Hazards as a result of the handling of hazardous materials / Form 2.1
met / n/
a
yes / *no
Risk assessment pursuant to § 6 Ordinance on Hazardous Substances (Gefahrstoffverordnung) and
§ 5 of the Occupational Safety and Health Act (Arbeitsschutzgesetz)
Workstations in laboratories
Hazards as a result of handling of hazardous materials / Form 2.1
Seq. No.:
Office:
Group / Author / DateFirst assessment / Yes No last assessment on (date)
Number of employees
1. General / met / n/
a
yes / *no
1. Only qualified personnel are used when handling hazardous substances.
2. Employees, who have not attained the qualifications needed to perform the tests, are supervised.
3. The hazardous substances register is maintained using the central university system, DaMaRIS, and is updated annually. (If not yet listed in DaMaRIS, indicate in Item 14 how it is listed, e.g., in Excel and when it will be entered into DaMaRIS.)
4. Current safety data sheets are accessible at all times for all hazardous substances, e.g., via DaMaRIS.
6. Current individual or group instruction manuals are available for hazardous substances, are known to employees and made accessible at a suitable location in the laboratory.
7. Before starting work with hazardous substances, employees are informed of the potential hazards and handling procedures based on the instruction manuals.
8. The measures in the instruction manuals are observed.
9. The first aid remedies (antidotes) specified in the instruction manuals are available.
10. Steps have been taken to ensure that all employees (including those who do not speak German) have understood the contents of the operating instructions.
11. Employees in a work area or in a laboratory are mutually informed about the occurrence of potential hazards.
12. Test equipment containing hazardous substances and reactions are not left unattended.
13. Activities involving hazardous substances are not performed while working alone. If this is the case, additional organisational and technical measures are taken. Corresponding activities and the measures taken are listed in Item 14.
14. Activities and work processes are designed in such a way that no breathing protection needs be worn during normal daily handling.
15. There are separate storage options available for work clothing and street clothing.
16. Employees are aware that for occupational health care (activities involving hazardous substances, wearing protective gloves) there are mandatory and optional examinations with the company medical officer, see Annex 1.
2. Technical safety measures
1. Full-body emergency showers are located in the vicinity of the exits and can be reached from every workstation within five seconds.
2. Eyewash stations are mounted at every drainage basin and are connected to a cold water feed.
3. The functioning of the full-body showers and eyewash stations is inspected and recorded on a monthly basis.
4. Defects are remedied immediately and notification is forwarded to the designated authority without delay.
5. The working surfaces of the laboratory work tables are resistant to the chemicals used and have a backsplash.
3. Handling of solids and liquids yes no
1. Only those quantities needed for ordinary use are kept on hand in the laboratory; as a rule, these are containers with a maximum nominal content of 1 l.
2. Hazardous substances are not stored in food containers.
3. Only those hazardous substances are located at the workstation – the daily requirement.
4. Hazardous substances are not stored on work tables, in fume cupboards or on shelves.
5. All hazardous substances and preparations are properly labelled. - Name, components of the preparation, H and P phrases in accordance with the CLP-VO pictograms.
6. In the case of laboratory containers, the specification of the H and P phrases is omitted since these can be found in the instruction manual.
7. In the case of laboratory containers that are labelled by means of the simplified labelling system in accordance with the CLP-VO (http://www.bgrci.de/fachwissen-portal/topic-list/laboratories/guidelines-for-laboratories/simplified-labelling-of-laboratory-containers/), the entire categorisation, including H and P phrases, originates from the instruction manual.
8. The quantities used for each test may not exceed the following quantities used in laboratories:
- Liquids: 2.5 l
- Solids: 1 kg
9. When working with larger quantities than those specified in Section 8, special measures are implemented. The activities and measures are listed in Item 14.
10. Weighing processes with hazardous, powdered substances or substances that form an aerosol are performed in the fume cupboard or in an exhausted enclosure, e.g., a safety weighing cupboard.
11. After removing the hazardous substance, the containers are immediately closed again.
12. Pipetting aids are used for pipetting.
13. In the case of hazardous substances with a known or suspected allergenic potential, the formation of an aerosol is avoided, e.g., through the use of closed containers, the use of a septum. In the case of open containers, work is performed as much as possible in a closed fume cupboard.
14. Multiple tests or apparatuses with different hazard potential are not run in a single fume cupboard unless these cannot result in a mutual hazard.
15. When handling larger quantities (≥ 2 l) of aggressive substances, the apparatuses are set up in a collection basin.
16. Activities involving very aggressive substances, e.g., hydrofluoric acid, perchloric acid, sulphuric acid, under specific conditions such as open chemical digestion or evaporation with fuming, are performed in a fume cupboard (with fume scrubber and, if necessary, a neutralisation system).
17. Hazardous substances, e.g., concentrated acids or bases, or activities such as the heating or spraying of hazardous substances, which could release gases / vapours / suspended solids in hazardous concentrations or quantities, are handled or performed in a fume cupboard in apparatuses that ideally are closed or in equipment that provides comparable safety, e.g., vacuum apparatuses.
18. If there is a nighttime reduction of the ventilation or if there is no technical ventilation, no test equipment or open containers, from which hazardous gases or vapours are released, may be left overnight in the fume cupboard or on the work tables.
19. Test equipment that is not constantly monitored or that must be left running overnight is operated in special rooms, e.g., nighttime laboratory.
20. Test equipment that releases especially odour-intensive substances is operated in separate spaces, e.g., a gas chamber with increased ventilation.
21. When handling odour-intensive substances, where odour issues cannot be avoided, e.g., when weighing, suitable breathing protection is worn. The operating time is kept as low as possible.
22. If when handling atomised substances, significant dust formation cannot be avoided, e.g., filling columns with finely granulated silica gel, suitable breathing protection is worn.
23. Apparatuses, equipment and systems that may release hazardous emissions, e.g., column
chromatography, are operated in the fume cupboard or the emissions are captured and discharged in an exhaust system, e.g., fume extraction.
24. Tests, over the course of which corrosive, toxic /very toxic or CMR substances arise and may be released, are performed in the fume cupboard in apparatuses that ideally are closed or in closed systems (vacuum apparatus, glovebox, sealed apparatuses whose openings are connected to an exhaust system).
25. New substances, nanoparticles, substances or by-products that arise over the course of the reaction either intentionally or unintentionally, in which the properties are insufficiently known, are handled with particular care:
- Work is performed in the fume cupboard or in the glovebox and / or
- closed apparatuses are used whose exhaust streams are discharged.
- The use of limited quantities.
- Skin contact and inhalation are reliably avoided.
- Ignition sources and contact with flammable substances are excluded.
26. Contamination at the workstation is avoided or immediately removed.
27. Emptied containers are properly cleaned before disposal or reuse.
28. Prior to the disposal of cleaned containers, the hazardous substance designation, the hazard symbols or the label is removed or rendered illegible.
29. Uncleaned, empty containers are not disposed of in the glass recycling container or with household waste.
3.1 Handling of toxic/very toxic solids and liquids
(acutely toxic) yes no
1. A search for an alternative was done and documented. (A substitution results in a reduction in risk.)
2. The substances and preparations are kept under lock and key, and only qualified personnel have access to these substances.
3. Current, individual instruction manuals are available. The measures are observed.
4. The work is performed in a functioning fume cupboard in apparatuses that are as closed as possible.
5. When working, the front sash is kept closed or kept closed as much as possible.
6. Work done outside of the fume cupboard is done in closed systems (see 3.24).
7. The following maximum quantities may not be exceeded for each test approach:
- T Solids: 0.5 kg
- T+ Solids: 0.1 kg
- T Liquids: 0.5 l
- T+ Liquids: 0.1 l
3.2. Handling of carcinogenic (C), mutagenic (M) and reprotoxic (R) substances belonging to categories 1A and 1B
H340-350-350i-360F-360FD-360Fd yes no
1. A search for an alternative was done and documented.
2. The substances and preparations are kept under lock and key, and only qualified personnel have access to these substances.
3. Current, individual instruction manuals are available. The measures are observed.
4. As much as possible, the substances are used in a form that is ready for use and that prevents the formation of dust.
5. The work area is delimited and marked using university-internal identification labels.
6. The following maximum quantities may not be exceeded for each test approach:
- Liquids: 0.5 l
- Solids: 0.5 kg
7. These substances are handled as follows:
1. Handling in closed systems such as:
- apparatus that is set up in the closed fume cupboard and operated in a non-open state, or
- vacuum apparatus or
- glovebox or
- apparatus with tight junctions, where all the openings are connected to an efficient exhaust system, e.g., gas chromatographs.
2. The use of a closed system is not possible for technical reasons.
- Work is performed in the fume cupboard in apparatuses that ideally are closed and
- the fume cupboard windows are kept closed, and
- no activities involving another potential hazard are performed in the fume cupboard at the same time.
8. Weighing processes are performed in a fume cupboard, in a glovebox or in a correspondingly exhausted enclosure, e.g., a safety weighing cabinet.
9. If it is assumed that there is no exposure via the respiratory tract, the weighing process is performed at a protected location, e.g., a shielded lab space with minimal air movement.
3.2.2 Additional measures when handling cytostatic drugs yes no
1. The current version of GUV-I 8533 “Cytostatic drugs in the health service” is available and known to employees.
2. The preparation is carried out in a cytostatic drugs safety workbench in accordance with DIN 12980 or DIN EN 12469 (DIN 1295, Section 10). Specifically, these are:
- Dissolving the dry substance.
- Loading syringes with the drug solution.
- Dosing a drug solution, e.g., in an infusion solution.
3. Cytostatic drugs are prepared in a separate work space. This is accessible only to authorised personnel and labelled pursuant to GUV-I 8533, page 19.
4. The workspace corresponds to the installation conditions for safety cabinets – TRGS 525 “Requirements for the operation of safety cabinets …”
5. No other activities are carried out in the preparation room and in the safety workbench at the same time.
6. An instruction manual for the safety workbench is available and known to the employees.
7. An instruction manual for the handling of cytostatic drugs is available. The specified requirements are observed.
8. Employees are regularly trained on the basis of the instruction manuals.
9. The safety workbench is inspected annually, and the inspection recorded in an inspection log.
10. Wipe tests are carried out in order to monitor the work areas for contamination.
4. Handling of compressed gases and cryogenic liquefied gases yes no
1. Compressed gases are supplied via a central gas supply, and if this is not the case,
- the gas cylinders are operated in compressed gas cylinder cabinets (T90), and the gas is supplied via permanently installed lines, or
- at the end of work, gas cylinders that are placed in the laboratory are placed in a gas cylinder storage or a compressed gas cylinder cabinet.
2. Compressed gas cylinders containing inert gases for supplying equipment and apparatuses are only permanently installed in rooms with no increased risk of fire (no activities involving larger quantities of flammable liquids, low fire load).
3. If it is not possible to reliably prevent the formation of an explosive atmosphere when using flammable gases for apparatuses and equipment, warning devices, e.g., ex-sensors, are installed.
4. Before carrying out any activities with gases, as a result of which a risk cannot be excluded, e.g., asphyxiating gases, oxidising gases, the apparatus is inspected for leaks, e.g., by brushing on a detergent solution or spraying with a leak detection spray.
5. Cryogenic containers containing cryogenic liquefied gases are installed and operated:
- in rooms with suitable exhaust ventilation, e.g., near the floor for liquid nitrogen,
- in spaces with a ventilation function display, outside the room or near the door, or
- in rooms with an oxygen deficiency display or
- outdoors.
6. When handling frozen gases, additional protective clothing is worn, e.g., protective gloves for the cold, safety visor.
4.1 Handling of very toxic/toxic gases (acutely toxic) and CMR gases (categories 1/1A and 2/1B) yes no
1. If gas is not supplied via a central gas supply, the following container sizes for the compressed gas cylinders are not exceeded:
- T Gases: smallest possible container, a maximum of 50 l
- T+ Gases: lecture bottle or a maximum of 10 l
- CMR gases: lecture bottle or a maximum of 10 l
2. Toxic / very toxic and CMR gases are handled in the following manner:
- The gases are centrally supplied via permanently installed lines, or