Research outputs
Listing of Research outputs
The fecal metabolome as a functional readout of the gut microbiome
Zierer, J., Jackson, M. A., Kastenmüller, G., Mangino, M., Long, T., Telenti, A., Mohney, R. P., Small, K. S., Bell, J. T., Steves, C. J., Valdes, A. M., Spector, T. D. & Menni, C. 28 May 2018 In : Nature Genetics. 50, p. 790-795
Research output: Contribution to journal › Article
Gut microbial diversity is associated with lower arterial stiffness in women
Menni, C., Lin, C., Cecelja, M., Mangino, M., Matey-Hernandez, M. L., Keehn, L., Mohney, R. P., Steves, C. J., Spector, T. D., Kuo, C-F., Chowienczyk, P. & Valdes, A. M. 9 May 2018 In : European Heart Journal.
Research output: Contribution to journal › Article
Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure
Visconti, A. , Duffy, D. , Liu, F. , Zhu, G. , Wu, W. , Chen, Y. , Hysi, P. , Zeng, C. , Sanna, M. , Iles, M. M. , Kanetsky, P. A. , Demenais, F. , Hamer, M. A. , Uitterlinden, A. G. , Ikram, M. A. , Nijsten, T. E. C. , Martin, N. G. , Kayser, M. , Spector, T. D. , Han, J. & 2 others Bataille, V. & Falchi, M. 8 May 2018 In : Nature Communications. 1684
Research output: Contribution to journal › Article
Use of dietary indices to control for diet in human gut microbiota studies
Bowyer, R. C. E., Jackson, M. A., Pallister, T., Skinner, J., Spector, T. D., Welch, A. A. & Steves, C. J. 25 Apr 2018 In : Microbiome. 6, 1, p. 77
Research output: Contribution to journal › Article
Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability
Hysi, P. , Valdes, A. M. , Liu, F. , Furlotte, N. A. , Evans, D. M. , Bataille, V. , Visconti, A. , Hemani, G. , McMahon, G. , Ring, S. M. , Smith, G. D. , Duffy, D. L. , Zhu, G. , Gordon, S. D. , Medland, S. E. , Danae Lin, B. , Willemsen, G. , Hottenga, J-J. , Vuckovic, D. , Girotto, G. & 23 others Gandin, I., Sala, C., Brumat, M., Gasparini, P., Daniela, T., Cocca, M., Robino, A., Yazar, S., Hewitt, A. W., Chen, Y., Zeng, C., Uitterlinden, A. G., Ikram, M. A., Hamer, M. A., van Duijn, C. M., Nijsten, T. E. C., Mackey, D. A., Falchi, M., Boomsma, D. I., Martin, N. G., Hinds, D. A., Kayser, M. & Spector, T. D. 16 Apr 2018 In : Nature Genetics.
Research output: Contribution to journal › Letter
Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero
23 and Me Research Team 12 Apr 2018 In : Human Molecular Genetics.
Research output: Contribution to journal › Article
Definitive zygosity scores in the peas in the pod questionnaire is a sensitive and accurate assessment of the zygosity of adult twins
Jarrar, Z. A., Ward, K. J., Mangino, M., Cherkas, L. F., Gill, R., Gillham-Nasenya, I., Yarand, D., Hart, D., Hammond, C. J. & Spector, T. D. Apr 2018 In : TWIN RESEARCH AND HUMAN GENETICS. 21, 2, p. 146-154
Research output: Contribution to journal › Article
Arterial stiffening is a heritable trait associated with arterial dilation but not wall thickening: a longitudinal study in the twins UK cohort
Cecelja, M., Jiang, B., Keehn, L., Hussain, T., Silva Vieira, M., Phinikaridou, A., Greil, G., Spector, T. D. & Chowienczyk, P. 26 Mar 2018 In : European Heart Journal.
Research output: Contribution to journal › Article
Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated with Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts
Menni, C., Gudelj, I., MacDonald-Dunlop, E., Mangino, M., Zierer, J., Bešić, E., Joshi, P., Trbojević-Akmačić, I., Chowienczyk, P. J., Spector, T. D., Wilson, J. F., Lauc, G. & Valdes, A. M. 16 Mar 2018 In : Circulation Research.
Research output: Contribution to journal › Article
Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota
Mullaney, J. A., Stephens, J. E., Costello, M. E., Fong, C., Geeling, B. E., Gavin, P. G., Wright, C. M., Spector, T. D., Brown, M. A. & Hamilton-Williams, E. E. 17 Feb 2018 In : Microbiome. 6, 1, 35
Research output: Contribution to journal › Article
Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones
Cohen, I. V., Cirulli, E. T., Mitchell, M. W., Jonsson, T. J., Yu, J., Shah, N., Spector, T. D., Guo, L., Venter, J. C. & Telenti, A. 15 Feb 2018 In : EBioMedicine.
Research output: Contribution to journal › Article
Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort
Viñuela, A., Brown, A. A., Buil, A., Tsai, P-C., Davies, M. N., Bell, J. T., Dermitzakis, E. T., Spector, T. D. & Small, K. S. 15 Feb 2018 In : Human Molecular Genetics. 27, 4, p. 732–741
Research output: Contribution to journal › Article
Detection of stable community structures within gut microbiota co-occurrence networks from different human populations
Jackson, M. A., Bonder, M. J., Kuncheva, Z., Zierer, J., Fu, J., Kurilshikov, A., Wijmenga, C., Zhernakova, A., Bell, J. T., Spector, T. D. & Steves, C. J. 7 Feb 2018 In : PeerJ. 6, p. e4303
Research output: Contribution to journal › Article
Genetic and microbiome influence on lipid metabolism and dyslipidemia
Matey-Hernandez, M. L., Williams, F. M. K., Potter, T., Valdes, A. M., Spector, T. D. & Menni, C. 1 Feb 2018 In : PHYSIOLOGICAL GENOMICS. 50, 2, p. 117-126 10 p.
Research output: Contribution to journal › Article
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Jiang, X. , O'Reilly, P. F. , Aschard, H. , Hsu, Y. H. , Richards, J. B. , Dupuis, J. , Ingelsson, E. , Karasik, D. , Pilz, S. , Berry, D. I. , Kestenbaum, B. , Zheng, J. , Luan, J. , Sofianopoulou, E. , Streeten, E. A. , Albanes, D. , Lutsey, P. L. , Yao, L. , Tang, W. , Econs, M. J. & 30 others Wallaschofski, H., Völzke, H., Zhou, A., Power, C., McCarthy, M. I., Michos, E. D., Boerwinkle, E., Weinstein, S. J., Freedman, N. D., Huang, W. Y., Van Schoor, N. M., Van Der Velde, N., Groot, L. C. P. G. M. D., Enneman, A., Cupples, L. A., Booth, S. L., Vasan, R. S., Liu, C. T., Zhou, Y., Ripatti, S., Ohlsson, C., Vandenput, L., Lorentzon, M., Eriksson, J. G., Shea, M. K., Houston, D. K., Kritchevsky, S. B., Liu, Y., Valdes, A. M. & Spector, T. 17 Jan 2018 In : Nature Communications. 9, 1, 260
Research output: Contribution to journal › Article
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation
Zaghlool, S. B. , Mook-Kanamori, D. O. , Kader, S. , Stephan, N. , Halama, A. , Engelke, R. , Sarwath, H. , Al-Dous, E. K. , Mohamoud, Y. A. , Roemisch-Margl, W. , Adamski, J. , Kastenmüller, G. , Friedrich, N. , Visconti, A. , Tsai, P-C. , Spector, T. , Bell, J. , Falchi, M. , Wahl, A. , Waldenberger, M. & 7 others Peters, A., Gieger, C., Pezer, M., Lauc, G., Graumann, J., Malek, J. A. & Suhre, K. 8 Jan 2018 In : Human Molecular Genetics.
Research output: Contribution to journal › Article
Ensemble landmarking of 3D facial surface scans
de Jong, M. A., Hysi, P., Spector, T., Niessen, W., Koudstaal, M. J., Wolvius, E. B., Kayser, M. & Böhringer, S. 8 Jan 2018 In : Scientific Reports. 8, 1, p. 12
Research output: Contribution to journal › Article
Meta-analysis of epigenome-wide association studies of cognitive abilities
Marioni, R. E. , McRae, A. F. , Bressler, J. , Colicino, E. , Hannon, E. , Li, S. , Prada, D. , Smith, J. A. , Trevisi, L. , Tsai, P-C. , Vojinovic, D. , Simino, J. , Levy, D. , Liu, C. , Mendelson, M. , Satizabal, C. L. , Yang, Q. , Jhun, M. A. , Kardia, S. L. R. , Zhao, W. & 27 others Bandinelli, S., Ferrucci, L., Hernandez, D. G., Singleton, A. B., Harris, S. E., Starr, J. M., Kiel, D. P., McLean, R. R., Just, A. C., Schwartz, J., Spiro, A., Vokonas, P., Amin, N., Ikram, M. A., Uitterlinden, A. G., van Meurs, J. B. J., Spector, T. D., Steves, C., Baccarelli, A. A., Bell, J. T., van Duijn, C. M., Fornage, M., Hsu, Y-H., Mill, J., Mosley, T. H., Seshadri, S. & Deary, I. J. 8 Jan 2018 In : Molecular Psychiatry.
Research output: Contribution to journal › Article
Genetics of the human face: Identification of large-effect single gene variants
Crouch, D. J. M., Winney, B., Koppen, W. P., Christmas, W. J., Hutnik, K., Day, T., Meena, D., Boumertit, A., Hysi, P., Nessa, A., Spector, T. D., Kittler, J. & Bodmer, W. F. 4 Jan 2018 In : Proceedings of the National Academy of Sciences of the United States of America.
Research output: Contribution to journal › Article
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects
Medina-Gomez, C. , Kemp, J. P. , Trajanoska, K. , Luan, J. , Chesi, A. , Ahluwalia, T. S. , Mook-Kanamori, D. O. , Ham, A. , Hartwig, F. P. , Evans, D. S. , Joro, R. , Nedeljkovic, I. , Zheng, H-F. , Zhu, K. , Atalay, M. , Liu, C-T. , Nethander, M. , Broer, L. , Porleifsson, G. , Mullin, B. H. & 69 others Handelman, S. K., Nalls, M. A., Jessen, L. E., Heppe, D. H. M., Richards, J. B., Wang, C., Chawes, B., Schraut, K. E., Amin, N., Wareham, N., Karasik, D., Van der Velde, N., Ikram, M. A., Zemel, B. S., Zhou, Y., Carlsson, C. J., Liu, Y., McGuigan, F. E., Boer, C. G., Bønnelykke, K., Ralston, S. H., Robbins, J. A., Walsh, J. P., Zillikens, M. C., Langenberg, C., Li-Gao, R., Williams, F. M. K., Harris, T. B., Akesson, K., Jackson, R. D., Sigurdsson, G., den Heijer, M., van der Eerden, B. C. J., van de Peppel, J., Spector, T. D., Pennell, C., Horta, B. L., Felix, J. F., Zhao, J. H., Wilson, S. G., de Mutsert, R., Bisgaard, H., Styrkársdóttir, U., Jaddoe, V. W., Orwoll, E., Lakka, T. A., Scott, R., Grant, S. F. A., Lorentzon, M., van Duijn, C. M., Wilson, J. F., Stefansson, K., Psaty, B. M., Kiel, D. P., Ohlsson, C., Ntzani, E., van Wijnen, A. J., Forgetta, V., Ghanbari, M., Logan, J. G., Williams, G. R., Bassett, J. H. D., Croucher, P. I., Evangelou, E., Uitterlinden, A. G., Ackert-Bicknell, C. L., Tobias, J. H., Evans, D. M. & Rivadeneira, F. 4 Jan 2018 In : American Journal of Human Genetics. 102, 1, p. 88-102 15 p.
Research output: Contribution to journal › Article
Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics
Beaumont, R. N. , Warrington, N. M. , Cavadino, A. , Tyrrell, J. , Nodzenski, M. , Horikoshi, M. , Geller, F. , Myhre, R. , Richmond, R. C. , Paternoster, L. , Bradfield, J. P. , Kreiner-Møller, E. , Huikari, V. , Metrustry, S. , Lunetta, K. L. , Painter, J. N. , Hottenga, J-J. , Allard, C. , Barton, S. J. , Espinosa, A. & 31 others Marsh, J. A., Potter, C., Zhang, G., Ang, W., Berry, D. J., Bouchard, L., Das, S., Hakonarson, H., Heikkinen, J., Helgeland, Ø., Hocher, B., Hofman, A., Inskip, H. M., Jones, S. E., Kogevinas, M., Lind, P. A., Marullo, L., Medland, S. E., Murray, A., Murray, J. C., Njølstad, P. R., Nohr, E. A., Reichetzeder, C., Ring, S. M., Ruth, K. S., Santa-Marina, L., Scholtens, D. M., Sebert, S., Sengpiel, V., Spector, T. D. & Early Growth Genetics (EGG) Consortium 3 Jan 2018 In : Human Molecular Genetics.
Research output: Contribution to journal › Article
Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
Bell, C. G., Gao, F., Yuan, W., Roos, L., Acton, R. J., Xia, Y., Bell, J., Ward, K., Mangino, M., Hysi, P. G., Wang, J. & Spector, T. D. 2 Jan 2018 In : Nature communications. 9, 1, 13 p., 8
Research output: Contribution to journal › Article
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot, V. , Lu, Y. , Highland, H. M. , Schurmann, C. , Justice, A. E. , Fine, R. S. , Bradfield, J. P. , Esko, T. , Giri, A. , Graff, M. , Guo, X. , Hendricks, A. E. , Karaderi, T. , Lempradl, A. , Locke, A. E. , Mahajan, A. , Marouli, E. , Sivapalaratnam, S. , Young, K. L. , Alfred, T. & 31 others Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Breen, G., Small, K. S., Spector, T. D. & CHD Exome+ Consortium Jan 2018 In : Nature Genetics. 50, 1, p. 26-41 16 p.
Research output: Contribution to journal › Article
Metabolomic signatures of low birthweight: Pathways to insulin resistance and oxidative stress
Metrustry, S. J., Karhunen, V., Edwards, M. H., Menni, C., Geisendorfer, T., Huber, A., Reichel, C., Dennison, E. M., Cooper, C., Spector, T., Jarvelin, M-R. & Valdes, A. M. 2018 In : PloS one. 13, 3, p. e0194316
Research output: Contribution to journal › Article
Socioeconomic status and the gut microbiome: a TwinsUK cohort study
Bowyer, R. C. E., Jackson, M. A., Le Roy, C. I., Ni Lochlainn, M., Spector, T. D., Dowd, J. B. & Steves, C. J. 2018 (Submitted) In : BMC Medicine.
Research output: Contribution to journal › Article
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls