STEPHEN D. SMITH M.D.
5/17/12
OFFICE:
University of Kansas
Medical Center
Department of Pediatrics
3901 Rainbow Blvd
Kansas City, Kansas 66160
Phone: (913) 588-6340
Fax: (913) 588-2245
E-mail:
Education:
Dates Institution Degree
8/63-5/67 Creighton University B.S.
Omaha, NE
8/67-5/71 Creighton University M.D.
School of Medicine
Omaha, NE
Post Doctoral Training:
Dates Institution Specialty
6/71-6/72 University of Kansas Intern Pediatrics
Medical Center
Kansas City, KS
6/72-6/73 University of Kansas Resident Pediatrics
Medical Center
Kansas City
7/75-6/77 University of Kansas Fellow, Pediatric
Medical Center Hematology/Oncology
Kansas City, KS
Military Service:
7/73-6/75 U.S. Army Vint Hill Farm Station
Vint Hill, Virginia
Licensure:
Year Number State
8/30/71 12327 Nebraska
12/9/77 17361 Kansas
7/6/82 G48085 California
7/1/89 036-079523 Illinois
5/16/03 2003010756 Missouri
Board Certification:
Date of Certification Name of Board
1971 State of Healing Arts, Nebraska
1972 Diplomat: National Board of Medical
Examiners
7/1/77 Diplomat: American Board of Pediatrics
10/10/80 American Board of Pediatrics, Sub-Board
of Pediatric Hematology/Oncology
Professional Positions Held:
Month and Year Position & Institution
7/77-6/82 Assistant Professor of Pediatrics and
Pharmacology
University of Kansas Medical Center
Kansas City, KS
7/82-6/89 Associate Professor of Pediatrics
Stanford University School of Medicine
Stanford, CA
7/89-6/94 Associate Professor of Pediatrics and Medicine
University of Chicago Medical Center
Chicago, IL
7/94-6/97 Professor of Pediatrics and Medicine
University of Chicago Medical Center
Chicago, IL
7/97- 6/06 Professor of Pediatrics
University of Kansas Medical Center
Kansas City, KS
7/06 – 6/11 Professor of Pediatrics
University of Illinois,
College of Medicine at Peoria, Peoria, IL
7/11- present Professor of Pediatrics
University of Kansas Medical Center
Kansas City, KS
Teaching Experience:
All areas of pediatrics hematology/oncology with a focus on leukemia, solid tumors, coagulation, blood banking and bone marrow failure. Since 2011, I have been teaching pediatric hematology/oncology to the third year medical students and residents.
Didactic:
Academic Instruction Student
Year Course Title Type Hours No. Type
2006 -11 Pediatrics Pediatrics Residency 1 hours / wk 12-15 Residents
Non didactic:
Clinical Student
Year Hours No. Type Length of Service
2006-2011 10- 20 hours/week 6-9 Medical Students 4 Months / year
& Residents
Inpatient ward service with patient care, teaching and night call for 4 months each year.
Committee Service: Give dates of service and administrative positions held
Academic: PI, Children’s Oncology Group (2006-2011)
Hospital: Member, KUMC Institutional Review Board (2011-)
Funded Research Activity;
Past Grant Support:
1. Mid-America Cancer Center Program
In vitro culture and sensitivity of normal and malignant bone marrow cells.
Principal Investigator - Stephen D. Smith, M.D.
Percent Effort - 20%
3/77 - 6/78
Annual Direct Costs - $3,000
2. NIH Bio-Medical Research Support Grant, 5501-RR-5373, Research
Committee University of Kansas Medical Center
Principal Investigator - Stephen D. Smith, M.D.
Percent Effort - 20%
Colony forming potential of malignant lymphoblasts from the bone marrow
of Children with A.L.L. or N.H.L.
Annual Direct Costs - $1,110
9/1/78 - 3/31/79
3. Mid-America Cancer Center Program, CA-15080-05
Principal Investigator - Stephen D. Smith, M.D.
Percent Effort - 20%
Drug sensitivity of malignant lymphoblasts from children with acute
Lymphoblastic leukemia and non-Hodgkin’s lymphoma.
Annual Direct Costs - $2,603
7/1/78 - 6/30/79
4. Research Committee, Endowment Funds, University of Kansas Medical
Center
Principal Investigator - Stephen D. Smith, M.D.
Percent Effort - 20%
Differentiation of malignant colony forming cells from non-colony forming
cells in progressive lymphoid malignancies.
Annual Direct Costs - $2,577
12/10/79 - 12/10/80
5. National Cancer Institute RO1 CA34710
Principal Investigator - Stephen D. Smith, M.D.
Percent Effort - 33%
Culture, sensitivity of malignant lymphoid colonies.
Annual Direct Costs - $83,951
5/1/80 - 4/30/83
6. American Cancer Society CH-182
Principal Investigator - Stephen D. Smith, M.D.
Percent Effort - 25%
Differentiation of malignant colony forming cells from non-colony forming
cells in progressive lymphoid malignancies.
Annual Direct Costs - $50,131
7/1/81 - 6/30/82
7. Leukemia Society of America - Scholar’s Program - 16S-82
Principal Investigator - Stephen D. Smith, M.D.
Percent Effort - 10%
In vitro culture and drug sensitivity of leukemia cell populations
Annual Direct Costs - $27,000
7/01/83 - 8/31/87
8. The Council for Tobacco Research - USA, Inc.
Principal Investigator - Gerald R. Crabtree, M.D.
Percent Effort - 5%
Retroviral Insertion and Activation of the IL-2 Gene
Annual Direct Costs: $80,000
1/1/86 - 12/31/88
9. NIH Research Grant - Cyano-Morpholino Anthracyclines
Principal Investigator - Branimir I. Sikic, M.D.
Percent Effort - 5%
Annual Direct Costs: $96,481
9/1/86 - 8/31/89
10. NCI PO1 CA 34233-Clinical and Laboratory Studies of the Malignant
Lymphomas
Principal Investigator - Saul A. Rosenberg, M.D.
4/1/86 - 3/31/91
Annual Direct Costs - $1,447,044
Project 4 - CTL Target and Effector Antigens in Non-Hodgkin’s
Lymphoma
Project Investigator - Alan Krensky, M.D.
Co-investigator - 10%
Annual Direct Costs -$71,172
4/1/86-3/31/91
Project 5 - Patterns of Spread of Lymphoid Malignancies
Project Investigator - Jeffrey Sklar, M.D.
Co-investigator - 5%
Annual Direct Costs - $118,108
4/1/86-3/31/91
11. NIH Research Grant Application CA 42106
Principal Investigator - Stephen D. Smith, M.D.
Percent Effort - 20%
Characterization of lymphoblast peptide receptors
Annual Direct Costs - $106,389
9/1/87 - 8/31/90
12. NIH Research Grant Application
Principal Investigator - Branimir I. Sikic, M.D.
Percent Effort - 10%
Multi-drug resistance in human cancer
Annual Direct Costs - $125,430
12/1/87 - 11/30/90
13. NIH Research Grant Application
Principal Investigator - Jeffrey Sklar, M.D., Ph.D.
Percent Effort - 5%
Genetic studies of human B-cell cancers
Annual Direct Costs - $194, 431
4/1/88 - 3/31/93
14. National Institutes of Health
Principal Investigator - Michael P. Link, M.D.
Percent of Effort - 2.5%
Research Grant - Pediatric Oncology Group
Annual Direct Costs - $48,790
1/1/87 - 12/31/90
15. NCI PO1 CA 40046
Principal Investigator - Janet Rowley, M.D.
Percent Effort - 10%
Etiology of Treatment-Induced Secondary Leukemia
Annual Direct Costs - $550,000
12/1/91 - 11/30/96
16. Grant from Ronald McDonald Children’s Charities
Principal Investigator: Stephen D. Smith, M.D.
Percent Effort - 10%
Placental Blood Bank
Annual Direct Costs - $67,238
11/1/95 - 10/31/96
17. Grant from B. Meltzer Fund for Pediatric Cancer Research
Principal Investigator: Stephen D. Smith, M.D.
Richard L. Moldwin, M.D., Ph.D., became P.I. on 7/1/97
Percent Effort - 10%
Biology of Acute Lymphoblastic Leukemia
Annual Direct Costs - $50,000
1/1/91 - 6/30/98
18. Grant from Bear Necessities Pediatric Cancer Foundation
Principal Investigator: Stephen D. Smith, M.D.
Richard L. Moldwin, M.D., Ph.D., became P.I. on 7/1/97
Percent Effort - 10%
Cord Blood Banking and Research
Annual Direct Costs - $35,000
7/1/95 - 6/30/98
19. Grant from Blood Systems Foundation
Principal Investigator: Stephen D. Smith, M.D.
Richard L. Moldwin, M.D., Ph.D., became P.I. on
7/1/97
Percent Effort - 10%
Placental Blood Banking and Transplantation
Annual Direct Costs - $100,000
9/1/95 - 8/31/98
20. National Cancer Institute U10 CA 98543
Principal Investigator: Robert Trueworthy, M.D.
S D Smith (co-investigator)
Children’s Oncology Group, Chair’s Grant,
1/1/03-12/31/08
21. National Childhood Cancer Foundation
The Children's Oncology Group
Master Subcontract
Principal Investigator: Stephen Smith, M.D.
Dr de Alarcon became PI on 7/1/11
3/1/08 – 2/28/14 (I left UICOMP 6/11)
Professional Society Memberships:
Year Organization (including offices held)
1977 American Academy of Pediatrics
1979 Sigma Xi
1980 Society for Pediatric Research
1980 American Society of Hematology
1981 American Society of Pediatric
Hematology/Oncology
1984 American Society of Clinical Oncology
1984 American Association for Cancer Research
2005 American Pediatric Society
Honors, Awards, Recognition:
Year Award
1978 American Cancer Society Junior Faculty Clinical Fellowship
1978 Pediatric Department “Teacher of the Year” Award
1982 Scholar of the Leukemia Society of America
1986 Stohlman Memorial Scholar Award, Leukemia Society of America
2001 Student Voice Award, Excellence in Teaching
2002 Pediatric Department “Teacher of the Year” Award
2002 Student voice Award, Excellence in Teaching
2003 Finalist, University of Kansas School of Medicine Rainbow Award
2003 Student Voice Award, Excellence in Teaching
2004 Student Voice Award, Excellence in Teaching
2004 Bohan Teaching Award ($5,000)
2004 W. T. Kemper Fellowship for Teaching Excellence ($5,000)
2004 Medical School Marshal at Graduation
2005 Student Voice Award, Excellence in Teaching
2006 Student Voice Award, Excellence in Teaching
BIBLIOGRAPHY
REFEREED PUBLICATIONS: (Underline Senior Author) TOTAL 91
1. Khoo HB, Cho CT, Smith SD and Dudding BA: Cervical lymphadenitis due to candida albicans infection. J Pediatr 86:812-813, 1975.
2. Smith SD and Cho CT: Cytomegalovirus in sudden infant death syndrome (SIDS). JAMA 233:861, 1975.
3. Smith SD, Cho CT, Brahmacupta N and Lenahan MF: Pulmonary involvement associated with cytomegalovirus infection in children. Arch Dis Child 52:441- 446, 1977.
4. Smith SD, Uyeki EM and Lowman JT: Colony formation in vitro by leukemic cells in acute lymphoblastic leukemia. Blood 52:712-718, 1978.
5. Smith SD, Rosen D, Trueworthy RC and Lowman JT: A reliable method for evaluating drug compliance in children with cancer. Cancer 43:169-173, 1979.
6. Smith SD, Sturgeon JK, Rosen D, Vats TS, Trueworthy R, Cairns N, Klopovich P, Briscoe K and Lansky S: Total care. Recent advances in the treatment of children with cancer. J Kans Med Soc 80:113-118, 1979.
7. Smith SD, and Rosen D: Establishment and characterization of a human null cell lymphoblastic lymphoma cell line (K-LL-3). Int J Cancer 23:494-503, 1979.
8. Smith SD, and Sachs L: Differences in the cell proliferation and colony forming ability of normal human T lymphocytes. Clin Exp Immuno 37:348-351, 1979.
9. Cairns NU, Clark GM, Smith SD, and Lansky SB: Adaptation of siblings to childhood malignancy. J Pediatr 95:484-351, 1979.
10. Smith SD: Update on sarcoma in children. Cancer Control for the Professional. 6:33-34, 1979.Smith SD, Lindsley C, and Abdou NI: Suppressor cell-mediated leukopenia and T-cell dysfunction in Nezelof’s Syndrome: Clin Immunol Immunopathol 197:406-414, 1980.
11. Smith SD, Cairns NU, Sturgeon JK and Lansky SB: Poor drug compliance in an adolescent with leukemia. Am J Pediatr Hematol/Oncol 3:297-300, 1981.
12. Vats TS, Mehta P, Trueworthy RC, Smith SD and Klopovich P: Vindesine and prednisone for remission induction in children with acute lymphocytic leukemia. Cancer 47:2789-1792, 1981.
13. Smith SD, Wood GW, Fried P and Lowman JT: In vitro growth of lymphoma colonies from children with non-Hodgkin’s lymphoma. Cancer 48:2612-2623, 1981.
14. Smith SD: Advances in the pharmacology of cancer chemotherapy. Pediatr Clin North Am 28:145-160, 1981.
15. Smith SD, Trueworthy RC, Kisker SE, Noller LG, and Lowman JT: In vitro sensitivity of normal granulocytic and lymphoma colonies to vinca alkaloids. Cancer 53:417-422, 1983.
16. Roper M, Crist WM, Metzger R, Ragab AH, Smith, S, Starling K, Pullen J, Leventhal B, Bartolucci AA and Cooper MD: Monoclonal antibody characterization of surface antigens in childhood T-cell lymphoid malignancies. Blood 61:830-837, 1983.
17. Lansky SB, Smith SD, Cairns NU and Cairns GF Jr: Psychological correlates of compliance. J Pediatr Hematol/Oncol 5:87-92, 1983.
18. Wittek AE, Cohen PS, Arvin AM, Smith SD, Koropchak CM and DeClercq E: Effects of (E)-5(-bromovinyl)-2’-deoxyuridine on proliferation of human fibroblasts, peripheral blood mononuclear cells and granulocyte-monocyte progenitor cells in vitro . Antimicro Agents and Chemother 24:803-806, 1983.
19. Smith SD, Kisker S, Bush L and Trueworthy RC: Utilization of a human tumor cloning system to monitor for bone marrow involvement in children with non-Hodgkin’s lymphoma. Cancer 53:1724-1729, 1984.
20. Smith SD, Trueworthy RC, Klopovich PM, Vats TS and Snodgrass W: Management of children with isolated testicular leukemia. Cancer 54:2854-2858, 1984.
21. Smith SD, Shatsky M, Cohen PS, Warnke R, Link MP and Glader BE: Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines. Cancer Research 44:5657-5660, 1984.
22. Hecht F, Morgan R, Kaiser-McCaw Hecht B and Smith SD: Common region on chromosome 14 in T-cell leukemia and lymphoma. Science 226:1445-1447, 1984.
23. Cohen PS and Smith SD: In vitro and in vivo chemotherapy screening of the divalent cations chelator 1, 10-orthophenanthroline. Cancer Chemother Pharmacol 15:6-10, 1985.
24. Wu N, Foung SK, Hoopes P, Lizak G and Smith SD: Microwave heat-induced hemolysis. Clin Pediatr 24:645, 1985.
25. Baer R, Chen K-C, Smith SD and Rabbitts TH: Fusion of an immunoglobulin variable gene and a T-cell receptor constant gene in the chromosome 14 inversion associated with T-cell tumors. Cell 43:705-713, 1985.
26. Smith SD, Morgan R, Link MP, McFall P and Hecht F: Cytogenetic and immunophenotypic analysis of cell lines established from patients with T-cell leukemia/lymphoma. Blood 67:650-656, 1986.
27. Lee PDK, Rosenfeld RG, Hintz RL and Smith SD: Characterization of insulin, insulin-like growth factors I and II, and growth hormone receptors on human leukemic lymphoblasts. J Clin Endocrinol Metab 62:28-35, 1986.
28. Denny CT, Yoshikai Y, Mak TW, Smith SD, Hollis GF and Kirsch IR: A chromosome 14 inversion in a T cell lymphoma is caused by site-specific recombination between immunoglobulin and T cell receptor loci. Nature 320:549-551, 1986.
29. Cleary ML, Smith SD and Sklar J: Cloning and Structural Analysis of cDNAs for bcl-2 and a Hybrid bcl-2/Immunoglobulin Transcript Resulting from the t(14;18) Translocation. Cell 47:19-28, 1986.
30. Denny CT, Hollis GF, Hecht F, Morgan R, Link MP, Smith SD and Kirsch IR: A common mechanism of chromosomal inversion in B and T cell tumors: Relevance to lymphocyte development. Science 234:197-200, 1986.
31. Westbrook CA, Rubin CM, Le Beau MM, Kaminer LS, Smith SD, Rowley JD and Diaz MO: Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia. Proc Natl Acad Sci 84:251-255, 1987.
32. Barletta C. Pelicci P-G, Kenyon LC, Smith SD and Dalla-Favera R: Relationship between the c- myb locus and the 6q-chromosomal aberration in leukemias and lymphomas. Science 235:1064-1067, 1987.
33. Smith SD, Morgan R, Galili N, Amylon MD, Link MP, Hecht F, Sklar J Glader BE. Establishment and characterization of a common acute lymphoblastic leukemia cell line with a deletion of chromosome 3 band q26. 1987 Cancer Res. 1987 March 15;47(6):1652-6.
34. Reynolds TC, Smith SD and Sklar J: Analysis of DNA surrounding the breakpoint of a chromosomal translocation involving the beta T cell receptor gene in human lymphoblastic neoplasms. Cell 50:107-117, 1987.