1

Supplementary Information

Figure S1 Individual mice clustering of video tracker data using a PhenoChipping approach(1). We used GeneSpring GX (Agilent Technologies, Palo Alto, CA) a microarray gene expression analysis software, for the novel use of analyzing and visualizing phenotypic data. Unsupervised two-way hierarchical clustering of normalized (Z-scored) behavioral data from locomotor pattern test was carried out, using methodology previously described(2) . (a) Male mice (b) Female mice. Center Time-time spent in the center zone; Center entry-number of time entering center zone; V.max-maximal velocity; Red-increased; blue-decreased.

Figure S2. Effects of diet on food intake and weight changes.

Table S1. Female blood top gene expression changes in response to DHA. Red- candidate biomarkers for human studies, changed in expression by DHA in opposite direction to that seen in human blood in mood disorders and stress disorders.

Gene Symbol /Name / Blood Change / Animal Brain Evidence / Animal Blood Evidence / Animal Genetic Evidence / Human Brain Evidence / Human Blood
Evidence / Human Genetic Evidence / CFG Score
FOS
FBJ osteosarcoma oncogene / D / (I)
Alcohol
(3)
(D)
MDD
Fluoxetine(4)
(I)
Anxiety
Plaza-Zabala A
2010
(I)
Stress
(5)
DBP-STAMY (I)(2) / Bipolar (6) / (Transgenic)
Decreased anxiety-related response, abnormal frequency of paradoxical sleep,
/ (I)
BP
(7) /
(I)
PTSD(8)
(I)
Stress (9) / 14q24.3
(Linkage)
BP (10)
Alcohol (11) / 5.5
CD44
CD44 antigen / D / Bipolar CP (12) / Bipolar (6) / QTL
Abnormal eating/drinking behavior;Abnormal circadian rhythm / (D)
Alcohol
(13) / (I)
BP
(14) / 11p13
(Linkage)
Alcohol (15),
/ 5.0
DUSP1
dual specificity phosphatase 1 / D / (I)
Alcohol
(3)
Alcohol AMY, CP,NAC,PFC (16) / Bipolar (6) / QTL
Abnormal eating/drinking behavior;Abnormal circadian rhythm / (D)
BP,MDD
(17) / (I)
Stress (9)
/ 5q35.1
(Linkage)
PD (18)
/ 5.0
MBP
myelin basic protein / D / (I)
BP
(19)
(I)
Anxiety
(20)
DBP-NST PFC (D);DBP-STAMY (I);DBP-STPFC(D); DBP-STAMY(I)(2) / Bipolar (6) / (I)
BP
(21)
(I)
Alcohol (22) / (I) MOOD BIOMARKER (6) / 18q23
(Association)
BP
(23)
/ 5.0
PSEN1
presenilin 1 / D / Alcohol NAC (16) / QTL
Abnormal eating/drinking behavior; Abnormal circadian rhythm / (D)
MDD
(24)
(D)
Alcohol
(25)
(D)
Suicide-MDD
(26) / (D)
BP
(27)
(D)
Chronic stress
(28)
/ 14q24.2
(Association)
Depression(29)
/ 5.0
SPP1
secreted phosphoprotein 1 / D / Bipolar VT (12) / Bipolar (6) / (QTL)
Abnormal emotion/affect behavior
Addiction/drug abuse / (D)
(D)
Suicide-MDD
(26)
(I)
BP
(17) / (D) Hallucinations(30)
/ 4q22.1
(Linkage)
Anxiety (31)
BP (10)
/ 5.0
ATXN1
ataxin 1 / D / (D)
Alcohol
(32)
Bipolar CP(12)
DBP-ST PFC (D) (2) / (QTL)
Abnormal emotion/affect behavior; Addiction/drug abuse / (D)
Alcohol
(33) / (D) Delusion ,Hallucinations (30)
(I) MOOD BIOMARKER (6)
(D)
Chronic stress(28) / 6p22.3
(Association)
BP/substance abuse
(23) / 4.5
GLO1
glyoxalase 1 / I / (D)
Anxiety (34)
Bipolar CP(12) / QTL
Abnormal eating/drinking behavior; Abnormal circadian rhythm / (D)
BP
(35) / (D)
BP,MDD(36) / 6p21.2
(Association)
PD(37),
(38)
/ 4.5
PBRM1
polybromo 1 / I / DBP-ST AMY (I)(2) / (QTL)
Abnormal emotion/affect behavior, Addiction/drug abuse / (I)
BP
(39) / (I) MOOD BIOMARKER (6) / 3p21.1
(Association)
BP/MDD(39)
BP (40) / 4.5
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 / D / (I)
Avoidance learning (fear)
(41) / (Transgenic)
Abnormal response to novel object/Abnormal anxiety-related response/Behavioal despair/Abnormal sleep pattern/ Cocaine preference / (D)
Suicide-MDD
(42)
(D)
PD
(43)
(D)
Suicide-MDD
(44) / (I)
MDD(45) / 17q11.2
(Association)
Alcohol(46),(47)
Anxiety (48),(49)
BP(50)
MDD
(51, 52),(53) / 4.5
WNK1
WNK lysine deficient protein kinase 1 / I /
Bipolar VT (12)
DBP-STPFC (D); DBP-ST AMY (I)(2) / (QTL)
Abnormal emotion/affect behavior
Addiction/drug abuse / (D)
Alcohol
(54) / (I)
BP
(14)
/ 12p13.33
(Association)
Alcohol(55) / 4.5

Table S2. Male blood top gene expression changes in response to DHA. Red- candidate biomarkers for human studies, changed in expression by DHA in opposite direction to that seen in human blood in mood disorders and stress disorders.

Gene Symbol /Name / Blood
Change / Animal Brain Evidence / Animal Blood Evidence / Animal Genetic Evidence / Human Brain Evidence / Human Blood
Evidence / Human Genetic Evidence / CFG Score
APOE
apolipoprotein E / D / (I)
Stress(56)
(I)
Alcohol (McBride, Kimpel et al. 2010
Alcohol HIP(16) / (Transgenic)
Increased anxiety-related response / (D)
Alcohol
(13)
Alcohol
(57) / (D) Delusion(30) / 19q13.32
(Association)
MDD(51)
PTSD(58) / 5.0
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1 / D / (I)
Alcohol
(McBride, Kimpel et al. 2010
(I)
Anxiety
(59)
Bipolar CP(12) / (Transgenic)
Impaired passive avoidance behavior, depression-related behavior / (I)
BP
(60)
(I)
Alcohol
(54), (25) / (D)
PTSD
(8) / 6p22.1
(Association)
MDD
(52)
OCD(61) / 5.0
MBP
myelin basic protein / D / (I)
BP(19)
(I)
Anxiety(20)
(I)
Anxiety;DBP-ST AMY (I);DBP-ST PFC(D); DBP-ST AMY(I)(2) / Bipolar (6) / (I)
BP
(21)
(I)
Alcohol (22) / (I) MOOD BIOMARKER (6) / 18q23
(Association)
BP
(23) / 5.0
PTGDS
prostaglandin D2 synthase (brain) / D / (I)
Anxiety
(34)
Bipolar AMY (12) / (Transgenic)
Decreased aggression / (D)
Alcohol
(13) / (D)
BP
(62) / 9q34.3
(Association)
Anxiety(63) / 5.0
SNCA
synuclein, alpha / I / (D)
Alcohol
Liang 2010
(D)
Response to antidepressant(64)
(D)BP(65)
DBP ST AMY (D)(2)
Alcohol AMY,HIP(16) / Bipolar (6)
DBP-ST BLOOD (D)(2) /
(D)
Alcohol (33),
(66) / 4q22.1
(Association)
Alcohol (67) / 5.0
GLO1
glyoxalase 1 / I / (D)
Anxiety(34)
(D)
Anxiety(68),(69)
Bipolar CP (12) / QTL
Abnormal eating/drinking behavior;Abnormal circadian rhythm / (D)
BP
(35) / (D)
BP
(36) / 6p21.2
(Association)
PD(37),(70) / 4.5
GPM6A
glycoprotein m6a / D / (I)
Alcohol (3) / Bipolar (6) / QTL
Abnormal emotion/affect behavior Abnormal circadian rhythm / (D)
Alcohol
(13) / (D) Delusion (30) / 4q34.2
(Linkage)
Alcohol MDD(71)
Anxiety (31)
BP (72) / 4.5

1.Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ, et al. PhenoChipping of psychotic disorders: A novel approach for deconstructing and quantitating psychiatric phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5;141(6):653-62.

2.Le-Niculescu H, McFarland M, Ogden C, Balaraman Y, Patel S, Tan J, et al. Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. American Journal of Medical Genetics B. 2008;147B(2):134-66.

3.Bell RL, Kimpel MW, McClintick JN, Strother WN, Carr LG, Liang T, et al. Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption. Pharmacol Biochem Behav. 2009 Nov;94(1):131-47.

4.Conti B, Maier R, Barr AM, Morale MC, Lu X, Sanna PP, et al. Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine. Mol Psychiatry. 2007 Feb;12(2):167-89.

5.Reyes TM, Walker JR, DeCino C, Hogenesch JB, Sawchenko PE. Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus. J Neurosci. 2003 Jul 2;23(13):5607-16.

6.Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, et al. Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry. 2009 Feb;14(2):156-74.

7.Rao JS, Harry GJ, Rapoport SI, Kim HW. Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry. 2009 Jun 2.

8.Segman RH, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev AY. Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol Psychiatry. 2005 May;10(5):500-13, 425.

9.Morita K, Saito T, Ohta M, Ohmori T, Kawai K, Teshima-Kondo S, et al. Expression analysis of psychological stress-associated genes in peripheral blood leukocytes. Neurosci Lett. 2005 Jun 10-17;381(1-2):57-62.

10.Cassidy F, Zhao C, Badger J, Claffey E, Dobrin S, Roche S, et al. Genome-wide scan of bipolar disorder and investigation of population stratification effects on linkage: support for susceptibility loci at 4q21, 7q36, 9p21, 12q24, 14q24, and 16p13. Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 5;144B(6):791-801.

11.Hill SY, Shen S, Zezza N, Hoffman EK, Perlin M, Allan W. A genome wide search for alcoholism susceptibility genes. Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128(1):102-13.

12.Ogden CA, Rich ME, Schork NJ, Paulus MP, Geyer MA, Lohr JB, et al. Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach. Mol Psychiatry. 2004 Nov;9(11):1007-29.

13.Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA. Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res. 2000 Dec;24(12):1873-82.

14.Middleton FA, Pato CN, Gentile KL, McGann L, Brown AM, Trauzzi M, et al. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136(1):12-25.

15.Schuckit MA, Edenberg HJ, Kalmijn J, Flury L, Smith TL, Reich T, et al. A genome-wide search for genes that relate to a low level of response to alcohol. Alcohol Clin Exp Res. 2001 Mar;25(3):323-9.

16.Bertsch B, Ogden CA, Sidhu K, Le-Niculescu H, Kuczenski R, Niculescu AB. Convergent functional genomics: a Bayesian candidate gene identification approach for complex disorders. Methods. 2005 Nov;37(3):274-9.

17.Vawter MP, Tomita H, Meng F, Bolstad B, Li J, Evans S, et al. Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders. Mol Psychiatry. 2006 Apr 25.

18.Hamilton SP, Fyer AJ, Durner M, Heiman GA, Baisre de Leon A, Hodge SE, et al. Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2550-5.

19.McQuillin A, Rizig M, Gurling HM. A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder. Pharmacogenet Genomics. 2007 Aug;17(8):605-17.

20.Sherrin T, Blank T, Saravana R, Rayner M, Spiess J, Todorovic C. Region specific gene expression profile in mouse brain after chronic corticotropin releasing factor receptor 1 activation: the novel role for diazepam binding inhibitor in contextual fear conditioning. Neuroscience. 2009 Aug 4;162(1):14-22.

21.Chambers JS, Perrone-Bizzozero NI. Altered myelination of the hippocampal formation in subjects with schizophrenia and bipolar disorder. Neurochem Res. 2004 Dec;29(12):2293-302.

22.Liu J, Lewohl JM, Dodd PR, Randall PK, Harris RA, Mayfield RD. Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain. J Neurochem. 2004 Sep;90(5):1050-8.

23.Johnson C, Drgon T, McMahon FJ, Uhl GR. Convergent genome wide association results for bipolar disorder and substance dependence. Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):182-90.

24.Aston C, Jiang L, Sokolov BP. Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol Psychiatry. 2005 Mar;10(3):309-22.

25.Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, Randall PK, et al. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology. 2006 Jul;31(7):1574-82.

26.Sequeira A, Mamdani F, Ernst C, Vawter MP, Bunney WE, Lebel V, et al. Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS One. 2009;4(8):e6585.

27.Sugawara H, Iwamoto K, Bundo M, Ishiwata M, Ueda J, Kakiuchi C, et al. Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm. 2010 Feb;117(2):155-64.

28.Miller GE, Chen E, Sze J, Marin T, Arevalo JM, Doll R, et al. A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. Biol Psychiatry. 2008 Aug 15;64(4):266-72.

29.Luciano M, Houlihan LM, Harris SE, Gow AJ, Hayward C, Starr JM, et al. Association of existing and new candidate genes for anxiety, depression and personality traits in older people. Behav Genet. 2010 Jul;40(4):518-32.

30.Kurian SM, Le-Niculescu H, Patel SD, Bertram D, Davis J, Dike C, et al. Identification of blood biomarkers for psychosis using convergent functional genomics. Mol Psychiatry. 2009 Nov 24.

31.Kaabi B, Gelernter J, Woods SW, Goddard A, Page GP, Elston RC. Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus. Am J Hum Genet. 2006 Apr;78(4):543-53.

32.Worst TJ, Tan JC, Robertson DJ, Freeman WM, Hyytia P, Kiianmaa K, et al. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. J Neurosci Res. 2005 May 15;80(4):529-38.

33.Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, Harris RA. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem. 2002 May;81(4):802-13.

34.Hovatta I, Tennant RS, Helton R, Marr RA, Singer O, Redwine JM, et al. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature. 2005 Dec 1;438(7068):662-6.

35.Benes FM, Matzilevich D, Burke RE, Walsh J. The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia. Mol Psychiatry. 2006 Mar;11(3):241-51.

36.Fujimoto M, Uchida S, Watanuki T, Wakabayashi Y, Otsuki K, Matsubara T, et al. Reduced expression of glyoxalase-1 mRNA in mood disorder patients. Neurosci Lett. 2008 Jun 20;438(2):196-9.

37.Politi P, Minoretti P, Falcone C, Martinelli V, Emanuele E. Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorder. Neurosci Lett. 2006 Mar 27;396(2):163-6.

38.Maron E, Hettema JM, Shlik J. Advances in molecular genetics of panic disorder. Mol Psychiatry. 2010 Jul;15(7):681-701.

39.McMahon FJ, Akula N, Schulze TG, Muglia P, Tozzi F, Detera-Wadleigh SD, et al. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nat Genet. 2010 Feb;42(2):128-31.

40.Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, et al. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7501-6.

41.Zhang S, Amstein T, Shen J, Brush FR, Gershenfeld HK. Molecular correlates of emotional learning using genetically selected rat lines. Genes Brain Behav. 2005 Mar;4(2):99-109.

42.Arango V, Underwood MD, Boldrini M, Tamir H, Kassir SA, Hsiung S, et al. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology. 2001 Dec;25(6):892-903.

43.Gyawali S, Subaran R, Weissman MM, Hershkowitz D, McKenna MC, Talati A, et al. Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder. Biol Psychiatry. 2010 Feb 15;67(4):331-8.

44.Mann JJ, Huang YY, Underwood MD, Kassir SA, Oppenheim S, Kelly TM, et al. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry. 2000 Aug;57(8):729-38.

45.Belzeaux R, Formisano-Treziny C, Loundou A, Boyer L, Gabert J, Samuelian JC, et al. Clinical variations modulate patterns of gene expression and define blood biomarkers in major depression. J Psychiatr Res. 2010 May 12.

46.Feinn R, Nellissery M, Kranzler HR. Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):79-84.

47.Seneviratne C, Ait-Daoud N, Ma JZ, Chen G, Johnson BA, Li MD. Susceptibility locus in neurokinin-1 receptor gene associated with alcohol dependence. Neuropsychopharmacology. 2009 Oct;34(11):2442-9.

48.Mizuno T, Aoki M, Shimada Y, Inoue M, Nakaya K, Takahashi T, et al. Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety. J Psychosom Res. 2006 Jan;60(1):91-7.

49.Costas J, Gratacos M, Escaramis G, Martin-Santos R, de Diego Y, Baca-Garcia E, et al. Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women. J Psychiatr Res. 2010 Aug;44(11):717-24.

50.Rotondo A, Mazzanti C, Dell'Osso L, Rucci P, Sullivan P, Bouanani S, et al. Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. Am J Psychiatry. 2002 Jan;159(1):23-9.

51.Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM, Del-Favero J, Claes SJ, Oostra BA, et al. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry. 2008 Aug;13(8):772-85.

52.Muglia P, Tozzi F, Galwey NW, Francks C, Upmanyu R, Kong XQ, et al. Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Mol Psychiatry. 2010 Jun;15(6):589-601.

53.Lewis CM, Ng MY, Butler AW, Cohen-Woods S, Uher R, Pirlo K, et al. Genome-wide association study of major recurrent depression in the U.K. population. Am J Psychiatry. 2010 Aug;167(8):949-57.

54.Flatscher-Bader T, van der Brug M, Hwang JW, Gochee PA, Matsumoto I, Niwa S, et al. Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. J Neurochem. 2005 Apr;93(2):359-70.

55.Edenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, et al. Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res. 2010 May;34(5):840-52.

56.Lee HC, Chang DE, Yeom M, Kim GH, Choi KD, Shim I, et al. Gene expression profiling in hypothalamus of immobilization-stressed mouse using cDNA microarray. Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):293-300.

57.Dodd PR, Buckley ST, Eckert AL, Foley PF, Innes DJ. Genes and gene expression in the brains of human alcoholics. Ann N Y Acad Sci. 2006 Aug;1074:104-15.

58.Freeman T, Roca V, Guggenheim F, Kimbrell T, Griffin WS. Neuropsychiatric associations of apolipoprotein E alleles in subjects with combat-related posttraumatic stress disorder. J Neuropsychiatry Clin Neurosci. 2005 Fall;17(4):541-3.

59.Wang H, Zhu YZ, Wong PT, Farook JM, Teo AL, Lee LK, et al. cDNA microarray analysis of gene expression in anxious PVG and SD rats after cat-freezing test. Exp Brain Res. 2003 Apr;149(4):413-21.

60.Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, et al. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15653-8.

61.Zai G, Arnold P, Burroughs E, Barr CL, Richter MA, Kennedy JL. Evidence for the gamma-amino-butyric acid type B receptor 1 (GABBR1) gene as a susceptibility factor in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134(1):25-9.

62.Begemann M, Sargin D, Rossner MJ, Bartels C, Theis F, Wichert SP, et al. Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches. Mol Med. 2008 Sep-Oct;14(9-10):546-52.

63.Donner J, Pirkola S, Silander K, Kananen L, Terwilliger JD, Lonnqvist J, et al. An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders. Biol Psychiatry. 2008 Oct 15;64(8):672-80.

64.McHugh PC, Rogers GR, Glubb DM, Joyce PR, Kennedy MA. Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine. J Psychopharmacol. 2010 Aug;24(8):1243-51.

65.Mukherjee S, Coque L, Cao JL, Kumar J, Chakravarty S, Asaithamby A, et al. Knockdown of Clock in the Ventral Tegmental Area Through RNA Interference Results in a Mixed State of Mania and Depression-Like Behavior. Biol Psychiatry. 2010 Jun 28.

66.Lewohl JM, Van Dyk DD, Craft GE, Innes DJ, Mayfield RD, Cobon G, et al. The application of proteomics to the human alcoholic brain. Ann N Y Acad Sci. 2004 Oct;1025:14-26.

67.Foroud T, Wetherill LF, Liang T, Dick DM, Hesselbrock V, Kramer J, et al. Association of alcohol craving with alpha-synuclein (SNCA). Alcohol Clin Exp Res. 2007 Apr;31(4):537-45.

68.Kromer SA, Kessler MS, Milfay D, Birg IN, Bunck M, Czibere L, et al. Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety. J Neurosci. 2005 Apr 27;25(17):4375-84.

69.Landgraf R, Kessler MS, Bunck M, Murgatroyd C, Spengler D, Zimbelmann M, et al. Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I. Neurosci Biobehav Rev. 2007;31(1):89-102.

70.Maron E, Hettema JM, Shlik J. Advances in molecular genetics of panic disorder. Molecular psychiatry. 2010 Jan 5.

71.Kuo PH, Neale MC, Walsh D, Patterson DG, Riley B, Prescott CA, et al. Genome-wide linkage scans for major depression in individuals with alcohol dependence. J Psychiatr Res. 2010 Jan 12.

72.Fullerton JM, Donald JA, Mitchell PB, Schofield PR. Two-dimensional genome scan identifies multiple genetic interactions in bipolar affective disorder. Biol Psychiatry. 2010 Mar 1;67(5):478-86.