Supplementarytable 1 Characteristics of the Randomized Controlled Trialsincluded in the Review

SupplementaryTable 1 Characteristics of the randomized controlled trialsincluded in the Review

Studies included / Total, number / Mean age (years) / Men, number (%) / Clinical diagnosis / Medication comparison / Follow-up (weeks) / Endpoints / Quality assessment (Jadad score)
TCHM / Control / Total / TCHM / Control / Total / TCHM / Control
Chen LQ. 2007.5 [20] / 60 / 60 / 68.05 / 67.4 / 68.7 / 65 (54.17) / 33 (55) / 32 (53.33) / Hypertension / Rehmannia spp. bolus plus decoction of tall gastrodia and Uncaria tomentosaplusamlodipine versus amlodipine / 8 / Effective response; SBP; DBP / 2
Chen LQ. 2007.6 [21] / 60 / 60 / 51.9 / 51.6 / 52.2 / 73 (60.83) / 37 (61.67) / 36 (60) / Hypertension / Decoctions ofPinellia ternata plus Atractylodes macrocephala rhizome, tall gastrodia plus Alisma spp. plus losartan versus losartan / 12 / SBP; DBP / 2
Chen XJ. 2008 [19] / 50 / 50 / 56.35 / 56.4 / 56.3 / 63 (63) / 31 (62) / 32 (64) / Hypertension / Decoction of tall gastrodia and Uncaria tomentosa plus captopril versus captopril / 6 / Effective response; SBP; DBP / 3
Cheng GS. 2012 [24] / 75 / 75 / NA / NA / NA / 78 (52) / 37 (49.33) / 41 (54.67) / Hypertension / Mixed TCM formula plus WM versus WM / 12 / Effective response; SBP; DBP / 2
Wang L, et al. 2012 [22] / 60 / 60 / 43.95 / 42.3 / 45.6 / 58 (48.33) / 27 (45) / 31 (51.67) / Hypertension / Erbai jiangya decoction plus telmisartan versus telmisartan / 4 / SBP; DBP / 2
Wu Q, et al. 2013 [23] / 60 / 60 / 53.78 / 52.23 / 55.32 / 67 (55.83) / 34 (56.7) / 33 (55) / Hypertension / Sini decoction plus WMversus WM / 4 / Effective response; SBP; DBP / 2
Cai CL, et al. 2005 [25] / 60 / 52 / 54.66 / 54.8 / 54.5 / 69 (61.61) / 38 (63.33) / 31 (59.62) / Hypertension / Decoction of tall gastrodia and Uncaria tomentosa versusnitrendipin / 4 / SBP; DBP / 2
Jin LL, et al. 2010 [28] / 60 / 60 / 64.75 / 65.8 / 63.7 / 68 (56.67) / 35 (58.33) / 33 (55) / Isolated systolic hypertension / Compound qima capsules versus nifedipine / 4 / Effective response; SBP; DBP / 2
Qiu ZA, et al. 2011 [27] / 289 / 289 / 53 / 53.7 / 52.3 / 342 (59.17) / 173 (59.86) / 169 (58.48) / Hypertension / Decoction of tall gastrodia and Uncaria tomentosa versus captopril / 5 / Effective response; SBP; DBP / 2
Xing ZH, et al. 2004 [26] / 60 / 58 / 54.51 / 55.0 / 54.0 / 83 (70.34) / 41 (68.33) / 42 (72.41) / Hypertension / Decoction of tall gastrodia and Uncaria tomentosa versusnitrendipin / 4 / SBP; DBP / 2
Geng XY, et al. 2000 [34] / 76 / 52 / 58.32 / 58.4 / 58.2 / 83 (64.84) / 48 (63.16) / 35 (67.31) / Angina pectoris / Buyang huanwu decoction plus isosorbide dinitrate plus aspirin versus isosorbide dinitrate plus aspirin / 4 / Effective response / 2
Guo QH, et al. 2006 [35] / 68 / 67 / 59.1 / 59.6 / 58.6 / 93 (68.89) / 47 (69.12) / 46 (68.66) / Angina pectoris / Yiqi huatan quyu formula plus isosorbide dinitrate versus isosorbide dinitrate / 4 / Effective response / 2
He QY, 2010 [15] / 54 / 54 / 62.47 / 65.06 / 59.88 / 42 (38.89) / 20 (30.7) / 22 (40.7) / Unstable angina pectoris / Yiqi yangyin decoction plus WM versus WM / 4 / Effective response; adverse cardiovascular events / 3
Huang SR. 2013 [36] / 50 / 50 / NA / NA / NA / 49 (49) / 26 (52) / 23 (46) / Angina pectoris / Hewei jiangzhuoformula plus WM versus WM / 4 / Effective response / 2
Li CL, et al. 2008 [37] / 50 / 50 / 62.5 / 62 / 63 / 65 (65) / 32 (64) / 33 (66) / Angina pectoris / Jiangtang shengmai decoction pieces plus WMversus WM / 8 / Effective response / 2
Liu HY, et al. 2012 [14] / 50 / 50 / 62.23 / 61.68 / 62.78 / 89 （89） / 45 (90) / 44 (88) / Acute coronary syndrome / Compond chuanxiong capsulesplusxinyue capsules plus WMversus WM / 52 / NYHA functional class; LVEF; adverse cardiovascular events / 3
Lu ZL, et al. 2008 [13] / 2429 / 2441 / 58.9 / 58.96 / 58.83 / 3994 (82) / 1992 (82) / 2002 (82) / Previous myocardial infarction / Xuezhikang plus WM versus placebo plus WM / 234 / Adverse cardiovascular events / 5
Luo YH. 2013 [37] / 56 / 56 / 62 / 61 / 63 / 64 (57.14) / 32 (57.14) / 32 (57.14) / Unstable angina pectoris / Maixuekang capsulesplus WM versus WM / 4 / Effective response / 2
Nie CY. 2011 [29] / 68 / 68 / 66.2 / 67.1 / 65.3 / 82 (60.29) / 42 (61.76) / 40 (58.82) / Stable angina pectoris / Decoction of snakegourd fruit plus macrostem onion plus Pinellia ternataplus WM versus WM / 4 / Effective response / 3
Shao GL, et al. 2012 [39] / 60 / 60 / 61.08 / 61.85 / 60.30 / 60 (50) / 29 (48.33) / 31 (51.67) / Angina pectoris / Yangxinshi plus isosorbide mononitrate plus aspirin versus isosorbide mononitrate plus aspirin / 6 / Effective response / 2
Wang XM, et al. 2013 [40] / 60 / 60 / 58.87 / 59.83 / 57.91 / 66 (55) / 32 (53.33) / 34 (56.67) / Angina pectoris / Qingre jiedu huoxue jianpidecoction plus isosorbide mononitrate plus aspirin versus isosorbide mononitrate plus aspirin / 8 / Effective response / 2
Yu Y, et al. 2009 [41] / 68 / 68 / 60.5 / 65.6 / 55.4 / 70 (51.47) / 36 (52.94) / 34 (50) / Angina pectoris / Ershen pseudoginseng decoctionplus isosorbide mononitrate versus isosorbide mononitrate / 4 / Effective response / 2
Zeng CS. 2010 [42] / 55 / 55 / 62 / NA / NA / 58 (52.73) / NA / NA / Angina pectoris / Tongxinluo capsulesplus WM versus WM / 24 / Effective response / 2
Zhao CP, et al. 2012 [43] / 90 / 90 / 75.8 / 75.2 / 76.4 / 93 (51.67) / 47 (52.22) / 46 (51.11) / Angina pectoris / Qishenyiqi pills plus WM versus placeboplus WM / 4 / Effective response / 2
Zou ST, et al. 2006 [44] / 126 / 112 / 42.59 / 43.12 / 42 / 136 (57.14) / 72 (57.14) / 64 (57.14) / Angina pectoris / Tongxinluo capsulesplus WM versus WM / 24 / Effective response / 2
Ding XM, et al. 1999 [30] / 52 / 50 / NA / NA / NA / 74 (72.55) / NA / NA / Stable angina pectoris / Compound danshen dripping pills versus isosorbide dinitrate / 8 / Effective response / 3
Feng J, et al. 1999 [47] / 64 / 72 / 57.82 / 57.5 / 58.1 / 77 (56.62) / 35 (54.69) / 42 (58.33) / Angina pectoris / Yiqi tongmai capsulesversus isosorbide dinitrate plusdiltiazem / 4 / Effective response / 2
Guo JJ, et al. 2013 [48] / 70 / 70 / 57.16 / 57.36 / 56.96 / NA / NA / NA / Angina pectoris / Shenhong huazhuo tongluo granules versus isosorbide mononitrate / 4 / Effective response / 2
He HT, et al. 2011 [49] / 60 / 60 / 64 / 63 / 65 / 68 (56.67) / 33 (55) / 35 (58.33) / Angina pectoris / Ziyin qianyang huoxue formulaversus isosorbide dinitrate plus captopril / 8 / Effective response / 2
Jiang P, et al. 2011 [50] / 100 / 100 / 63 / NA / NA / 118 (59) / NA / NA / Unstable angina pectoris / Musk baoxin pills versus isosorbide dinitrate / 24 / Effective response / 2
Li YH, et al. 2011 [51] / 50 / 50 / 49.47 / NA / NA / 52 (52) / NA / NA / Angina pectoris / Xuefu zhuyudecoction versus isosorbide dinitrate / 4 / Effective response / 2
Sun L, et al. 2000 [45] / 142 / 142 / 56.6 / 54.8 / 58.4 / 234 (82.39) / 113 (79.58) / 121 (85.21) / Angina pectoris / Compound danshen dripping pills versus isosorbide dinitrate / 8 / Effective response / 2
Tan RJ, et al. 2009 [46] / 60 / 60 / 55.91 / 56.23 / 55.58 / 76 (63.33) / 44 (73.33) / 32 (53.33) / Angina pectoris / Compound danshen dripping pills versus isosorbide dinitrate / 8 / Effective response / 2
Wang JS, et al. 2003 [31] / 56 / 50 / 57.2 / NA / NA / 66 (62.26) / NA / NA / Stable angina pectoris / Compound danshen dripping pills versus isosorbide dinitrate / 8 / Effective response / 3
Xie B, et al. 2011 [52] / 70 / 70 / 53 / NA / NA / 83 (59.29) / NA / NA / Angina pectoris / Shugan yiqi tongyudecoction versus aspirin plus clopidogrel plus isosorbide dinitrate plusmetoprolol / 4 / Effective response / 2
Xu KH, et al. 2012 [33] / 57 / 56 / 52.49 / 51.8 / 53.2 / 65 (57.52) / 32 (56.14) / 33 (58.93) / Stable angina pectoris / Zhuyu decoction versus aspirin plus beta receptor blockers plusangiotension converting enzyme inhibitors or angiotensin receptor blockers / 4 / Effective response / 3
Xu MS, et al. 2007 [53] / 84 / 83 / 48.95 / 49.24 / 48.66 / 89 (53.29) / 46 (54.76) / 43 (51.81) / Angina pectoris / Buqi huayu decoction versus isosorbide mononitrate / 4 / Effective response / 2
Xu XM 2000 [32] / 160 / 140 / 59.2 / NA / NA / 220 (73.33) / NA / NA / Stable angina pectoris / Compound danshen dripping pills versus isosorbide dinitrate / 8 / Effective response / 3
Zhang CQ, et al. 2006 [54] / 60 / 60 / 57.86 / 57.55 / 58.16 / 72 (60) / 35 (58.33) / 37 (61.67) / Angina pectoris / Guanxin tongluo capsulesversus isosorbide mononitrate / 4 / Effective response / 2
Zhang DC, et al. 2008 [55] / 120 / 120 / 54 / 55 / 53 / 128 (53.33) / 67 (55.83) / 61 (50.83) / Angina pectoris / TCMhot compress versus isosorbide mononitrate / 4 / Effective response / 2
Zhu C, et al. 2012 [56] / 64 / 64 / 63.06 / 61.5 / 62.5 / 90 (70.31) / 44 (68.75) / 46 (71.88) / Stable angina pectoris / Sini decoction versus ferulic acid / 4 / Effective response / 2
Li XB, et al. 2004 [58] / 150 / 62 / NA / NA / NA / 125 (58.96) / 87 (58) / 38 (61.29) / Premature ventricular beats / Fried Glycyrrhizae uralensisdecoction plus propafenone versus propafenone / 8 / Effective response; number of premature beats during 24h / 2
Liu YF, et al. 2014 [17] / 115 / 104 / NA / NA / NA / 107 (48.86) / 60 (52.17) / 47 (45.19) / Bradycardia (sick-sinus syndrome; atrioventricular block; chronic bifascicular and trifascicular block;bradycardia-tachycardia syndrome) / Shensongyangxin capsules versus placebo / 4 / Effective response / 5
Zhao WX, et al. 2009 [59] / 76 / 62 / 58.23 / 58.53 / 57.86 / 80 (57.97) / 42 (55.26) / 38 (61.29) / Paroxysmal atrial fibrillation / Yangxue fumai decoction plus propafenone versus propafenone / 4 / Effective response / 2
Fu HB, et al. 2013 [60] / 56 / 56 / 54.9 / 55.6 / 54.2 / 41 (36.61) / 20 (35.71) / 21 (37.5) / Premature ventricular beats / Wenxin granulesversus propafenone / 8 / Effective response / 2
He XP, et al. 2004 [64] / 110 / 70 / 43.17 / 42 / 45 / 94 (52.22) / 56 (50.91) / 38 (54.29) / Premature ventricular or atrial beats / Jianxin pinglu pillsversus amiodarone / 4 / Effective response; / 2
Liang BW, et al. 2005 [65] / 92 / 88 / NA / NA / NA / 70 (38.89) / 38 (41.30) / 32 (36.36) / Premature ventricular or atrial beats; atrial fibrillation / Huangyangning versus propafenone / 4 / Effective response / 2
Liu Y, et al. 2013 [57] / 56 / 60 / 71.5 / 71.54 / 71.47 / 67 (57.76) / 32 (57.14) / 35 (58.33) / Premature ventricular bearts / Shensongyangxin capsulesversus bisoprolol / 8 / Effective response / 3
Mao CL, et al. 1998 [66] / 90 / 90 / 71.8 / 73.63 / 69.97 / 78 (43.33) / 30 (33.33) / 48(53.33) / Premature ventricular beats / Decoction of bupleurum root plus longmuversus Western medicine / 8 / Effective response / 2
Niu TF, et al. 2000 [67] / 200 / 100 / 50.17 / 50.7 / 49.1 / 167 (55.67) / 113 (56.5) / 54 (54) / Premature ventricular beats / Anfuer capsulesversus mexiletine / 4 / Effective response / 2
Sun G, et al. 2005 [61] / 126 / 83 / 48.69 / 49.6 / 47.3 / 106 (50.72) / 64 (50.79) / 42 (50.60) / Premature ventricular beats / Wenxin granulesversus propafenone / 4 / Effective response / 2
Wang FJ, et al. 2005 [62] / 50 / 50 / 39 / 39 / 39 / 39 (39) / 21 (42) / 18 (36) / Premature ventricular or atrial beats / Wenxin granulesplus oryzanol versus propafenone / 4 / Effective response / 2
Xue CL, et al. 2004 [68] / 100 / 100 / NA / NA / NA / 121 (60.5) / 60 (60) / 61 (61) / Premature ventricular beats / Dingxin granulesversus mexiletine / 4 / Effective response / 2
Yu SY, et al. 2004 [63] / 75 / 70 / NA / NA / NA / NA / NA / NA / Premature ventricular or atrial beats / Wenxin granules versus mexiletine / 4 / Effective response; number of premature beats during 24h / 2
Zou JG, et al. 2011 [16] / 387 / 382 / 54.16 / 54.2 / 54.12 / NA / NA / NA / Premature ventricular beats / Shensongyangxin capsulesversus placebo (non-organic heart disease); Shensongyangxin capsulesversus mexiletine (organic heart disease) / 8 / Effective response; number of premature beats during 24h / 5
Gong FS. 2011 [75] / 60 / 60 / 57.2 / 57.6 / 56.8 / 69 (57.5) / 35 (58.33) / 34 (56.67) / Chronic congestive heart failure / Qiangxin kangshuai decoction plus WM versus WM / 8 / Effective response; LVEF / 2
He MC. 2007 [73] / 62 / 58 / NA / NA / NA / 77 (64.17) / 41 (66.13) / 36 (62.07) / Chronic systolic heart failure / Ningxin formulaplus WM versus WM / 6 / Effective response; LVEF; 6MWD / 2
Li XL, et al. 2013 [18] / 244 / 247 / 57.25 / 56.98 / 57.53 / 75.36 / 182 (74.59) / 188 (76.11) / Chronic heart failure / Qili qiangxin capsules plus WM versus placeboplus WM / 12 / NYHA functional classification; LVEF;6MWD; reduction in NT-proBNP / 5
Li XM, et al. 2009 [70] / 54 / 54 / 73.01 / 72.61 / 73.41 / 62 (57.41) / 30 (55.56) / 32 (59.26) / Chronic systolic heart failure / Shenmai injection plusastragalus injection plus WM versus WM / 8 / Effective response; LVEF / 2
Ni WB, et al. 2006 [71] / 60 / 60 / NA / NA / NA / NA / NA / NA / Chronic systolic heart failure / Lixin decoction plus WM versus WM / 12 / Effective response; LVEF / 2
Qin CL, et al. 2013 [76] / 118 / 115 / 60.7 / 60.6 / 60.8 / 132 (56.65) / 67 (56.78) / 65 (56.52) / Chronic congestive heart failure / Qianglixin capsulesplus WM versus WM / 6 / Effective response; LVEF; E/A / 2
Sun XD. 2013 [69] / 60 / 60 / 69.35 / 69.74 / 68.95 / 73 (60.83) / 36 (60) / 37 (61.67) / Congestive heart failure / TCM formula plus WM versus WM / 24 / Effective response; LVEF / 3
Tan WM. 2012 [77] / 125 / 125 / 63 / NA / NA / 146 (58.4) / NA / NA / Chronic heart failure / Shenqi yangxin decoction plus WM versus WM / 8 / Effective response; LVEF; E/A / 2
Tian XT, et al. 2008 [78] / 60 / 60 / 48.24 / 48.62 / 47.86 / 73 (60.83) / 36 (60) / 37 (61.67) / Chronic heart failure / Shengmai powder plus WM versus WM / 4 / Effective response; LVEF / 2
Yang QH, et al. 2012 [79] / 50 / 50 / 65.05 / 65.3 / 64.8 / 55 (55) / 27 (54) / 28 (56) / Chronic heart failure / Modified baoyuan decoctionplus WM versus WM / 4 / Effective response; LVEF / 2
Zhang GH. 2010 [72] / 65 / 63 / NA / NA / NA / 85 (66.41) / 44 (67.69) / 41 (65.08) / Chronic heart failure / TCM decoction plus WM versus WM / 8 / Effective response; LVEF; BNP / 2
Zhang JH, et al. 2005 [80] / 100 / 82 / 66.83 / 67.10 / 66.51 / 114 (62.64) / 62 (62) / 52 (63.41) / Chronic heart failure / Xinshuai decoction plus WM versus WM / 4 / Effective response; LVEF / 2
Zhang Y, et al. 2013 [74] / 76 / 76 / 66.25 / 67.2 / 65.3 / 110 (72.37) / 57 (75) / 53 (69.74) / Chronic congestive heart failure / Qili qiangxin capsules plus WM versus WM / 12 / Effective response; LVEF;6MWD / 2

BNP, B-type natriuretic peptide; DBP,diastolic blood pressure;E/A,ratio of early to late left ventricular filling velocity; LVEF, left ventricular ejection fraction; 6MWD, 6-minute walking distance; NA, not available;NT-proBNP, N-terminal pro–B-type natriuretic peptide; SBP, systolic blood pressure;TCM, Traditional Chinese medication; WM, Western medication.