Symposium on Molecular and Metabolic Dysfunction in Diabetes
COST BM0602 - WG 3 and WG 4 -
Institute of Cellular Biology and Pathology “Nicolae Simionescu”
Bucharest, Romania
13-14 February 2009
Thursday 12 February 2009: Arrival of the participants – Get together and Dinner
Friday, 13 February 2009
9:30-9:45 Opening Remarks
Maya Simionescu (RO)
Juergen Eckel (DE)
9:45-13:00 Session 1: Diabetic complications
Chair: Shlomo Sasson
9:45-10:15 Juergen Eckel (DE): Adipokines and their functional implications for human smooth muscle cells
10:15-10:45 Paul Trayhurn (UK): Microarray studies of macrophage-adipocyte / preadipocyte inflammatory cross-talk
10:45-11:00 Coffee break
11:00-11:30 Maya Simionescu (RO): Diabetic endotheliopathy
11:30-12:00 Doina Popov (RO): Lights and shadows in exploration of the arterial smooth muscle cells dysfunction in hyperglycaemia
12:00-12:30 Aldona Dembinska-Kieć (PL): Stromal vascular fraction and growth and
function of adipose tissue. Role of nutrients
12:30-13:00 Cristian Guja (RO): Genetic particularities of type 1 diabetes in the Romanian population
13:00 -14:00 Lunch
14:00-15:30 Session 2: Beta-cell survival and function: Role of lipids and cytokines
Chair: Juergen Eckel
14:00-14:30 Guy Cohen (IL): Products of lipid peroxidation and beta cell function
14:30-15:00 Anneli Bjorklund (SE): Regulation of CD36 and its role in beta-cell functioning
15:00-15:30 Francesco Giorgino (IT): Mechanism of cytokine and incretin cross-talk in beta cells
15:30-15:45 Coffee break
15:45-16:45 Session 3: STSM presentations
Chair: Hans-G Joost
15:45-16:15 Annika Taube (DE): Adipokines and fatty acid metabolism in human skeletal muscle cells
16:15-16:45 Viorel Suica (RO): Lipid raft proteomics in hyperlipidemic conditions.
16:45-17:30 WG 3 meeting
17:30-18:15 WG4 meeting
19:00 Dinner
Saturday, 14 February 2009
9:30 –10:00 Session 4: Future treatments of type 2 diabetes
Chair: Paul Trayhurn
9:30-10:00 Nicolae Hancu, Cristina Nita, Cornelia Bala (RO): Early insulin therapy in type 2 diabetes
10:00- 12:15 Session 5: Beta-cell survival and function: Cellular stress
Chair: Nurit Kaiser
10:00-10:30 Valdemar Grill (NO): Effect of hypoxia on beta-cell function
10:30-11:00 Shlomo Sasson (IL): High glucose-induced antiangiogenic environment impairs b-cells and microcapillary endothelial cells interactions
11:00-11:15 Coffee break
11:15-11:45 Margriet Ouwens (NL): ER-stress and inhibition of mTOR: partners in glucocorticoid-induced beta cell dysfunction
11:45-12:15 Markus Niessen (CH): Phenotypic analysis of pancreatic islets from mice deficient for any of the three isoforms of Protein Kinase B/Akt
12:15-13:15 Lunch
13:15-14:45 Session 6: Skeletal muscle physiology and pathophysiology
Chair: Francesco Giorgino
13:15-13:45 Jorgen Jensen (NO): Contraction mediated regulation of glycogen synthase activity and phosphorylation
13:45-14:15 Hans-G Joost (DE): Positional cloning of an obesity and diabetes suppressor and elucidation of its role in muscle metabolism
14:15-14:45 Margarita Lorenzo (ES): Dual role of IL-6 in regulating insulin sensitivity in skeletal muscle
14:45-15:00 Coffee break
15:00-16:00 Session 7: Vascular cell dysfunction in diabetes
Chair: Margarita Lorenzo
15:00-15:30 Anca Sima (RO): Effect of AGE-LDL on endothelial and smooth muscle cells
15:30-16:00 Adrian Manea (RO): Crossways between inflammation and oxidative
stress in vascular disorders
16:00-17:00 General discussion and summary of the meeting
Chair: Maya Simionescu (RO), Shlomo Sasson (IL), Juergen Eckel (DE)
19:00 Dinner
PARTICIPANTS
Anneli Bjorklund, Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institute and Hospital, S-17176 Stockholm, Sweden,
Daniela Baus, Sanofi Aventis, Frankfurt, Germany
Guy Cohen, The Hebrew University Faculty of Medicine, Jerusalem, Israel
Aldona Dembinska-Kiec, Department of Clinical Biochemistry. Collegium Medicum Jagiellonan University, Krakow. Poland,
Juergen Eckel, Institute of Clinical Biochemistry and Pathobiochemistry , German Diabetes Center, Düsseldorf, Germany,
Daniela Gasperikova, Diabetes Laboratory & Diabgene Institute of Experimental Endocrinology, Slovak Academy of Sciences Bratislava, Slovak Republic,
Francesco Giorgino, Department of Emergency and Organ Transplantation - Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Chief, Division of Endocrinology, University Hospital Policlinico, Bari, Italy, ;
Valdemar Grill, Institute of Cancer Research and Molecular Medicine, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway,
Cristian Guja, “N.C. Paulescu” DNMD Institute, Bucharest, Romania,
Nicolae Hancu, “I. Hatieganu” Medicine and Pharmacy University, Cluj Napoca, Romania,
Diana Ivanova, Department of Biochemistry, Molecular Medicine and Nutrigenomics & Laboratory of Nutrigenomics, Functional Foods and Nutraceuticals, Medical University Varna, Bulgaria,
Jorgen Jensen, Department of Physiology, National Institute of Occupational Health, Oslo, Norway,
Hans-Georg Joost, German Institute of Human Nutrition, Nuthetal, Germany,
Nurit Kaiser, Endocrinology and Metabolism service, Department of Medicine, Hadassah Hospital, Jerusalem, Israel,
Iwar Klimes, Diabetes Laboratory & Diabgene Institute of Experimental Endocrinology, Slovak Academy of Sciences Bratislava, Slovak Republic,
Marko Kreft, Laboratory of Neuroendocrinology - Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia,
Stefan Lehr, German Diabetes Center, Inst. of Clinical Biochemistry and Pathobiochemistry, Duesseldorf, Germany,
Margarita Lorenzo, Dpto Bioquimica y Biologia Molecular II Facultad de Farmacia, Universidad Complutense, Madrid, Spain,
Adrian Manea, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,
Pierre Marche, CNRS UMR 7131, Hôpital Broussais, Paris, France,
Markus Nissen, University of Zurich, Universitätsspital Zürich, DIM/Endocrinology and Diabetology, Zürich, Switzerland,
Margriet Ouwens, Leiden University Medical Centre, Leiden, Netherlands
Ferruh Özcan, Gebze Institute of Technology Molecular Cell Biology Lab. Muallimköy, Gebze Kocaeli, Turkey,
Doina Popov, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,
Shlomo Sasson, Department of Pharmacology, Head, the Diabetes Research Center, Hebrew University Faculty of Medicine, Jerusalem, Israel,
Anca Sima, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,
Maya Simionescu, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,
Viorel Suica, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,
Annika Taube, Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany,
Paul Trayhurn, Neuroendocrinology & Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, United Kingdom,
PARTICIPANTS of ICBP “N. Simionescu”research team (www.icbp.ro)
Dorin Alexandru, Ph.D.
Nicoleta Alexandru, Ph.D. student
Eugen Andrei, researcher
Felicia Antohe, Ph.D.
Gabriela Botez, Ph.D. student
Alexandrina Burlacu, Ph.D.
Elena Butoi (Dragomir), Ph.D.
Cosmin Buzila, student
Manuela Calin, Ph.D.
Alina Constantin, Ph.D. student
Andrei Constantinescu, Ph.D. student
Elena Constantinescu, Ph.D.
Gabriela Costache, Ph.D.
Emanuel Dragan, vet M.D.
Madalina Dumitresu, Ph.D. student
Madalina Fenyo, Ph.D. student
Irina Florea, Master student
Anca Gafencu, Ph.D.
Ana Maria Gan, Ph.D. student
Adriana Georgescu, Ph.D.
Gabriela Grigorescu, Ph.D. student
Raluca Haraba, Ph.D. student
Constantina Heltianu, Ph.D
Mugurel Ionita, Master student
Florin Iordache, student
Luminita Ivan, Ph.D.
Victor V. Jinga, M.D., Ph.D.
Ana Maria Krapal, Master student
Marilena Lupu, Ph.D.
Ileana Manduteanu, Ph.D.
Simona Manea, Ph.D. student
Horia Maniu, Ph.D.
Adina Mihai, Ph.D. student
Claudia Musina, Master student
Ciprian Neagoe, Ph.D. student
Miruna Nemecz, Ph.D. student
Loredan Stefan Niculescu, Ph.D.
Monica Pirvulescu, student
Mirel Adrian Popa, Master student
Mihai Bogdan Preda, student
Monica Raicu, Ph.D.
Ana Maria Rosca, Ph.D. student
Florentina Safciuc, Ph.D. student
Viorel Simion, student
Daniela Stan, Ph.D. student
Camelia Stancu, Ph.D.
Istvan Svab, Ph.D.
Laurentia Tanase, Master student
Irina Titorencu, Ph.D.
Laura Toma, Ph.D. student
Violeta Trusca, Ph.D. student
Elena Uyy, Ph.D. student