Notes:

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The general structure of these sequences is Target DNA - extranucs (if any) - L1 cDNA.

ks500= Bluescript KS- origin of replication (L1 target DNA).

Microhomology often exists between the L1 polyT tail and the T rich target sequence (and occasionally between internally initiated L1 cDNA and the target). For the purpose of this supplementary data, this has ambiguous sequence has been assigned to the L1 cDNA.

Non-templated nucleotides are typically separated from the target and L1 cDNA by spaces. In several instances (RNAs #2: 28, 35; #4: 19/T7, 28Bq, 25Bq; and #7: 4, 15), other segments of KS- DNA are found between the target DNA and L1 cDNA. These clones were not excluded from the analysis, but may be the product of an abberant mechanism.

For clarity, the internal polyT heterogeneity with L1 cDNA #4 is not shown in Figure #4c.

The data set is non-redundant. This may have resulted in the exclusion of a few identical yet independent insertions.

Wild-type L1 ORF2, L1 RNA #1

ks500 TGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTT

3/T7 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTT

32•14/T7 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTT

ks500 ACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAG

3/T7 ACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

32•14/T7 ACTCATATATACTTTAGATTGAT:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

ks500 ATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAG

3/T7 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATA

32•14/T7 .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::GCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTAT

L1 3' end ACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTAT

ks500 AGCGCAGATACCAAATACTGTCCTTCTAGTGTAGC

3/T7 TCTCCCAATG:CTATCCCTCCCCAAGGGCGAATTC

32•14/T7 ATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

L1 3' end ATCTCCCAATGCTATCCCTCCCC

Wild-type L1 ORF2, L1 RNA #2

ks500 TGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATAT

27 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATAT

25 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATAT

26 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATAT

36 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATAT

29 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

28 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAG:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

35 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

33 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

ks500 ACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGA

27 ACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAGTCTCATGACCAAAGTCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCT::ACATGT

25 ACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTT:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACATGT

26 ACTTTAGATTGATTTAAAACTTCAT:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACATGT

36 ACTT::::G:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACATGT

29 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACATGT

28 :::::::::::::::::::::::::GAAGGGCCGAACACAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAAAGTAAGTAGTTCGCCCAACCCA:::::::::::::::::::::ACATGT

35 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::GAGTAAGTAGTTCGCCAGTTAATACGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGCCCG:::::::::::::ACATGT

33 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACATGT

L1 3' .ACATGT

ks500 TCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAG

27 GCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCGCCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

25 GCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

26 GCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

36 GCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTGATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTA CCCTCCCCAA GGGCGAATTC

29 GCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

28 GCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

35 GCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTAT CCTCCCCAA GGGCGAATTC

33 GCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

L1 3' .GCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCC

Wild-type L1 ORF2, L1 RNA #3

ks 5 TGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

102 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

QF5 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

QF6 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

17 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

119/T7 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

87 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACNACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

QF7 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACNACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

QF1 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACNACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

QF4 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACNACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

85 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATCGGTAACTGTCA

86 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAGCGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAAATGTCA

106 GAATTNGCCCTTTGGTAAGCCCTCCCGNNTTGTAGTTATTTANANGACGGGGNGTNAGGCAANTATGGATGNACGAAATAGACAGATTGNTGAGATAGGTGCCTNACTGATTAAGCATTGGTAACTGTCA

61 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

108 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

64 GAATTCGCCCTTTGGTAAGCCCTCCCGTATTGTAGTTATTTANACGACGGGGAGTCAGGCAANTATGGGTGAACGAAATAGACAGATNGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

116/T73 GAATTCGCCCTTTGGTAAGCCCTCCCGTATNGTAGTTATNTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACCGATTAAGCATTGGTAACTGTCA

QF2 GAATTCGCCCTTTGGTAAGCCCTCCCGTATNGTAGTTATNTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACCGATTAAGCATTGGTAACTGTCA

28•7/T7 ACCTGCCNNNANGCAAGCTCNACCNTNTTNTAGTGTCATACTAAACGGGNAGTCNGGCANCTATGGATGAACGAANTCTNCNGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

80 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA

94 AAATNCGCCCTTTGGTAANCCCNCCCGTATCGTATTTATCTACACNANGGGGANTCNGGCAACTATGGATGAACNAAATAAACANATCGCTGAAATNGGTGCCNCACTGATTAANCATNGGTAACTGTCA

115 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATACACAGATCGCTGAGATAGGCGCCTCACTGATTAAGCATTGGTAACTGTCA

101 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATACACAGATCGCTGAGATAGGCGCCTCACTGATTAAGCATTGGTAACTGTCA

QF3 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAANTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCANTGGTAACTGTCA

111 GAATTCGCCCTTTGGTAAGCCCTCCCGTATNGTAGTTATNTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTG:::

109 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCA:::::::::::::

65 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTNTGGATGAACGAAATAGACAGATNGCTGAGATAGGTGCCTCACTGATTAA::::::::::::::::

24 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAG::::::::::::::::::::::::::::::::

55 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATA:::::::::::::::::::::::::::::::::

114 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCANGCAACTATGGATGAAC::::::::::::::::::::::::::::::::::::::::::::::::::::::::

20 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGGTGAA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::

84 NAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGAT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

118/T72 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTANTTATCTACACGACGGGGAGTCAGGCAACTATG:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

113 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAAC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

69 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

14 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGAC::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

112 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGAC::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

ks GACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAG

102 AACCAAGTTTACTCATATATACTTTANATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAANATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAG

QF5 AACCAAGTTTACTCATATATACTTTANATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAANATCC::::::::::::::::::::::::::::::::::::::::::::::::::::::

QF6 GACCAAGTTTACTCATATATACTTTAGATTGATTTAAGACTTCATTTTTAATTTA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

17 GACCAAGTTTACTCATATATACTTTAGATTGATTTAAGACTTCATTTTTAA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

119/T7 GACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

87 NACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

QF7 NACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

QF1 NACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

QF4 NACCAAGTTTACTCATATATACTTTAGATTGATTTAAAAC:::::::::::::::::::::::::::::::::::::::::::::::::::AAATG::::::::::::::::::::::::::::::::::

85 GACCAAGTTTACTCATATATACTTTAGATTGATT::::::::::::::::::::::::::ATTTTCGTTTTGTTATTGCAGATTACTTTATTAATAAGGCGCCTAAAGTCCTTTATCTGGATGCAGATAT

86 GACCAAGTTTACTCATATATACTTTAGATTGAT:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AGAG::::

106 GGCCAAGTTTAATNATATATAATTTAGNTTGA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

61 GACCAAGTTTACTCATATATACTTTAGATTGA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

108 GACCAAGTTTACTCATATATACTTTAGATTGA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

64 GACCAAGTTTAATNATATATANTTTAGA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

116/T73 GACCAAGTTTACTCATATATACTTTA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

QF2 GACCAAGTTTACTCATATATACTTTA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

28•7/T7 GACCAAGTTTACTCATATATACTT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

80 GACCAAGTTTA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

94 AACCAAGTTNA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

115 GACCAAG:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

101 GACCAAG:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

QF3 GACCAA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAG:::::::::::::::::::::::::::::::::::

111 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

109 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

65 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

24 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

55 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AACAATTATGAAACTGATAAGTTTTGTGAGCAATTTTAACAAAATAATGTACTTATTGTTACAAATAAAA

114 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

20 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TAAAAAAAAAAAAAAAAAAAAAAAAAAAGAGTTTTA:::::::::::::::

84 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

118/T72 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

113 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

69 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

14 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

112 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TAAAAA::::::::::::::::::::::::::::::::::::::

ks CGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAAC

102 CGTCAGACCCCGTANAAAAGATCAAAGGATCTTCTTGAGATCC::::TTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

QF5 ::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

QF6 :::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

17 :::::::::::::::::::::::::::::::::::::::: ::::::::TTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

119/T7 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

87 ::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

QF7 :::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTNTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

QF1 :::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

QF4 :::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

85 CA::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTATACNCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

86 :::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

106 :::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

61 :::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

108 ::::::::::::::::::::::::::::::::::::TTTTTTTTTTNTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

64 :::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTNTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

116/T73 :::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

QF2 :::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

28•7/T7 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

80 :::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

94 :::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAATNACACNCTAGTTTTNGGGTACATNTNCNCATTGTGCNGGTTANTTACATNTNTATACNTNTNCCATGC

115 ::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTCTTTNATNATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

101 ::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTATACTGTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

QF3 ::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

111 ::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

109 ::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

65 :::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

24 ::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

55 CG::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

114 ::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

20 :::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

84 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::GTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

118/T72 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::CTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

113 :::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

69 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

14 ::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACACGTGCCATGC

112 :::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

L1.3 3' end TTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGC

102 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCTAGGGCGAATTC

QF5 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCTAGGGCGAATTC

QF6 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCTAGGGCGAATTC

17 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

119/T7 TGGTGCGCTGCACCCACTAATGTGTCGTCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

87 TGGTGCGCTGCACCCACTAATGTGTCATCTANCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

QF7 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCTAGGGCGAATTC

QF1 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCTAGGGCGAATTC

QF4 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCTAGGGCGAATTC

85 TGGTGCGCTGCACCCACNAATGTGTCATCTACCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

86 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

106 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

61 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

108 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

64 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGNTATCCCTCCCCAAGGGCGAATTC

116/T73 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

QF2 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

28•7/T7 TGGNGCGCTGCACCCACTAATGTGTNATCTAGCATTAGGTATATCTNCCAATGCTATCCCTCCCCAAGGGCGAATTC

80 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

94 NGGTGCNCNNCCCCCACTANTNTNTCNTCTACCATTNGGTATNTCNCCCAATGCTNNCCCNCCCCNGGGGCNAATNC

115 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

101 TGGTGCGCTGCACCCAGTAATGTGTNATCTAGCNTTAGGTATATCTCCCAATGATATCCCTCCCCAAGGGCGAATTN

QF3 TGGTGCGCTGCACCCAGTAATGTGTNATCTAGCNTTAGGTATATCTCCCAATGATATCCCTCCCCAAGGGCGAATTN

111 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

109 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

65 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

24 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

55 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

114 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

20 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

84 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

118/T72 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

113 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

69 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

14 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

112 TGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

EN Mutant ORF2, L1 RNA #3

ks 500 from 2084 TGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

17/M13-F* GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

16/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

6/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

19/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

52 GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTANTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATANATACATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAAACCAAGTTTA

44 GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTATTTATCTACACGACGGGGANTCAGGCAACTATGGATGAACGAAATACATAGATCGCTGAGATAGGTGCCTCNCTGATTAANCATTGGTAACTGTCANACCAANTTTA

53 AACGGAANGGGGGGGAGTCAAGGGCCAAACTAATGGGATGGAACGGAAAATANGAACAGAATGCGGCTGGAAGATAAGGTGCCTCCAACTGATTAAAGNCATTGGGTAAACNNGTCAGACCAAAGTGTTAACTTCAATNN

79/M13-F.1 TGGTAAGCCCTCCCGGATTGGAGTTATTTAAAAGACGGGGNGTNAGGCAAATATGGNTGNANGAAATAGANAGATTGNTGAGATAGGNGCCTNANTGATTAAGNATTGGNAAATGTNAGACCAAGNTTA

7/M13-F GAATTCGGNTTTGGTAAGCCCTCCCGTNTGGAGNTNTTTAANANGAAGGGGNGTNAGGCAANTATGGGTGNACGAAATAGANAGATNGNTGAGATAGGNGCCTCANTGATTAAGNATTGGNAANTGTNAGNCCAAGNTTA

36/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

37/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

67/M13-F.1 GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

2/M13-F* GAATTGGGTTTGGNAANCCCCCCCGTTTNGGAGTTATNAAAAAGGGGGGGGGGNGAGGCAANTTTGGGTGNANGAAANANANAGATNGGTGNGANAGGNGCCTCANTGATTAAGNATTGGTAACTGTCAGACCAAGTTTA

21/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

35/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

56/M13-R GAATTCGGCTTTGGTAANCCCTCCCGTATCGTATTTATCTACACGACGGGGAGTCAGGCAACTATGGATNAACNAAATAAACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAAACCAATTTTA

66 GAATTNGGNTTTGGTAAGCCCTCCCGTATNGTAGTTATNTACANGACGGGGAGTCAGGCAANTATGGNTGAANGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

10/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

83/M13-F.1 GAATTCNGGCANNTATGNATAANCAAAATAAACAANTCNCTAAAATNGGTNCCNCNCNNATNAACCNTNGGTANNNGTCAAACCAAGTTTA

50 NAATTCGGCTTTGGTAAGCCCTCCCGTATCGTATTTATCTACACNACGGGGAGTCAGGCAACTATGGATGAACAAAATAAACAGATCGCTGAAATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAAACCAATTTTA

49 CCGTATCGTAGTGGTAAGCCCTCCCGTATNGTAGTTATNTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

39/M13-F* GAATTCGGNTTTGGTAANCCCTCCCGNATTGNAGTTATTTANANGANGGGGNGTNAGGNAANTNTGGNTGNACGNAATANANAGATTGNTGAGNTAGGNGCCTCANTGATTAAGCATTGGNAANTGTNAGACCAAGNTTA

15/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

28/M13-F* GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

84 M13 F+R GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTA

29/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGAC::::::::

9/M13-F* GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACT:::::::::::::::

48 GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTCATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATANACAGATCGCTGAGATAGGTGCCTCACTGATTAAG::::::::::::::::::::::::::

38/M13-F GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGG::::::::::::::::::::::::::::::::::::::::::

77/M13-F.1 GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTANTTATCTACACNACGGGGANTCAGGCAACTATGGATGAAC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

42 GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAAC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

46 NAATTCGGCTTTGGTAAGCCCTCCCGTATCGTANTTATCTACACAACGGGGAG:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

76 M13 F+R GAATTCGGCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAG:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

57/M13-F.1 AAAATNCGGNTTGGTAACCCCNCCCNTATCNTATTTATCTACNCAACGGGGA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

ks 500 from 2084 CTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGA

23/M13-F* AAAATTTTTTTTTNATTTNAAAGGATTTNGGGGGANAACCNTTTTGGNAATTTTANGNCCCAAATNCCCTAAAGTGAGTTTTTTTTCCANTGGGGGTCNNACCCCNGNGNAAAAA

17/M13-F* CTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTNCCACTGAGCGTC:::::::::::::::::

16/M13-F CTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGC::::::::::::::::::::

6/M13-F CTNATATATACTTTAGATTGATTTAAAANTTCATTTTTAATTTAAAAGGATNTAGGTGAAGATCCTTTTTGATAATTTCATGACCAAAATCCCTTAANGTGAGTTTT:::::::::::::::::::::::::::::::::

19/M13-F CTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAG:::::::::::::::::::::::::::::::::::::

52 CTCNTATATNCTTTANATTGATTTAAAACTTCNTTTTTAATTTAAAAGGATCTAGGTGAAAATCCTTTTTGATAATCTCATGACCAA:::::::::::::::::::::::::::::::::::::::::::::::::::::

44 CTCATATATACTTTANATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAANATCCTTTTTGATAATCNCATGACCA::::::::::::::::::::::::::::::::::::::::::::::::::::::

53 TATAACTTTTTNAGATTGGATTTAAAANTTCGATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGNTAATCTCAT:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

79/M13-F.1 ATTANANATAATTTAGNTTGNTTTAAAAATTNATTTTTAATTTAAAAGGATTTAGGNGNAGATCCTTTTTGNTAAT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

7/M13-F ATTANATGTAATTTAGNTTGNTTTAAAAATTNATTTTTAATTTAAAAGGATTTAGGGGNAGATCCTTTTTGATAA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

36/M13-F CTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

37/M13-F CTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTT:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

67/M13-F.1 CTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAANATCC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

2/M13-F* ATTANAAANAATNNNGNNNGNTTTAAAAATTCATTT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

21/M13-F CTCATATATACTTTAGATTGATTTAAAACTTCA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

35/M13-F CTCATATATACTTTAGATTGATTTAAAANTTCA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

56/M13-R CTCATATATACTTTAAATTGATTTAAAACTTCA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

66 NTCATATATANTTTAGATTGATTTAAAANTTC::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

10/M13-F CTCATATATACTTTAGATTGATTTAAAAC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

83/M13-F.1 CNCATNTNTNCTTNAAATTGAT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

50 CTCATATATACTTTAAATTGA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

49 CTC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

39/M13-F* CTC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

15/M13-F CT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

28/M13-F* CT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

84 M13 F+R C:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

29/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

9/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

48 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

38/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

77/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

42 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

46 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

76 M13 F+R ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

57/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

L1.3 3' end :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

ks 500 from 2084 TCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGA

23/M13-F* TCAAA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

17/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

16/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

6/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

19/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

52 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

44 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

53 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

79/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

7/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

36/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

37/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

67/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

2/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

21/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

35/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

56/M13-R ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

66 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

10/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

83/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

50 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

49 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

39/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

15/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

28/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

84 M13 F+R ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

29/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

9/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

48 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

38/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

77/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

42 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

46 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

76 M13 F+R ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

57/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

L1.3 3' end ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

ks 500 from 2084 GCGCAGATACCAAATACTGTCCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGC

34/M13-F GAATTCGGCTTATACTGTTCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTAC

23/M13-F* :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTT

17/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

16/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

6/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

19/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

52 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

44 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

53 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

79/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

7/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

36/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

37/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

67/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

2/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

21/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

35/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

56/M13-R ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

66 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

10/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

83/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

50 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

49 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

39/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

15/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

28/M13-F* ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAAAAA

84 M13 F+R :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TAAAAAA

29/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

9/M13-F* :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAAAAAAAAAAAAAAAAAAAAAANCTTTTTTTTTTTTTTTTTTTTTTTNCTTTTTTTTTTTTT

48 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

38/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

77/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

42 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

46 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTT

76 M13 F+R ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TATTTTTTTTTTTTTTTTTTTTTT

57/M13-F.1 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTT

L1.3 3' end ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

34/M13-F CGGGTTGGACTCAAGACNATAGTTACCGGATAAGGCGGACAGTTACCAATGCTTAATCAGTG:TTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTANATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

23/M13-F* TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGTTATACTCTAAGTTTTAGGGTACATGTGCACACTGTGCAGGTTAGTTACATATGTATAC

17/M13-F* :::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTNTTTTTTTTTNANAANACTCNANNTTTTAGGGTTNATGTTTCCATTGTGCAGGTNGGNTTACATATNTTTN

16/M13-F ::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTNAATNATACTCTAANTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATNTATAC

6/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAACTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

19/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

52 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAGTTTTAGGGTTANATGTGCACATTNGTTGGCANNGGTTANTTCACATC

44 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAGTTTTAGGGTGACATGTTGCCACNTTGGTGCCAGGTTTAGNTTNANCA

53 :::::::::::::::::::::::::::::::::::::::::::::::::::::::ACAATTGAACGTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

79/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTAAGTTTTAGGGNAAANGTGCANATTGTGCAGGTTAGNTANANANGTANAA

7/M13-F :::::::::::::::::::::::::TTTAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTNTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

36/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

37/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

67/M13-F.1 :TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTTTTTTTTTTTTTTTTTNTTTTTTTTTTTTTATNNAAAAAANCCCNAATTTTTAGGGTTCNTNTTTCCATTGTGCAGGTTNGTTACATATNTTTAC

2/M13-F* :::::::::::::::::::::::::::AAAAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTNNNAATAANACTCTAAGTTTTAGGGAACATGTGCACATTGTGCAGGTTAGTNACATATGTANAC

21/M13-F :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTANTTACATATGTATAC

35/M13-F :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

56/M13-R :::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAATNANNCNCTAATTTTTNGGGTNCNTNTNCNCNTTGNGCNGGTTATTTACATNTTTTTAC

66 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ATTATACTTTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

10/M13-F :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTANTTACATATGTATAC

83/M13-F.1 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTACNTNTTTTTNC

50 ::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTNTTTTANNATACNCNAATTTTAGGGTNNTNTNCNCCATTGTGCAGGTTTANATTACATTAATNC

49 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

39/M13-F* ::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

15/M13-F :::::::::::::::::::::::::::::::::::::::::::::::::::::::::GAAGGCAATCTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

28/M13-F* AAAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTANAAANCNCNAATTTTTNGGGTNNNTTTTCCCNTTNTGCGGGTTATTTNCATNTTTTTAC

84 M13 F+R AAAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTANTANANTTTAAGTTTTAGGGTANATGTGCANATTGTGCAGGTTAGTTANATATGTATAN

29/M13-F ::::::::::::::::::::::::::::::::::::::::::::::AAAAAAAAAGTTTTTTTTTTTTTTTTTTTTTTTTATTANACTCTAAGTTTTAGGGTNCATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

9/M13-F* TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAAAANCNNTATTTTTTGGGGTTNNTTTTCNCNTTNNGNGGGTTNTTTCCATNTTTTNAN

48 ::::::::::::::::::::::::::::::::CCGCATCAAAAAAATAAAAACTTTTTTTTTTTTTTTTTTTTTTTTTTTATNATACTCNAAGTTTTAGGGTACATGTNCACATTGTGCAGGTTAGTTACATATGTATAC

38/M13-F ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::GTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

77/M13-F.1 :::::::::::::::TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTNTTTTTTTTTTTTTTTTNTGNTTNTTCTGATTTTGGGGTTGTTTTNTACNTTTTTNANGTTTTTCNNTTGTNTTNNN

42 ::::::::::TCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAANNAAACNCTAATTTTAGGGTNCATTTNCNCATTGTGCAGGTTANTTACATNTTTNTAC

46 TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTANTNNNAANCCNNANTTTTTNGGGNTANTTTTNCCATTTNNCNGGTTTTTTNCNTTTTTTNCC

76 M13 F+R TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAATANAATTTAANNTTTAGGGNAAANGNGCAAANTGNGCNGGNTAGNTAAANANGNANAA

57/M13-F.1 TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTANNAANAANCCCNNNTTTTTNGGGNTNNTTTTCCNNTTNNGGGGGNTTNTTNNANTTTTTTT

L1.3 3' end ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTATTATACTCTAAGTTTTAGGGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATAC

34/M13-F ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTANCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

23/M13-F* ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCT::::::::::AAGCCGAATTC

17/M13-F* CATGTTNCCCATGCTGCGCCGCACCCACNAATGTTTTTTCTANCATTAGGTTTTTCTCCCCATGCTTTCCCNCCCCCNGCCNAATTC

16/M13-F ATGTGCCATGCNGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTNTATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

6/M13-F ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

19/M13-F ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

52 ATGNTATACATGTTGTCCCATGCCTGGGTGCCGCCNTGCACCCCACTAAATAGTTGTCCATCCNTAAGCAATTTAAGGGTTATTATC

44 TACTGTTATTACCANNGTTGCCCATGCTGGTTGCNCNTTGCACCCCANCNTAANTGTTGTCCANCCTNANCCATCTAGGGTTATNAT

53 ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTN

79/M13-F.1 ANGTGCCATGGTGGNGNGNTGCANCCAATAATGNGTNACCTNGCATTAGGNANATTTNCCAATGGTATCCCTCCCCNAGCCGNATTT

7/M13-F ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

36/M13-F :::::::::::::::::::TGCCCC:::::::::GTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

37/M13-F :::::::::::::::::::::::::::::::::::::::::::::::::::::ATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

67/M13-F.1 ATNTTCCCAGCCGGGGCCCCNNCCCCNCTAATNTTTTCCCCCAACATTAGGTTTATCCCCCCAATGCTTCCCCCCCAAACCNAATTC

2/M13-F* ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATNTCCCAATGCTATCCCTCCCCAAGCCGAATTC

21/M13-F ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

35/M13-F ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

56/M13-R NTTTNCCANGCNGGTGCCCTNCNCCCACTANTTTTTCCCCTACCATTAGGTTTTTCNCCCCNAATGGCNANCCCCCCCCAAGCCAAA

66 ATGTGCCATGGTGGTGCGNTGCACCCANTAATGTGTCATCTAGCATTAGGTATATNTCCCAATGCTATCCCTCCCCAAGCCGAATTC

10/M13-F ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

83/M13-F.1 NTTTNCCANGCTGGTGCCCTNCNCCCNNTANTNTTTCNNCNACCATNAGGTNTNNCNCCCANNGCTNNCCCCCCCAANCAANTCCAC

50 TNTACATTTNNCCATGCCTGGTTGCCGCTNCCCCCCAACTAAATGTTNTCACCCNCAGCCNTTTAGGTTTTANTCNCCCCCAATGCC

49 :::::::::::::::::::::::::::::::::::::::::::::CGCCC:ATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

39/M13-F* ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

15/M13-F ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTANCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

28/M13-F* NTTTNCCNNGCGGGNGCCCCCCCCCCNCNAATNTTTTNNCNACCATTNGGTTTTTCCCCCAATGCTNNCCCCCCCCAANCCAAATTC

84 M13 F+R ATGTGCCATGNTGGTGCGNTGCACCCANTAATGTGTNATTTAGCATTAGGTATATTTCCCAATGNTATCCCTCCCCAAGCCGAATTT

29/M13-F ATGTGCCATGCTGGTGCGCNGCACCCACTAATGTGTCNTCTANCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGCCGAATTC

9/M13-F* NTTTTCCNGGNGGGGGCCCCCNCCCCNNNNTTTTTTNNNCCNNCAANGGNTTNTTTCCCCAATGTTTCCCCCCCCCNANCCAANTTC

48 ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTTTCATCTACCATTAGGTATATTCCCCAATGCTATCCCTCCCCAAGCCGAATTC

38/M13-F ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCATTGCTATCCCTCCCCAAGCCGAATTC

77/M13-F.1 CTNTNCCNANTTTNTTNTCTGCNACCATTTANTTTTNCTCNNTGNNCCCGTCCAATCNCCAATGAATACCCGGCCCNGGCCGAANTC

42 ATTTNCCANGCTGGTGCNCNNCNCCCNCTAATNTTTNNTCNANCATTAGGTNTNTCTCCCAATGCTANCCCCCCCCAANCCNAATTC

46 TTTTTCCAGNGCCCCCCCCCCCTNATNNANTTTTTCCCNCNAACGTGGGTTTTCAACCNCTCCCCCCCCNAACAATCCACCNNATTC

76 M13 F+R ANGNGCCNTGGTGGNGGGGTGCANCCAATAANGNGTTATTTNGCATTAGGGANATTTNCCNANGGTATCCCTCCCC

57/M13-F.1 NNTTTTCCNNGGGGGGNNCCCCCCCCCNNNNNTTTTTTNNNCAANNANGNTTTTNNCCCCAANNNTNCCCCCCCCCNAANCAAATTC

L1.3 3' end ATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCC

Wild-type L1 ORF2, L1 RNA #4

ks500 TGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATAT

18b GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCGGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCGTATAT

25 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATAT

14 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATAT

11Bq GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATGGACAGATCGCTGTGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCTTATAT

3 GAATTCGCCCTTTGGTAAGCCCTCCCGTATNGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGNTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGNCCAAGTTTACTCATATAT

26 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTCACTCATATAT

6 GAATTCGCCCTTAGGTAAGCCCTNCCGTATCGNAGTNATNTACNCNANGGGGAGNCNGGCANCTATGGATGAACGAAATAGACAGATCGCTGANATAGGTGCCTCACTGATTAANCATTGGTGACTGTCAGACCAAGTTTACTCATNNAT

1Bq GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCA::::::::::::::::::::

8 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACNACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAAC:::::::::::::::::::::::::

23 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAACCCTCACTAA::::::::::::::::::::::::::

5 GAATTCGCCCTTTGGTAAGCCCTCCCGNATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAA::::::::::::::::::::::::::::::::::::

20 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAA::::::::::::::::::::::::::::::::::::

27 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAA::::::::::::::::::::::::::::::::::::

17 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTA:::::::::::::::::::::::::::::::::::::

18B/T7 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACT::::::::::::::::::::::::::::::::::::::::::

13 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACNACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACT::::::::::::::::::::::::::::::::::::::::::

14Bq GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::

21 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

16 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

19/T7 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACT:::::GGGCGAATTGGAGCTCCACCGCGGTGGCGTCCGCTCTAGAACTAGTGGATCCATGGAATACTATGCAGCCATAA:::::::

24 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

5Bq GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

18 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTGGGGC::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

28Bq GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGT:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACACTTTATGCTTCCGGCTCGTATGTTGTGTGGA

17b GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGAC::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

25Bq GAATTCGCCCTTAGGTAAGCCCTCCCGTATCGTAGTTA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::CGCCTGTATTAGTACCCAATTGCTATTGGCGCATAATCTTTGCCTGT

19b GAATTCGCCCTTGGGTAAGCCCTCCCGTATNGTAGT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

ks500 ACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGA

18b ACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATC:::::::::::::::AACTA::::ACCCTCACTAAAGGGAACAAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

25 ACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGAT:::::::::::::::::::::::::::::ACTAAAGGGAACAAAAGCTGGAGCTCGGTCTCTCTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

14 ACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAG::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

11Bq ACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

3 ACTTTAGATTGATTTAAAACTTCATTTTTAATTT::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTATTATNCTCTAAGTTTTAG

26 ACTTTAGATTGATTTAAAACTTCATTTTTA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTATACTCTAAGTTTTAG

6 ACTTTAGATTGA:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::GTTTTAG

1Bq ::::::::::::::::::::::::::::::::::::::::::TCCCCG::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTATTATACTCTAAGTTTTAG

8 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AGGTA::::::::::::ACCCTCACTAAAGGGAACAAAAGCTGGAGCTCGGACTCTTTTTTTTTTTTTATTATNCTCTAAGTTTTAG

23 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AGGGAACAAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

5 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::CCCTCACTAAAGGGAACAAAAGCTGGAGNTCGGTCTCTTTATTTTTTTTTTTTTATTATACTCTAAGTTTTAG

20 :::::::::::::::::::CCCTCACTAAAGGGAACAAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTTTTATT::::::ACTAAAGGGAACAAAAGCTGGAGCTCGGNCTCTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

27 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::CCCTCACTAAAGGGAACAAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTATNCTCTAAGTTTTAG

17 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACCCTCACTAAAGGGAACAAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

18B/T7 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

13 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ATTATTATACTCTAAGTTTTAG

14Bq ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAACC CGGGGTAACC CTCACTAAAG GGAACAAAAGC TGGAGCTCGG TCTCTTTTTT TTTTTTTTTT TATTATACTC TAAGTTTTAG

21 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAAGCAC::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

16 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AGTTTTAG

19/T7 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

24 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::CTAAGTTTTAG

5Bq ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACTCTAAGTTTTAG

18 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ATTATACTCTAAGTTTTAG

28Bq ATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCGAGCGCGCAATTA::::::::::::ACCCTCACTAAAGGGAACAAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

17b :::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAACCCAGAGCCGA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ATTATACTCTAAGTTTTAG

25Bq GTGAAAATGACGCGAAAGAATTCCATTTACGTGACTTGTTTTAAAATAAATTAATATTTTTGCA::::::::::::::::::::::::GGAACAAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

19b ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ACCCTCNCTAAAGGGAACAAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

L1 3' plus u.ACCCTCACTAAAGGGAACAAAAGCTGGAGCTCGGTCTCTTTTTTTTTTTTTTTATTATACTCTAAGTTTTAG

ks500 TCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGAT

18b GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGNGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCGAAGGGCGAATTC

25 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

14 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

11Bq ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AAAACCTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

3 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCANTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

26 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

6 GGTNCATGTGCACATTGNCGCATGTTNGTACNTATGTATNCATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCNTTAGGTATATCTCCCAATGCTATCCCTCCCCANGGGCGAATTC

1Bq GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

8 GGTACNTGTGCACATTGNGCAGGTTNGNTACATATGTATACATGTGCCATGCTGGNGCNCTGCACCCACTAATGTGCCATCTATCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

23 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

5 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

20 GGTACATGTGCACATTGNGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGNGTCATCTAGCATTAGGTATATNTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

27 GGNNCNTGNGCCCATTGNGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGGGCGCTGCACCCACTAATGGGGNATATANCATTAGGTATATNTNCCAATGCTATCCCTCCCCAAGGGCGAATTC

17 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

18B/T7 :ATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGNCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

13 GGTACATGTGCACATTGTGCAGGTTAGNTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTANCATTAGGTATATGTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

14Bq GGTACATGTG CACATTGTGC AGGTTAGTTA CATATGTATA CATGTGCCAT GCTGGTGCGC TGCACCCACT AATGTGTCAT CTAGCATTAG GTATATCTCC CAATGCTATC CCTCCCCAAG GGCGAATTC

21 :::::::::::::::::::::::::AGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

16 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

19/T7 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

24 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

5Bq GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

18 GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

28Bq GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

17b GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

25Bq GGTACATGTGCACATTGNGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGNGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

19b GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCCAAGGGCGAATTC

L1 3' plus u.GGTACATGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAATGTGTCATCTAGCATTAGGTATATCTCCCAATGCTATCCCTCCCC

Wild-type L1 ORF2, Alu RNA #6

ks500 TGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATA

22b GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATCGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATA

2 GAATTCGCCCTTTGGTAACGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTC:::::

11b GAATTCGCCCTTTGGTAA:GCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATA::::::::::::::::::::::::::::::::::::::::::::::::::::

1 GAATTCGCCCTTTGGTAA:GCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTA::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

ks500 TACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAG

22b TACTTTAGATTGATTTAAAACTTCA::::::::::::::::::::::::::::::GCTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCG

2 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AGCTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTAGG

11b ::::::::::::::::::::::::::::::::::::::::::::::::::::::::TTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCG

1 :::::::::::::TTTCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTTTTTTTTTTTTTTTTTTTTTGANACGGAGTNTCGCTNTGTTGCCCAGGCTGGAGNGCAGNGGCGGGATCTCGGCTCACTGNAAGCTCCGCCTCCCG

TPA Alu - 25 TTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCG

ks500 ATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACA

22b GGTTCATGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTAGGACTACAGGCGCCCGCCACTACGCCCGGCTATTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCGTTTTAGCCGAAGGGCGAATTC

2 ACTACAGGCGCCCGCCACTACGCCCGGCTATTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCGTTTTAGCCGAAGGGCGAATTC

11b GGTTCATGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTAGGACTACAGGCGCCCGCCACTACGCCCGGCTATTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCGTTTTAGCCGAAGGGCGAATTC

1 GGTTCATGCCATTNTCCTGCCTCAGCCTCCCAAGTAGCTAGGACTACAGGNGCCCGCCACTACGCCCGGNTATTTTTTGNAGTTTTAGTANANACGGGGTTTCACCGTTTTAGCCGAAGGGCGAATTC

TPA Alu - 25 GGTTCATGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTAGGACTACAGGCGCCCGCCACTACGCCCGGCTATTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCGTTTTAGCCGGGATGGTCTCGATC

Wild-type L1 ORF2, anti-sense, S. cerevisiae URA3 RNA

ks500 TGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATA

16 GAATTCGCCCTTTGGTAACGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAGATAGACAGATCGCTGAGATAGGTGCCTCCCTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATA

9 GAATTCGCCCTTTGGTAAGGCCCTCCCGTATCGTAGTTACCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATA

4 GAATTCGCCCTTTGGTAACGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCC::::::::::::::::::::::::::::::::::::::::::::::

15 GAATTCGCCCTTTGGTAAGCCCTCCCGTATCGTAGTTATCTACAC::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

antisense ur.ATGTCGAAAGCTACATATAAGGAACGTGCTGCTACTCATCCTAGTCCTGTTGCTGCCAAGCTATTTAATATCATGCACGAAAAGCAAACAAACTTGTGTGCTTCATTGGAT

ks500 TACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAG

16 TACTTTAGATTGATTTAAAACTTC::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

9 TACTTTAGATTAATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTT:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

4 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::AATTCCTGCAGCCCGGGGGATCCATGTCGAAAGCTACATATAAGGAACGTGCTGCTACTCATCCTAGTCCTGTTGCTGCCAAGCTATTT

15 ::::::::::::::::::::::::::::::::::::::::::::::::::::CTCCCGTATCGTAGTTATCTACACCTCCCGTATCGTAGTTATCTACACCTCCCGTATCGTAGTTATCTACACCTCCCGTATCGTAGTTATCTACACCC

antisense ur.GTTCGTACCACCAAGGAATTACTGGAGTTAGTTGAAGCATTAGGTCCCAAAATTTGTTTACTAAAAACACATGTGGATATCTTGACTGATTTTTCCATGGAGGGCACAGTTAAGCCGCTAAAGGCATTATCCGCCAAGTACAATTTTTAC

ks500 ATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTCCTTCTAG

16 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

9 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

4 AATATCACGCACGAAGAGCAAACAAACTTGTAGAGCACTGGGCAGAAATCACATTGCGTCAACACCCGC:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

15 CCC::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::TACGAATGCACACGGTGTGGTGGGCCCAGGTATTGTTAGCGGTTTGAAGCAGGCGGCAG

antisense ur.TCTTCGAAGACAGAAAATTTGCTGACATTGGTAATACAGTCAAATTGCAGTACTCTGCGGGTGTATACAGAATAGCAGAATGGGCAGACATTACGAATGCACACGGTGTGGTGGGCCCAGGTATTGTTAGCGGTTTGAAGCAGGCGGCAG

ks500 TGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGC

16 :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::C::::::

9 :::::::::CC::::::::::::::::::::GATGTTAGCAGAATTGTCATGCAAGGGCTCCCTATCTACTGGAGAATATACTAAGGGTACTGTTGACATTGCGAAGAGCGACAAAGATTTTGTTATCGGCTTTATTGCTCAAAGAGACA

4 ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

15 AAGAAGTAACAAAGGAACCTAGAGGCCTTTTGATGTTAGCAGAATTGTCATGCAAGGGCTCCCTATCTACTGGAGAATATACTAAGGGTACTGTTGACATTGCGAAGAGCGACAAAGATTTTGTTATCGGCTTTATTGCTCAAAGAGACA

antisense ur.AAGAAGTAACAAAGGAACCTAGAGGCCTTTTGATGTTAGCAGAATTGTCATGCAAGGGCTCCCTATCTACTGGAGAATATACTAAGGGTACTGTTGACATTGCGAAGAGCGACAAAGATTTTGTTATCGGCTTTATTGCTCAAAGAGACA

16 ::::::::::::::GAAGGTTACGATTGGTTGATTATGACACCCGGTGTGGGTTTAGATGACAAGGGAGACGCATTGGGTCAACAGTATAGAACCGTGGATGATGTGGTCTCTACAGGATCTGACATTATTATTGTTGGAAGAGGACTAT

9 TGGGTGGAAGAGATGAAGGTTACGATTGGTTGATTATGACACCCGGTGNGGGTTTAGATGACAAGGGAGACGCATTGGGTCAACAGTATAGAACCGTGGATGATGTGGTCTCTACAGGATCTAACATTATTATTGNTGGAAGAGGACTAT

4 :::::::::::::::AAGGTTACGATTGGTTGATTATGACACCCGGTGTGGGTTTAGATGACAAGGGAGACGCATTGGGTCAACAGTATAGAACCGTGGATGATGTGGTCTCTACAGGATCTGACATTATTATTGTTGGAAGAGGACTAT

15 TGGGTGGAAGAGATGAAGGTTACGATTGGTTGATTATGACACCCGGTGTGGGTTTAGATGACAAGGGAGACGCATTGGGTCAACAGTATAGAACCGTGGATGATGTGGTCTCTACAGGACCTGACATTATTATTGTTGGAAGAGGACTAT

antisense ur.TGGGTGGAAGAGATGAAGGTTACGATTGGTTGATTATGACACCCGGTGTGGGTTTAGATGACAAGGGAGACGCATTGGGTCAACAGTATAGAACCGTGGATGATGTGGTCTCTACAGGATCTGACATTATTATTGTTGGAAGAGGACTAT

16 TTGCAAAGGGAAGGGATGCTAAGGTAGAGGGTGAACGTTACAGAAAAGCAGGCTGGGAAGCATATTTGAGAAGATGCGGCCAGCAAAACTAAGATCTGCGAAGGGCGAATTC

9 TTGCAAAGGGAAGGGATGCTAAGGTAGAGGGTGAACGTTACACAAAAGCAGGCTGGGAAGCATATTTGAGAAGATGCGGCCAGCAAAACTAAGATCTGCGAAGGGCGAATTC

4 TTGCAAAGGGAAGGGATGCTAAGGTAGAGGGTGAACGTTACAGAAAAGCAGGCTGGGAAGCATATTTGAGAAGATGCGGCCAGCAAAACTAAGATCTGCGAAGGGCGAATTC

15 TTGCAAAGGGAAGGGATGCTAAGGTAGAGGGTGAACGTTACAGAAAAGCAGGCTGGGAAGCATATTTGAGAAGATGCGGCCAGCAAAACTAAGATCTGCGAAGGGCGAATTC

antisense ur.TTGCAAAGGGAAGGGATGCTAAGGTAGAGGGTGAACGTTACAGAAAAGCAGGCTGGGAAGCATATTTGAGAAGATGCGGCCAGCAAAACTAA

Five prime end L1 insertions (TPRT using the second nick):

First capitalized sequence: JB1180 oligo

Following lower case sequence: target DNA

Terminal capitalized sequence: 5' end of the transposed cDNA

(N)= deletion or missing sequence

)N(= addition or extra nucleotides

01/03- 7nt 5' cDNA deletion

(TGGTAA)GCCCTCCCGTATCGTAGTtatctacgcgacggggagtcaggcaactatggatgaacgaaatagacagatcgctgagataggtgcctcactgattaagcattggtaactgtcagacc(GGGCGAA)TTGGAGCTTCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCATGGAATACTATGCAGCCATAAAAAATGATGAGTTCTATCCTTTGTAGGGACATGGATGAAATTGGAAACCATCATTCTCAG

05/09- 1nt 5' cDNA addition

TGGTAAGCCCTCCCGTATCGTAGTtatctacacgacggggagtcaggcaactatggatgaacgaaatagacagatcgctgagataggtgcctcactgattaagcattggtaactgtcagaccaagtttactcatatatactttagattgatttaaaacttcatttttaatttaaaaggatctaggtg)t(GGGCGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCATGGAATACTATGCAGCCATAAAAAATGATAAGTTCATATCCTTTGTAGGGACATGGATGAAATTGGAAACCATCATTCTCAG

08/12- 1-3nt cDNA deletion

TGGTAAGCCCTCCCGTATCGTAGTtatctacacgacggggagtcaggcaactatggatgagcgacatagacagatcgctgagataggtgcctcactgattaagcattggtaactgtcagaccaagtttactcatatatactttagattgatttaaaacttcatttttaatttaaaa)g(GGCGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCATGGAATACTATGCAGCCATAAAAAATGATGAGTTCATATCCTTTGTAGGGACATGGATGAAATTGGAAACCATCATTCTCAG

13- 1nt cDNA addition

TGGTAAGCCCTCCCGTATCGTAGTtatctacacgacggggagtccaggcaactatggatgaacgaaatagacagatcgctgagataggtgcctcactgattaagcattggtaactgtcagaccaagtttactcatatatactttagattgattta)t(GGGCGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCATGGAATACTATGCAGCCATAAAAAATGATGAGTTCATATCCTTTGTAGGGACATGGATGAAATTGGAAACCATCATTCTCAG

18- 1nt cDNA addition

TGGTAAGCCCTCCCGTATCGTAGTtatctacacgacggggagtcaggcaactatggatgaacgaaatagacagatcgctgagataggtgcctcactgattaagcattggtaactgtcagaccaagtttactcatatatactttagattgatttaaaacttcatttttaatttaaaaggatctaggtgaagatcctttttgataatctcatga)t(GGGCGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCATGGAATACTATGCAGCCATAAAAAATGATGAGTTCATATCCTTTGTAGGGACATGGATGAAATTGGAAACCATCATTCTCAG

20- no additions or deletions

TGGTAAGCCCTCCCGTATCGTAGTtatctacacGGGCGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAACTAGTGGATCCATGGAATACTATGCAG

CCATAAAAAATGATGAGTTCATATCCTTTGTAGGGACATGGATGAAATTGGAAACCATCATTCTCAG