Symposium on Molecular and Metabolic Dysfunction in Diabetes

COST BM0602 - WG 3 and WG 4 -

Institute of Cellular Biology and Pathology “Nicolae Simionescu”

Bucharest, Romania

13-14 February 2009

Thursday 12 February 2009: Arrival of the participants – Get together and Dinner

Friday, 13 February 2009

9:30-9:45 Opening Remarks

Maya Simionescu (RO)

Juergen Eckel (DE)

9:45-13:00 Session 1: Diabetic complications

Chair: Shlomo Sasson

9:45-10:15 Juergen Eckel (DE): Adipokines and their functional implications for human smooth muscle cells

10:15-10:45 Paul Trayhurn (UK): Microarray studies of macrophage-adipocyte / preadipocyte inflammatory cross-talk

10:45-11:00 Coffee break

11:00-11:30 Maya Simionescu (RO): Diabetic endotheliopathy

11:30-12:00 Doina Popov (RO): Lights and shadows in exploration of the arterial smooth muscle cells dysfunction in hyperglycaemia

12:00-12:30 Aldona Dembinska-Kieć (PL): Stromal vascular fraction and growth and

function of adipose tissue. Role of nutrients

12:30-13:00 Cristian Guja (RO): Genetic particularities of type 1 diabetes in the Romanian population

13:00 -14:00 Lunch

14:00-15:30 Session 2: Beta-cell survival and function: Role of lipids and cytokines

Chair: Juergen Eckel

14:00-14:30 Guy Cohen (IL): Products of lipid peroxidation and beta cell function

14:30-15:00 Anneli Bjorklund (SE): Regulation of CD36 and its role in beta-cell functioning

15:00-15:30 Francesco Giorgino (IT): Mechanism of cytokine and incretin cross-talk in beta cells

15:30-15:45 Coffee break


15:45-16:45 Session 3: STSM presentations

Chair: Hans-G Joost

15:45-16:15 Annika Taube (DE): Adipokines and fatty acid metabolism in human skeletal muscle cells

16:15-16:45 Viorel Suica (RO): Lipid raft proteomics in hyperlipidemic conditions.

16:45-17:30 WG 3 meeting

17:30-18:15 WG4 meeting

19:00 Dinner

Saturday, 14 February 2009

9:30 –10:00 Session 4: Future treatments of type 2 diabetes

Chair: Paul Trayhurn

9:30-10:00 Nicolae Hancu, Cristina Nita, Cornelia Bala (RO): Early insulin therapy in type 2 diabetes

10:00- 12:15 Session 5: Beta-cell survival and function: Cellular stress

Chair: Nurit Kaiser

10:00-10:30 Valdemar Grill (NO): Effect of hypoxia on beta-cell function

10:30-11:00 Shlomo Sasson (IL): High glucose-induced antiangiogenic environment impairs b-cells and microcapillary endothelial cells interactions

11:00-11:15 Coffee break

11:15-11:45 Margriet Ouwens (NL): ER-stress and inhibition of mTOR: partners in glucocorticoid-induced beta cell dysfunction

11:45-12:15 Markus Niessen (CH): Phenotypic analysis of pancreatic islets from mice deficient for any of the three isoforms of Protein Kinase B/Akt

12:15-13:15 Lunch

13:15-14:45 Session 6: Skeletal muscle physiology and pathophysiology

Chair: Francesco Giorgino

13:15-13:45 Jorgen Jensen (NO): Contraction mediated regulation of glycogen synthase activity and phosphorylation

13:45-14:15 Hans-G Joost (DE): Positional cloning of an obesity and diabetes suppressor and elucidation of its role in muscle metabolism

14:15-14:45 Margarita Lorenzo (ES): Dual role of IL-6 in regulating insulin sensitivity in skeletal muscle

14:45-15:00 Coffee break


15:00-16:00 Session 7: Vascular cell dysfunction in diabetes

Chair: Margarita Lorenzo

15:00-15:30 Anca Sima (RO): Effect of AGE-LDL on endothelial and smooth muscle cells

15:30-16:00 Adrian Manea (RO): Crossways between inflammation and oxidative

stress in vascular disorders

16:00-17:00 General discussion and summary of the meeting

Chair: Maya Simionescu (RO), Shlomo Sasson (IL), Juergen Eckel (DE)

19:00 Dinner


PARTICIPANTS

Anneli Bjorklund, Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institute and Hospital, S-17176 Stockholm, Sweden,

Daniela Baus, Sanofi Aventis, Frankfurt, Germany

Guy Cohen, The Hebrew University Faculty of Medicine, Jerusalem, Israel

Aldona Dembinska-Kiec, Department of Clinical Biochemistry. Collegium Medicum Jagiellonan University, Krakow. Poland,

Juergen Eckel, Institute of Clinical Biochemistry and Pathobiochemistry , German Diabetes Center, Düsseldorf, Germany,

Daniela Gasperikova, Diabetes Laboratory & Diabgene Institute of Experimental Endocrinology, Slovak Academy of Sciences Bratislava, Slovak Republic,

Francesco Giorgino, Department of Emergency and Organ Transplantation - Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Chief, Division of Endocrinology, University Hospital Policlinico, Bari, Italy, ;

Valdemar Grill, Institute of Cancer Research and Molecular Medicine, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway,

Cristian Guja, “N.C. Paulescu” DNMD Institute, Bucharest, Romania,

Nicolae Hancu, “I. Hatieganu” Medicine and Pharmacy University, Cluj Napoca, Romania,

Diana Ivanova, Department of Biochemistry, Molecular Medicine and Nutrigenomics & Laboratory of Nutrigenomics, Functional Foods and Nutraceuticals, Medical University Varna, Bulgaria,

Jorgen Jensen, Department of Physiology, National Institute of Occupational Health, Oslo, Norway,

Hans-Georg Joost, German Institute of Human Nutrition, Nuthetal, Germany,

Nurit Kaiser, Endocrinology and Metabolism service, Department of Medicine, Hadassah Hospital, Jerusalem, Israel,

Iwar Klimes, Diabetes Laboratory & Diabgene Institute of Experimental Endocrinology, Slovak Academy of Sciences Bratislava, Slovak Republic,

Marko Kreft, Laboratory of Neuroendocrinology - Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia,

Stefan Lehr, German Diabetes Center, Inst. of Clinical Biochemistry and Pathobiochemistry, Duesseldorf, Germany,

Margarita Lorenzo, Dpto Bioquimica y Biologia Molecular II Facultad de Farmacia, Universidad Complutense, Madrid, Spain,

Adrian Manea, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,

Pierre Marche, CNRS UMR 7131, Hôpital Broussais, Paris, France,

Markus Nissen, University of Zurich, Universitätsspital Zürich, DIM/Endocrinology and Diabetology, Zürich, Switzerland,

Margriet Ouwens, Leiden University Medical Centre, Leiden, Netherlands

Ferruh Özcan, Gebze Institute of Technology Molecular Cell Biology Lab. Muallimköy, Gebze Kocaeli, Turkey,

Doina Popov, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,

Shlomo Sasson, Department of Pharmacology, Head, the Diabetes Research Center, Hebrew University Faculty of Medicine, Jerusalem, Israel,

Anca Sima, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,

Maya Simionescu, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,

Viorel Suica, Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest, Romania,

Annika Taube, Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany,

Paul Trayhurn, Neuroendocrinology & Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, United Kingdom,


PARTICIPANTS of ICBP “N. Simionescu”research team (www.icbp.ro)

Dorin Alexandru, Ph.D.

Nicoleta Alexandru, Ph.D. student

Eugen Andrei, researcher

Felicia Antohe, Ph.D.

Gabriela Botez, Ph.D. student

Alexandrina Burlacu, Ph.D.

Elena Butoi (Dragomir), Ph.D.

Cosmin Buzila, student

Manuela Calin, Ph.D.

Alina Constantin, Ph.D. student

Andrei Constantinescu, Ph.D. student

Elena Constantinescu, Ph.D.

Gabriela Costache, Ph.D.

Emanuel Dragan, vet M.D.

Madalina Dumitresu, Ph.D. student

Madalina Fenyo, Ph.D. student

Irina Florea, Master student

Anca Gafencu, Ph.D.

Ana Maria Gan, Ph.D. student

Adriana Georgescu, Ph.D.

Gabriela Grigorescu, Ph.D. student

Raluca Haraba, Ph.D. student

Constantina Heltianu, Ph.D

Mugurel Ionita, Master student

Florin Iordache, student

Luminita Ivan, Ph.D.

Victor V. Jinga, M.D., Ph.D.

Ana Maria Krapal, Master student

Marilena Lupu, Ph.D.

Ileana Manduteanu, Ph.D.

Simona Manea, Ph.D. student

Horia Maniu, Ph.D.

Adina Mihai, Ph.D. student

Claudia Musina, Master student

Ciprian Neagoe, Ph.D. student

Miruna Nemecz, Ph.D. student

Loredan Stefan Niculescu, Ph.D.

Monica Pirvulescu, student

Mirel Adrian Popa, Master student

Mihai Bogdan Preda, student

Monica Raicu, Ph.D.

Ana Maria Rosca, Ph.D. student

Florentina Safciuc, Ph.D. student

Viorel Simion, student

Daniela Stan, Ph.D. student

Camelia Stancu, Ph.D.

Istvan Svab, Ph.D.

Laurentia Tanase, Master student

Irina Titorencu, Ph.D.

Laura Toma, Ph.D. student

Violeta Trusca, Ph.D. student

Elena Uyy, Ph.D. student