKP LISEETDLIE PTLLDELICH

LRDRGYIYWR LLST--DPVA AKEVVLAEKP LISEETDLIE PTLLDELICY

VRDMAMMYWR CLSMPNNESL VNDLCQNKLP MISNTLEKFS PEVLEKLLME

ASETTFSSPT VVQGSLTSGN LRALLLTGDF FLGAVVACTL TKLVLRLEEV

RFEIKMVLKE LIEFFENLSY SSTFEVQERS VEVLEFLRLS LEALEEDTEG

YYDFSGSRIS QMYN-----A VLYLAKYDDE FDIRDRARMI SSLFDSGKYE

LRDKTLMYWR LLSLTKTSRI SNAITFESLK SVLDGELPLI EMNTKLDPTV

IRDRTRFLKK LLSCKLASHE PAEDSVASQE NIAAHVVEHV FGRKLKSVSP

LQQRAYELQA LLALDARAVE TILPLDASCE DIEVDKDLSF LNGYIQQAIE

DAKNIEKLRQ LILSYTDSTD LSLQMKSNQY EIFFNQSISV KKIILETMPK

RKKRKEKEKK GKRRHSSLPT ESDEDIAPAQ QVDIVTEEMP ENALPSDEDD

LGTLSHTLNI KATGYLELSN WPEVAPDPSV RNVEVIELAK EWTPAGKAKQ

LGSLSHLLNA KATGYQELPD WPEEAPDPSV RNVEVPEWTK CSN---REKR

FNSLSVIYQK PSYMFTDKEH RGPFEFSDEV GNISITPEAS SDIVPAQQYE

VNSWASDFN------

ISTLSSVYHK PPEAFVTRLK TTVQKTEDED FAEGSEAGY- -SSSNPVDSA

ISTLSSVYHK PPEAFVTRLK TTVQKTEDED YVEGSETGYP EASGNPVDGA

IGSLASVYHK PPNAFVEGSH GIHRKHLPIH HGSTDAGDSP -VGTTTATNL

IGTLASVYHK PPSAFVEGGR GVVHKSLPPR TASSESAESP ETAPTGAPPG

LGTISSIYFK PDSNRRKGKK ------

QSSKTEVNKT VTQALLIMVS MLQLGQSPVS PHPIDNDSYE RIVLCIKLLC

QSSKTEVNKT VSQALLIMVS ILQLGQSPVS PHPIDNDSYE RIMLCIKLLC

LPMLLSEVLP SFFNAYELAP IARGTQLKLA VDENLDLETP FLTKEAADEL

IVSLLLQAPK PTAR------

LEELELNIG------

ITLHNRFYLP GSLSQIVLHA APGYEPLPKP CSFVYEEQDQ LSDLDKQREA

SGAQPYISER ERSGMFETTD YHPQDHHEVP THALRFEAYE LPKPS-----

FEKITEEQDN GK------

KDPNDPYRAL DIDLDKPLAD SEKLPIQKHR NTETSKSPEK DVPMVEKKSK

ENSAKKFYSE SEE------EEDSSDSS- SDSESESGSE

KEKEKPFYSD SEG------ESGPTESAD SDPESESESD

ANDKDLLLGI DEK------

-----TLVPV YGK------

ASPPGNIPQP SGR------Q PAPAVPAPVP DLLG----DL

ASPSATTGYV T------KLAAAPAPVP DLLG----DL

EQPQVIPSQG DLLGDLLNLD LGPPVNVP-- QVSSMQMGAV DLLGGGLDSL

EQPDVIPAQG DLLGDLLNLD LGPPVSGPPL ATSSVQMGAV DLLGGGLDSL

------

HRNDEMKKIW LES------

HRNVEMKKIW LES------

LDEQKSDAIS DLMS------

------

AADLDGSEES SETGD------ENGSSDYDSE SSNGSDFSSE

------

KPKKKEKKHK EKERDKEKKK EKEKKAEDLD FWLSTTPPPA PAPAPAPVPS

KPKKKEKKHK EKERDKEKKK EKEK------

SGEQGESGEE GDSNEDSSED SSSEQDSE------SGRESG

SKSSSESG-- --SGESSSES DNEDQDED------EEKGRG

------

MGL------DN AAIVP------

MGS------DN AAIVP------

VGQSFIPSSV PAT-FAPSPT PAVVS------SG

MGD--EPEGI GGTNFVAPPT AAVPANLG------APIGSG

------

GDERTVSN------DA

------

TDECEDAKTE AQGEEDDAEG QDQDKKSPKP KKKKHRKEKE ERTKGKKKSK

------KKSPKP KKKKHRKEKE ERTKGKKKSK

LENKRTAKRN SKAKGKSDSE DGEKENEKSK TSDSSNDESS SIEDSSSDSE

SESEQSEE-- -DGKRKTKKK VPERKGEAS- SSDEGSDSSS SSSESEMTSE

------DENK GVSNNNGSAY TAPSLESSSN

------AHWA TISKCQGAER CDPELPKTS-

VDDPITQSG------P PLPVVVPASS GQGLQISAQL SRKDGQVFYS

VDEPTTPSG------R PLPVVLPASK GQGLQISAQL TRQDGQVFYS

LNDLFELSTG IGMAPGGYVA PKAVWLPAVK AKGLEISGTF THRQGHIYME

LSDLFDLTSG VGTLSGSYVA PKAVWLPAMK AKGLEISGTF TRQVGSISMD

------YVQNIV KGKHIEELES

--CRQSFVKM ISEKQLREME ELKAKTQTTH AQPDDLIDFF HLKSRKGMSQ

------DI SMDEQVELKF VDDSDTSYEE KEKLDDFENP

------SDDFI VSARLETHTP

------TI VSIYLKPVSH

NDPAAPLIQI SETSVSADQE ELRSRRALDL WLDDQPSTSN QTPSALNSNQ

------VPPQ ASNELVPVPE PSYYSESHQP

------ALSKNLI SNEPVDLLSD

KQPPGSEEAA GEPVQNGAPE EEQLPPESSY SLLAENSYVK MTCDIRGSLQ

SESEPESESE SRRVTKEKEK KTKQDRTPLT KDVSLLDLDD FNPVSTPVAL

SEEEQLEPAS WSRKTPPSSK -----SAPAT KEISLLDLED FTPPSVQPVS

ITSQMQELAI SGPATSATTP QSFGFDDLFG LGLSTAPAPT PSPPLLKLNA

------SFAA SGPLIPEENK E------RVQEL PDSGALMLVP

MLFENNSQSV LDGFMIQFNK NTFGLAAAGS LQIP-PLHPA TSARTMLPMV

MLLENNSQSL LDGFMIQFNK NSFGLAAVGS LQVP-PLQPG ASARTMMPMV

MNFTNKALQH MTDFAIQFNK NSFGVIPSTP LAIHTPLMPN QSIDVSLPLN

LQLTNKALQV MTDFAIQFNR NSFGLAPATP LQVHAPLSPN QTVEISLPLS

MAKNEISSKA NDDVLLDFDE RDD------VTN TNAGMLNTLT

LELEDQVQDD LKRATGEFTK DENDANKLNR ILQLTGFSDP VYAEAYVTVH

FEIEREKERM SNPYYLGEED EERTKNSKDL LDLNEEESSD KKPETIRLNR

EIKEFFRMLP WNTEITEVGE TGNDIREGAE LKDYNKYKKS FSSQSFITNN

IFRLNKTKLL PQSPILNPNK D------LLPVV

SSYAKISIGD VGSRVKPKSY SLVDPGNGSG LKVDYAFLSE VSNVSPLHVC

ISTSLVSERE SSEIKLRLDG VKQKWGRPSY QSTTAASSTT PQAANGISTH

LLGEDSKAES KASTGDNVKP IDILEEIFGE KNDIAQVPKN ANKEESINHS

EDSQVTVAIV LENRSSSILK GMELSVLDSL NARMARPQGS SVHDGVPVPF

PTPALSPSLM ADLEGLHLST SSSVISVSTP AFVPTKTHVL LHRMSGKGLA

PPAIVSTSLA ADLEGLTLTD STLVPSLLSP VSG-VGRQEL LHRVAGEGLA

RAALDPGAFQ QKWRQLPISL T------QECSVNP

NRQLTADYFE KTWLSLKVAH Q------QVLPWR-

LFQNMSAGPP SSLLQVAVKN NQQPVWYFTD KIILHALFGE DGRMERGTFL

LSQNMSTGST SSVLQVAVKN NQQPVWYFED KIVLNALFSE DGRMERGTFL

TLGPVMKMEP LNNLQVAVKN N-IDVFYFSC LIPLNVLFVE DGKMERQVFL

TVGSVMKMEP LNNLQVAVKN N-IDVFYFST LYPLHILFVE DGKMDRQMFL

TLGDLDDLFD FGPSEDATQI N------

HYDIALEVTV INRTKETLQN LCLELATMG------DLK LVERPQNYSL

TDNSLNSLSL STTEISRKKK K------GKKKNRV

SARSFTSSSN AKLTGINDGD S------

GNSFPPTGAN RDRQN------

VEVLFENSSA EPILEVNLED EESMKVADSS EQTLVGKANA SYNNIPTLIP

SDAGVGSSSS KPRSSYEPKK P------E IDPEKQRLAA

SAVEANSGVT LPLDANKIYD S------SSL

QLPPGVSNEA QYVFTIQSIV MAQKLKGTLS FIAKND------

AHYFFPRQPC IFGDKMVSIQ ITLNNTTDRK IENIHIGEKK LPIGMKMHVF

VDYTFSRQPF SGDPHMVSVH IHFSNSSDTP IKGLHVGTPK LPAGISIQEF

QGIAALTVPQ SLIKHMQSHS IHCIASGGQS PNFKFF------

----GEFHPD TLQMALQVVN IQTIAMSRAG SRPWKA------

ETWRSLPDSN EVLKEFPGIT ITSVESTIEL LTAFNM------

ETWKSLPDSN EVQKEFPGIT ITSVESTLDL LAASNM------

ATWKDIPNEN ELQFQIKECH LN-ADTVSSK LQNNNV------

ATWKDIPNEN EAQFQIRDCP LN-AEAASSK LQSSNI------

------TNDT KAVQGLKELK LG-GDSNGIS SGGKNN------

APERSMQIKA NIKVSSTETG VIFGNIVYET SNVMER------

QVLSDEPVIE AAPKRKDAFQ KPHDNHSTQN PLKKDK------

------NSI SGKGNVNTFT SQNGKKYRLQ SLDEFFS------

------SESQ SSTKSRKTAM MDDYDKPAEK INQLKG------

MEEISCLEPH QSTKRLIQVR FHHHLLPMRL TLHYNEKKVP VKLRPDLG--

SLFGGSSSRT DKRSSSGGHK PAKGTANKTA TVPKEN------

NVYASLLSAN SGLAHLDLYF QAKSLISDLK TFCAVP------

------EGATHE KLDFRLHFSC SSYLITTPCY

NPIDSLEPEG SITVSMGIDF CDSTQTASFQ LCTKDDCFNV NIQPPVGELL

PEIESLAPGE SATAVMGINF CDSTQAANFQ LCTQTRQFYV SIQPPVGELM

------FFAQKE SEPSNYLTEC IINTSSAKAQ

------YLSAQD DTGCLFLTEL LLEPGNSEMQ

------FFIAKR KNGNQDVIYL SAKDPRDVPF

------FFIAKR KNGNQDVLYL SAKVPRGIPF

------YTIAKR NVEGQDMLYQ SLKLTNGIWI

------FTVAKR NVEGQDMLYQ SLKLTNGIWV

------PDVSGG NIVSQDLLDL F------

------NVVVL NDIHIDIMDY ISPAVCSEVA

------INLRMH SQLENFDFSN FGQSSNAGRG

------DIPER KSKPRKIIKV VEESSDEDED

------KR KSSSNNPSKL SRKPSTLLRK

------YLVKPF SMSIEEFLAT ESRLPGMFEY

------QTPVQP PPDLLDFGEP TATTATAMDP

------KAQK LTLGQLYPSS TINASQICKQ

SDAFAKLLES GDLSMSSIKV DGIRMSFQNL LAKICFHHHF SVVERVDSCA

LPVAMSEKDF KKEQGVLTGM NETSAVIIAA PQNFTPSVIF QKVVNVANVG

APVFMSENEF KKEQGKLMGM NEITEKLMLP DTCRSDHIVV QKVTATANLG

IKVKADEQ-- STCQAFTTVF ETALSKFGMP ------

ISVKQNEART ETLNSFISVL ETVIGTIEEI KS------

LIELTAMVGQ PGLK---CAV KTPTPEIAPL FFEALELLFK A------

LIELTAIVGQ PGLK---CAV KTPTPEIAPL FFEAVEILFK A------

LAELRIQPGN PNYT---LSL KCRAPEVSQY IYQVYDSILK N------

LAELRIQPGN PSCTDLELSL KCRAPEVSQH VYQAYETILK N------

------

FRTMWAEFEW ENKVAVNTTI QNEREFLDHI IKSTNMKCLT APSAIEG---

FRTMWAEFEW ENKVAVNTTI QNEREFLDHI IKSTNMKCLT APSAIAG---

SQEEGNLRKE DELELSRLEA NLIVKDEKDN LSDTEEVIVI KK------

ESEESSDDDE YSDSSLGTSS SGTSSSHLEL ------

LSMKRPFS------

SRRCTFDDHV KDSRTENGKD KFLSICESIT LKVLSNSNLH LVSVDLPVAN

FKELEGLMDS SSQDGGSSDV MGLYSDAAPV TTTTSVDSLL SELSDSSKGN

SLKISGSGKL KLRVKLDFHL NGSSSITNEQ FDHKFDETL------

SMYSRSIQGH HVCLLVKKGE NSVSVDGKCS DSTLLSNLLE EMKATLAKC-

AVPSGQDNIH RFAAKTVHSG SLMLVTVELK EGSTAQLIIN TEKTVIGSVL

RVPCGTSDEY RFAGRTLTGG SLVLLTLDAR PAGAAQLTVN SEKMVIGTML

------

--ECGFLAAN LYAKSVFGED ALVNVSIEKQ TDGALSGYIR IRSKTQGIAL

--ECGFLAAN LYAKSVFGED ALVNLSIEKQ TDGTLSGYIR IRSKTQGIAL

------KKKGKKSK SKNKLKTKAK NSPEPNEFLR DQSTDI----

------

SLEDATGLRL RFSSKILSSE IPLLITITVE GKCTEVLNLT VKINCEETVF

SRTYQPQTSK GPNTKEALEK DALVRQMGVN PTSQNPTLFK DLLG------

------

LRELKPVLSQ G------

VKDVIQALTQ ------

------

SLGDKITLKQ KGSS------

SLGDKITLKQ KGGS------

------

GLNLLNRIAN FMVEPSSSAT

------

Supplemental Data Set 1. Sequence alignment used for the calculation of the tree shown in Supplemental Figure 5.

Sequence names show abbreviations of the organism, the adapter protein complex, and the name of the subunit (e.g.: Hs-AP3-D1 = Homo sapiens, AP-3 complex, subunit d1). At = Arabidopsis thaliana, Sc = Saccharomyces cerevisiae. MIPS numbers (At4g11380 and At4g23460) are given for two Arabidopsis proteins, as these proteins cannot clearly be assigned as b subunits of the AP-1 or AP-2 complexes. Sequences were aligned using ClustalW2 (http://www.ebi.ac.uk/Tools/msa/clustalw2/) and stored in the PHYLIP output format.