Supplementary Table 1 X-Ray Scoring Methods.

Variable / Modified Sharp method / van der Heijde modification of Sharp method / Genant modification of Sharp method
Hands
Erosions (number of joints) / 17 per hand, 34 total / 16 per hand, 32 total / 14 per hand, 28 total
Joints assessed for erosions / IP 1
PIP 2–5
MCP 1–5
The first metacarpal base
Multiangular
Navicular
Lunate
Combination of pisiform and triquetrum
Distal radius
Distal ulna / IP 1
PIP 2–5
MCP 1–5
Separate components of CMC 1
Scaphoid
Lunate
Distal radius
Distal ulna / IP 1
PIP 2–5
MCP 1–5
CMC 1
Scaphoid
Distal radius
Distal ulna
Erosion scoring range / 0 normal
1 1 erosion
2 2 erosions
3 3 erosions
4 4 erosions
5 destruction >50% of the surface area / 0 normal
1 1 erosion
2 2 erosions
3 3 erosions
4 4 erosions
5 destruction >50% of the surface area / 0 normal
0.5 subtle change
1 mild
1.5 mild worse
2 moderate
2.5 moderate worse
3 severe
3.5 severe worse
JSN (number of joints) / 18 per hand, 36 total / 15 per hand, 30 total / 13 per hand, 26 total
Joints assessed for JSN / IP 1
PIP 2–5
MCP 1–5
CMC 3–5
Multiangular–navicular
Lunate–triquetrum
Capitate–navicular
Radio–carpal
Radio–ulnar / PIP 2–5
MCP 1–5
CMC 3–5
Scaphoid–lunate
Scaphoid–radius
Scaphoid–trapezoid / IP 1
PIP 2–5
MCP 1–5
CMC 3–5
Capitate–scaphoid–lunate
Radio–carpal
JSN scoring range / 0 normal
1 focal or minimal narrowing
2 narrowing <50% of the original space
3 narrowing >50% of the original space
4 ankylosis / 0 normal
1 focal or minimal narrowing
2 narrowing <50% of the original space
3 narrowing >50% of the original space
4 ankylosis / 0 normal
0.5 subtle change
1 mild
1.5 mild worse
2 moderate
2.5 moderate worse
3 severe
3.5 severe worse
4 ankylosis
Feet
Erosions (number of joints) / 6 per foot, 12 total / 6 per foot, 12 total / 6 per foot, 12 total
Joints reviewed for erosion / IP 1
MTP 1–5 / IP 1
MTP 1–5 / IP 1
MTP 1–5
Erosion scoring range / 0 normal
1 1 erosion
2 2 erosions
3 3 erosions
4 4 erosions
5 destruction >50% of the surface area / 0–10 / 0 normal
0.5 subtle change
1 mild
1.5 mild worse
2 moderate
2.5 moderate worse
3 severe
3.5 severe worse
JSN (number of joints) / 6 per foot, 12 total / 6 per foot, 12 total / 6 per foot, 12 total
Joints reviewed for JSN / IP 1
MTP 1–5 / IP 1
MTP 1–5 / IP 1
MTP 1–5
JSN scoring range / 0 normal
1 focal/minimal narrowing
2 narrowing <50% of the original space
3 narrowing >50% of the original space
4 ankylosis / 0 normal
1 focal/minimal narrowing
2 narrowing <50% of the original space
3 narrowing >50% of the original space
4 ankylosis / 0 normal
0.5 subtle change
1 mild
1.5 mild worse
2 moderate
2.5 moderate worse
3 severe
3.5 severe worse
4 ankylosis
Maximum total score / 432 / 448 / 292 (normalized to 290)
Range of reported change scores in recent RCTs / 0.5–2.9 / -0.54–3.8 / 0–3.5, IL-1ra
Range of estimated yearly progression in recent RCTs / 8.0–9.0* / 6.4–11.0* / 6.3–7.4*

CMC, carpometacarpal; DIP, distal interphalangeal; IL-1ra, anakinra; IP, interphalangeal; JSN, joint-space narrowing; MCP, metacarpophalangeal; MTP, metatarsophalangeal; PIP, proximal interphalangeal; RCTs, randomized controlled trials.