SupplementaryTable1

GO and Pathway Analysis of Up-regulatedGenesinLumbar SpinalCords of 120A vs.30AMice(Top 90)

Genebank NO. / Protein / Fold Change / Molecularfunction / KEGG
NM_017372 / Lyz2 / 13.142 / lysozyme activity;hydrolase activity, acting on glycosyl bonds; / ---
NM_013532 / Lilrb4 / 13.084 / receptor activity; / ---
NM_007807 / Cybb / 9.835 / electron carrier activity;voltage-gated ion channel activityheme binding; / Leukocyte transendothelial migration;
NM_053110 / Gpnmb / 7.939 / integrin binding; heparin binding; / ---
NM_001044384 / Timp1 / 7.730 / protein binding;metalloendopeptidase inhibitor activity;enzyme inhibitor activity; / ---
NM_028595 / Ms4a6c / 7.529 / receptor activity; / ---
NM_011337 / Ccl3 / 7.277 / protein binding;chemokine activity; / Toll-like receptor signaling pathway;Cytokine-cytokine receptor interaction;
NM_009264 / Sprr1a / 7.252 / --- / ---
NM_009780 / C4b / 6.701 / endopeptidase inhibitor activity;protein binding; / ---
NM_153098 / Cd109 / 6.537 / protein binding;serine-type endopeptidase inhibitor activity; wide-spectrum protease inhibitor activity; / ---
NM_009252 / Serpina3n / 6.527 / serine-type endopeptidase inhibitor activity; / ---
NM_019984 / Tgm1 / 6.373 / protein binding; calcium ion binding; protein-glutamine gamma-glutamyltransferase activity / ---
NM_009853 / Cd68 / 6.259 / --- / ---
NM_011662 / Tyrobp / 5.385 / protein binding; / Natural killer cell mediated cytotoxicity;
NM_021334 / Itgax / 5.228 / protein binding;calcium ion binding; receptor activity; / Regulation of actin cytoskeleton;
NM_013706 / Cd52 / 5.181 / --- / ---
NM_011313 / S100a6 / 5.104 / protein homodimerization activity;S100 beta binding;growth factor activity;calcium ion binding; / ---
NM_008278 / Hpgd / 5.055 / prostaglandin E receptor activity; oxidoreductase activity; binding; / ---
NM_007572 / C1qa / 5.045 / --- / Systemic lupus erythematosus;Alzheimer's disease;Complement and coagulation cascades;
NM_010185 / Fcer1g / 4.969 / IgE receptor activity; protein binding; / Natural killer cell mediated cytotoxicity;Asthma;Fc epsilon RI signaling pathway;
NM_011701 / Vim / 4.729 / protein binding; structural constituent of cytoskeleton; / Cell Communication;
NM_009776 / Serping1 / 4.630 / serine-type endopeptidase inhibitor activity;complement binding; / Complement and coagulation cascades;
NM_013489 / Cd84 / 4.55 / protein binding;receptor activity; / ---
NM_013470 / Anxa3 / 4.475 / calcium ion binding;phospholipase inhibitor activity;calcium-dependent phospholipid binding; / ---
NM_011019 / Osmr / 4.432 / receptor activity;oncostatin-M receptor activity; / Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;
NM_009779 / C3ar1 / 4.407 / G-protein coupled receptor activity; receptor activity; C3a anaphylatoxin receptor activity; / Neuroactive ligand-receptor interaction;Complement and coagulation cascades;
NM_007574 / C1qc / 4.401 / tumor necrosis factor receptor binding; / Systemic lupus erythematosus;Alzheimer's disease;Complement and coagulation cascades;
NM_020568 / Kiaa1881 / 4.396 / --- / ---
NM_010705 / Lgals3 / 4.321 / IgE binding; protein binding;sugar binding; / ---
NM_010516 / Cyr61 / 4.302 / insulin-like growth factor binding;extracellular matrix binding;heparin binding; / ---
NM_009777 / C1qb / 4.241 / protein homodimerization activity; / Systemic lupus erythematosus;Alzheimer's disease;Complement and coagulation cascades;
NM_011150 / Lgals3bp / 4.235 / scavenger receptor activity; protein binding; / ---
NM_008404 / Itgb2 / 4.214 / protein kinase binding;protein heterodimerization activity;receptor activity; / Natural killer cell mediated cytotoxicity;Cell adhesion molecules (CAMs);Regulation of actin cytoskeleton;Leukocyte transendothelial migration;
NM_008491 / Lcn2 / 4.180 / binding;transporter activity; / ---
NM_010512 / Igf1 / 4.032 / hormone activity;protein binding;Ginsulin-like growth factor receptor binding; / mTOR signaling pathway;Long-term depression;p53 signaling pathway;Glioma;Melanoma;Focal adhesion;Prostate cancer;
NM_021398 / Slc43a3 / 3.969 / --- / ---
NM_008509 / Lpl / 3.922 / hydrolase activity; triglyceride binding; lipid transporter activity; receptor binding; / Glycerolipid metabolism;Alzheimer'sdisease;PPAR signalingpathway;
NM_011254 / Rbp1 / 3.899 / retinal binding;lipid binding; transporter activity; / ---
NM_008342 / Igfbp2 / 3.847 / insulin-like growth factor I binding;insulin-like growth factor II binding; / ---
NM_011723 / Xdh / 3.789 / electron carrier activity;FAD binding;metal ion binding; / Purine metabolism;Drug metabolism - other enzymes;Caffeine metabolism;
NM_023275 / Rhoj / 3.748 / --- / ---
NM_011854 / Oasl2 / 3.715 / RNA binding;transferase activity;ATP binding; 2'-5'-oligoadenylate synthetase activity; / ---
NM_010686 / Laptm5 / 3.715 / --- / ---
NM_023158 / Cxcl16 / 3.702 / low-density lipoprotein receptor activity;scavenger receptor activity;chemokine activity; / Cytokine-cytokine receptor interaction;
NM_022325 / Ctsz / 3.687 / cysteine-type endopeptidase activity; / ---
NM_020008 / Clec7a / 3.635 / binding;opsonin binding;receptor activity;zymosan receptor activity; / ---
NM_007806 / Cyba / 3.603 / heme binding; metal ion binding; protein binding; oxidoreductase activity; / Leukocyte transendothelial migration;
NM_010745 / Ly86 / 3.571 / protein binding; / ---
NM_010380 / H2-D1 / 3.570 / protein binding; / Natural killer cell mediated cytotoxicity;Cell adhesion molecules (CAMs);Graft-versus-host disease;Allograft rejection;Autoimmune thyroid disease;Antigen processing and presentation;Type I diabetes mellitus;
NM_001111316 / Ptprc / 3.560 / hydrolase activity; protein binding; protein kinase binding; / Cell adhesion molecules (CAMs);Primary immunodeficiency;T cell receptor signaling pathway;
NM_010130 / Emr1 / 3.538 / G-protein coupled receptor activity; calcium ion binding; / ---
NM_007599 / Capg / 3.504 / actin binding; / ---
NM_009778 / C3 / 3.469 / endopeptidase inhibitor activity;protein binding; / Systemic lupus erythematosus;Complement and coagulation cascades;
NM_175628 / A2mp / 3.461 / protein binding;serine-type endopeptidase inhibitor activity;wide-spectrum protease inhibitor activity; / Alzheimer's disease;Complement and coagulation cascades;
NM_031159 / Apobec1 / 3.431 / hydrolase activity;metal ion binding; protein binding; / Atrazine degradation;
NM_001005485 / Olfr111 / 3.423 / receptor activity;olfactory receptor activity; / ---
NM_007498 / Atf3 / 3.398 / protein dimerization activity;transcription factor activity;sequence-specific DNA binding; / ---
NM_031254 / Trem2 / 3.390 / receptor activity; / ---
NM_008479 / Lag3 / 3.388 / MHC class II protein binding;transmembrane receptor activity; / ---
NM_009982 / Ctsc / 3.373 / peptidase activity;cysteine-type endopeptidase activity;chloride ion binding; / ---
NM_013612 / Slc11a1 / 3.372 / transporter activity;iron ion binding; / ---
NM_001111059 / Cd34 / 3.321 / --- / Cell adhesion molecules (CAMs);Hematopoietic cell lineage;
NM_010283 / Ggta1 / 3.318 / --- / Glycan structures - biosynthesis 2;Glycosphingolipid biosynthesis - lactoseries;Glycosphingolipid biosynthesis–neo-
lactoseries;
NM_007801 / Ctsh / 3.318 / protein binding;peptidase activity;cysteine-type endopeptidase activity; / ---
NM_028266 / Col16a1 / 3.314 / integrin binding; protein binding;structural molecule activity; / ---
NM_001042489 / Hvcn1 / 3.307 / voltage-gated ion channel activity;voltage-gated proton channel activity; / ---
NM_007782 / Csf3r / 3.245 / protein binding; receptor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; / Hematopoietic cell lineage;Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;
NM_008533 / Cd180 / 3.221 / protein binding;receptor activity; / ---
NM_023044 / Slc15a3 / 3.215 / oligopeptide transporter activity;transporter activity;symporter activity; / ---
NM_008873 / Plau / 3.212 / serine-type endopeptidase activity;peptidase activity; / Complement and coagulation cascades;
NM_153505 / Nckap1l / 3.208 / --- / Regulation of actin cytoskeleton;
NM_008878 / Serpinf2 / 3.202 / protein binding;serine-type endopeptidase inhibitor activity; / Complement and coagulation cascades;
NM_133211 / Tlr7 / 3.194 / double-stranded RNA binding; protein binding;siRNA binding / Toll-like receptor signaling pathway;
NM_007651 / Cd53 / 3.187 / --- / ---
NM_021281 / Ctss / 3.184 / peptidase activity;cysteine-type endopeptidase activity; / Antigen processing and presentation;
NM_009890 / Ch25h / 3.181 / metal ion binding;iron ion binding;cholesterol 25-hydroxylase activity; / ---
NM_008605 / Mmp12 / 3.160 / metalloendopeptidase activity;peptidase activity;calcium ion binding; / ---
NM_008175 / Grn / 3.148 / --- / ---
NM_008536 / Tm4sf1 / 3.083 / --- / ---
NM_010442 / Hmox1 / 3.075 / metal ion binding;oxidoreductase activity;iron ion binding; / Porphyrin and chlorophyll metabolism;
NM_026819 / Dhrs1 / 3.051 / oxidoreductase activity; binding; / ---
NM_027450 / Glipr2 / 3.050 / --- / ---

GO analysis of differentially expressed genes was focus on molecular function, and pathway analysis was performed based on KEGG. Some genes with unknown functions and pathways.