Table S3 (related to Figure 1). Senescence Geneset

Genes upregulated in senescent cells and genes implicated in the senescence-associated secretory phenotype (SASP) significantlyaltered between presenescent and senescent states. Genes present in Cluster G1are indicated in red (31 genes), and genes significantly upregulated in sarcopenic satellite cells are in bold (13 genes).

Gene Symbol / Name
Aldh1a3 / Aldehyde dehydrogenase 1 family, member A3
Ang / Angiogenin, ribonuclease, rnase A family, 5
Areg / Amphiregulin; amphiregulin B
Bhlhe40 / Basic helix-loop-helix family, member e40 (DEC1)
C9orf3 / Chromosome 9 open readingframe 3
Ccl1 / Chemokine (C-C motif) ligand 1 (I-309)
Ccl13 / Chemokine (C-C motif) ligand 13 (MCP-4)
Ccl16 / Chemokine (C-C motif) ligand 16 (HCC-)
Ccl20 / Chemokine (C-C motif) ligand 20 (MIP-3a)
Ccl25 / Chemokine (C-C motif) ligand 25 (TECK)
Ccl26 / Chemokine (C-C motif) ligand 26 (Eotaxin-3)
Ccl3 / Chemokine (C-C motif) ligand 3 (MIP-1a)
Ccl8 / Chemokine (C-C motif) ligand 8 (MCP-2)
Ccnd1 / Cyclin D1
Cd44 / CD44 molecule (Indian blood group)
Cdkn1a / Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Cdkn1c / Cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Cdkn2a / Cyclin-dependent kinase inhibitor 2A (p16, Ink4a)
Cdkn2b / Cyclin-dependent kinase inhibitor 2B (p15, Ink4b)
Cdkn2d / Cyclin-dependent kinase inhibitor 2D (p19)
Cited2 / Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Cltb / Clathrin, light chain (Lcb)
Col1a1 / Collagen, type I, alpha 1
Col1a2 / Collagen, type I, alpha 2
Creg1 / Cellular repressor of E1A-stimulated genes 1
Cryab / Crystallin, alpha B
Csf2rb / Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Csf3 / Colonystimulating factor 3 (granulocyte)
Ctgf / Connectivetissuegrowth factor
Ctsb / Cathepsin B
Cxcl1 / Chemokine (C-X-C motif) ligand 1 (GRO-alpha)
Cxcl11 / Chemokine (C-X-C motif) ligand 11 (IP-9/I-TAC)
Cxcl12 / Chemokine (C-X-C motif) ligand 12 (SDF-1)
Cxcl13 / Chemokine (C-X-C motif) ligand 13(BCA-1)
Cxcl14 / Chemokine (C-X-C motif) ligand 14
Cxcl2 / Chemokine (C-X-C motif) ligand 2 (GRO-beta)
Cxcl3 / Chemokine (C-X-C motif) ligand 3 (GRO-gamma)
Cxcl5 / Chemokine (C-X-C motif) ligand 5 (ENA-78)
Cyp1b1 / Cytochrome P450, family 1, subfamily B, polypeptide 1
Egf / Epidermal growth factor
Egfr / Epidermalgrowth factor receptor
Egr1 / Earlygrowth response 1
Eif2s2 / Eukaryotic translation initiation factor 2, subunit 2 beta, 38kda
Ereg / Epiregulin
Esm1 / Endothelialcell-specificmolecule 1
F3 / Coagulation factor III (thromboplastin, tissue factor)
Fas / Fas (TNF receptor superfamily, member 6)
Fgf2 / Fibroblastgrowth factor 2 (basic)
Fgf7 / Fibroblast growth factor 7
Filip1l / Filamin A interacting protein 1-like
Fn1 / Fibronectin 1
Gsn / Gelsolin (amyloidosis, Finnishtype)
Guk1 / Guanylate kinase 1
Hbs1l / HBS1-like (S. Cerevisiae)
Hgf / Hepatocyte growth factor (hepapoietin A)
Hps5 / Hermansky-Pudlaksyndrome 5
Hspa2 / Heat shock 70kda protein 2
Htatip2 / HIV-1 Tat interactive protein 2, 30kda
Icam1 / Intercellularadhesionmolecule 1
Icam3 / Intercellularadhesionmolecule 3
Ifi16 / Interferon, gamma-inducible protein 16
Ifng / Interferon, gamma
Igfbp1 / Insulin-like growth factor binding protein 1
Igfbp2 / Insulin-like growth factor binding protein 2
Igfbp3 / Insulin-like growth factor binding protein 3
Igfbp4 / Insulin-like growth factor binding protein 4
Igfbp5 / Insulin-like growth factor binding protein 5
Igfbp6 / Insulin-like growth factor binding protein 6
Igfbp7 / Insulin-like growth factor binding protein 7
Igsf3 / Immunoglobulinsuperfamily, member 3
Il13 / Interleukin 13
Il15 / Interleukin 15
Il1a / Interleukin 1, alpha
Il1b / Interleukin 1, beta
Il6 / Interleukin 6 (interferon, beta 2)
Il6st / Interleukin 6 signaltransducer (gp130, oncostatin M receptor)
Il7 / Interleukin 7
Il8 / Interleukin 8
Ing1 / Inhibitor of growth family, member 1
Irf5 / Interferonregulatory factor 5
Irf7 / Interferonregulatory factor 7
Isg15 / ISG15 ubiquitin-likemodifier
Kitlg / KIT ligand
Map1lc3b / Microtubule-associated protein 1 light chain 3 beta
Map2k3 / Mitogen-activated protein kinase kinase 3 (MKK3)
Mdm2 / Mdm2 p53 binding protein homolog (mouse)
Mif / Macrophage migration inhibitory factor
Mmp1 / Matrixmetallopeptidase 1 (interstitialcollagenase)
Mmp10 / Matrixmetallopeptidase 10 (stromelysin 2)
Mmp12 / Matrixmetallopeptidase 12 (macrophageelastase)
Mmp13 / Matrixmetallopeptidase 13 (collagenase 3)
Mmp14 / Matrixmetallopeptidase 14 (membrane-inserted)
Mmp3 / Matrixmetallopeptidase 3 (stromelysin 1, progelatinase)
Ndn / Necdinhomolog
Ngf / Nerve growth factor (beta polypeptide)
Nme2 / NME/NM23 nucleoside diphosphate kinase 2
Nrg1 / Neuregulin 1
Optn / Optineurin
Pea15 / Phosphoproteinenriched in astrocytes 15
Pigf / Phosphatidylinositol glycan anchor biosynthesis, class F
Plat / Plasminogenactivator, tissue (tPA)
Plau / Plasminogenactivator, urokinase (uPA)
Plaur / Plasminogenactivator, urokinase receptor (uPAR)
Rab13 / RAB13, member RAS oncogene family
Rab31 / RAB31, member RAS oncogene family
Rab5b / RAB5B, member RAS oncogene family
Rabggta / Rabgeranylgeranyltransferase, alphasubunit
Rac1 / Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Rb1 / Retinoblastoma 1
Rgl2 / Ral guanine nucleotide dissociation stimulator-like 2
Rhob / Ras homolog gene family, member B
Rras / Related RAS viral (r-ras) oncogenehomolog
S100a11 / S100 calcium binding protein A11; S100 calcium binding protein A11 pseudogene
Serpinb2 / Serpin peptidase inhibitor, clade B (ovalbumin), member 2
Serpine1 / Serpinpeptidaseinhibitor, clade E (PAI-1)
Smpd1 / Sphingomyelinphosphodiesterase 1, acidlysosomal
Smurf2 / SMAD specific E3 ubiquitin protein ligase 2
Sod1 / Superoxidedismutase 1, soluble
Sparc / Secreted protein, acidic, cysteine-rich (osteonectin)
Stat1 / Signal transducer and activator of transcription 1
Tes / Testis derived transcript (3 LIM domains)
Tfap2a / Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Tgfb1i1 / Transforming growth factor beta 1 induced transcript 1
Thbs1 / Thrombospondin 1
Timp2 / TIMP metallopeptidaseinhibitor 2
Tnfaip2 / Tumor necrosis factor, alpha-inducedprotein 2
Tnfaip3 / Tumor necrosis factor, alpha-inducedprotein 3
Tnfrsf10b / Tumor necrosis factor receptor superfamily, member 10b (human Tnfrsf10d, DCR2)
Tnfrsf10c / Tumor necrosis factor receptor superfamily, member 10c (TRAIL-R3)
Tnfrsf11b / Tumor necrosis factor receptor superfamily, member 11b
Tnfrsf1b / Tumor necrosis factor receptor superfamily, member 1B (sTNFRI)
Tp53 / Tumor protein p53
Tspyl5 / TSPY-like 5
Vegfa / Vascular endothelial growth factor A
Vim / Vimentin