APPENDIX 1: Specific search combinations used in each database

Search protocol of the literature search in electronic databases

MEDLINE via Pubmed:

First search:

  1. Patient Compliance[Mesh]
  2. Treatment Refusal[Mesh]
  3. Medication Therapy Management[Mesh]
  4. #1 OR #2 OR #3
  5. monitor*
  6. MEMS
  7. eDEM
  8. electronic
  9. microelectronic
  10. #5 OR #6 OR # 7 OR # 8 OR #9
  11. interven*
  12. feedback
  13. improv*
  14. #11 OR #12 OR #13
  15. #4 AND#10 AND# 14
  16. Limits: Publication date from inception to 2011/12/31

Second search:

  1. Patient Compliance[Mesh]
  2. Treatment Refusal[Mesh]
  3. Medication Therapy Management[Mesh]
  4. #1 OR #2 OR #3
  5. MEMS
  6. eDEM
  7. electronic
  8. microelectronic
  9. monitor*
  10. device
  11. pill bottle
  12. inhal*
  13. drop
  14. blister
  15. #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14
  16. #4 AND #15
  17. Limits: Publication date from inception to 2011/12/31

EMBASE

First search:

  1. Patient compliance/ exp
  2. Treatment refusal/exp
  3. #1 OR #2
  4. MEMS
  5. monitor
  6. edem
  7. electronic
  8. microelectronic
  9. #4 OR #5 OR #6 OR #7 OR #8
  10. Medication therapy management/ exp
  11. Intervention study/ exp
  12. Patient counseling/exp
  13. #10 OR #11 OR #12
  14. Limits: Publication date from inception to 2011/12/31; Humans, embase/lim

Second search:

  1. Patient compliance/ exp
  2. Treatment refusal/exp
  3. #1 OR #2
  4. MEMS
  5. monitor
  6. edem
  7. electronic
  8. microelectronic
  9. #4 OR #5 OR #6 OR #7 OR #8
  10. Patient counseling/exp
  11. Medication therapy management/ exp
  12. #10 OR #11
  13. #3 AND #9 AND #12
  14. Limits: Publication date from inception to 2011/12/31; Humans, embase/lim

Cinahl EBSCOhost

  1. (MH "Medication Compliance")
  2. (MH "Treatment Refusal")
  3. "medication adherence"
  4. (MH "Self Administration")
  5. #1 OR #2 OR #3 OR #4
  6. monitor*
  7. MEMS
  8. eDEM
  9. electronic*
  10. microelectronic*
  11. #6 OR #7 OR #8 OR #9 OR #10
  12. interven*
  13. feedback
  14. improv*
  15. #12 OR #13 OR #14
  16. #5 AND #11 AND #15
  17. Limits: Publication date from inception to 2011/12/31

PsycINFO

  1. adheren*
  2. nonadheren*
  3. non-adheren*
  4. complian*
  5. noncomplian*
  6. non-complian*
  7. 1 or 2 or 3 or 4 or 5 or 6
  8. monitor*
  9. MEMS
  10. eDEM
  11. electronic*
  12. microelectronic*
  13. 8 or 9 or 10 or 11 or 12
  14. interven*
  15. feedback
  16. improv*
  17. 14 or 15 or 16
  18. 7 and 13 and 17
  19. Limits: Publication date from inception to 2011/12/31

The Cochrane Library

  1. MeSH descriptor Patient Compliance explode all trees
  2. MeSH descriptor Treatment Refusal explode all trees
  3. MeSH descriptor Medication Therapy Management explode all trees
  4. MeSH descriptor Electronics, Medical explode all trees
  5. (monitor*)
  6. (MEMS)
  7. (eDEM)
  8. (electronic*)
  9. (microelectronic*)
  10. (interven*) or (feedback) or (improv*)
  11. (( #4 OR #5 OR #6 OR #7 OR #8 OR #9 ) AND #10)
  12. (#1 OR #2 OR #3)
  13. (#12 AND #11)
  14. Limits: Publication date from inception to 2011/12/31

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