United Kingdom Clinical Scholars Research Training (UKCSRT) Program

Harvard Medical School

United Kingdom Clinical Scholars Research Training (UKCSRT) program

Program Curriculum

Epidemiology - Heather Baer, PhD

Lecture 1: Introduction and Outcome Measures

Lecture 2: Measures of Association

Lecture 3: Study Design: Randomized Controlled Trials (RCTs)

Lecture 4: Study Design: Cohort Studies

Lecture 5: Study Design: Case-Control Studies

Lecture 6: Threats to Validity: Bias and Confounding

Lecture 7: Matching and Effect Modification

Lecture 8: Regression in Epidemiology

Medical Statistics - Brian Healy, PhD

Lecture 1: Introduction to Biostatistics

Lecture 2: Estimation

Lecture 3: Hypothesis testing

Lecture 4: Sample Size and Study Design

Lecture 5: Nonparametrics

Lecture 6: Analysis of proportions

Lecture 7: Linear Regression and Correlation

Lecture 8: Multiple linear regression

Lecture 9: Logistic regression

Lecture 10: Survival analysis

Research Ethics - Susan Kornetsky, Harvard Medical School

Lecture 1: History, Ethics, and Good Practice

Lecture 2: Preparing Research Protocol Applications & Informed Consent

Lecture 3: Research Involving Children and Adolescents

Clinical Trials, David Wypij, PhD

Lecture 1: Clinical Trials Introduction

Lecture 2: Study Design and Ethical Considerations

Lecture 3: Elements of a Study Protocol and Study Endpoints

Lecture 4: Study Population, Recruitment, and Baseline Assessment

Lecture 5: Randomization, Stratification, and Blinding

Lecture 6: Advanced Topics in Clinical Trials

Lecture 7: Data Analysis Plan and Sample Size and Power

Lecture 8: Monitoring and Interim Analysis Plans

Lecture 9: Miscellaneous Protocol Issues and Study Close-Out

Lecture 10: Case Study: The Influence of Haemodilution on Outcomes after Hypothermic Cardiopulmonary Bypass

Applied Regression - David Wypij, PhD

Lecture 1: Linear Regression: General Concepts

Lecture 2: Linear Regression: Residual Analysis and Data Transformations

Lecture 3: Linear Regression (Part III): Multiple Linear Regression, Confounding and Effect Modification

Lecture 4: Linear Regression (Part IV): Case Study: Circulatory Arrest Study

Lecture 5: Linear Regression (Part V): Model Building

Lecture 6: Logistic Regression (Part I): 2x2 Tables and Stratification

Lecture 7: Logistic Regression (Part II): Introduction to Logistic Regression Modeling

Lecture 8: Logistic Regression (Part III): Introduction to Logistic Regression Modeling

Lecture 9: Logistic Regression (Part IV): Model Building and Assessment of Goodness of Fit

Lecture 10: Logistic Regression (Part V): Smoothing and Generalized Additive Models

Special Topics

Lecture 1: Writing a Manuscript, Sushrut S. Waikar, MD

Lecture 2: Writing a Successful Grant, Sushrut S. Waikar, MD

Lecture 3: Peer Review Process, Gary Curhan, MD, ScD

Genetic Epidemiology, Ben Raby

Lecture 1: Overview of the Principles of Genetic Epidemiology Research

Lecture 2: Genetic Mapping of Rare Diseases

Lecture 3: Genetic Mapping of Common Disease

Lecture 4: Technical Aspects: Sequencing and Genotyping

Lecture 5: Statistical Analysis of Genetic Epidemiologic Data

Lecture 6: The Ethical, Legal, and Social Issues of Genetic Research

Lecture 7: The Clinical Impact of Genetic Research: Where we have been and where we are going

Evidence Based Medicine

Lecture 1: Introduction to Systematic Review, Ethan Balk, MD, MPH

Lecture 2: Introduction to Meta-Analysis, Ethan Balk, MD, MPH

Lecture 3: Introduction to Comparative-Effectiveness Research, Niteesh K. Choudhry, MD, PhD

Lecture 4: Introduction and Elements of Decision Analysis, DjoraSoeteman, PhD

Lecture 5: Structuring and Analyzing Decision Problems, DjoraSoeteman, PhD

Lecture 6: Intro to Cost Effective Analysis (Part 1), DjoraSoeteman, PhD

Lecture 7: Intro to Cost Effective Analysis (Part 2), DjoraSoeteman, PhD