Female Genital System Lecture Objectives, Page 1

Female genital system lecture objectives, page 1

Female Genital System

Lecture Objectives

Reading

Basic Robbins Chapter 18, pages 681-704

Big Robbins Chapter 22

Slides

22, 34, 37, 94, 104, 153, 155, 163, 181, 192, 198, 223 and normal uterus slide.

Online clinical case

#12 A woman with vaginal bleeding

TBL cases 5 – 7 (located after the breast lecture notes)

Vulva

Vulvitis etiologies (irritant, allergic, infectious dermatitis)

Bartholin gland cyst

Lichen sclerosus et atrophicus

Lichen simplex chronicus

Condylomata lata

Condylomata acuminata

Carcinoma subtypes (HPV and non-HPV associated)

Extramammary Paget Disease

Vagina

Embryologic development

Arcuate, septate, bicornuate, didelphic uteri

Vaginitis etiologies (Candida, Trichomonas, Gardnerella, Molluscum contagiosum)

Carcinoma subtypes (squamous cell and clear cell)

Sarcoma botryoides

Cervix

Cervicitis etiologies (Chlamydia, N. gonorrhea, Ureaplasma, HSV-2)

Cervical dysplasia/neoplasia

Transformation zone

CIN risk factors

HPV subtypes

Pap testing

Colposcopy, LEEP

Carcinoma subtypes (in situ and invasive squamous and endocervical carcinomas)

Corpus uteri

Endometritis etiologies (infectious, retained products, IUD) and complications

Adenomyosis

Endometriosis (etiologies, complications)

Endometrial cycle

menorrhagia, metrorrhagia, oligomenorrhea, amenorrhea, menopause, postmenopause

Abnormal uterine bleeding

Etiologies by age group

Organic uterine lesions vis-à-vis functional etiologies

Endometrial hyperplasia, endometrial polyps

Leiomyomata

Leiomyosarcoma, STUMP

Endometrial carcinoma subtypes

Malignant Mixed Müllerian Tumor (Triple MT)

Fallopian Tubes

Salpingitis

Tubo-ovarian abscess

Pelvic inflammatory disease (PID)

Ovaries

Hypothalamic-pituitary-ovarian-placental endocrinology

Gonadotropin releasing hormone, FSH, LH, estrogen, progesterone, hCG

Follicular and luteal cysts

Polycystic ovary disease (POCD)

Torsion of ovary

Tumors of the ovary

Surface epithelial tumors

Cystadenoma, cystadenofibroma, tumors of low malignant potential,

cystadenocarcinoma, carcinoma

Serous tumors

Psammoma bodies

Mucinous tumors

Pseduomyxoma peritonei, Omental caking

Endometrioid tumors

Brenner tumors

Germ cell tumors

Benign (mature) cystic teratoma/dermoid cyst

Malignant (immature) teratoma

Struma ovarii

Dysgerminoma

Yolk sac (endodermal sinus) tumor

Schiller-Duval body, α-feto protein

Choriocarcinoma

Syncytiotrophoblasts, β-hCG

Sec cord-stromal tumors

Derivation

Granulosa cell tumor (granulosa cell-thecoma tumor)

Call-Exner bodies

Juvenile granulosa cell tumor

Fibroma-thecoma

Meigs syndrome

Sertoli-Leydig cell tumor (androblastoma)

Metastatic tumors to the ovary

Müllerian and extra-Müllerian origin

Krukenberg tumor

Diseases of Pregnancy

Placentation

Syncytiotrophoblasts, trophoblasts, chorionic villi, intervillous space

Single umbilical artery, umbilical knot, cord prolapse, nuchal cord, amniotic band

syndrome, placental infarction, abruption, placenta accrete/increta/

percreta, succenturiate lobe, velamentous insertion, placenta previa

Twin gestation

Zygosity

Monoamnionic monochorionic (MoMo)

Diamnionic monochorionic (DiMo)

Diamnionic dichorionic (DiDi), fused or separate

Twin-twin transfusion syndrome

Placental infections

Ascending (transcervical) infections

PPROM, PROM, chorioamnionitis, funisitis

Hematogenous (transplacental) infections

TORCH

Ectopic pregnancy

Gestational trophoblastic disease

Hydatidiform mole

Complete and partial, cytogenetics

Invasive mole

Choriocarcinoma

Gestational and non-gestational/gonadal

Preeclampsia/Eclampsia

Hypertension, edema, proteinuria

Seizure, coma

Decreased uteroplacental blood flow

Placental infarcts, maternal endothelial dysfunction, end organ failure

HELLP